Mariana Brait

Mariana Brait

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Mariana Brait

Mariana Brait

Publications by authors named "Mariana Brait"

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Integrated transcriptomic and epigenomic analysis of ovarian cancer reveals epigenetically silenced GULP1.

Cancer Lett 2018 10 28;433:242-251. Epub 2018 Jun 28.

Department of Otolaryngology and Head & Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.06.030DOI Listing
October 2018

Tobacco and alcohol-induced epigenetic changes in oral carcinoma.

Curr Opin Oncol 2018 05;30(3):152-158

Department of Otolaryngology and Head and Neck Surgery, Head and Neck Cancer Research Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1097/CCO.0000000000000444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085092PMC
May 2018

A Panel of Novel Detection and Prognostic Methylated DNA Markers in Primary Non-Small Cell Lung Cancer and Serum DNA.

Clin Cancer Res 2017 Nov 29;23(22):7141-7152. Epub 2017 Aug 29.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1222DOI Listing
November 2017

Advancing toward a molecular characterization of polymorphous low grade adenocarcinoma.

Oral Oncol 2017 11 20;74:192-193. Epub 2017 Sep 20.

Department of Otolaryngology and Head & Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2017.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889926PMC
November 2017

Expression of GULP1 in bronchial epithelium is associated with the progression of emphysema in chronic obstructive pulmonary disease.

Respir Med 2017 03 17;124:72-78. Epub 2017 Feb 17.

Department of Otolaryngology and Head & Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA; Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2017.02.011DOI Listing
March 2017

Comparative mutational landscape analysis of patient-derived tumour xenografts.

Br J Cancer 2017 Feb 24;116(4):515-523. Epub 2017 Jan 24.

Department of Otolaryngology and Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1038/bjc.2016.450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318980PMC
February 2017

Adenoid cystic carcinoma: emerging role of translocations and gene fusions.

Oncotarget 2016 Oct;7(40):66239-66254

Department of Otolaryngology and Head & Neck Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.18632/oncotarget.11288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5323230PMC
October 2016

High-performance detection of somatic D-loop mutation in urothelial cell carcinoma patients by polymorphism ratio sequencing.

J Mol Med (Berl) 2016 09 31;94(9):1015-24. Epub 2016 Mar 31.

Department of Chemistry, University of California, 307 Lewis Hall, Berkeley, CA, 94720, USA.

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http://dx.doi.org/10.1007/s00109-016-1407-2DOI Listing
September 2016

Milk derived colloid as a novel drug delivery carrier for breast cancer.

Cancer Biol Ther 2015 ;16(8):1184-93

a Department of Otolaryngology-Head and Neck Surgery ; Johns Hopkins School of Medicine ; Baltimore , MD USA.

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http://dx.doi.org/10.1080/15384047.2015.1056416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623025PMC
May 2016

Expression microarray analysis reveals alternative splicing of LAMA3 and DST genes in head and neck squamous cell carcinoma.

PLoS One 2014 27;9(3):e91263. Epub 2014 Mar 27.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America; Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091263PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967989PMC
December 2015

Epigenetic screening of salivary gland mucoepidermoid carcinoma identifies hypomethylation of CLIC3 as a common alteration.

Oral Oncol 2015 Dec 17;51(12):1120-5. Epub 2015 Oct 17.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USA; Milton J. Dance Jr. Head and Neck Center at the Greater Baltimore Medical Center, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2015.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663116PMC
December 2015

Epigenetic silencing of S100A2 in bladder and head and neck cancers.

Oncoscience 2015 16;2(4):410-8. Epub 2015 Mar 16.

Graduate Program in Human Genetics and Molecular Biology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Department of Otolaryngology - Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA ; Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468326PMC
http://dx.doi.org/10.18632/oncoscience.140DOI Listing
June 2015

Involvement of epigenetics and EMT-related miRNA in arsenic-induced neoplastic transformation and their potential clinical use.

Cancer Prev Res (Phila) 2015 Mar 13;8(3):208-21. Epub 2015 Jan 13.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland. Department of Urology, Johns Hopkins University, Baltimore, Maryland. Department of Oncology, Johns Hopkins University, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355280PMC
March 2015

GSTP1 promoter methylation is associated with recurrence in early stage prostate cancer.

J Urol 2014 Nov 21;192(5):1542-8. Epub 2014 Apr 21.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2014.04.082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390043PMC
November 2014

Association of promoter methylation of VGF and PGP9.5 with ovarian cancer progression.

PLoS One 2013 27;8(9):e70878. Epub 2013 Sep 27.

Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America ; Clinical Research Coordination, Instituto Nacional de Câncer (INCA)-Brazilian National Cancer Institute, Rio de Janeiro, Brazil.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070878PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785492PMC
July 2014

The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors.

Cancer Res 2014 Jul 15;74(14):3995-4005. Epub 2014 May 15.

Authors' Affiliations: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine; and

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122100PMC
July 2014

An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine.

Oncotarget 2014 Jul;5(14):5218-33

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. Department of Urology, Johns Hopkins University, Baltimore, Maryland, USA. Department of Oncology, Johns Hopkins University, Baltimore, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170626PMC
http://dx.doi.org/10.18632/oncotarget.2129DOI Listing
July 2014

Genome-wide and gene-specific epigenomic platforms for hepatocellular carcinoma biomarker development trials.

Gastroenterol Res Pract 2014 17;2014:597164. Epub 2014 Apr 17.

Department of Otolaryngology, Division of Head and Neck Cancer Research, School of Medicine, The Johns Hopkins University, Baltimore, MD 21231, USA ; Department of Obstetrics and Gynecology, University of Puerto Rico School of Medicine, San Juan, PR 00927, USA.

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http://dx.doi.org/10.1155/2014/597164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009191PMC
May 2014

SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling.

J Mol Med (Berl) 2013 Mar 12;91(3):381-93. Epub 2012 Sep 12.

Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA.

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http://dx.doi.org/10.1007/s00109-012-0955-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691869PMC
March 2013

Cysteine dioxygenase 1 is a tumor suppressor gene silenced by promoter methylation in multiple human cancers.

PLoS One 2012 27;7(9):e44951. Epub 2012 Sep 27.

Department of Otolaryngology, Head and Neck Cancer Research Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044951PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459978PMC
March 2013

AIM1 promoter hypermethylation as a predictor of decreased risk of recurrence following radical prostatectomy.

Prostate 2012 Jul 29;72(10):1133-9. Epub 2011 Nov 29.

Department of Otolaryngology and Head & Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1002/pros.22461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3360823PMC
July 2012

Downregulation of insulin-like growth factor-binding protein 7 in cisplatin-resistant non-small cell lung cancer.

Cancer Biol Ther 2012 Feb 1;13(3):148-55. Epub 2012 Feb 1.

Department of Otolaryngology, Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.4161/cbt.13.3.18695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336071PMC
February 2012

An epigenetic marker panel for detection of lung cancer using cell-free serum DNA.

Clin Cancer Res 2011 Jul 24;17(13):4494-503. Epub 2011 May 24.

Department of Otolaryngology and Head and Neck Surgery, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-3436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131425PMC
July 2011

Genome-wide analysis of genetic alterations in testicular primary seminoma using high resolution single nucleotide polymorphism arrays.

Genomics 2011 Jun 2;97(6):341-9. Epub 2011 Mar 2.

Johns Hopkins University, School of Medicine, Department of Otolaryngology, Head and Neck Cancer Research, Baltimore MD, USA.

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http://dx.doi.org/10.1016/j.ygeno.2011.02.011DOI Listing
June 2011

Cancer epigenetics: above and beyond.

Toxicol Mech Methods 2011 May;21(4):275-88

Division of Head and Neck Cancer Research, Department of Otolaryngology and Head & Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.3109/15376516.2011.562671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309610PMC
May 2011

DeltaNp63alpha confers tumor cell resistance to cisplatin through the AKT1 transcriptional regulation.

Cancer Res 2011 Feb 25;71(3):1167-76. Epub 2011 Jan 25.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076926PMC
February 2011

Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer.

J Thorac Oncol 2010 Dec;5(12):1887-93

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1097/JTO.0b013e3181f77a53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057519PMC
December 2010

Association between lifestyle factors and CpG island methylation in a cancer-free population.

Cancer Epidemiol Biomarkers Prev 2009 Nov 27;18(11):2984-91. Epub 2009 Oct 27.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-08-1245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878974PMC
November 2009

Aberrant promoter methylation of multiple genes during pathogenesis of bladder cancer.

Cancer Epidemiol Biomarkers Prev 2008 Oct;17(10):2786-94

Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB II, 5M, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-08-0192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778751PMC
October 2008

Aberrant promoter methylation can be useful as a marker of recurrent disease in patients with cervical intraepithelial neoplasia grade III.

Tumori 2007 Nov-Dec;93(6):572-9

Discipline of Special Pathology, Research Institute of Oncology, Federal University of Triângulo Mineiro, Uberaba, Brazil.

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March 2008

Aberrant methylation in pediatric myelodysplastic syndrome.

Leuk Res 2007 Feb 4;31(2):175-81. Epub 2006 Aug 4.

Ludwig Institute for Cancer Research, São Paulo Branch, Rua Prof. Antônio Prudente, 109, 4 andar, CEP 01509-010 São Paulo, S.P., Brazil.

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http://dx.doi.org/10.1016/j.leukres.2006.06.013DOI Listing
February 2007

Detection of serum deoxyribonucleic acid methylation markers: a novel diagnostic tool for thyroid cancer.

J Clin Endocrinol Metab 2006 Jan 1;91(1):98-104. Epub 2005 Nov 1.

Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://dx.doi.org/10.1210/jc.2005-1810DOI Listing
January 2006

p16 gene methylation lacks correlation with angiogenesis and prognosis in multiple myeloma.

Cancer Lett 2005 May 11;222(2):247-54. Epub 2004 Nov 11.

Discipline of Hematology and Hemotherapy, Universidade Federal de São Paulo, UNIFESP/EPM, Rua Botucatu, 740, 3 andar, Hematologia, CEP 04023-900 Vila Clementino, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1016/j.canlet.2004.09.038DOI Listing
May 2005