Marie-Cecile Le Deley

Marie-Cecile Le Deley

UNVERIFIED PROFILE

Are you Marie-Cecile Le Deley?   Register this Author

Register author
Marie-Cecile Le Deley

Marie-Cecile Le Deley

Publications by authors named "Marie-Cecile Le Deley"

Are you Marie-Cecile Le Deley?   Register this Author

85Publications

3343Reads

18Profile Views

Group sequential adaptive designs in series of time-to-event randomised trials in rare diseases: A simulation study.

Stat Methods Med Res 2019 Jul 29:962280219862313. Epub 2019 Jul 29.

1 Service de Biostatistique et d'Épidémiologie, Gustave Roussy, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0962280219862313DOI Listing
July 2019

Variations in the breast reconstruction rate in France: A nationwide study of 19,466 patients based on the French medico-administrative database.

Breast 2018 Dec 6;42:74-80. Epub 2018 Aug 6.

Biostatistical and Epidemiological Division, Institut Gustave Roussy, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.breast.2018.07.009DOI Listing
December 2018

High-Dose Chemotherapy and Blood Autologous Stem-Cell Rescue Compared With Standard Chemotherapy in Localized High-Risk Ewing Sarcoma: Results of Euro-E.W.I.N.G.99 and Ewing-2008.

J Clin Oncol 2018 Sep 6:JCO2018782516. Epub 2018 Sep 6.

Jeremy Whelan, University College Hospital; Ian Judson, Institute of Cancer Research, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Bruce Morland, Birmingham Children's Hospital; Keith Wheatley, University of Birmingham, Birmingham; Ian Lewis, Leeds Community Healthcare National Health Service Trust, Leeds; Alan Craft, Newcastle University, Newcastle upon Tyne, United Kingdom; Marie-Cecile Le Deley and Cyril Lervat, Centre Oscar Lambret, Lille; Gwénaël Le Teuff, Nathalie Gaspar, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Jean-Yves Blay, Centre Léon Bérard; Perrine Marec-Berard, Institute of Pediatric Onco-Haematology, Lyon; Marie-Pierre Castex, Centre Hospitalier Universitaire de Toulouse, Toulouse; Jean-Claude Gentet, Centre Hospitalier Universitaire La Timone, Marseille; Marta Jimenez, Unicancer; Valerie Laurence and Jean Michon, Institut Curie, Paris; France; Uta Dirksen, Sebastian Bauer, Andreas Ranft, University Hospital Essen, Essen; Susanne Amler, Institut für Biometrie und Klinische Forschung; Wolfgang Hartmann and Heribert Juergens, Universitätsklinikum, Münster, Münster; Stefan Bielack, Klinikum Stuttgart, Stuttgart; Stefan Burdach, Comprehensive Cancer Center, München; Dagmar Dilloo, University-Clinic Bonn, Bonn; Angelika Eggert, Charité University; Peter Reichardt, HELIOS Klinikum Berlin-Buch, Berlin; Wolf-Achim Hassenpflug, University Medical Center Hamburg-Eppendorf, Hamburg; Thomas Klingebiel, Childrens University Hospital, Frankfurt; Udo Kontny, University Medical Center Aachen, Aachen; Michael Paulussen, Children's and Adolescents' Hospital, Datteln; Germany; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Hans Gelderblom, Leiden University Medical Center, Leiden; Hendrik van den Berg, University of Amsterdam, Amsterdam, the Netherlands; Lars Hjorth, Skane University Hospital, Lund, Sweden; Jarmila Kruseova, Faculty Hospital Motol Prague, Prague, Czech Republic; Ruth Ladenstein, St Anna Children's Hospital and Children's Cancer Research Institute, Vienna, Austria; Sandrine Marreaud, European Organisation for Research and Treatment of Cancer, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://ascopubs.org/doi/10.1200/JCO.2018.78.2516
Publisher Site
http://dx.doi.org/10.1200/JCO.2018.78.2516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209090PMC
September 2018

Efficacy and safety of regorafenib compared to placebo and to post-cross-over regorafenib in advanced non-adipocytic soft tissue sarcoma.

Eur J Cancer 2018 08 11;99:28-36. Epub 2018 Jun 11.

Department of Clinical Research and Innovation, Centre Oscar Lambret, 3 rue Combemale, 59000 Lille, France; Paris-Saclay University, Univ. Paris-Sud, CESP, INSERM, Gustave Roussy, 94805 Villejuif, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2018.05.008DOI Listing
August 2018

Phase II, Open-Label, Randomized, Multicenter Trial (HERBY) of Bevacizumab in Pediatric Patients With Newly Diagnosed High-Grade Glioma.

J Clin Oncol 2018 04 7;36(10):951-958. Epub 2018 Feb 7.

Jacques Grill, Marie-Cécile Le Deley, and Gilles Vassal, Institut Gustave-Roussy, Villejuif; Marie-Cécile Le Deley, Paris-Saclay and Paris-Sud Universities, CESP, Institut National de la Santé et de la Recherche Médicale, Orsay; Pascale Varlet, Sainte-Anne Hospital, Paris, France; Maura Massimino, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milan; Felice Giangaspero, Sapienza University, Rome; Felice Giangaspero, IRCCS Neuromed, Pozzilli, Italy; Eric Bouffet, Hospital for Sick Children, Toronto, Ontario, Canada; Amedeo A. Azizi, Medical University of Vienna, Vienna, Austria; Geoffrey McCowage, Australasian Children's Cancer Trials, Clayton, Victoria, Australia; Adela Cañete, Hospital La Fe, Valencia, Spain; Frank Saran, The Royal Marsden Hospital; Chris Jones, The Institute of Cancer Research; Darren Hargrave, Great Ormond Street Hospital, London; Paul S. Morgan and Tim Jaspan, Nottingham University Hospitals, Queen's Medical Centre, Nottingham, United Kingdom; Helen Smith, Josep Garcia, Markus C. Elze, and Lauren Abrey, F. Hoffmann-La Roche Ltd, Basel, Switzerland; and Raphaël F. Rousseau, Gritstone Oncology, Emeryville, CA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2017.76.0611DOI Listing
April 2018

RECIST response and variation of circulating tumour cells in phase 1 trials: A prospective multicentric study.

Eur J Cancer 2017 09 22;83:185-193. Epub 2017 Jul 22.

Drug Development Department (DITEP), Gustave Roussy, 94805, Villejuif, France; Université Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Orsay, 91405, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2017.05.016DOI Listing
September 2017

Phase-II trials in osteosarcoma recurrences: A systematic review of past experience.

Eur J Cancer 2017 04 20;75:98-108. Epub 2017 Feb 20.

Department of Oncology for Child and Adolescents, Institut Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2017.01.005DOI Listing
April 2017

Bayesian survival analysis in clinical trials: What methods are used in practice?

Clin Trials 2017 Feb 11;14(1):78-87. Epub 2016 Oct 11.

3 Medical and Pharmaceutical Statistics Research Unit, Department of Mathematics and Statistics, Fylde College, Lancaster University, Lancaster, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1740774516673362DOI Listing
February 2017

New insights into the evaluation of randomized controlled trials for rare diseases over a long-term research horizon: a simulation study.

Stat Med 2016 08 30;35(19):3245-58. Epub 2016 Mar 30.

Biostatistics and Epidemiology Unit, Gustave Roussy, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/sim.6942DOI Listing
August 2016

Can postoperative radiotherapy be omitted in localised standard-risk Ewing sarcoma? An observational study of the Euro-E.W.I.N.G group.

Eur J Cancer 2016 07 10;61:128-36. Epub 2016 May 10.

Biostatistics Unit, Gustave Roussy, Villejuif, France; CESP Centre for Research in Epidemiology and Population Health, INSERM U1018, Team-2, Paris-Sud University, Villejuif, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2016.03.075DOI Listing
July 2016

Circulating Cell-Free Tumor DNA Analysis of 50 Genes by Next-Generation Sequencing in the Prospective MOSCATO Trial.

Clin Cancer Res 2016 06 12;22(12):2960-8. Epub 2016 Jan 12.

Laboratoire de Recherche Translationnelle et Centre de RessourcesBiologiques, AMMICA, INSERM US23/CNRS UMS3655, Gustave Roussy, Villejuif, France. INSERM U981, Gustave Roussy, Villejuif, France. Département de Biologie et Pathologie Médicales, Gustave Roussy, Villejuif, France. Faculté de Pharmacie, Université Paris Sud, Châtenay-Malabry, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-15-2470DOI Listing
June 2016

Equal access to innovative therapies and precision cancer care.

Nat Rev Clin Oncol 2016 06 22;13(6):385-93. Epub 2016 Mar 22.

Gustave Roussy, 114 rue Edouard Vaillant, F-94805, Villejuif, France and University Paris-SUD, Faculté de Médecine, 63 Rue Gabriel Péri, F-94270 Le Kremlin Bicêtre, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrclinonc.2016.31DOI Listing
June 2016

Primary cutaneous and subcutaneous Ewing sarcoma.

Pediatr Blood Cancer 2015 Sep 20;62(9):1555-61. Epub 2015 Apr 20.

MD, Pediatric and Adolescent Oncology, Gustave Roussy, 114 Rue Eduard Vaillant, 94805, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.25535DOI Listing
September 2015

Ewing Sarcoma: Current Management and Future Approaches Through Collaboration.

J Clin Oncol 2015 Sep 24;33(27):3036-46. Epub 2015 Aug 24.

Nathalie Gaspar, Marie-Cecile Le Deley, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Nathalie Gaspar, Marie-Cecile Le Deley, Line Claude, Olivier Delattre, Jean Michon, Perrine Marec-Bérard, and Odile Oberlin, Société Française de Lutte Contre les Cancers et les Leucémies de l'Enfant et de l'Adolescent; Marie-Cecile Le Deley, Paris-Sud University, Le Kremlin-Bicêtre; Line Claude and Perrine Marec-Bérard, Centre Léon-Bérard, Lyon; Olivier Delattre and Jean Michon, Institut Curie, Paris, France; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Douglas S. Hawkins, Mark L. Bernstein, and Richard B. Womer, Children's Oncology Group; Uta Dirksen and Heribert Juergens, University Hospital Münster, Münster; Uta Dirksen, Michael Paulussen, and Heribert Juergens, Gesellschaft für Pädiatrische Onkologie und Hämatologie; Michael Paulussen, Children's and Adolescents' Hospital, Witten/Herdecke University, Datteln, Germany; Ian J. Lewis, Alder Hey Children's National Health Service (NHS) Foundation Trust, Liverpool; Ian J. Lewis, Robert Grimer, Bernadette Brennan, and Alan W. Craft, Children's Cancer and Leukaemia Group; Robert Grimer, Royal Orthopaedic Hospital, Birmingham; Jeremy Whelan, University College London Hospital NHS Foundation Trust; Ian Judson, Royal Marsden Hospital, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Alan W. Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Stefano Ferrari and Piero Picci, Rizzoli Institute, Bologna; Stefano Ferrari, Piero Picci, Roberto Luksch, Italian Sarcoma Group; Roberto Luksch, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy; Heinrich Kovar and Ruth Ladenstein, Children's Cancer Institute, St Anna Kinderkrebsforschung, Wien; Heinrich Kovar and Ruth Ladenstein, Arbeitsgemeinschaft Ambulant Tätiger Pädiatrischer Onkologen und Hämatologen, Vienna, Austria; Jeremy Whelan and Ian Judson, European O

View Article

Download full-text PDF

Source
http://jco.ascopubs.org/content/33/27/3036.full.pdf
Web Search
http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.59.5256
Publisher Site
http://dx.doi.org/10.1200/JCO.2014.59.5256DOI Listing
September 2015

Non-Hodgkin Lymphoma in Children and Adolescents: Progress Through Effective Collaboration, Current Knowledge, and Challenges Ahead.

J Clin Oncol 2015 Sep 24;33(27):2963-74. Epub 2015 Aug 24.

Véronique Minard-Colin, Laurence Brugières, Anne Auperin, Marie-Cécile Le Deley, and Catherine Patte, Institut Gustave Roussy, Villejuif; Martine Raphael, Centre National de la Recherche Scientifique UMR 8126, Université Paris Sud; Elizabeth Macintyre, Université Paris Descartes Sorbonne Cité, Institut Necker-Enfants Malades, Institut National de Recherche Médicale U1151, and Assistance Publique-Hôpitaux de Paris, Hôpital Necker Enfants-Malades, Paris; Laurence Lamant, Institut Universitaire du Cancer Toulouse Oncopole and Université Paul-Sabatier, Toulouse, France; Alfred Reiter, Wilhelm Woessmann, and Christine Damm-Welk, Justus-Liebig-University Giessen, Giessen; Birgit Burkhardt, Children University Hospital, Münster; Martin Zimmerman, Medizinische Hochschule, Hannover; Wolfram Klapper, Christian-Albrechts-University Kiel, Kiel, Germany; Mitchell S. Cairo, New York Medical College, Valhalla, NY; Thomas G. Gross, National Cancer Institute, Bethesda, MD; John T. Sandlund, St Jude Children's Research Hospital and University of Tennessee Health Science Center, College of Medicine, Memphis, TN; Sherrie L. Perkins, University of Utah Health Sciences, Salt Lake City, UT; Denise Williams, Cambridge University Hospitals Foundation Trust, Cambridge, United Kingdom; Marta Pillon and Angelo Rosolen, University of Padova, Padova; Lara Mussolin, Istituto di Ricerca Pediatrico-Fondazione Cittàdella Speranza and University of Padua, Padua, Italy; Keizo Horibe, National Hospital Organization Nagoya Medical Center, Nagoya, Japan; and Hélène A. Poirel, Center for Human Genetics, Cliniques Universitaires Saint-Luc-Université Catholique de Louvain, Belgium, Brussels.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2014.59.5827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979194PMC
September 2015

Overexpression of smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma.

Clin Cancer Res 2014 Oct 8;20(19):5097-112. Epub 2014 Aug 8.

INSERM, UMR 957, Equipe labellisée Ligue contre le Cancer 2012, Nantes, France. Université de Nantes, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, France. CHU Hôtel Dieu, Nantes, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-13-3191DOI Listing
October 2014

Cyclophosphamide compared with ifosfamide in consolidation treatment of standard-risk Ewing sarcoma: results of the randomized noninferiority Euro-EWING99-R1 trial.

J Clin Oncol 2014 Aug 30;32(23):2440-8. Epub 2014 Jun 30.

Odile Oberlin, Gustave Roussy Institute, Villejuif; Marie-Cécile Le Deley, Université Paris-Sud, Le Kremlin-Bicêtre; Jean Michon, Institut Curie, Paris; Perrine Marec-Bérard, Centre Léon-Bérard, Lyon, France; Michael Paulussen, Vestische Kinder-und Jugendklinik Datteln, Witten/Herdecke University, Datteln; Andreas Ranft, Heribert Juergens, and Uta Dirksen, University Hospital Münster, Münster, Germany; Ian Lewis, Alder Hey Children's National Health Service Foundation Trust, Liverpool; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Jeremy Whelan, University College London Hospital National Health Service Foundation Trust; Ian Judson, The Royal Marsden Hospital, London; Keith Wheatley, University of Birmingham, Birmingham; Alan Craft, Royal Victoria Infirmary, Newcastle, United Kingdom; Ruth Ladenstein, St Anna Children's Cancer Research Institute, Vienna, Austria; Henk van den Berg, Emma Children Hospital AMC, Amsterdam, the Netherlands; and Lars Hjorth, Skåne University Hospital, Lund University, Lund, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2013.54.4833DOI Listing
August 2014

Paediatric anaplastic large cell lymphoma with leukaemic presentation in children: a report of nine French cases.

Br J Haematol 2014 May 14;165(4):545-51. Epub 2014 Feb 14.

CHU de Strasbourg, Service d'hématologie oncologie pédiatrique, pédiatrie 3, Hopital Hautepierre, Strasbourg, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjh.12777DOI Listing
May 2014

Central nervous system involvement in anaplastic large cell lymphoma in childhood: results from a multicentre European and Japanese study.

Pediatr Blood Cancer 2013 Oct 29;60(10):E118-21. Epub 2013 May 29.

Department of Pediatric Oncology, Cambridge University Hospital NHS Trust, Cambridge, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.24591DOI Listing
October 2013

Dose-finding designs using a novel quasi-continuous endpoint for multiple toxicities.

Stat Med 2013 Jul 21;32(16):2728-46. Epub 2013 Jan 21.

Biostatistics Department, Institut Gustave-Roussy, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/sim.5737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813987PMC
July 2013

New drugs for children and adolescents with cancer: the need for novel development pathways.

Lancet Oncol 2013 Mar 20;14(3):e117-24. Epub 2013 Feb 20.

Division of Clinical Research, Institut Gustave Roussy, Paris-Sud University, Paris, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(13)70013-5DOI Listing
March 2013

Prognostic value of circulating VEGFR2+ bone marrow-derived progenitor cells in patients with advanced cancer.

Eur J Cancer 2012 Jun 25;48(9):1354-62. Epub 2012 Feb 25.

Department of Medicine, Institut de Cancérologie Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2012.01.021DOI Listing
June 2012

Taking the long view: how to design a series of Phase III trials to maximize cumulative therapeutic benefit.

Clin Trials 2012 Jun 8;9(3):283-92. Epub 2012 May 8.

Department of Biostatistics, Institut Gustave-Roussy, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1740774512443430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904223PMC
June 2012

Safety assessment of intensive induction therapy in childhood anaplastic large cell lymphoma: report of the ALCL99 randomised trial.

Pediatr Blood Cancer 2011 Jul 28;56(7):1071-7. Epub 2011 Jan 28.

Department of Pediatric Bone Marrow Transplantation, Oncology and Haematology, Medical University of Wroclaw, Wroclaw, Poland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.22940DOI Listing
July 2011

Effect of a misspecification of response rates on type I and type II errors, in a phase II Simon design.

Eur J Cancer 2011 Jul 13;47(11):1647-52. Epub 2011 Apr 13.

Service de Biostatistique et d'Épidémiologie, Institut Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2011.03.013DOI Listing
July 2011

Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial.

J Clin Oncol 2010 Jul 14;28(20):3284-91. Epub 2010 Jun 14.

St Anna Children's Hospital, SIRP-CCRI Studies and Statistics on Integrated Research and Projects, Children's Cancer Research Institute, Vienna, Austria.

View Article

Download full-text PDF

Source
http://ascopubs.org/doi/10.1200/JCO.2009.22.9864
Publisher Site
http://dx.doi.org/10.1200/JCO.2009.22.9864DOI Listing
July 2010

Operating characteristics of two independent sample design in phase I trials in paediatric oncology.

Eur J Cancer 2010 May 20;46(8):1392-8. Epub 2010 Feb 20.

Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2010.01.024DOI Listing
May 2010

Role of radiotherapy and chemotherapy in the risk of secondary leukaemia after a solid tumour in childhood.

Eur J Cancer 2006 Nov 11;42(16):2757-64. Epub 2006 Sep 11.

National Institute of Public Health and Medical Research (INSERM) Unit 605, Institut Gustave-Roussy, rue Camille Desmoulins, 94805 Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2006.05.034DOI Listing
November 2006

[Neoadjuvant treatment in osteosarcomas].

Bull Cancer 2006 Nov;93(11):1115-20

Département de cancérologie de l'enfant et de l'adolescent, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex.

View Article

Download full-text PDF

Source
November 2006

High cumulative rate of secondary leukemia after continuous etoposide treatment for solid tumors in children and young adults.

Pediatr Blood Cancer 2005 Jul;45(1):25-31

Biostatistics and Epidemiology Unit, Institut Gustave-Roussy, 94805 Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.20380DOI Listing
July 2005