Publications by authors named "Marie Guerin"

3 Publications

  • Page 1 of 1

Did the Brain and Oral Microbiota Talk to Each Other? A Review of the Literature.

J Clin Med 2020 Nov 28;9(12). Epub 2020 Nov 28.

Department of Odontology, Tours University Hospital, 37261 Tours, France.

This systematic review aims to investigate the role of the oral microbiome in the pathophysiology of mental health disorders and to appraise the methodological quality of research of the oral-brain axis which is a growing interest area. The PRISMA guideline was adopted, to carry out an electronic search through the MEDLINE database, to identify studies that have explored the role of the oral microbiome in the pathophysiology of mental health disorders published from 2000 up to June 2020. The search resulted in 140 records; after exclusions, a total of 22 papers were included in the present review. In accordance with the role of the oral microbiome in the pathophysiology of mental disorders, four mental disorders were identified: Alzheimer's disease, dementia, and cognitive disorders; autism spectrum disorder; Down's syndrome and mental retardation; and Bipolar disorders. Studies argue for correlations between oral microbiota and Alzheimer's disease, autism spectrum disorders, Down's syndrome, and bipolar disorders. This field is still under-studied, and studies are needed to clarify the biological links and interconnections between the oral microbiota and the pathophysiology of all mental health disorders. Researchers should focus their efforts to develop research on the oral-brain axis in the future.
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http://dx.doi.org/10.3390/jcm9123876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760025PMC
November 2020

Healthcare pathway and patients' expectations in pulmonary fibrosis.

ERJ Open Res 2017 Apr 12;3(2). Epub 2017 Apr 12.

Opened Mind Health and Associates, Roubaix, France.

http://ow.ly/pidy30abNoH.
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http://dx.doi.org/10.1183/23120541.00134-2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555763PMC
April 2017

Molecular Dissection of the Interface between the Type VI Secretion TssM Cytoplasmic Domain and the TssG Baseplate Component.

J Mol Biol 2016 11 4;428(22):4424-4437. Epub 2016 Sep 4.

Laboratoire d'Ingénierie des Systèmes Macromoléculaires, Institut de Microbiologie de la Méditerranée, Aix-Marseille Université, CNRS - UMR 7255, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France. Electronic address:

The type VI secretion system (T6SS) is a multiprotein complex that catalyses toxin secretion through the bacterial cell envelope of various Gram-negative bacteria including important human pathogens. This machine uses a bacteriophage-like contractile tail to puncture the prey cell and inject harmful toxins. The T6SS tail comprises an inner tube capped by the cell-puncturing spike and wrapped by the contractile sheath. This structure is built on an assembly platform, the baseplate, which is anchored to the bacterial cell envelope by the TssJLM membrane complex (MC). This MC serves as both a tail docking station and a channel for the passage of the inner tube. The TssM transmembrane protein is a key component of the MC as it connects the inner and outer membranes. In this study, we define the TssM topology, highlighting a large but poorly studied 35-kDa cytoplasmic domain, TssM, located between two transmembrane segments. Protein-protein interaction assays further show that TssM oligomerises and makes contacts with several baseplate components. Using computer predictions, we delineate two subdomains in TssM, including a nucleotide triphosphatase (NTPase) domain, followed by a 110-aa extension. Finally, site-directed mutagenesis coupled to functional assays reveals the contribution of these subdomains and conserved motifs to the interaction with T6SS partners and to the function of the secretion apparatus.
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http://dx.doi.org/10.1016/j.jmb.2016.08.032DOI Listing
November 2016