Publications by authors named "Maria Laura Messi"

36 Publications

The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia.

Ageing Res Rev 2021 Feb 18;67:101305. Epub 2021 Feb 18.

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.

View Article and Find Full Text PDF
February 2021

Heart and neural crest derivative 2-induced preservation of sympathetic neurons attenuates sarcopenia with aging.

J Cachexia Sarcopenia Muscle 2021 Feb 30;12(1):91-108. Epub 2020 Nov 30.

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.

View Article and Find Full Text PDF
February 2021

Aging Blunts Sympathetic Neuron Regulation of Motoneurons Synaptic Vesicle Release Mediated by β1- and α2B-Adrenergic Receptors in Geriatric Mice.

J Gerontol A Biol Sci Med Sci 2020 07;75(8):1473-1480

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.

View Article and Find Full Text PDF
July 2020

Sympathomimetics regulate neuromuscular junction transmission through TRPV1, P/Q- and N-type Ca channels.

Mol Cell Neurosci 2019 03 11;95:59-70. Epub 2019 Feb 11.

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States of America; Neuroscience Program, Wake Forest School of Medicine, Winston-Salem, NC, United States of America. Electronic address:

View Article and Find Full Text PDF
March 2019

Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs.

Exp Gerontol 2018 07 27;108:35-40. Epub 2018 Mar 27.

Departments of Internal Medicine, Section of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, United States. Electronic address:

View Article and Find Full Text PDF
July 2018

BDA-410 Treatment Reduces Body Weight and Fat Content by Enhancing Lipolysis in Sedentary Senescent Mice.

J Gerontol A Biol Sci Med Sci 2017 Aug;72(8):1045-1053

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina.

View Article and Find Full Text PDF
August 2017

Resistance Training Enhances Skeletal Muscle Innervation Without Modifying the Number of Satellite Cells or their Myofiber Association in Obese Older Adults.

J Gerontol A Biol Sci Med Sci 2016 10 7;71(10):1273-80. Epub 2015 Oct 7.

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine and J Paul Sticht Center on Aging, Wake Forest School of Medicine, Winston-Salem, North Carolina.

View Article and Find Full Text PDF
October 2016

Troponin T3 regulates nuclear localization of the calcium channel Cavβ1a subunit in skeletal muscle.

Exp Cell Res 2015 Aug 15;336(2):276-86. Epub 2015 May 15.

Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Neuroscience Program, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA. Electronic address:

View Article and Find Full Text PDF
August 2015

Pericytes at the intersection between tissue regeneration and pathology.

Clin Sci (Lond) 2015 Jan;128(2):81-93

‡Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, Medical Center Boulevard, Winston Salem, NC 27157, U.S.A.

View Article and Find Full Text PDF
January 2015

The Cavβ1a subunit regulates gene expression and suppresses myogenin in muscle progenitor cells.

J Cell Biol 2014 Jun 16;205(6):829-46. Epub 2014 Jun 16.

Department of Internal Medicine-Gerontology, Neuroscience Program, Wake Forest School of Medicine, Winston-Salem, NC 27157Department of Internal Medicine-Gerontology, Neuroscience Program, Wake Forest School of Medicine, Winston-Salem, NC 27157

View Article and Find Full Text PDF
June 2014

Type-2 pericytes participate in normal and tumoral angiogenesis.

Am J Physiol Cell Physiol 2014 Jul 30;307(1):C25-38. Epub 2014 Apr 30.

Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina; Neuroscience Program, Wake Forest School of Medicine, Winston-Salem, North Carolina;

View Article and Find Full Text PDF
July 2014

Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle.

Am J Physiol Cell Physiol 2013 Dec 25;305(11):C1098-113. Epub 2013 Sep 25.

Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina;

View Article and Find Full Text PDF
December 2013

Role of pericytes in skeletal muscle regeneration and fat accumulation.

Stem Cells Dev 2013 Aug 27;22(16):2298-314. Epub 2013 Apr 27.

Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.

View Article and Find Full Text PDF
August 2013

Skeletal muscle pericyte subtypes differ in their differentiation potential.

Stem Cell Res 2013 Jan 29;10(1):67-84. Epub 2012 Sep 29.

Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina, Medical Center Boulevard, Winston Salem, NC 27157, USA.

View Article and Find Full Text PDF
January 2013

Skeletal muscle neural progenitor cells exhibit properties of NG2-glia.

Exp Cell Res 2013 Jan 20;319(1):45-63. Epub 2012 Sep 20.

Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston Salem, NC 27157, United States.

View Article and Find Full Text PDF
January 2013

Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging.

Exp Gerontol 2012 Apr 25;47(4):304-16. Epub 2012 Jan 25.

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, United States.

View Article and Find Full Text PDF
April 2012

Residual sarcoplasmic reticulum Ca2+ concentration after Ca2+ release in skeletal myofibers from young adult and old mice.

Pflugers Arch 2012 Apr 17;463(4):615-24. Epub 2012 Jan 17.

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157, USA.

View Article and Find Full Text PDF
April 2012

Troponin T nuclear localization and its role in aging skeletal muscle.

Age (Dordr) 2013 Apr 22;35(2):353-70. Epub 2011 Dec 22.

Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest School of Medicine, 1 Medical Center Blvd., Winston-Salem, NC 27157, USA.

View Article and Find Full Text PDF
April 2013

Nestin-GFP transgene reveals neural precursor cells in adult skeletal muscle.

PLoS One 2011 Feb 3;6(2):e16816. Epub 2011 Feb 3.

Department of Internal Medicine-Gerontology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

View Article and Find Full Text PDF
February 2011

Sarcoplasmic reticulum Ca2+ depletion in adult skeletal muscle fibres measured with the biosensor D1ER.

Pflugers Arch 2010 Apr 13;459(5):725-35. Epub 2010 Jan 13.

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

View Article and Find Full Text PDF
April 2010

Role of Ca2+, membrane excitability, and Ca2+ stores in failing muscle contraction with aging.

Exp Gerontol 2009 Apr 10;44(4):261-73. Epub 2008 Oct 10.

Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

View Article and Find Full Text PDF
April 2009

Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45.

Proc Natl Acad Sci U S A 2007 Dec 5;104(50):20108-13. Epub 2007 Dec 5.

Departments of Anaesthesia and Research, Basel University Hospital, Hebelstrasse 20, 4031 Basel, Switzerland.

View Article and Find Full Text PDF
December 2007

The lack of effect of specific overexpression of IGF-1 in the central nervous system or skeletal muscle on pathophysiology in the G93A SOD-1 mouse model of ALS.

Exp Neurol 2007 Sep 2;207(1):52-63. Epub 2007 Jun 2.

Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

View Article and Find Full Text PDF
September 2007

Role of sustained overexpression of central nervous system IGF-I in the age-dependent decline of mouse excitation-contraction coupling.

J Membr Biol 2006 28;212(3):147-61. Epub 2007 Feb 28.

Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.

View Article and Find Full Text PDF
August 2007

Motor neuron targeting of IGF-1 attenuates age-related external Ca2+-dependent skeletal muscle contraction in senescent mice.

Exp Gerontol 2007 Apr 14;42(4):309-19. Epub 2006 Dec 14.

Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

View Article and Find Full Text PDF
April 2007

Motor neurone targeting of IGF-1 prevents specific force decline in ageing mouse muscle.

J Physiol 2006 Jan 17;570(Pt 2):283-94. Epub 2005 Nov 17.

Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.

View Article and Find Full Text PDF
January 2006