Publications by authors named "Maria Kleppe"

32Publications

Underlying Causes and Therapeutic Targeting of the Inflammatory Tumor Microenvironment.

Front Cell Dev Biol 2018 12;6:56. Epub 2018 Jun 12.

Center for Hematopoietic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcell.2018.00056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005853PMC
June 2018

LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone.

Hemasphere 2018 Jun 8;2(3):e54. Epub 2018 Jun 8.

Department of Hematology, Oncology and Stem Cell Transplantation, University Medical Center Freiburg, Center for Tumor Biology, Freiburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/HS9.0000000000000054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745991PMC
June 2018

TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis.

Cell Rep 2018 01;22(5):1250-1262

Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247183003
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2018.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971064PMC
January 2018

Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.

Cancer Cell 2018 01 14;33(1):29-43.e7. Epub 2017 Dec 14.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2017.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760343PMC
January 2018

Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis.

Cell Stem Cell 2017 10 28;21(4):489-501.e7. Epub 2017 Sep 28.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2017.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847260PMC
October 2017

Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis.

Nat Commun 2016 12 21;7:13829. Epub 2016 Dec 21.

Department of Genetic Medicine, Ansary Stem Cell Institute, Weill Cornell Medical College, New York, New York 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms13829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187502PMC
December 2016

An Unexpected Chink in the Transcriptional Armor of Plasmacytoid Dendritic Neoplasms.

Cancer Cell 2016 11;30(5):659-660

Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccell.2016.10.016DOI Listing
November 2016

Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis.

Blood 2014 Oct 12;124(14):2280-4. Epub 2014 Aug 12.

Human Oncology and Pathogenesis Program, Gerstner Sloan Kettering School of Biomedical Sciences, and Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-03-560441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183987PMC
October 2014

Tumor heterogeneity confounds and illuminates: assessing the implications.

Nat Med 2014 Apr;20(4):342-4

Human Oncology and Pathogenesis Program and Ross L. Levine is also a member of the Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center. New York, New York, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nm.3522
Publisher Site
http://dx.doi.org/10.1038/nm.3522DOI Listing
April 2014

New pieces of a puzzle: the current biological picture of MPN.

Biochim Biophys Acta 2012 Dec 20;1826(2):415-22. Epub 2012 Jul 20.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbcan.2012.07.002DOI Listing
December 2012

Targeting β-catenin in CML: leukemia stem cells beware!

Cell Stem Cell 2012 Apr;10(4):351-3

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2012.03.006DOI Listing
April 2012

MOHITO, a novel mouse cytokine-dependent T-cell line, enables studies of oncogenic signaling in the T-cell context.

Haematologica 2011 May 29;96(5):779-83. Epub 2010 Dec 29.

Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2010.035931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084928PMC
May 2011