Publications by authors named "Maria Vasilyeva"

5 Publications

  • Page 1 of 1

Efficacy of a Probiotic Consisting of Lacticaseibacillus rhamnosus PDV 1705, Bifidobacterium bifidum PDV 0903, Bifidobacterium longum subsp. infantis PDV 1911, and Bifidobacterium longum subsp. longum PDV 2301 in the Treatment of Hospitalized Patients with COVID-19: a Randomized Controlled Trial.

Probiotics Antimicrob Proteins 2021 Oct 13. Epub 2021 Oct 13.

Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Moscow, Russian Federation.

The treatment of coronavirus disease (COVID-19) and COVID-19-associated diarrhea remains challenging. This study aimed to evaluate the efficacy of a multi-strain probiotic in the treatment of COVID-19. This was a randomized, controlled, single-center, open-label trial (NCT04854941). Inpatients with confirmed COVID-19 and pneumonia were randomly assigned to a group that received a multi-strain probiotic (PRO group) or to the control group (CON group). There were 99 and 101 patients in the PRO and CON groups, respectively. No significant differences in mortality, total duration of disease and hospital stay, incidence of intensive care unit admission, need for mechanical ventilation or oxygen support, liver injury development, and changes in inflammatory biomarker levels were observed between the PRO and CON groups among all included patients as well as among subgroups delineated based on age younger or older than 65 years, and subgroups with chronic cardiovascular diseases and diabetes. Diarrhea on admission was observed in 11.5% of patients; it resolved earlier in the PRO group than in the CON group (2 [1-4] vs. 4 [3-6] days; p = 0.049). Hospital-acquired diarrhea developed less frequently in the PRO group than in the CON group among patients who received a single antibiotic (0% vs. 12.5%; p = 0.023) unlike among those who received > 1 antibiotic (10.5% vs. 13.3%; p = 0.696). The studied probiotic had no significant effect on mortality and changes in most biomarkers in COVID-19. However, it was effective in treating diarrhea associated with COVID-19 and in preventing hospital-acquired diarrhea in patients who received a single antibiotic.
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http://dx.doi.org/10.1007/s12602-021-09858-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8512595PMC
October 2021

Research on Dynamic and Mechanical Properties of Magnetoactive Elastomers with High Permeability Magnetic Filling Agent at Complex Magneto-Temperature Exposure.

Materials (Basel) 2021 May 3;14(9). Epub 2021 May 3.

Department of Automation of Technological Processes and Production, Saint-Petersburg Mining University, 199106 Saint-Petersburg, Russia.

We consider magnetically active elastomer as a potentially applicable material for manufacturing a working channel of a magnetic pump unit. During the study, the samples were exposed to a magnetic field, a temperature field, and their combination to assess the change in the elastic-strength properties of the final material. For the preparation of samples, high permeability magnetic fillers of various sizes were used in the concentration range of 50-70%. Samples were made with an isotropic and an anisotropic structure. Studies have shown that when using a filler with a relatively coarse fraction, the material has more stable dynamic and mechanical characteristics: the tensile strength of the sample increases by an average of 38%. With the combined effect of magnetic and temperature fields on the material, its elasticity and strength increase by an average of 30% in comparison with the material without external influence. Based on the results obtained, the composition and structural organization of the material, which has the best complex of elastic strength characteristics, has been substantiated. For the manufacture of a pumping unit tube, it is preferable to use an isotropic magnetoactive elastomer with a coarser filler content of about 60%.
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http://dx.doi.org/10.3390/ma14092376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8125213PMC
May 2021

Globular chitosan treatment of bovine jugular veins: evidence of anticalcification efficacy in the subcutaneous rat model.

Cardiovasc Pathol 2018 Jan - Feb;32:1-7. Epub 2017 Sep 14.

«E. Meshalkin National Medical Research Center» of the Ministry of Health of the Russian Federation, 15 Rechkunovskaya Str., 630055 Novosibirsk, Russian Federation.

Vascular xenografts are widely used in cardiovascular surgery as an alternative to autologous vessels and vascular allografts. Calcification is one of the main drawbacks of vascular grafts, especially among young patients and children. Among different anticalcification approaches, chitosan emerges as a highly promising candidate due to its versatility, natural origin, and biocompatibility. We investigated the anticalcification efficacy of globular chitosan ("Chitozol") as it demonstrated the improved rate of water solubility as compared with conventional linear macromolecules of chitosan. In addition, we supposed that compact globular form of "Chitozol" molecules could provide effective penetration of extracellular matrix of bovine jugular veins (BJVs). Our results revealed that "Chitozol" treatment mitigated calcification in the experimental groups as compared to the control groups (without any treatment, conventional treatment with glutaraldehyde, and commercially available Contegra conduit). Different concentrations of "Chitozol" (0.3% and 3%), as well as different incubation times (15 and 30min), were equally effective in the prevention of calcification. In addition, "Chitozol" treatment with decellularization of BJVs demonstrated slightly improved stress-strain properties of unimplanted samples. Thus, the filling of fresh BJV with globular chitosan is proposed as a promising emerging treatment for the mitigation of calcific degeneration in BJVs xenografts.
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http://dx.doi.org/10.1016/j.carpath.2017.08.003DOI Listing
August 2018

The role of microsomal oxidation in the regulation of monoamine oxidase activity in the brain and liver of rats.

Gen Physiol Biophys 2017 Oct 27;36(4):455-464. Epub 2017 Jun 27.

South Ural State University Biomedical School, Chelyabinsk, Russia.

It has been shown in our previous study that monoamine oxidase (MAO) activity in different brain regions are correlated with a microsomal oxidation phenotype. The data obtained in this study, using the microsomal oxidation inhibitor SKF525, and using animals with different duration of hexobarbital sleep, has shown that increased intensity of microsomal oxidation might be associated with increased MAO activity. Since the rats with short hexobarbital sleep time had higher content of hepatic microsomal cytochrome P450 than did rats with long hexobarbital sleep time. In addition, the rats with higher hepatic content of CYP450 had higher activities of MAO-A and MAO-B. Moreover, the microsomal oxidation inhibitor SKF-525 reduced brain and liver activities of MAOA and MAO-B. Consequently, MAO activities in a brain and a liver depend on the microsomal oxidation process.
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http://dx.doi.org/10.4149/gpb_2017012DOI Listing
October 2017

Modeling nucleotide excision repair and its impact on UV-induced mutagenesis during SOS-response in bacterial cells.

J Theor Biol 2015 Jan 4;364:7-20. Epub 2014 Sep 4.

Laboratory of Radiation Biology, Joint Institute for Nuclear Research, 6 Joliot-Curie Street, 141980 Dubna, Moscow Region, Russia.

A model of the UV-induced mutation process in Escherichia coli bacteria has been developed taking into account the whole sequence of molecular events starting from initial photo-damage and finishing with the fixation of point mutations. The wild-type phenotype bacterial cells are compared with UV-sensitive repair-deficient mutant cells. Attention is mainly paid to excision repair system functioning as regards induced mutagenesis.
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http://dx.doi.org/10.1016/j.jtbi.2014.08.041DOI Listing
January 2015
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