Publications by authors named "Mariano Barbacid"

99Publications

Targeting the MAPK Pathway in KRAS-Driven Tumors.

Cancer Cell 2020 04;37(4):543-550

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2020.03.013DOI Listing
April 2020

Requirement for epithelial p38α in KRAS-driven lung tumor progression.

Proc Natl Acad Sci U S A 2020 02 22;117(5):2588-2596. Epub 2020 Jan 22.

Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology, 08028 Barcelona, Spain;

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http://dx.doi.org/10.1073/pnas.1921404117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007552PMC
February 2020

Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27.

Sci Rep 2019 12 10;9(1):18693. Epub 2019 Dec 10.

Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC, and Departmento de Biología Molecular, Universidad de Cantabria, Santander, Spain.

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http://dx.doi.org/10.1038/s41598-019-54917-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904551PMC
December 2019

Correction for Agudo-Ibáñez et al., "H-Ras Distribution and Signaling in Plasma Membrane Microdomains Are Regulated by Acylation and Deacylation Events".

Mol Cell Biol 2018 09 15;38(17). Epub 2018 Aug 15.

Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Cantabria, Departamento de Biología Molecular, Facultad de Medicina, Santander, Cantabria, Spain.

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http://dx.doi.org/10.1128/MCB.00335-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094049PMC
September 2018

Effects of a Ketogenic Diet on [F]FDG-PET Imaging in a Mouse Model of Lung Cancer.

Mol Imaging Biol 2019 04;21(2):279-285

Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Avenida de la Universidad 30, 28911, Leganés, Madrid, Spain.

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http://link.springer.com/10.1007/s11307-018-1233-8
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http://dx.doi.org/10.1007/s11307-018-1233-8DOI Listing
April 2019

ERF deletion rescues RAS deficiency in mouse embryonic stem cells.

Genes Dev 2018 04 12;32(7-8):568-576. Epub 2018 Apr 12.

Genomic Instability Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.

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http://dx.doi.org/10.1101/gad.310086.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959239PMC
April 2018

The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer.

Cell Cycle 2018 ;17(6):702-711

a Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO) , Melchor Fernández Almagro 3, Madrid , Spain.

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http://dx.doi.org/10.1080/15384101.2018.1450029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969551PMC
September 2019

Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma.

Genes Dev 2017 07 21;31(14):1456-1468. Epub 2017 Aug 21.

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.1101/gad.300244.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588927PMC
July 2017

A Braf kinase-inactive mutant induces lung adenocarcinoma.

Nature 2017 08 2;548(7666):239-243. Epub 2017 Aug 2.

Experimental Oncology, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.1038/nature23297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648056PMC
August 2017

Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets.

Cold Spring Harb Perspect Med 2018 05 1;8(5). Epub 2018 May 1.

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), E-28029 Madrid, Spain.

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http://dx.doi.org/10.1101/cshperspect.a031542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932580PMC
May 2018

KRAS-driven lung adenocarcinoma: combined DDR1/Notch inhibition as an effective therapy.

ESMO Open 2016 6;1(5):e000076. Epub 2016 Sep 6.

Experimental Oncology, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO) , Madrid , Spain.

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http://dx.doi.org/10.1136/esmoopen-2016-000076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070278PMC
September 2016

Severe Intellectual Disability and Enhanced Gamma-Aminobutyric Acidergic Synaptogenesis in a Novel Model of Rare RASopathies.

Biol Psychiatry 2017 02 27;81(3):179-192. Epub 2016 Jun 27.

Neuroscience and Mental Health Research Institute, Division of Neuroscience, School of Biosciences, Cardiff University, Cardiff, United Kingdom; Institute of Experimental Neurology, Division of Neuroscience, IRCCS-San Raffaele Scientific Institute, Milano. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2016.06.016DOI Listing
February 2017

Ras and p53: An unsuspected liaison.

Mol Cell Oncol 2016 Mar 23;3(2):e996001. Epub 2015 Jan 23.

Molecular Oncology Program; Centro Nacional de Investigaciones Oncológicas (CNIO) ; Madrid, Spain.

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http://dx.doi.org/10.1080/23723556.2014.996001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905429PMC
March 2016

Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets.

J Mol Med (Berl) 2016 Feb 3;94(2):121-35. Epub 2015 Nov 3.

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, 28029, Madrid, Spain.

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http://dx.doi.org/10.1007/s00109-015-1360-5DOI Listing
February 2016

H-ras distribution and signaling in plasma membrane microdomains are regulated by acylation and deacylation events.

Mol Cell Biol 2015 Jun 16;35(11):1898-914. Epub 2015 Mar 16.

Instituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Cantabria, Departamento de Biología Molecular, Facultad de Medicina Santander, Cantabria, Spain

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http://mcb.asm.org/content/early/2015/03/10/MCB.01398-14.ful
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http://mcb.asm.org/content/35/11/1898.full.pdf
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http://mcb.asm.org/lookup/doi/10.1128/MCB.01398-14
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http://dx.doi.org/10.1128/MCB.01398-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420920PMC
June 2015

Functional reprogramming of polyploidization in megakaryocytes.

Dev Cell 2015 Jan;32(2):155-67

Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.12.015DOI Listing
January 2015

Lentiviral-based approach for the validation of cancer therapeutic targets in vivo.

Biotechniques 2014 Oct 1;57(4):179, 181-7. Epub 2014 Oct 1.

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Spanish National Cancer Research Center, Madrid, Spain.

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http://dx.doi.org/10.2144/000114214DOI Listing
October 2014

Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts.

Cancer Res 2014 Nov 12;74(21):5978-88. Epub 2014 Sep 12.

Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. XenOPAT S.L., Business Bioincubator, Bellvitge Health Science Campus, Barcelona, Spain.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1606DOI Listing
November 2014

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

Gastroenterology 2014 Nov 12;147(5):1119-33.e4. Epub 2014 Aug 12.

Stem Cells and Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain; Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London, UK. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.08.002DOI Listing
November 2014

Ras in epidermal proliferation.

Oncotarget 2014 Jul;5(14):5194-5

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170609PMC
http://dx.doi.org/10.18632/oncotarget.2275DOI Listing
July 2014

Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors.

Mol Cell Biol 2014 Apr 10;34(8):1452-9. Epub 2014 Feb 10.

Experimental Oncology, Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01163-13
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http://dx.doi.org/10.1128/MCB.01163-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993583PMC
April 2014

Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma.

Proc Natl Acad Sci U S A 2014 Jan 23;111(1):255-60. Epub 2013 Dec 23.

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, 28029 Madrid, Spain.

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http://dx.doi.org/10.1073/pnas.1320383110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890787PMC
January 2014

Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications.

BMC Genomics 2013 Oct 25;14:731. Epub 2013 Oct 25.

Centro de Investigacion del Cancer, IBMCC (CSIC-USAL), University of Salamanca, Campus Unamuno, 37007, Salamanca, Spain.

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http://dx.doi.org/10.1186/1471-2164-14-731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007593PMC
October 2013

Genetic analysis of Ras genes in epidermal development and tumorigenesis.

Small GTPases 2013 Oct-Dec;4(4):236-41. Epub 2013 Oct 22.

Molecular Oncology Programme; Centro Nacional de Investigaciones Oncológicas (CNIO); Madrid, Spain.

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http://dx.doi.org/10.4161/sgtp.26905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011819PMC
January 2015

Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas.

PLoS One 2013 25;8(6):e66933. Epub 2013 Jun 25.

Animal Models and Cancer Laboratory, Anatomy Pathology Department, Vall d'Hebron Institut of Research-Autonomous University of Barcelona (VHIR-UAB) Barcelona, Barcelona, Spain.

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http://public-files.prbb.org/publicacions/a6060c50-ca98-0130
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http://dx.plos.org/10.1371/journal.pone.0066933
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066933PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692542PMC
February 2014

Genetically engineered mouse models of pancreatic adenocarcinoma.

Mol Oncol 2013 Apr 11;7(2):232-47. Epub 2013 Feb 11.

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernandez Almagro 3, E-28029 Madrid, Spain.

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http://doi.wiley.com/10.1016/j.molonc.2013.02.002
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http://dx.doi.org/10.1016/j.molonc.2013.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528418PMC
April 2013

Mouse models of cancer.

Mol Oncol 2013 Apr 26;7(2):143-5. Epub 2013 Feb 26.

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http://dx.doi.org/10.1016/j.molonc.2013.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528419PMC
April 2013

EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.

Cancer Cell 2012 Sep;22(3):318-30

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, E-28029 Madrid, Spain.

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http://dx.doi.org/10.1016/j.ccr.2012.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601542PMC
September 2012

Opening a new GATAway for treating KRAS-driven lung tumors.

Authors:
Mariano Barbacid

Cancer Cell 2012 May;21(5):598-600

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), E-28029 Madrid, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S15356108120017
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http://dx.doi.org/10.1016/j.ccr.2012.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854325PMC
May 2012

Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.

EMBO J 2012 May 13;31(11):2498-510. Epub 2012 Apr 13.

Experimental Oncology, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1038/emboj.2012.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365431PMC
May 2012

What we have learned about pancreatic cancer from mouse models.

Gastroenterology 2012 May 8;142(5):1079-92. Epub 2012 Mar 8.

Li Ka Shing Centre, Cambridge Research Institute, and Department of Oncology, Cancer Research UK, Cambridge, England.

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http://linkinghub.elsevier.com/retrieve/pii/S001650851200315
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http://dx.doi.org/10.1053/j.gastro.2012.03.002DOI Listing
May 2012

A pericyte origin of spinal cord scar tissue.

Science 2011 Jul;333(6039):238-42

Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1126/science.1203165DOI Listing
July 2011

c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.

Cancer Cell 2011 May 21;19(5):652-63. Epub 2011 Apr 21.

Molecular Oncology, Centro Nacional de Investigaciones Oncológicas (CNIO), E-28029 Madrid, Spain.

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http://dx.doi.org/10.1016/j.ccr.2011.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854330PMC
May 2011

Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas.

Pigment Cell Melanoma Res 2010 Oct 9;23(5):635-48. Epub 2010 Jul 9.

Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, USA.

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http://doi.wiley.com/10.1111/j.1755-148X.2010.00732.x
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http://dx.doi.org/10.1111/j.1755-148X.2010.00732.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939934PMC
October 2010

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.

Nat Struct Mol Biol 2010 Jun 30;17(6):718-25. Epub 2010 May 30.

Karolinska Institutet, Center for Biosciences, Department of Biosciences and Nutrition, Huddinge, Sweden.

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http://dx.doi.org/10.1038/nsmb.1833DOI Listing
June 2010

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.

EMBO J 2010 Mar 11;29(6):1091-104. Epub 2010 Feb 11.

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, Madrid, Spain.

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http://dx.doi.org/10.1038/emboj.2010.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845279PMC
March 2010

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

Nat Cell Biol 2010 Jan 13;12(1):54-9; sup pp 1-14. Epub 2009 Dec 13.

Department of Experimental Oncology, European Institute of Oncology (IEO), IFOM-IEO Campus, Via Adamello 16, Milan 20139, Italy.

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http://dx.doi.org/10.1038/ncb2004DOI Listing
January 2010

Overall Cdk activity modulates the DNA damage response in mammalian cells.

J Cell Biol 2009 Dec;187(6):773-80

Experimental Oncology Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, E-28029 Madrid, Spain.

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http://jcb.rupress.org/content/jcb/187/6/773.full.pdf
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http://www.jcb.org/lookup/doi/10.1083/jcb.200903033
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http://dx.doi.org/10.1083/jcb.200903033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806328PMC
December 2009

Using cells devoid of RAS proteins as tools for drug discovery.

Mol Carcinog 2009 Nov;48(11):1038-47

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain.

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http://dx.doi.org/10.1002/mc.20555DOI Listing
November 2009

Cell cycle, CDKs and cancer: a changing paradigm.

Nat Rev Cancer 2009 Mar;9(3):153-66

Cell Division and Cancer Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

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http://www.nature.com/articles/nrc2602
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http://dx.doi.org/10.1038/nrc2602DOI Listing
March 2009

A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition.

J Clin Invest 2008 Jun;118(6):2169-79

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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http://dx.doi.org/10.1172/JCI34385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2381749PMC
June 2008

CDK inhibitors in cancer therapy: what is next?

Trends Pharmacol Sci 2008 Jan 4;29(1):16-21. Epub 2007 Dec 4.

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1016/j.tips.2007.10.012DOI Listing
January 2008

Cdk1 is sufficient to drive the mammalian cell cycle.

Nature 2007 Aug;448(7155):811-5

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, E-28029 Madrid, Spain.

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http://www.nature.com/articles/nature06046
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http://dx.doi.org/10.1038/nature06046DOI Listing
August 2007

Mice thrive without Cdk4 and Cdk2.

Mol Oncol 2007 Jun 14;1(1):72-83. Epub 2007 Mar 14.

Molecular Oncology, Centro Nacional de Investigaciones Oncológicas, E-28029 Madrid, Spain.

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http://dx.doi.org/10.1016/j.molonc.2007.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543859PMC
June 2007

Returning home.

Authors:
Mariano Barbacid

Cell 2007 May;129(4):641-4

Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernandez Almagro 3, 28029 Madrid, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740700601
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http://dx.doi.org/10.1016/j.cell.2007.05.010DOI Listing
May 2007

p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation.

Nat Genet 2007 Jun 29;39(6):750-8. Epub 2007 Apr 29.

CNIO (Spanish National Cancer Center), Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1038/ng2037DOI Listing
June 2007

Cell cycle kinases in cancer.

Curr Opin Genet Dev 2007 Feb;17(1):60-5

Cell Division and Cancer, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.1016/j.gde.2006.12.008DOI Listing
February 2007

Is Cyclin D1-CDK4 kinase a bona fide cancer target?

Cancer Cell 2006 Jan;9(1):2-4

Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas, Madrid E-28029, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S153561080500402
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http://dx.doi.org/10.1016/j.ccr.2005.12.026DOI Listing
January 2006

Mammalian cyclin-dependent kinases.

Trends Biochem Sci 2005 Nov 19;30(11):630-41. Epub 2005 Oct 19.

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, E-28029 Madrid, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S096800040500276
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http://dx.doi.org/10.1016/j.tibs.2005.09.005DOI Listing
November 2005

Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1).

Cancer Cell 2005 Jun;7(6):591-8

Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.

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http://dx.doi.org/10.1016/j.ccr.2005.05.006DOI Listing
June 2005

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6.

Cell 2004 Aug;118(4):493-504

Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas (CNIO), E-28029 Madrid, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740400750
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http://dx.doi.org/10.1016/j.cell.2004.08.002DOI Listing
August 2004

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context.

Cancer Cell 2003 Aug;4(2):111-20

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, 28029, Madrid, Spain.

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http://dx.doi.org/10.1016/s1535-6108(03)00191-0DOI Listing
August 2003

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

Nat Genet 2003 Sep 17;35(1):25-31. Epub 2003 Aug 17.

Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, Madrid E-28029, Spain.

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http://dx.doi.org/10.1038/ng1232DOI Listing
September 2003

Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number.

Oncogene 2003 Aug;22(34):5261-9

Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1038/sj.onc.1206506DOI Listing
August 2003

Driving the cell cycle to cancer.

Adv Exp Med Biol 2003 ;532:1-11

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain.

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http://dx.doi.org/10.1007/978-1-4615-0081-0_1DOI Listing
February 2004

RAS oncogenes: the first 30 years.

Nat Rev Cancer 2003 06;3(6):459-65

Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, 28029 Madrid, Spain.

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http://www.nature.com/articles/nrc1097
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http://dx.doi.org/10.1038/nrc1097DOI Listing
June 2003

Cyclin D-dependent kinases, INK4 inhibitors and cancer.

Biochim Biophys Acta 2002 Mar;1602(1):73-87

Molecular Oncology Program, Centro Nacional de Investigaciones Oncológicas, Melchor Fernandez Almagro 3, 28029 Madrid, Spain.

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http://dx.doi.org/10.1016/s0304-419x(02)00037-9DOI Listing
March 2002