Marian DiFiglia

Marian DiFiglia

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Marian DiFiglia

Marian DiFiglia

Publications by authors named "Marian DiFiglia"

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Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity.

Mol Ther 2018 12 22;26(12):2838-2847. Epub 2018 Sep 22.

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277553PMC
December 2018

Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.

Mol Ther 2018 11 8;26(11):2580-2591. Epub 2018 Aug 8.

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225091PMC
November 2018

Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin.

Cell Rep 2018 09;24(10):2553-2560.e5

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.07.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245656PMC
September 2018

Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles.

Mol Ther 2018 08 21;26(8):1973-1982. Epub 2018 Jun 21.

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094392PMC
August 2018

The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.

Sci Rep 2018 05 22;8(1):8000. Epub 2018 May 22.

Laboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1038/s41598-018-26255-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964228PMC
May 2018

A toxic mutant huntingtin species is resistant to selective autophagy.

Nat Chem Biol 2017 Nov 4;13(11):1152-1154. Epub 2017 Sep 4.

State Key Laboratory of Medical Neurobiology, Neurology Department at Huashan Hospital, School of Life Sciences, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1038/nchembio.2461DOI Listing
November 2017

Retracted: Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease.

Hum Mol Genet 2017 11;26(21):4314

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1093/hmg/ddx303DOI Listing
November 2017

Does the Mutant CAG Expansion in Huntingtin mRNA Interfere with Exonucleolytic Cleavage of its First Exon?

J Huntingtons Dis 2016 ;5(1):33-8

RNA Therapeutics Institute and Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.3233/JHD-150183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816656PMC
December 2016

Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice.

J Huntingtons Dis 2016 10;5(3):249-260

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.

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http://dx.doi.org/10.3233/JHD-160211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088406PMC
October 2016

Effects of Exogenous NUB1 Expression in the Striatum of HDQ175/Q7 Mice.

J Huntingtons Dis 2016 06;5(2):163-74

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.

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http://dx.doi.org/10.3233/JHD-160195DOI Listing
June 2016

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.

Elife 2015 Mar 4;4. Epub 2015 Mar 4.

State Key Laboratory of Genetic Engineering, Department of Biophysics, School of Life Sciences, Fudan University, Shanghai, China.

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http://dx.doi.org/10.7554/eLife.05449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372774PMC
March 2015

Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington's disease mice.

Acta Neuropathol Commun 2014 Dec 20;2:179. Epub 2014 Dec 20.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1186/s40478-014-0178-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297405PMC
December 2014

Increased Steady-State Mutant Huntingtin mRNA in Huntington's Disease Brain.

J Huntingtons Dis 2013 ;2(4):491-500

RNA Therapeutics Institute and Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.3233/JHD-130079DOI Listing
September 2014

Huntingtin-lowering strategies in Huntington's disease: antisense oligonucleotides, small RNAs, and gene editing.

Mov Disord 2014 Sep 27;29(11):1455-61. Epub 2014 Aug 27.

Department of Medicine and RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.26020DOI Listing
September 2014

Drugging unconventional targets: insights from Huntington's disease.

Trends Pharmacol Sci 2014 Feb 2;35(2):53-62. Epub 2014 Jan 2.

State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China; Mass General Institute for Neurodegenerative Disease, Charlestown, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2013.12.001DOI Listing
February 2014

The role of chaperone-mediated autophagy in huntingtin degradation.

PLoS One 2012 11;7(10):e46834. Epub 2012 Oct 11.

Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046834PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469570PMC
April 2013

Elevated NADPH oxidase activity contributes to oxidative stress and cell death in Huntington's disease.

Hum Mol Genet 2013 Mar 7;22(6):1112-31. Epub 2012 Dec 7.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1093/hmg/dds516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578411PMC
March 2013

The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1.

Acta Pharmacol Sin 2012 Jun 30;33(6):743-51. Epub 2012 Apr 30.

Department of Pharmacology, Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China.

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http://dx.doi.org/10.1038/aps.2012.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010368PMC
June 2012

The recycling endosome and its role in neurological disorders.

Prog Neurobiol 2012 May 20;97(2):127-41. Epub 2011 Oct 20.

Laboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.pneurobio.2011.10.002DOI Listing
May 2012

Multiple phenotypes in Huntington disease mouse neural stem cells.

Mol Cell Neurosci 2012 May 6;50(1):70-81. Epub 2012 Apr 6.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, United States.

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http://dx.doi.org/10.1016/j.mcn.2012.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383872PMC
May 2012

Deficient Rab11 activity underlies glucose hypometabolism in primary neurons of Huntington's disease mice.

Biochem Biophys Res Commun 2012 May 20;421(4):727-30. Epub 2012 Apr 20.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.bbrc.2012.04.070DOI Listing
May 2012

Native mutant huntingtin in human brain: evidence for prevalence of full-length monomer.

J Biol Chem 2012 Apr 27;287(16):13487-99. Epub 2012 Feb 27.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1074/jbc.M111.286609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339996PMC
April 2012

Expression of mutant N-terminal huntingtin fragment (htt552-100Q) in astrocytes suppresses the secretion of BDNF.

Brain Res 2012 Apr 23;1449:69-82. Epub 2012 Feb 23.

Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmacy, Suzhou 215123, China.

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http://dx.doi.org/10.1016/j.brainres.2012.01.077DOI Listing
April 2012

Truncated N-terminal huntingtin fragment with expanded-polyglutamine (htt552-100Q) suppresses brain-derived neurotrophic factor transcription in astrocytes.

Acta Biochim Biophys Sin (Shanghai) 2012 Mar 9;44(3):249-58. Epub 2012 Jan 9.

Department of Physiology, Soochow University School of Biology and Basic Medical Sciences, Suzhou, China.

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https://academic.oup.com/abbs/article-lookup/doi/10.1093/abb
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http://dx.doi.org/10.1093/abbs/gmr125DOI Listing
March 2012

Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes.

Acta Pharmacol Sin 2012 Mar 23;33(3):385-92. Epub 2012 Jan 23.

Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmaceutical Science, Suzhou, China.

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http://dx.doi.org/10.1038/aps.2011.162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077128PMC
March 2012

Reagents that block neuronal death from Huntington's disease also curb oxidative stress.

Neuroreport 2012 Jan;23(1):10-5

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1097/WNR.0b013e32834d92e6DOI Listing
January 2012

Optimization of an HTRF Assay for the Detection of Soluble Mutant Huntingtin in Human Buffy Coats: A Potential Biomarker in Blood for Huntington Disease.

PLoS Curr 2010 Dec 29;2:RRN1205. Epub 2010 Dec 29.

Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts; Novartis Institutes for Biomedical Research, Neuroscience; Boston University; Massachusetts General Hospital/Harvard Medical School; Massachusetts General Hospital; Neuroscience Research, Head Neurodegeneration at Novartis, Basel, Switzerland; Novartis Institutes for Biomedical Research and AC Immune SA.

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http://dx.doi.org/10.1371/currents.RRN1205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015780PMC
December 2010

Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease.

J Neurosci 2010 Mar;30(13):4552-61

Cellular Neurobiology Laboratory and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5865-09.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842456PMC
March 2010

Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease.

Neurobiol Dis 2009 Nov 20;36(2):374-83. Epub 2009 Aug 20.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.nbd.2009.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798579PMC
November 2009

Polyglutamine expansion in huntingtin alters its interaction with phospholipids.

J Neurochem 2009 Sep 29;110(5):1585-97. Epub 2009 Jun 29.

Laboratory of Cellular Neurobiology, Department of Neurology, Massachusetts General Hospital, 11416th Street, Room 2150, Charlestown, MA 02129, USA.

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http://lpmt.biomed.uni-erlangen.de/mediafiles/publications/K
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http://doi.wiley.com/10.1111/j.1471-4159.2009.06255.x
Publisher Site
http://dx.doi.org/10.1111/j.1471-4159.2009.06255.xDOI Listing
September 2009

Polyglutamine expansion in huntingtin increases its insertion into lipid bilayers.

Biochem Biophys Res Commun 2009 Sep 14;387(3):472-5. Epub 2009 Jul 14.

Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.07.039DOI Listing
September 2009

Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patients.

Curr Biol 2009 May 9;19(9):774-8. Epub 2009 Apr 9.

Department of Medicine, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01655, USA.

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http://dx.doi.org/10.1016/j.cub.2009.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746439PMC
May 2009

A function of huntingtin in guanine nucleotide exchange on Rab11.

Neuroreport 2008 Oct;19(16):1643-7

Laboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1097/WNR.0b013e328315cd4cDOI Listing
October 2008

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Authors:
Daniel J Klionsky Hagai Abeliovich Patrizia Agostinis Devendra K Agrawal Gjumrakch Aliev David S Askew Misuzu Baba Eric H Baehrecke Ben A Bahr Andrea Ballabio Bruce A Bamber Diane C Bassham Ettore Bergamini Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Dale E Bredesen Jeffrey L Brodsky John H Brumell Ulf T Brunk Wilfried Bursch Nadine Camougrand Eduardo Cebollero Francesco Cecconi Yingyu Chen Lih-Shen Chin Augustine Choi Charleen T Chu Jongkyeong Chung Peter G H Clarke Robert S B Clark Steven G Clarke Corinne Clavé John L Cleveland Patrice Codogno María I Colombo Ana Coto-Montes James M Cregg Ana Maria Cuervo Jayanta Debnath Francesca Demarchi Patrick B Dennis Phillip A Dennis Vojo Deretic Rodney J Devenish Federica Di Sano J Fred Dice Marian Difiglia Savithramma Dinesh-Kumar Clark W Distelhorst Mojgan Djavaheri-Mergny Frank C Dorsey Wulf Dröge Michel Dron William A Dunn Michael Duszenko N Tony Eissa Zvulun Elazar Audrey Esclatine Eeva-Liisa Eskelinen László Fésüs Kim D Finley José M Fuentes Juan Fueyo Kozo Fujisaki Brigitte Galliot Fen-Biao Gao David A Gewirtz Spencer B Gibson Antje Gohla Alfred L Goldberg Ramon Gonzalez Cristina González-Estévez Sharon Gorski Roberta A Gottlieb Dieter Häussinger You-Wen He Kim Heidenreich Joseph A Hill Maria Høyer-Hansen Xun Hu Wei-Pang Huang Akiko Iwasaki Marja Jäättelä William T Jackson Xuejun Jiang Shengkan Jin Terje Johansen Jae U Jung Motoni Kadowaki Chanhee Kang Ameeta Kelekar David H Kessel Jan A K W Kiel Hong Pyo Kim Adi Kimchi Timothy J Kinsella Kirill Kiselyov Katsuhiko Kitamoto Erwin Knecht Masaaki Komatsu Eiki Kominami Seiji Kondo Attila L Kovács Guido Kroemer Chia-Yi Kuan Rakesh Kumar Mondira Kundu Jacques Landry Marianne Laporte Weidong Le Huan-Yao Lei Michael J Lenardo Beth Levine Andrew Lieberman Kah-Leong Lim Fu-Cheng Lin Willisa Liou Leroy F Liu Gabriel Lopez-Berestein Carlos López-Otín Bo Lu Kay F Macleod Walter Malorni Wim Martinet Ken Matsuoka Josef Mautner Alfred J Meijer Alicia Meléndez Paul Michels Giovanni Miotto Wilhelm P Mistiaen Noboru Mizushima Baharia Mograbi Iryna Monastyrska Michael N Moore Paula I Moreira Yuji Moriyasu Tomasz Motyl Christian Münz Leon O Murphy Naweed I Naqvi Thomas P Neufeld Ichizo Nishino Ralph A Nixon Takeshi Noda Bernd Nürnberg Michinaga Ogawa Nancy L Oleinick Laura J Olsen Bulent Ozpolat Shoshana Paglin Glen E Palmer Issidora Papassideri Miles Parkes David H Perlmutter George Perry Mauro Piacentini Ronit Pinkas-Kramarski Mark Prescott Tassula Proikas-Cezanne Nina Raben Abdelhaq Rami Fulvio Reggiori Bärbel Rohrer David C Rubinsztein Kevin M Ryan Junichi Sadoshima Hiroshi Sakagami Yasuyoshi Sakai Marco Sandri Chihiro Sasakawa Miklós Sass Claudio Schneider Per O Seglen Oleksandr Seleverstov Jeffrey Settleman John J Shacka Irving M Shapiro Andrei Sibirny Elaine C M Silva-Zacarin Hans-Uwe Simon Cristiano Simone Anne Simonsen Mark A Smith Katharina Spanel-Borowski Vickram Srinivas Meredith Steeves Harald Stenmark Per E Stromhaug Carlos S Subauste Seiichiro Sugimoto David Sulzer Toshihiko Suzuki Michele S Swanson Ira Tabas Fumihiko Takeshita Nicholas J Talbot Zsolt Tallóczy Keiji Tanaka Kozo Tanaka Isei Tanida Graham S Taylor J Paul Taylor Alexei Terman Gianluca Tettamanti Craig B Thompson Michael Thumm Aviva M Tolkovsky Sharon A Tooze Ray Truant Lesya V Tumanovska Yasuo Uchiyama Takashi Ueno Néstor L Uzcátegui Ida van der Klei Eva C Vaquero Tibor Vellai Michael W Vogel Hong-Gang Wang Paul Webster John W Wiley Zhijun Xi Gutian Xiao Joachim Yahalom Jin-Ming Yang George Yap Xiao-Ming Yin Tamotsu Yoshimori Li Yu Zhenyu Yue Michisuke Yuzaki Olga Zabirnyk Xiaoxiang Zheng Xiongwei Zhu Russell L Deter

Autophagy 2008 Feb 21;4(2):151-75. Epub 2007 Nov 21.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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http://www.dwalab.ca/common/pdf/cdd200944a.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654259PMC
http://dx.doi.org/10.4161/auto.5338DOI Listing
February 2008

Lysosomal proteases are involved in generation of N-terminal huntingtin fragments.

Neurobiol Dis 2006 May 19;22(2):346-56. Epub 2006 Jan 19.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09699961050031
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http://dx.doi.org/10.1016/j.nbd.2005.11.012DOI Listing
May 2006

Huntingtin associates with acidic phospholipids at the plasma membrane.

J Biol Chem 2005 Oct 5;280(43):36464-73. Epub 2005 Aug 5.

Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1074/jbc.M503672200DOI Listing
October 2005

Striatal potassium channel dysfunction in Huntington's disease transgenic mice.

J Neurophysiol 2005 May 29;93(5):2565-74. Epub 2004 Dec 29.

Mental Retardation Research Center, NPI Room 58-258, 760 Westwood Plaza, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1152/jn.00791.2004DOI Listing
May 2005

Autophagy and its possible roles in nervous system diseases, damage and repair.

Autophagy 2005 Apr 30;1(1):11-22. Epub 2005 Apr 30.

Departments of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge, UK.

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http://dx.doi.org/10.4161/auto.1.1.1513DOI Listing
April 2005

Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction.

J Neurosci 2004 Jan;24(1):269-81

Laboratory of Cellular Neurobiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1409-03.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729557PMC
January 2004

Autophagy regulates the processing of amino terminal huntingtin fragments.

Hum Mol Genet 2003 Dec 21;12(24):3231-44. Epub 2003 Oct 21.

Laboratory of Cellular Neurobiology, Masschusetts General Hospital and Harvard Medical School, Charlestown 02129, USA.

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http://dx.doi.org/10.1093/hmg/ddg346DOI Listing
December 2003

Huntingtin is degraded to small fragments by calpain after ischemic injury.

Exp Neurol 2003 Sep;183(1):109-15

Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea.

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http://dx.doi.org/10.1016/s0014-4886(03)00132-8DOI Listing
September 2003

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease.

Hum Mol Genet 2002 Aug;11(17):1939-51

Center for Molecular Medicine and Therapeutics, Department of Medical Genetics, Children's and Women's Hospital, University of British Columbia, Vancouver, British Columbia, Canada, V5H 4H4.

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http://dx.doi.org/10.1093/hmg/11.17.1939DOI Listing
August 2002

Huntingtin fragments that aggregate go their separate ways.

Authors:
Marian DiFiglia

Mol Cell 2002 Aug;10(2):224-5

Massachusetts General Hospital, Department of Neurology, Charlestown, MA 02114, USA.

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http://dx.doi.org/10.1016/s1097-2765(02)00609-3DOI Listing
August 2002

Striatal neurochemical changes in transgenic models of Huntington's disease.

J Neurosci Res 2002 Jun;68(6):716-29

Department of Neuroscience, The Chicago Medical School, North Chicago, Illinois 60064, USA.

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http://dx.doi.org/10.1002/jnr.10272DOI Listing
June 2002