Publications by authors named "Mariella Filbin"

28Publications

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.

Cell 2020 Nov 20. Epub 2020 Nov 20.

Department of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada; Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada; Department of Pediatrics, McGill University, and The Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.11.012DOI Listing
November 2020

Trametinib for the treatment of recurrent/progressive pediatric low-grade glioma.

J Neurooncol 2020 Sep 11;149(2):253-262. Epub 2020 Aug 11.

Dana-Farber Cancer Institute, Boston Children's Cancer and Blood Disorder Center, 450 Brookline Ave, Boston, MA, 02215-5450, USA.

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http://dx.doi.org/10.1007/s11060-020-03592-8DOI Listing
September 2020

Into Thin Air: Hypoxia Drives Metabolic and Epigenomic Deregulation of Lethal Pediatric Ependymoma.

Dev Cell 2020 Jul;54(2):134-136

Department of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2020.06.020DOI Listing
July 2020

The growing role of epigenetics in childhood cancers.

Curr Opin Pediatr 2020 02;32(1):67-75

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Broad Institute of Harvard and MIT, Cambridge, MA.

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http://dx.doi.org/10.1097/MOP.0000000000000867DOI Listing
February 2020

Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG.

Cancer Cell 2019 11 17;36(5):528-544.e10. Epub 2019 Oct 17.

Division of Newborn Medicine and Epigenetics Program, Department of Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.09.005DOI Listing
November 2019

Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State.

Mol Cell 2019 12 3;76(6):965-980.e12. Epub 2019 Oct 3.

Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104854PMC
December 2019

Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements.

Cell 2019 09;179(1):251-267.e24

Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Center for Neural Sciences in Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934691PMC
September 2019

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma.

Cell 2019 08 18;178(4):835-849.e21. Epub 2019 Jul 18.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703186PMC
August 2019

Developmental origins and emerging therapeutic opportunities for childhood cancer.

Nat Med 2019 03 6;25(3):367-376. Epub 2019 Mar 6.

Department of Neurology, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1038/s41591-019-0383-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631320PMC
March 2019

Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma.

Acta Neuropathol Commun 2018 06 28;6(1):51. Epub 2018 Jun 28.

Department of Neurology, Stanford University, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1186/s40478-018-0553-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022714PMC
June 2018

Gliomas in Children.

Semin Neurol 2018 02 16;38(1):121-130. Epub 2018 Mar 16.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1055/s-0038-1635106DOI Listing
February 2018

Molecular pathogenesis and therapeutic implications in pediatric high-grade gliomas.

Pharmacol Ther 2018 02 19;182:70-79. Epub 2017 Aug 19.

Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01637258173021
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http://dx.doi.org/10.1016/j.pharmthera.2017.08.006DOI Listing
February 2018

Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors.

Neuro Oncol 2017 Jul;19(7):986-996

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Department of Pathology, Department of Radiology, Department of Neurosurgery, Boston Children's Hospital, Boston, Massachusetts; Department of Medical Oncology, Oncologic Pathology, Department of Pediatric Oncology, Department of Cancer Biology, Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Pathology, Department of Neurosurgery, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts; Pratiti Bandopadhayay, Broad Institute of MIT and Harvard, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/now294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570190PMC
July 2017

Gliomas Genomics and Epigenomics: Arriving at the Start and Knowing It for the First Time.

Annu Rev Pathol 2016 05 2;11:497-521. Epub 2016 Mar 2.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; email:

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http://dx.doi.org/10.1146/annurev-pathol-012615-044208DOI Listing
May 2016

Of Brains and Blood: Developmental Origins of Glioma Diversity?

Cancer Cell 2015 Oct;28(4):403-404

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.09.013DOI Listing
October 2015

How neuronal activity regulates glioma cell proliferation.

Neuro Oncol 2015 Dec 10;17(12):1543-4. Epub 2015 Sep 10.

Departments of Cancer Biology and Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (M.G.F., R.A.S.).

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https://academic.oup.com/neuro-oncology/article-lookup/doi/1
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http://dx.doi.org/10.1093/neuonc/nov188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633934PMC
December 2015

Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.

Nat Med 2013 Nov 29;19(11):1518-23. Epub 2013 Sep 29.

1] Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Pediatric Oncology, Dana-Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA. [4] Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1038/nm.3328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923315PMC
November 2013