Publications by authors named "Maria Romina Girotti"

22Publications

Unveiling the immune infiltrate modulation in cancer and response to immunotherapy by MIXTURE-an enhanced deconvolution method.

Authors:
Elmer A Fernández Yamil D Mahmoud Florencia Veigas Darío Rocha Matías Miranda Joaquín Merlo Mónica Balzarini Hugo D Lujan Gabriel A Rabinovich María Romina Girotti

Brief Bioinform 2020 Dec 16. Epub 2020 Dec 16.

Translational Immuno Oncology Lab at the Institute of Biology and Experimental Medicine in Buenos Aires, Argentina.

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December 2020

The Paradoxical Roles of Inflammation during PD-1 Blockade in Cancer.

Authors:
Marcelo Hill Mercedes Segovia Sofía Russo Maria Romina Girotti Gabriel A Rabinovich

Trends Immunol 2020 Nov 6;41(11):982-993. Epub 2020 Oct 6.

Laboratory of Immunopathology, Institute of Biology and Experimental Medicine (IBYME), National Council of Scientific and Technical Investigations (CONICET), C1428 Buenos Aires, Argentina; Faculty of Exact and Natural Sciences, University of Buenos Aires, C1428 Buenos Aires, Argentina. Electronic address:

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November 2020

Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression.

Authors:
María Romina Girotti Mariana Salatino Tomás Dalotto-Moreno Gabriel A Rabinovich

J Exp Med 2020 02;217(2)

Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.

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February 2020

Glycans Pave the Way for Immunotherapy in Triple-Negative Breast Cancer.

Authors:
Mariana Salatino María Romina Girotti Gabriel A Rabinovich

Cancer Cell 2018 02;33(2):155-157

Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490, C1428ADN Buenos Aires, Argentina; Laboratorio de Inmuno-Oncología Traslacional, Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490, C1428ADN Buenos Aires, Argentina; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160, C1428EGA Buenos Aires, Argentina. Electronic address:

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February 2018

Next-Generation Sequencing Analysis and Algorithms for PDX and CDX Models.

Authors:
Garima Khandelwal María Romina Girotti Christopher Smowton Sam Taylor Christopher Wirth Marek Dynowski Kristopher K Frese Ged Brady Caroline Dive Richard Marais Crispin Miller

Mol Cancer Res 2017 08 25;15(8):1012-1016. Epub 2017 Apr 25.

RNA Biology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester, United Kingdom.

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August 2017

Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma.

Authors:
Maria Romina Girotti Filipa Lopes Natasha Preece Dan Niculescu-Duvaz Alfonso Zambon Lawrence Davies Steven Whittaker Grazia Saturno Amaya Viros Malin Pedersen Bart M J M Suijkerbuijk Delphine Menard Robert McLeary Louise Johnson Laura Fish Sarah Ejiama Berta Sanchez-Laorden Juliane Hohloch Neil Carragher Kenneth Macleod Garry Ashton Anna A Marusiak Alberto Fusi John Brognard Margaret Frame Paul Lorigan Richard Marais Caroline Springer

Cancer Cell 2017 03;31(3):466

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March 2017

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.

Authors:
Lindsay C Spender G John Ferguson Sijia Liu Chao Cui Maria Romina Girotti Gary Sibbet Ellen B Higgs Morven K Shuttleworth Tom Hamilton Paul Lorigan Michael Weller David F Vincent Owen J Sansom Margaret Frame Peter Ten Dijke Richard Marais Gareth J Inman

Oncotarget 2016 Dec;7(50):81995-82012

Growth Factor Signalling Laboratory, The Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom.

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December 2016

So You Can Teach Old Fibroblasts New Tricks.

Authors:
Amaya Virós Maria Romina Girotti Richard Marais

Cancer Discov 2016 06;6(6):581-3

Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom.

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June 2016

Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma.

Authors:
Maria Romina Girotti Gabriela Gremel Rebecca Lee Elena Galvani Dominic Rothwell Amaya Viros Amit Kumar Mandal Kok Haw Jonathan Lim Grazia Saturno Simon J Furney Franziska Baenke Malin Pedersen Jane Rogan Jacqueline Swan Matthew Smith Alberto Fusi Deemesh Oudit Nathalie Dhomen Ged Brady Paul Lorigan Caroline Dive Richard Marais

Cancer Discov 2016 Mar 29;6(3):286-99. Epub 2015 Dec 29.

Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, United Kingdom.

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March 2016

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

Authors:
Santiago Zelenay Annemarthe G van der Veen Jan P Böttcher Kathryn J Snelgrove Neil Rogers Sophie E Acton Probir Chakravarty Maria Romina Girotti Richard Marais Sergio A Quezada Erik Sahai Caetano Reis e Sousa

Cell 2015 Sep 3;162(6):1257-70. Epub 2015 Sep 3.

Immunobiology Laboratory, The Francis Crick Institute, Lincoln's Inn Fields Laboratory, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. Electronic address:

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September 2015

Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR.

Authors:
Miguel Vizoso Humberto J Ferreira Paula Lopez-Serra F Javier Carmona Anna Martínez-Cardús Maria Romina Girotti Alberto Villanueva Sonia Guil Catia Moutinho Julia Liz Anna Portela Holger Heyn Sebastian Moran August Vidal Maria Martinez-Iniesta Jose L Manzano Maria Teresa Fernandez-Figueras Elena Elez Eva Muñoz-Couselo Rafael Botella-Estrada Alfonso Berrocal Fredrik Pontén Joost van den Oord William M Gallagher Dennie T Frederick Keith T Flaherty Ultan McDermott Paul Lorigan Richard Marais Manel Esteller

Nat Med 2015 Jul 1;21(7):741-50. Epub 2015 Jun 1.

1] Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, L'Hospitalet, Barcelona, Catalonia, Spain. [2] Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain. [3] Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Catalonia, Spain.

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July 2015

OECI-EACR precision medicine for cancer: Conference report 1-4 March 2015, Luxembourg.

Authors:
Anna Golebiewska Sabrina Fritah Maria Romina Girotti

Ecancermedicalscience 2015 3;9:519. Epub 2015 Apr 3.

Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, M20 4BX, UK.

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May 2015

Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling.

Authors:
Eishu Hirata Maria Romina Girotti Amaya Viros Steven Hooper Bradley Spencer-Dene Michiyuki Matsuda James Larkin Richard Marais Erik Sahai

Cancer Cell 2015 Apr;27(4):574-88

Tumor Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3LY, UK. Electronic address:

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April 2015

Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma.

Authors:
Maria Romina Girotti Filipa Lopes Natasha Preece Dan Niculescu-Duvaz Alfonso Zambon Lawrence Davies Steven Whittaker Grazia Saturno Amaya Viros Malin Pedersen Bart M J M Suijkerbuijk Delphine Menard Robert McLeary Louise Johnson Laura Fish Sarah Ejiama Berta Sanchez-Laorden Juliane Hohloch Neil Carragher Kenneth Macleod Garry Ashton Anna A Marusiak Alberto Fusi John Brognard Margaret Frame Paul Lorigan Richard Marais Caroline Springer

Cancer Cell 2015 Jan 11;27(1):85-96. Epub 2014 Dec 11.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK. Electronic address:

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January 2015

No longer an untreatable disease: how targeted and immunotherapies have changed the management of melanoma patients.

Authors:
Maria Romina Girotti Grazia Saturno Paul Lorigan Richard Marais

Mol Oncol 2014 Sep 15;8(6):1140-58. Epub 2014 Aug 15.

Molecular Oncology Group, Cancer Research UK Manchester Institute, Manchester, UK. Electronic address:

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September 2014

Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53.

Authors:
Amaya Viros Berta Sanchez-Laorden Malin Pedersen Simon J Furney Joel Rae Kate Hogan Sarah Ejiama Maria Romina Girotti Martin Cook Nathalie Dhomen Richard Marais

Nature 2014 Jul 11;511(7510):478-482. Epub 2014 Jun 11.

Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK.

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July 2014

BRAF inhibitors induce metastasis in RAS mutant or inhibitor-resistant melanoma cells by reactivating MEK and ERK signaling.

Authors:
Berta Sanchez-Laorden Amaya Viros Maria Romina Girotti Malin Pedersen Grazia Saturno Alfonso Zambon Dan Niculescu-Duvaz Samra Turajlic Andrew Hayes Martin Gore James Larkin Paul Lorigan Martin Cook Caroline Springer Richard Marais

Sci Signal 2014 Mar 25;7(318):ra30. Epub 2014 Mar 25.

1Molecular Oncology Group, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.

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March 2014

Deja Vu: EGF receptors drive resistance to BRAF inhibitors.

Authors:
Maria Romina Girotti Richard Marais

Cancer Discov 2013 May;3(5):487-90

The University of Manchester, Manchester, UK.

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May 2013

Matricellular proteins and inflammatory cells: a task force to promote or defeat cancer?

Authors:
Andrea Sabina Llera Maria Romina Girotti Lorena Gabriela Benedetti Osvaldo Luis Podhajcer

Cytokine Growth Factor Rev 2010 Feb 16;21(1):67-76. Epub 2009 Dec 16.

Laboratory of Molecular and Cellular Therapy, Fundacion Instituto Leloir, University of Buenos Aires, National Council for Scientific and Technological Research (CONICET), Buenos Aires, Argentina.

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February 2010

The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host.

Authors:
Osvaldo L Podhajcer Lorena Gabriela Benedetti Maria Romina Girotti Federico Prada Edgardo Salvatierra Andrea S Llera

Cancer Metastasis Rev 2008 Dec;27(4):691-705

Laboratory of Molecular and Cellular Therapy, Fundacion Instituto Leloir, University of Buenos Aires, National Council for Scientific and Technological Research (CONICET), Buenos Aires, Argentina.

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December 2008

The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host.

Authors:
Osvaldo L Podhajcer Lorena Benedetti Maria Romina Girotti Federico Prada Edgardo Salvatierra Andrea S Llera

Cancer Metastasis Rev 2008 Sep;27(3):523-37

Laboratory of Molecular and Cellular Therapy, Fundacion Instituto Leloir, University of Buenos Aires, National Council for Scientific and Technological Research (CONICET), Buenos Aires, Argentina.

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September 2008

Proteomic analysis identified N-cadherin, clusterin, and HSP27 as mediators of SPARC (secreted protein, acidic and rich in cysteines) activity in melanoma cells.

Authors:
María Soledad Sosa María Romina Girotti Edgardo Salvatierra Federico Prada Juan Antonio López de Olmo Silvia Juárez Gallango Juan Pablo Albar Osvaldo Luis Podhajcer Andrea Sabina Llera

Proteomics 2007 Nov;7(22):4123-34

Laboratory of Molecular and Cellular Therapy, Fundación Instituto Leloir-CONICET and Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.

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November 2007