Publications by authors named "Maria Mariana Barros Melo da Silveira"

6 Publications

  • Page 1 of 1

Beautiful death: point of view.

Rev Assoc Med Bras (1992) 2021 Apr;67(4):481-484

Univervidade Federal de Pernambuco, Programa de Pós-Graduação em Ciências da Saúde - Recife (PE), Brazil.

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http://dx.doi.org/10.1590/1806-9282.20200999DOI Listing
April 2021

Triggering receptor expressed on myeloid cells-1 as pediatric sepsis biomarker.

Rev Assoc Med Bras (1992) 2021 Mar;67(3):449-453

Universidade Federal de Pernambuco, Postgraduate Program in Therapeutic Innovation - Recife (PE), Brazil.

Objective: Triggering receptor expressed on myeloid cells-1 concentration can be used as a predictive, diagnostic, and prognostic marker in patients with sepsis. The objective of this study was to determine the validity of triggering receptor expressed on myeloid cells-1 levels as a biomarker of sepsis in pediatric patients.

Methods: This was an integrative literature review. PubMed, ScienceDirect, LILACS, MEDLINE, and VHL databases were searched for papers published between 2015 and 2020, using the keywords triggering receptor expressed on myeloid cells-1, sepsis, and child.

Results: The review included ten studies, of which four used triggering receptor expressed on myeloid cells-1 as a predictive biomarker; four, as a diagnostic biomarker; and two, as a prognostic biomarker. A total of 1,409 and 1,628 patients were included in primary and review studies, respectively. There was a predominance of significant results for the validity of triggering receptor expressed on myeloid cells-1 levels in the prediction, diagnosis, and prognosis of sepsis in pediatric patients.

Conclusions: Triggering receptor expressed on myeloid cells-1 is a valid predictive, diagnostic, and prognostic biomarker of sepsis with good sensitivity and specificity in the pediatric population.
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http://dx.doi.org/10.1590/1806-9282.20200765DOI Listing
March 2021

How Can Galectin-3 as a Biomarker of Fibrosis Improve Atrial Fibrillation Diagnosis and Prognosis?

J Clin Med Res 2020 Oct 21;12(10):647-654. Epub 2020 Sep 21.

Postgraduate Program in Therapeutic Innovation, Federal University of Pernambuco (PPGIT/UFPE), Recife, PE, Brazil.

Galectin-3 (Gal-3) is a biomarker of fibrosis that has been associated with atrial remodeling. Acknowledging the presence of a biomarker in patients with atrial fibrillation (AF) can allow for a better clinical treatment. The aim of this study was to assess the association of Gal-3 with atrial fibrosis in patients with AF. This is a systematic review study. From the total number of studies analyzed, 12 demonstrated a relation between atrial fibrosis and Gal-3 in patients with AF and presented statistically significant association values. We conclude that Gal-3 is associated with atrial fibrosis in patients with AF in all types, as well as after the arrhythmia treatment by ablation.
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http://dx.doi.org/10.14740/jocmr4313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7524564PMC
October 2020

Polymorphisms of and genes related to time in therapeutic range in patients with atrial fibrillation using warfarin.

Appl Clin Genet 2019 2;12:151-159. Epub 2019 Aug 2.

Pronto Socorro Cardiológico Professor Luiz Tavares - PROCAPE/UPE , Recife, Brazil.

Introduction: Warfarin continues to be the most widely used anticoagulant in clinical practice around the world for the prevention of thromboembolic events in patients with atrial fibrillation (AF). The evaluation of the quality of anticoagulation control, estimated by time in therapeutic range (TTR), is accepted as a good method to evaluate the quality of anticoagulation. The variability of TTR can be explained by the presence of variants of the and genes.

Methods: This study examined the association between polymorphisms of the  and  genes and control of oral anticoagulation, through TTR, in patients with AF. A cross-sectional study was conducted within a cohort follow-up. The study comprised of 317 patients with AF, using warfarin, who were followed up for one year. The genotyping of genes (rs1057910), (rs1799853) and (rs923231) was performed by PCR in real time, using TaqMan probes.

Results: Patients who had variant genotypes for the gene (rs1057910) presented higher TTR (TTR 81-100%) when compared to when compared to the <45% and 46-60% TTR groups (=0.005 and =0.002, respectively). Regarding (rs923231), patients who had the variant genotype for the (rs923231) gene also presented a higher TTR (TTR 81-100%), when when compared to the <45% and 46-60% TTR groups (=0.005 and =0.004, respectively). In a multivariate model, (rs923231) remained associated for comparisons with the TTR groups (<45% vs 81-100% groups, =0.01; and 46-60% vs 81-100% groups, =0.01).

Conclusion: The genotypes of the (AA) and -1639 (GG) genes were associated with the worst quality of anticoagulation control (TTR) in patients with AF using warfarin in the northeast of Brazil.
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http://dx.doi.org/10.2147/TACG.S197316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684853PMC
August 2019

Expression of microRNAs (133b and 138) and Correlation with Echocardiographic Parameters in Patients with Alcoholic Cardiomyopathy.

Microrna 2020 ;9(2):112-120

Faculdade de Ciencias Medicas/ Universidade de Pernambuco - FCM/UPE, Recife, Pernambuco, Brazil.

Introduction: Alcoholic Cardiomyopathy (ACM) is a disease with a difficult diagnosis. The real mechanisms related to its pathophysiology are not fully understood.

Objective: The aims of this study were to investigate whether miR-133b and miR-138 could be associated with ACM.

Methods: Forty-four patients were included comprising 24 with ACM and 20 with cardiomyopathies of different etiologies (control group). Real-time PCR was performed to verify the relative expression among the studied groups. In the statistical analysis, the quantitative variables t-student Mann- Whitney and correlation of Pearson tests were carried out, while the qualitative variable comprised the chi-square test, with p<0.05 being considered statistically significant.

Results: There was no association between clinical and sociodemographic characteristics of the groups. The patients with ACM presented downregulation of miR-133b in comparison with control patients (p=0.004). On the other hand, for the miR-138, there was no association when the ACM group was compared with the control group. The presence of miR-133b among cases and controls was not correlated with any of the echocardiographic parameters. However, the increase in the expression of miR-138 was correlated with an increase in the ejection fraction (r=0.28, p=0.01) and the diameter of the left atrium (r=0.23, p=0.04) in patients with ACM.

Conclusion: The downregulation of miR-133b might be a marker for ACM and, in addition, miR- 138 could be used to correlate the increase in ejection fraction with and normalization of the diameter of the left atrium diameter in patients with this disease.
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http://dx.doi.org/10.2174/2211536608666190716151900DOI Listing
May 2021

Quality of life of patients who undergone myocardial revascularization surgery.

Rev Bras Enferm 2017 Apr;70(2):257-264

Postgraduate Program in Nursing, School of Nurning Nossa Senhora das Graças, Universidade de Pernambuco, Recife, Pernambuco, Brazil.

Objective: to evaluate the quality of life of patients who underwent revascularization surgery.

Method: a descriptive, cross sectional study, with quantitative approach carried out with 75 patients. The questionnaire WHOQOL-Bref was used to evaluate the quality of life (QOL).

Results: patients' QOL evaluation presented a moderate result, with need of improvement of all domains. Low income patients had the worst evaluation of QOL in the domain environment (p=0,021), and the ones from Recife/metropolitan area, in the domain social relationship (p=0,021). Smoker (p=0,047), diabetic (p=0,002) and alcohol consumption (p=0,035) patients presented the worst evaluation of the physical domain. Renal patients presented the worst evaluation of QOL in the physical (P=0,037), psychological (p=0,008), social relationship (p=0,006) domains and total score (p=0,009).

Conclusion: the improvement of QOL depends on the individual's process of behavioral change and the participation of health professionals is essential to formulate strategies to approach these patients, especially concerning health education.
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http://dx.doi.org/10.1590/0034-7167-2016-0201DOI Listing
April 2017
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