Maria Jasin

Maria Jasin

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Maria Jasin

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Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer.

Cells 2020 Jan 17;9(1). Epub 2020 Jan 17.

Laboratory of Radiobiology and Experimental Radiooncology, Center of Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

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http://dx.doi.org/10.3390/cells9010238DOI Listing
January 2020

Control of meiotic double-strand-break formation by ATM: local and global views.

Cell Cycle 2018 15;17(10):1155-1172. Epub 2018 Jul 15.

a Developmental Biology Program , Memorial Sloan Kettering Cancer Center , New York , NY , USA.

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https://www.tandfonline.com/doi/full/10.1080/15384101.2018.1
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http://dx.doi.org/10.1080/15384101.2018.1464847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110601PMC
November 2019

RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination.

DNA Repair (Amst) 2019 04 23;76:99-107. Epub 2019 Feb 23.

University of Pittsburgh School of Medicine, Department of Microbiology and Molecular Genetics, UPMC Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508892PMC
April 2019

Distinct Requirements of CHD4 during B Cell Development and Antibody Response.

Cell Rep 2019 04;27(5):1472-1486.e5

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527137PMC
April 2019

Induction of Chromosomal Translocations with CRISPR-Cas9 and Other Nucleases: Understanding the Repair Mechanisms That Give Rise to Translocations.

Adv Exp Med Biol 2018 ;1044:15-25

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1007/978-981-13-0593-1_2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333474PMC
November 2018

Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination.

Nat Commun 2018 10 10;9(1):3961. Epub 2018 Oct 10.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

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http://www.nature.com/articles/s41467-018-06384-x
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http://dx.doi.org/10.1038/s41467-018-06384-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180034PMC
October 2018

Inter-homologue repair in fertilized human eggs?

Nature 2018 08 8;560(7717):E5-E7. Epub 2018 Aug 8.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://www.nature.com/articles/s41586-018-0379-5
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http://dx.doi.org/10.1038/s41586-018-0379-5DOI Listing
August 2018

ATR is required to complete meiotic recombination in mice.

Nat Commun 2018 07 5;9(1):2622. Epub 2018 Jul 5.

Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193, Spain.

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http://dx.doi.org/10.1038/s41467-018-04851-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033890PMC
July 2018

Homologous Recombination and Replication Fork Protection: BRCA2 and More!

Cold Spring Harb Symp Quant Biol 2017 23;82:329-338. Epub 2018 Apr 23.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065.

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http://dx.doi.org/10.1101/sqb.2017.82.035006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333483PMC
April 2018

Under the Influence: Cas9 Ends and DNA Repair Outcomes.

Authors:
Maria Jasin

CRISPR J 2018 04;1:132-134

Developmental Biology Program, Memorial Sloan Kettering Cancer Center , New York, New York.

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http://dx.doi.org/10.1089/crispr.2018.29014.jasDOI Listing
April 2018

Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer.

Annu Rev Cancer Biol 2018 Mar 1;2:313-336. Epub 2017 Dec 1.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.

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http://www.annualreviews.org/doi/10.1146/annurev-cancerbio-0
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http://dx.doi.org/10.1146/annurev-cancerbio-030617-050502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193498PMC
March 2018

Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice.

Cell Cycle 2017 Oct 18;16(20):1870-1884. Epub 2017 Aug 18.

a Molecular Biology Program, Memorial Sloan Kettering Cancer Center , New York , NY , USA.

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http://dx.doi.org/10.1080/15384101.2017.1361065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5638367PMC
October 2017

EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells.

DNA Repair (Amst) 2017 09 10;57:98-106. Epub 2017 Jul 10.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY, 10065, USA; Department of Human Science, Georgetown University Medical Center, 3700 Reservoir Rd. NW, Washington, D.C., 20057, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2017.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584059PMC
September 2017

BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.

Nat Commun 2017 09 13;8(1):525. Epub 2017 Sep 13.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

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http://dx.doi.org/10.1038/s41467-017-00634-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597640PMC
September 2017

PARP Inhibitors in Clinical Use Induce Genomic Instability in Normal Human Cells.

PLoS One 2016 18;11(7):e0159341. Epub 2016 Jul 18.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159341PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948780PMC
July 2017

ATM loss leads to synthetic lethality in BRCA1 BRCT mutant mice associated with exacerbated defects in homology-directed repair.

Proc Natl Acad Sci U S A 2017 07 28;114(29):7665-7670. Epub 2017 Jun 28.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1706392114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530697PMC
July 2017

p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes.

PLoS Genet 2017 Jun 15;13(6):e1006845. Epub 2017 Jun 15.

Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Barcelona, Spain.

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http://dx.doi.org/10.1371/journal.pgen.1006845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491309PMC
June 2017

Generation of chromosomal translocations that lead to conditional fusion protein expression using CRISPR-Cas9 and homology-directed repair.

Methods 2017 05 15;121-122:138-145. Epub 2017 May 15.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2017.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531069PMC
May 2017

CRISPR-Cas9-guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells.

Proc Natl Acad Sci U S A 2017 04 21;114(14):3696-3701. Epub 2017 Mar 21.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1700622114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389291PMC
April 2017

Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice.

Nat Cell Biol 2016 Nov 10;18(11):1208-1220. Epub 2016 Oct 10.

Institute of Physiological Chemistry, Faculty of Medicine at the TU Dresden, Fetscherstraße 74, 01307 Dresden, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089853PMC
http://dx.doi.org/10.1038/ncb3417DOI Listing
November 2016

53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1.

EMBO Rep 2016 11 26;17(11):1532-1541. Epub 2016 Sep 26.

Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ, USA

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http://dx.doi.org/10.15252/embr.201642497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090706PMC
November 2016

The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair.

Cell 2016 Oct 13;167(3):695-708.e16. Epub 2016 Oct 13.

Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Memorial Sloan Kettering Cancer Center, Howard Hughes Medical Institute, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.09.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117687PMC
October 2016

Robust homology-directed repair within mouse mammary tissue is not specifically affected by Brca2 mutation.

Nat Commun 2016 10 25;7:13241. Epub 2016 Oct 25.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncomms13241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093336PMC
October 2016

Prolonged Particulate Hexavalent Chromium Exposure Suppresses Homologous Recombination Repair in Human Lung Cells.

Toxicol Sci 2016 09 22;153(1):70-8. Epub 2016 Jul 22.

*Wise Laboratory of Environmental and Genetic Toxicology, Portland, Maine 04104 Graduate School of Biomedical Science and Engineering, University of Maine, Orono, Maine 04469

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http://dx.doi.org/10.1093/toxsci/kfw103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601504PMC
September 2016

The democratization of gene editing: Insights from site-specific cleavage and double-strand break repair.

DNA Repair (Amst) 2016 08 12;44:6-16. Epub 2016 May 12.

Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 02454-9110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2016.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529214PMC
August 2016

Mechanisms of germ line genome instability.

Semin Cell Dev Biol 2016 06 12;54:177-87. Epub 2016 Feb 12.

Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA;; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2016.02.019DOI Listing
June 2016

Distinct genetic control of homologous recombination repair of Cas9-induced double-strand breaks, nicks and paired nicks.

Nucleic Acids Res 2016 06 21;44(11):5204-17. Epub 2016 Mar 21.

Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, 1105 AZ, The Netherlands Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1093/nar/gkw179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914091PMC
June 2016

When Genome Maintenance Goes Badly Awry.

Mol Cell 2016 06;62(5):777-87

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966655PMC
June 2016

Accolades for the DNA Damage Response.

Authors:
Maria Jasin

N Engl J Med 2015 Oct 8;373(16):1492-5. Epub 2015 Sep 8.

From Memorial Sloan Kettering Cancer Center, New York.

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http://dx.doi.org/10.1056/NEJMp1509698DOI Listing
October 2015

Local and sex-specific biases in crossover vs. noncrossover outcomes at meiotic recombination hot spots in mice.

Genes Dev 2015 Aug 6;29(16):1721-33. Epub 2015 Aug 6.

Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1101/gad.265561.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561481PMC
August 2015

Assaying break and nick-induced homologous recombination in mammalian cells using the DR-GFP reporter and Cas9 nucleases.

Methods Enzymol 2014 ;546:175-91

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, USA; Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-801185-0.00009-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408992PMC
July 2015

Creating cancer translocations in human cells using Cas9 DSBs and nCas9 paired nicks.

Methods Enzymol 2014 ;546:251-71

Museum National d'Histoire Naturelle, INSERM U1154, CNRS 7196, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-801185-0.00012-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398311PMC
July 2015

Genomic Complexity Profiling Reveals That HORMAD1 Overexpression Contributes to Homologous Recombination Deficiency in Triple-Negative Breast Cancers.

Cancer Discov 2015 May 13;5(5):488-505. Epub 2015 Mar 13.

Breakthrough Breast Cancer Research Unit, King's College London, London, United Kingdom. Department of Research Oncology, King's Health Partners AHSC, Life Sciences and Medicine, King's College London, London, United Kingdom. The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490184PMC
May 2015

Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins.

Cold Spring Harb Perspect Biol 2015 Apr 1;7(4):a016600. Epub 2015 Apr 1.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065 Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10065.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a016600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382744PMC
April 2015

The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes.

PLoS Genet 2015 Mar 13;11(3):e1005017. Epub 2015 Mar 13.

Genome Integrity and Instability Group, Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain; Cytology and Histology Unit, Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.

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http://dx.doi.org/10.1371/journal.pgen.1005017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358828PMC
March 2015

Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis.

PLoS Genet 2015 Jan 29;11(1):e1004954. Epub 2015 Jan 29.

Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4310598PMC
January 2015

Measuring recombination proficiency in mouse embryonic stem cells.

Methods Mol Biol 2014 ;1105:481-95

Markey Cancer Center, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1007/978-1-62703-739-6_34DOI Listing
November 2014

RAD51B Activity and Cell Cycle Regulation in Response to DNA Damage in Breast Cancer Cell Lines.

Breast Cancer (Auckl) 2014 12;8:135-44. Epub 2014 Oct 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.4137/BCBCR.S17766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213955PMC
November 2014

Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics.

Nat Genet 2014 Oct 24;46(10):1072-80. Epub 2014 Aug 24.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/ng.3068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207963PMC
October 2014

Biallelic targeting of expressed genes in mouse embryonic stem cells using the Cas9 system.

Methods 2014 Sep 12;69(2):171-178. Epub 2014 Jun 12.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA.

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http://dx.doi.org/10.1016/j.ymeth.2014.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405113PMC
September 2014

Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining.

Mol Cell 2014 Sep 4;55(6):829-842. Epub 2014 Sep 4.

Museum National d'Histoire Naturelle, 43 rue Cuvier, F-75005 Paris, France; CNRS, UMR7196, 43 rue Cuvier, F-75005 Paris, France; Inserm, U1154, 43 rue Cuvier, F-75005 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398060PMC
September 2014

Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice.

J Biol Chem 2014 Aug 11;289(35):24617-29. Epub 2014 Jul 11.

From the Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, the Departments of Radiation Oncology,

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http://dx.doi.org/10.1074/jbc.M114.566141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148885PMC
August 2014

Androgen receptor signaling regulates DNA repair in prostate cancers.

Cancer Discov 2013 Nov 11;3(11):1245-53. Epub 2013 Sep 11.

1Human Oncology Pathogenesis Program, 2Developmental Biology Program, and 3Immunology Program; Departments of 4Radiation Oncology, 5Medicine, 6Surgery, and 7Pathology; 8Molecular Cytology Core Facility, Memorial Sloan-Kettering Cancer Center; 9Department of Genetics, Albert Einstein College of Medicine, New York, New York; 10Department of Genetics; and 11Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888815PMC
November 2013

Repair of strand breaks by homologous recombination.

Cold Spring Harb Perspect Biol 2013 Nov 1;5(11):a012740. Epub 2013 Nov 1.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center New York, New York 10065.

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http://dx.doi.org/10.1101/cshperspect.a012740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809576PMC
November 2013

Mouse BAZ1A (ACF1) is dispensable for double-strand break repair but is essential for averting improper gene expression during spermatogenesis.

PLoS Genet 2013 Nov 7;9(11):e1003945. Epub 2013 Nov 7.

Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, New York, New York, United States of America ; Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America ; Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820798PMC
November 2013

How much is enough? Control of DNA double-strand break numbers in mouse meiosis.

Cell Cycle 2013 Sep 19;12(17):2719-20. Epub 2013 Aug 19.

Research Programs Unit (Genome-Scale Biology) and Institute of Biomedicine (Biochemistry and Developmental Biology); University of Helsinki; Helsinki, Finland.

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http://dx.doi.org/10.4161/cc.26079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899183PMC
September 2013

Analysis of recombinants in female mouse meiosis.

Methods Mol Biol 2013 ;957:19-45

Institut de Génétique et Microbiologie, Université Paris-Sud, Orsay, France.

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http://link.springer.com/10.1007/978-1-62703-191-2_2
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http://dx.doi.org/10.1007/978-1-62703-191-2_2DOI Listing
April 2013

Numerical constraints and feedback control of double-strand breaks in mouse meiosis.

Genes Dev 2013 Apr 18;27(8):873-86. Epub 2013 Apr 18.

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1101/gad.213652.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650225PMC
April 2013

53BP1 is a haploinsufficient tumor suppressor and protects cells from radiation response in glioma.

Cancer Res 2012 Oct 21;72(20):5250-60. Epub 2012 Aug 21.

Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-0045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771704PMC
October 2012

p21 promotes error-free replication-coupled DNA double-strand break repair.

Nucleic Acids Res 2012 Sep 26;40(17):8348-60. Epub 2012 Jun 26.

Department of Cell and Molecular Biology, University of Rhode Island, Kingston, RI 02881, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gks612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458556PMC
September 2012

The tricky path to recombining X and Y chromosomes in meiosis.

Ann N Y Acad Sci 2012 Sep;1267:18-23

Molecular Biology Program Developmental Biology Program Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2012.06593.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3631422PMC
September 2012

Preaching about the converted: how meiotic gene conversion influences genomic diversity.

Ann N Y Acad Sci 2012 Sep;1267:95-102

Developmental Biology Program, Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2012.06595.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625938PMC
September 2012

Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex.

Nucleic Acids Res 2012 Aug 9;40(14):6558-69. Epub 2012 Apr 9.

Institute of Biochemical Sciences, National Taiwan University, No. 1, Section 4, Roosevelt Road, Taipei, 10617, Taiwan.

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http://dx.doi.org/10.1093/nar/gks305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413116PMC
August 2012

A distinct replication fork protection pathway connects Fanconi anemia tumor suppressors to RAD51-BRCA1/2.

Cancer Cell 2012 Jul;22(1):106-16

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954744PMC
July 2012

RECQ1 plays a distinct role in cellular response to oxidative DNA damage.

DNA Repair (Amst) 2012 Jun 26;11(6):537-49. Epub 2012 Apr 26.

Department of Biochemistry and Molecular Biology, College of Medicine, Howard University, 520 W Street, NW, Washington, DC 20059, USA.

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http://dx.doi.org/10.1016/j.dnarep.2012.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420015PMC
June 2012

Homeostatic control of recombination is implemented progressively in mouse meiosis.

Nat Cell Biol 2012 Mar 4;14(4):424-30. Epub 2012 Mar 4.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncb2451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319518PMC
March 2012

Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.

PLoS Genet 2011 Dec 15;7(12):e1002409. Epub 2011 Dec 15.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240595PMC
December 2011

DNA ligase III: a spotty presence in eukaryotes, but an essential function where tested.

Cell Cycle 2011 Nov 1;10(21):3636-44. Epub 2011 Nov 1.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266004PMC
November 2011

ATM controls meiotic double-strand-break formation.

Nature 2011 Oct 16;479(7372):237-40. Epub 2011 Oct 16.

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA.

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http://www.nature.com/articles/nature10508
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3213282PMC
October 2011

Isolation of meiotic recombinants from mouse sperm.

Methods Mol Biol 2011 ;745:251-82

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/978-1-61779-129-1_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640831PMC
September 2011

Homologous recombination assay for interstrand cross-link repair.

Methods Mol Biol 2011 ;745:283-91

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1007/978-1-61779-129-1_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261721PMC
September 2011

Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells.

Proc Natl Acad Sci U S A 2011 Jul 5;108(29):11971-6. Epub 2011 Jul 5.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.1104421108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141969PMC
July 2011

Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells.

PLoS Genet 2011 Jul 21;7(7):e1002157. Epub 2011 Jul 21.

Howard Hughes Medical Institute, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141002PMC
July 2011

Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.

Nat Cell Biol 2011 May 10;13(5):599-610. Epub 2011 Apr 10.

Institute of Physiological Chemistry, Technische Universität Dresden, Fiedlerstrasse 42, 01307 Dresden, Germany.

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http://dx.doi.org/10.1038/ncb2213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087846PMC
May 2011

Homology-directed Fanconi anemia pathway cross-link repair is dependent on DNA replication.

Nat Struct Mol Biol 2011 Apr 20;18(4):500-3. Epub 2011 Mar 20.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.2029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273992PMC
April 2011

Distinct properties of the XY pseudoautosomal region crucial for male meiosis.

Science 2011 Feb;331(6019):916-20

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/science.1195774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151169PMC
February 2011

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway.

Nat Struct Mol Biol 2011 Jan 5;18(1):80-4. Epub 2010 Dec 5.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.1940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261752PMC
January 2011

Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination.

PLoS Genet 2010 Oct 14;6(10):e1001160. Epub 2010 Oct 14.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1371/journal.pgen.1001160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954829PMC
October 2010

Collaboration and competition between DNA double-strand break repair pathways.

FEBS Lett 2010 Sep 5;584(17):3703-8. Epub 2010 Aug 5.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.febslet.2010.07.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954739PMC
September 2010

Comprehensive, fine-scale dissection of homologous recombination outcomes at a hot spot in mouse meiosis.

Mol Cell 2010 Sep;39(5):700-10

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196603PMC
September 2010

Mouse TRIP13/PCH2 is required for recombination and normal higher-order chromosome structure during meiosis.

PLoS Genet 2010 Aug 12;6(8). Epub 2010 Aug 12.

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1371/journal.pgen.1001062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920839PMC
August 2010

The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations.

Cancer Genet Cytogenet 2010 Jul;200(2):184-90

Division of Hematology-Oncology, Cancer Research and Treatment Center, Department of Medicine, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA.

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http://dx.doi.org/10.1016/j.cancergencyto.2010.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904321PMC
July 2010

Evolutionary conservation of meiotic DSB proteins: more than just Spo11.

Genes Dev 2010 Jun;24(12):1201-7

Developmental Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1101/gad.1944710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885656PMC
June 2010

Loss of 53BP1 is a gain for BRCA1 mutant cells.

Cancer Cell 2010 May;17(5):423-5

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.ccr.2010.04.021DOI Listing
May 2010

Mechanisms of recombination between diverged sequences in wild-type and BLM-deficient mouse and human cells.

Mol Cell Biol 2010 Apr 12;30(8):1887-97. Epub 2010 Feb 12.

Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1128/MCB.01553-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849462PMC
April 2010

Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation.

Nat Struct Mol Biol 2010 Apr 7;17(4):410-6. Epub 2010 Mar 7.

Developmental Biology Program, Memorial Sloan-Kettering Cancer Center and Weill Cornell Graduate School of Medical Sciences, New York, New York, USA.

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http://www.nature.com/articles/nsmb.1773
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893185PMC
April 2010

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis.

Nat Rev Mol Cell Biol 2010 Mar;11(3):196-207

Developmental Biology Program, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nrm2851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261768PMC
March 2010

DNA damage responses by human ELG1 in S phase are important to maintain genomic integrity.

Cell Cycle 2009 Oct 7;8(19):3199-207. Epub 2009 Oct 7.

Genome Instability Section, Genetics and Molecular Biology Branch, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.4161/cc.8.19.9752DOI Listing
October 2009

Chromosomal translocations induced at specified loci in human stem cells.

Proc Natl Acad Sci U S A 2009 Jun 23;106(26):10620-5. Epub 2009 Jun 23.

Department of Medicine, Developmental Biology Program and Sloan-Kettering Institute Stem Cell Research Facility, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0902076106
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700748PMC
June 2009

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.

Proc Natl Acad Sci U S A 2008 Dec 16;105(52):20876-81. Epub 2008 Dec 16.

Institute for Cancer Genetics, Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.

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http://dx.doi.org/10.1073/pnas.0811203106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603436PMC
December 2008