Maria Paz Ocaranza

Maria Paz Ocaranza

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Maria Paz Ocaranza

Maria Paz Ocaranza

Publications by authors named "Maria Paz Ocaranza"

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36Publications

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AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells.

Cancers (Basel) 2019 Sep 3;11(9). Epub 2019 Sep 3.

Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences and Faculty of Medicine, University of Chile, Santiago 8380000, Chile.

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http://dx.doi.org/10.3390/cancers11091299DOI Listing
September 2019

Counter-regulatory renin-angiotensin system in cardiovascular disease.

Nat Rev Cardiol 2019 Aug 19. Epub 2019 Aug 19.

Advanced Center for Chronic Diseases (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1038/s41569-019-0244-8DOI Listing
August 2019

Effect of Early Normotension with Olmesartan on Rho-kinase Activity in Hypertensive Patients.

Curr Vasc Pharmacol 2019 Jan 20. Epub 2019 Jan 20.

Pontificia Universidad Católica de Chile, School of Medicine, Division of Cardiovascular Diseases, Santiago. Chile.

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http://dx.doi.org/10.2174/1570161117666190121103116DOI Listing
January 2019

Angiotensin-(1-9) reduces cardiovascular and renal inflammation in experimental renin-independent hypertension.

Biochem Pharmacol 2018 10 1;156:357-370. Epub 2018 Sep 1.

Advanced Center for Chronic Diseases (ACCDiS), Facultad de Medicina, Pontificia, Universidad Catolica de Chile, Santiago 8330024, Chile; Division Enfermedades Cardiovasculares, Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago 8330024, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.08.045DOI Listing
October 2018

Increased active phase atrial contraction is related to marathon runner performance.

Eur J Appl Physiol 2018 Sep 3;118(9):1931-1939. Epub 2018 Jul 3.

Advanced Center for Chronic Diseases (ACCDiS), Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1007/s00421-018-3927-7DOI Listing
September 2018

Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1-9) through an ATR and Akt-dependent mechanism.

Pharmacol Res 2018 09 23;135:112-121. Epub 2018 Jul 23.

Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences & Faculty of Medicine, Universidad de Chile, Santiago, Chile; Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile; Department of Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center, Dallas, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2018.07.022DOI Listing
September 2018

Novel Therapies Targeting Cardioprotection and Regeneration.

Curr Pharm Des 2017 ;23(18):2592-2615

Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Olivos 1007, Santiago 8380492. Chile.

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http://www.eurekaselect.com/149198/article
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http://dx.doi.org/10.2174/1381612823666170112122637DOI Listing
May 2018

Diuretics prevent Rho-kinase activation and expression of profibrotic/oxidative genes in the hypertensive aortic wall.

Ther Adv Cardiovasc Dis 2016 Dec 1;10(6):338-347. Epub 2016 Sep 1.

Pontificia Universidad Católica de Chile, School of Medicine, Division of Cardiovascular Diseases, Laboratory of Molecular Cardiology, Chile.

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http://dx.doi.org/10.1177/1753944716666208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933549PMC
December 2016

On Endogenous Angiotensin II Antagonism in Hypertension: The Role of Dipeptidyl Peptidase III.

Hypertension 2016 09 25;68(3):552-4. Epub 2016 Jul 25.

Division of Cardiovascular Diseases, School of Medicine, Pontificia Universidad Católica de Chile (M.P.O., J.E.J.) and Advanced Center for Chronic Diseases, Division of Cardiovascular Diseases, School of Medicine, Pontificia Universidad Católica de Chile (ACCDis), Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago (M.P.O.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.07471DOI Listing
September 2016

Simultaneous Rho kinase inhibition in circulating leukocytes and in cardiovascular tissue in rats with high angiotensin converting enzyme levels.

Int J Cardiol 2016 Jul 7;215:309-17. Epub 2016 Apr 7.

Division of Cardiovascular Diseases, School of Medicine, Pontificia Universidad Católica de Chile, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.04.004DOI Listing
July 2016

Mechanisms of favorable effects of Rho kinase inhibition on myocardial remodeling and systolic function after experimental myocardial infarction in the rat.

Ther Adv Cardiovasc Dis 2016 Feb 21;10(1):4-20. Epub 2015 Oct 21.

Pontificia Universidad Católica de Chile, School of Medicine, Division of Cardiovascular Diseases, Marcoleta 367 Piso 8, Santiago, Chile

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http://dx.doi.org/10.1177/1753944715609516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933601PMC
February 2016

Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9).

Pharmacol Res 2015 Nov 31;101:41-55. Epub 2015 Jul 31.

Advanced Center for Chronic Diseases (ACCDiS), Facultad Ciencias Químicas y Farmacéuticas & Facultad de Medicina, Universidad de Chile, Santiago, Chile; Departments of Internal Medicine (Division of Cardiology) and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2015.06.018DOI Listing
November 2015

ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension.

Ther Adv Cardiovasc Dis 2015 Aug 13;9(4):217-37. Epub 2015 Aug 13.

Advanced Center for Chronic Diseases(ACCDiS), Facultad de Medicina, PontificiaUniversidad Católica de Chile, Santiago, Chile.Division Enfermedades Cardiovasculares,Facultad de Medicina, Pontificia UniversidadCatólica de Chile, Santiago, Chile

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http://dx.doi.org/10.1177/1753944715597623DOI Listing
August 2015

Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system.

Clin Sci (Lond) 2014 Nov;127(9):549-57

*División de Enfermedades Cardiovasculares, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1042/CS20130449DOI Listing
November 2014

Reply: dissociating angiotensin 1-9 anticardiovascular remodeling effects from those on blood pressure.

J Hypertens 2014 Aug;32(8):1719-21

aDivisión de Enfermedades Cardiovasculares, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile bMillennium Institute of Immunology and Immunotherapy cInstituto de Ciencias Biomedicas, Facultad de Medicina dAdvanced Center for Chronic Diseases (ACCDiS) and Centro Estudios Moleculares de la Celula, Facultad Ciencias Quimicas y Farmaceuticas and Facultad Medicina, Universidad de Chile, Santiago, Chile eCardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1097/HJH.0000000000000247DOI Listing
August 2014

Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis.

J Hypertens 2014 Apr;32(4):771-83

aDivision de Enfermedades Cardiovasculares, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago bMillennium Institute on Immunology and Immunotherapy cInstituto de Ciencias Biomedicas, Facultad de Medicina, Santiago dAdvanced Center for Chronic Diseases & Centro Estudios Moleculares de la Celula, Facultad Ciencias Quimicas y Farmaceuticas & Facultad Medicina, Universidad de Chile, Santiago, Chile eDepartment of Internal Medicine (Cardiology Division), University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1097/HJH.0000000000000094DOI Listing
April 2014

Protective Role of the ACE2/Ang-(1-9) Axis in Cardiovascular Remodeling.

Int J Hypertens 2012 19;2012:594361. Epub 2012 Jan 19.

Cardiovascular Diseases Division, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Chile.

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http://dx.doi.org/10.1155/2012/594361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270559PMC
August 2012

Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure.

Am Heart J 2011 May;161(5):931-7

Pontificia Universidad Católica de Chile, Escuela de Medicina, Departamento De Enfermedades Cardiovasculares, Santiago, Chile.

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http://dx.doi.org/10.1016/j.ahj.2011.01.024DOI Listing
May 2011

Combined rho kinase and renin-angiotensin system inhibition: a new therapeutic perspective for renal and cardiovascular remodeling.

Hypertens Res 2010 Sep 22;33(9):883-5. Epub 2010 Jul 22.

Department of Cardiovascular Diseases, Pontificia Universidad Católica de Chile, Medical School, Marcoleta 367 Piso 8, Santiago, Chile.

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http://www.nature.com/articles/hr2010129
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http://dx.doi.org/10.1038/hr.2010.129DOI Listing
September 2010

Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro.

J Hypertens 2010 May;28(5):1054-64

Departamento de Enfermedades Cardiovasculares, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1097/hjh.0b013e328335d291DOI Listing
May 2010

Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes.

Biochem Biophys Res Commun 2008 Jul 23;372(2):326-30. Epub 2008 May 23.

Centro FONDAP de Estudios Moleculares de la Célula, Universidad de Chile, Olivos 1007, Santiago 838-0492, Chile.

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http://dx.doi.org/10.1016/j.bbrc.2008.05.067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2522383PMC
July 2008

Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I converting enzyme levels.

Hypertension 2007 Oct 4;50(4):792-8. Epub 2007 Sep 4.

Department of Cardiovascular Diseases, Medical School, P. Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.095117DOI Listing
October 2007

[Cardiac hypertrophy: molecular and cellular events].

Rev Esp Cardiol 2006 May;59(5):473-86

Laboratorio de Cardiología Molecular, Departamento de Enfermedades Cardiovasculares, Escuela de Medicina, Pontificia Universidad Católica de Chile, Lira 85, piso 2, Santiago, Chile.

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May 2006

Effect of hypertension on angiotensin-(1-7) levels in rats with different angiotensin-I converting enzyme polymorphism.

Life Sci 2006 Feb 17;78(14):1535-42. Epub 2005 Oct 17.

Department of Cardiovascular Diseases, Medical School, P. Catholic University of Chile, Santiago, Chile.

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http://dx.doi.org/10.1016/j.lfs.2005.07.026DOI Listing
February 2006

Increased aortic NADPH oxidase activity in rats with genetically high angiotensin-converting enzyme levels.

Hypertension 2005 Dec 17;46(6):1362-7. Epub 2005 Oct 17.

Department of Cardiovascular Diseases, Medical School, P. Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1161/01.HYP.0000188980.57312.63DOI Listing
December 2005

Perindopril regulates beta-agonist-induced cardiac apoptosis.

J Cardiovasc Pharmacol 2005 Sep;46(3):255-61

Departamento de Bioquímica y Biología Molecular, Facultad Ciencias Químicas y Farmacéuticas, Universidad de Chile, and Departamento de Enfermedades Cardiovasculares, Hospital Clínico, P. Universidad Católica de Chile, Santiago, Chile.

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http://dx.doi.org/10.1097/01.fjc.0000175234.95831.3eDOI Listing
September 2005

[Rho/Rho kinase signal transduction pathway in cardiovascular disease and cardiovascular remodeling].

Rev Esp Cardiol 2005 Aug;58(8):951-61

Departamento de Enfermedades Cardiovasculares, Hospital Clínico, Pontificia Universidad Católica de Chile, Chile.

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August 2005

Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats.

Am J Physiol Heart Circ Physiol 2004 Feb 2;286(2):H498-506. Epub 2003 Oct 2.

Departamento Enfermedades Cardiovasculares, Escuela de Medicina, P. Universidad Católica de Chile.

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http://dx.doi.org/10.1152/ajpheart.00102.2003DOI Listing
February 2004

Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-I-converting enzyme deletion/deletion genotype.

Am J Cardiol 2003 Sep;92(6):749-51

Department of Cardiovascular Diseases, Medical School, Pontifica Catholic University of Chile, Marcoleta 367, Room 19, Santiago, Chile.

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http://dx.doi.org/10.1016/s0002-9149(03)00847-6DOI Listing
September 2003

Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial hypertrophy and fibrosis.

J Cardiovasc Pharmacol 2002 Aug;40(2):246-54

Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Olivos 1007, Santiago, Chile.

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http://dx.doi.org/10.1097/00005344-200208000-00010DOI Listing
August 2002