Publications by authors named "Marie Migaud"

55Publications

Dihydronicotinamide riboside promotes cell-specific cytotoxicity by tipping the balance between metabolic regulation and oxidative stress.

PLoS One 2020 9;15(11):e0242174. Epub 2020 Nov 9.

Department of Physiology and Cell Biology, University of South Alabama College of Medicine, Mobile, AL, United States of America.

View Article and Find Full Text PDF
January 2021

SLC25A51 is a mammalian mitochondrial NAD transporter.

Nature 2020 12 9;588(7836):174-179. Epub 2020 Sep 9.

Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article and Find Full Text PDF
December 2020

Reply to: Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter.

Nat Metab 2019 07 12;1(7):662-665. Epub 2019 Jul 12.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.

View Article and Find Full Text PDF
July 2019

Nicotinamide riboside-amino acid conjugates that are stable to purine nucleoside phosphorylase.

Org Biomol Chem 2020 04;18(15):2877-2885

Mitchell Cancer Institute, Department of Pharmacology, University of South Alabama, 1660 Springhill Avenue, Mobile, AL 36693, USA.

View Article and Find Full Text PDF
April 2020

A reduced form of nicotinamide riboside defines a new path for NAD biosynthesis and acts as an orally bioavailable NAD precursor.

Mol Metab 2019 12 3;30:192-202. Epub 2019 Oct 3.

Nestlé Institute of Health Sciences, Nestlé Research, EPFL Innovation Park, 1015, Lausanne, Switzerland; School of Life Sciences, EPFL, Lausanne, 1015, Switzerland. Electronic address:

View Article and Find Full Text PDF
December 2019

Alginate/Chitosan Particle-Based Drug Delivery Systems for Pulmonary Applications.

Pharmaceutics 2019 Aug 2;11(8). Epub 2019 Aug 2.

School of Pharmacy, Queen's University Belfast Queen's University Belfast, Belfast BT7 1NN, UK.

View Article and Find Full Text PDF
August 2019

Dihydroxyacetone Exposure Alters NAD(P)H and Induces Mitochondrial Stress and Autophagy in HEK293T Cells.

Chem Res Toxicol 2019 08 2;32(8):1722-1731. Epub 2019 Aug 2.

Department of Physiology and Cell Biology , University of South Alabama College of Medicine , Mobile , Alabama 36688 , United States.

View Article and Find Full Text PDF
August 2019

Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT.

J Funct Biomater 2019 Jun 13;10(2). Epub 2019 Jun 13.

School of Pharmacy, Queen's University Belfast, Belfast BT7 1NN, UK.

View Article and Find Full Text PDF
June 2019

Slc12a8 is a nicotinamide mononucleotide transporter.

Nat Metab 2019 01 7;1(1):47-57. Epub 2019 Jan 7.

Department of Developmental Biology, Washington University School of Medicine,, St. Louis, MO 63110, USA.

View Article and Find Full Text PDF
January 2019

Syntheses and chemical properties of β-nicotinamide riboside and its analogues and derivatives.

Beilstein J Org Chem 2019 13;15:401-430. Epub 2019 Feb 13.

Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Ave., Mobile, AL 36604, USA.

View Article and Find Full Text PDF
February 2019

The chemistry of the vitamin B3 metabolome.

Biochem Soc Trans 2019 02 17;47(1):131-147. Epub 2018 Dec 17.

Mitchell Cancer Institute, University of South Alabama, 1660 Springhill Ave, Mobile 36604, AL, U.S.A.

View Article and Find Full Text PDF
February 2019

Pharmacological bypass of NAD salvage pathway protects neurons from chemotherapy-induced degeneration.

Proc Natl Acad Sci U S A 2018 10 26;115(42):10654-10659. Epub 2018 Sep 26.

Vollum Institute, Oregon Health & Science University, Portland, OR 97239;

View Article and Find Full Text PDF
October 2018

Nicotinamide adenine dinucleotide is transported into mammalian mitochondria.

Elife 2018 06 12;7. Epub 2018 Jun 12.

Department of Physiology, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.

View Article and Find Full Text PDF
June 2018

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.

Cell Metab 2018 May;27(5):1067-1080.e5

Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA; Department of Chemistry, Princeton University, Princeton, NJ 08540, USA; Diabetes Research Center, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

View Article and Find Full Text PDF
May 2018

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells.

Mol Metab 2017 08 29;6(8):819-832. Epub 2017 May 29.

Institute of Metabolism and Systems Research, 2nd Floor IBR Tower, University of Birmingham, Birmingham, B15 2TT, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, B15 2TH, UK. Electronic address:

View Article and Find Full Text PDF
August 2017

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.

Cell Metab 2016 12 27;24(6):795-806. Epub 2016 Oct 27.

Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

View Article and Find Full Text PDF
December 2016

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans.

Nat Commun 2016 10 10;7:12948. Epub 2016 Oct 10.

Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.

View Article and Find Full Text PDF
October 2016

Metabolomic profiling to dissect the role of visceral fat in cardiometabolic health.

Obesity (Silver Spring) 2016 06 30;24(6):1380-8. Epub 2016 Apr 30.

Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.

View Article and Find Full Text PDF
June 2016

Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk.

J Nutr 2016 05 6;146(5):957-63. Epub 2016 Apr 6.

Department of Biochemistry, Carver College of Medicine, Interdisciplinary Graduate Program in Genetics, and

View Article and Find Full Text PDF
May 2016

Derivatisable Cyanobactin Analogues: A Semisynthetic Approach.

Chembiochem 2015 Dec 10;16(18):2646-50. Epub 2015 Nov 10.

Biomedical Sciences Research Complex, University of St. Andrews, North Haugh, St. Andrews, KY16 9ST, UK.

View Article and Find Full Text PDF
December 2015

Generation, Release, and Uptake of the NAD Precursor Nicotinic Acid Riboside by Human Cells.

J Biol Chem 2015 Nov 18;290(45):27124-37. Epub 2015 Sep 18.

From Peter the Great St. Petersburg Polytechnic University, St. Petersburg 195251, Russia, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia

View Article and Find Full Text PDF
November 2015

Solventless synthesis of acyl phosphonamidates, precursors to masked bisphosphonates.

Chem Commun (Camb) 2015 Jul;51(55):11088-91

John King Laboratory, School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

View Article and Find Full Text PDF
July 2015

Facile access to new C-glycosides and C-glycoside scaffolds incorporating functionalised aromatic moieties.

Carbohydr Res 2015 Jan 11;402:25-34. Epub 2014 Nov 11.

Queen's University Belfast, School of Pharmacy, Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK; Queen's University Belfast, Centre for Cancer Research and Cell Biology, Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK. Electronic address:

View Article and Find Full Text PDF
January 2015

ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion.

Cell Rep 2014 Sep 15;8(6):1819-1831. Epub 2014 Sep 15.

Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA 15213, USA; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15213, USA. Electronic address:

View Article and Find Full Text PDF
September 2014

Synthesis of alkylcarbonate analogs of O-acetyl-ADP-ribose.

Org Biomol Chem 2013 Sep;11(34):5702-13

Institute of Experimental Botany, Academy of Sciences of Czech Republic, v.v.i., Rozvojova 263, Prague 6, 165 02, Czech Republic.

View Article and Find Full Text PDF
September 2013

The contribution of N₂O₃ to the cytotoxicity of the nitric oxide donor DETA/NO: an emerging role for S-nitrosylation.

Biosci Rep 2013 Mar 28;33(2). Epub 2013 Mar 28.

School of Pharmacy, McClay Research Centre, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, U.K.

View Article and Find Full Text PDF
March 2013

Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.

Org Biomol Chem 2012 Dec 7;10(48):9601-19. Epub 2012 Nov 7.

College of Liberal Arts and Sciences, Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, USA.

View Article and Find Full Text PDF
December 2012

Nucleoside phosphitylation using ionic liquid stabilised phosphorodiamidites and mechanochemistry.

Chem Commun (Camb) 2012 Dec;48(98):11969-71

QUILL/School of Chemistry and Chemical Engineering, Queen's University, Belfast, UK.

View Article and Find Full Text PDF
December 2012

Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside.

Bioorg Med Chem Lett 2012 Aug 28;22(16):5204-7. Epub 2012 Jun 28.

Queen's University Belfast, John King Laboratory, School of Pharmacy, Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK.

View Article and Find Full Text PDF
August 2012

Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill.

Org Biomol Chem 2011 Oct 4;9(19):6496-7. Epub 2011 Aug 4.

School of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast, Northern Ireland, UK BT9 5AG.

View Article and Find Full Text PDF
October 2011

Stable expression and purification of a functional processed Fab' fragment from a single nascent polypeptide in CHO cells expressing the mCAT-1 retroviral receptor.

J Immunol Methods 2011 Sep 19;372(1-2):30-41. Epub 2011 Jul 19.

Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Science, Queen's University of Belfast, 97 Lisburn Rd, Belfast BT9 7BL, Northern Ireland, United Kingdom.

View Article and Find Full Text PDF
September 2011

A one pot three-step process for the synthesis of an array of arylated benzimidazoribosyl nucleosides.

Org Biomol Chem 2011 Apr 4;9(8):2821-31. Epub 2011 Mar 4.

Queen's University Belfast, School of Pharmacy, Medical Biology Centre, 97 Lisburn Road, Belfast, UK BT9 7BL.

View Article and Find Full Text PDF
April 2011

ADP ribose is an endogenous ligand for the purinergic P2Y1 receptor.

Mol Cell Endocrinol 2011 Feb 19;333(1):8-19. Epub 2010 Nov 19.

Department of Clinical Science and Education, Karolinska Institutet, Research Centre, Stockholm South Hospital, Stockholm, Sweden.

View Article and Find Full Text PDF
February 2011

A stereocontrolled method for the synthesis of D- and L-2-deoxy-C-nucleosides using an intramolecular Sakurai-type cyclisation reaction.

Chem Commun (Camb) 2010 Jul 20;46(25):4538-40. Epub 2010 May 20.

Queen's University Belfast, School of Chemistry and Chemical Engineering, Belfast, BT9 5AG, UK.

View Article and Find Full Text PDF
July 2010

Analysis of betaine and choline contents of aleurone, bran, and flour fractions of wheat (Triticum aestivum L.) Using (1)H nuclear magnetic resonance (NMR) spectroscopy.

J Agric Food Chem 2009 Mar;57(5):1948-51

Institute of Agri-Food and Land Use, School of Biological Sciences, and School of Chemistry and Chemical Engineering, Queen's University, David Kier Building, Stranmillis Road, Belfast BT9 5AG, Northern Ireland.

View Article and Find Full Text PDF
March 2009

Synthesis of simple adenosine diphosphate ribose analogues.

Nucleosides Nucleotides Nucleic Acids 2008 Oct;27(10):1127-43

School of Chemistry and Chemical Engineering, Queen's University, Belfast, Northern Ireland, United Kingdom.

View Article and Find Full Text PDF
October 2008

A regio- and stereocontrolled approach to pyranosyl C-nucleoside synthesis.

Org Lett 2008 Aug 4;10(15):3323-6. Epub 2008 Jul 4.

Respiratory CEDD, Stevenage SG12NY, UK.

View Article and Find Full Text PDF
August 2008

Solvent-controlled regioselective protection of allyl-4,6-benzylidene glucopyranosides.

Beilstein J Org Chem 2007 Sep 26;3:26. Epub 2007 Sep 26.

School of Chemistry and Chemical Engineering, Stranmillis Road, Queens University, Belfast, BT9 5AG, Northern Ireland, UK.

View Article and Find Full Text PDF
September 2007

Ionic liquids--media for unique phosphorus chemistry.

Chem Commun (Camb) 2006 Jan 6(1):72-4. Epub 2005 Oct 6.

QUILL and School of Chemistry, Queens University Belfast, Belfast, Northern Ireland BT9 5AG.

View Article and Find Full Text PDF
January 2006

Isopolar phosphonate analogue of adenosine diphosphate ribose.

Org Lett 2004 Sep;6(20):3461-4

School of Chemistry, David Keir Building, Queen's University Belfast, Stranmillis Road, Belfast, BT9 5AG, Northern Ireland.

View Article and Find Full Text PDF
September 2004

Aplysia californica mediated cyclisation of novel 3'-modified NAD+ analogues: a role for hydrogen bonding in the recognition of cyclic adenosine 5'-diphosphate ribose.

Bioorg Med Chem 2004 Jan;12(2):475-87

Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK.

View Article and Find Full Text PDF
January 2004

5,5-Fused thiophene gamma-lactams as templates for serine protease inhibition.

Chem Commun (Camb) 2002 Jun(12):1274-5

Oxford Centre for Molecular Sciences, Dyson Perrins Laboratory, South Parks Road, Oxford, UK OX1 3QY.

View Article and Find Full Text PDF
June 2002