Maria I Loza

Maria I Loza

UNVERIFIED PROFILE

Are you Maria I Loza?   Register this Author

Register author
Maria I Loza

Maria I Loza

Publications by authors named "Maria I Loza"

Are you Maria I Loza?   Register this Author

34Publications

485Reads

6Profile Views

A Novel NMDA Receptor Antagonist Protects against Cognitive Decline Presented by Senescent Mice.

Pharmaceutics 2020 Mar 22;12(3). Epub 2020 Mar 22.

Pharmacology Section, Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Neuroscience, University of Barcelona (NeuroUB), Av. Joan XXIII 27-31, 08028 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pharmaceutics12030284DOI Listing
March 2020

A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade.

Thromb Haemost 2020 Feb 4;120(2):262-276. Epub 2020 Jan 4.

Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidad de Santiago de Compostela, and Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-3400295DOI Listing
February 2020

Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M.

Biomed Pharmacother 2020 Jan 15;121:109601. Epub 2019 Nov 15.

Department of Physiological Sciences, School of Medicine, University of Barcelona, L'Hospitalet del Llobregat, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2019.109601DOI Listing
January 2020

Synthesis, pharmacological and structural studies of 5-substituted-3-(1-arylmethyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as multi-target ligands of aminergic GPCRs.

Eur J Med Chem 2019 Oct 20;180:673-689. Epub 2019 Jul 20.

Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Faculty of Pharmacy with Division of Medical Analytics, Medical University of Lublin, 4A Chodźki St., PL-20093, Lublin, Poland; School of Pharmacy, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211, Kuopio, Finland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.07.050DOI Listing
October 2019

Trifluorinated Pyrimidine-Based A Antagonists: Optimization and Evidence of Stereospecific Recognition.

J Med Chem 2019 Oct 4;62(20):9315-9330. Epub 2019 Oct 4.

Department of Cell and Molecular Biology , Uppsala University , Uppsala SE-75124 , Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.9b01340DOI Listing
October 2019

5-HT2 receptor binding, functional activity and selectivity in N-benzyltryptamines.

PLoS One 2019 10;14(1):e0209804. Epub 2019 Jan 10.

Department of Chemistry, Faculty of Sciences, University of Chile, Ñuñoa, Santiago, Chile.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209804PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328172PMC
September 2019

2-Aryladenine derivatives as a potent scaffold for A, A and dual A/A adenosine receptor antagonists: Synthesis and structure-activity relationships.

Bioorg Med Chem 2019 Aug 20;27(16):3551-3558. Epub 2019 Jun 20.

Center of Chemistry, Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2019.06.034DOI Listing
August 2019

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy.

EBioMedicine 2019 Jul 5;45:588-605. Epub 2019 Jul 5.

Uxía Nogueira-Recalde, Irene Lorenzo Gómez, Francisco J. Blanco and Beatriz Caramés, Grupo de Biología del Cartílago, Servicio de Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complejo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2019.06.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642320PMC
July 2019

Editorial: Novel Approaches to the Neuropharmacology of Mood Disorders.

Front Pharmacol 2019 17;10:589. Epub 2019 May 17.

Department of Psychiatry, Alvaro Cunqueiro Hospital, Vigo, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2019.00589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533613PMC
May 2019

Computer-aided design of multi-target ligands at AR, AR and PDE10A, key proteins in neurodegenerative diseases.

J Cheminform 2017 Dec 30;9(1):67. Epub 2017 Dec 30.

Department of Chemistry, Centre for Molecular Informatics, University of Cambridge, Lensfield Road, Cambridge, CB21EW, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13321-017-0249-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748027PMC
December 2017

Development of Fluorescent Probes that Target Serotonin 5-HT Receptors.

Sci Rep 2017 09 7;7(1):10765. Epub 2017 Sep 7.

Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, E-15782, Santiago de Compostela, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-11370-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589878PMC
September 2017

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Authors:
Wesley C Van Voorhis John H Adams Roberto Adelfio Vida Ahyong Myles H Akabas Pietro Alano Aintzane Alday Yesmalie Alemán Resto Aishah Alsibaee Ainhoa Alzualde Katherine T Andrews Simon V Avery Vicky M Avery Lawrence Ayong Mark Baker Stephen Baker Choukri Ben Mamoun Sangeeta Bhatia Quentin Bickle Lotfi Bounaadja Tana Bowling Jürgen Bosch Lauren E Boucher Fabrice F Boyom Jose Brea Marian Brennan Audrey Burton Conor R Caffrey Grazia Camarda Manuela Carrasquilla Dee Carter Maria Belen Cassera Ken Chih-Chien Cheng Worathad Chindaudomsate Anthony Chubb Beatrice L Colon Daisy D Colón-López Yolanda Corbett Gregory J Crowther Noemi Cowan Sarah D'Alessandro Na Le Dang Michael Delves Joseph L DeRisi Alan Y Du Sandra Duffy Shimaa Abd El-Salam El-Sayed Michael T Ferdig José A Fernández Robledo David A Fidock Isabelle Florent Patrick V T Fokou Ani Galstian Francisco Javier Gamo Suzanne Gokool Ben Gold Todd Golub Gregory M Goldgof Rajarshi Guha W Armand Guiguemde Nil Gural R Kiplin Guy Michael A E Hansen Kirsten K Hanson Andrew Hemphill Rob Hooft van Huijsduijnen Takaaki Horii Paul Horrocks Tyler B Hughes Christopher Huston Ikuo Igarashi Katrin Ingram-Sieber Maurice A Itoe Ajit Jadhav Amornrat Naranuntarat Jensen Laran T Jensen Rays H Y Jiang Annette Kaiser Jennifer Keiser Thomas Ketas Sebastien Kicka Sunyoung Kim Kiaran Kirk Vidya P Kumar Dennis E Kyle Maria Jose Lafuente Scott Landfear Nathan Lee Sukjun Lee Adele M Lehane Fengwu Li David Little Liqiong Liu Manuel Llinás Maria I Loza Aristea Lubar Leonardo Lucantoni Isabelle Lucet Louis Maes Dalu Mancama Nuha R Mansour Sandra March Sheena McGowan Iset Medina Vera Stephan Meister Luke Mercer Jordi Mestres Alvine N Mfopa Raj N Misra Seunghyun Moon John P Moore Francielly Morais Rodrigues da Costa Joachim Müller Arantza Muriana Stephen Nakazawa Hewitt Bakela Nare Carl Nathan Nathalie Narraidoo Sujeevi Nawaratna Kayode K Ojo Diana Ortiz Gordana Panic George Papadatos Silvia Parapini Kailash Patra Ngoc Pham Sarah Prats David M Plouffe Sally-Ann Poulsen Anupam Pradhan Celia Quevedo Ronald J Quinn Christopher A Rice Mohamed Abdo Rizk Andrea Ruecker Robert St Onge Rafaela Salgado Ferreira Jasmeet Samra Natalie G Robinett Ulrich Schlecht Marjorie Schmitt Filipe Silva Villela Francesco Silvestrini Robert Sinden Dennis A Smith Thierry Soldati Andreas Spitzmüller Serge Maximilian Stamm David J Sullivan William Sullivan Sundari Suresh Brian M Suzuki Yo Suzuki S Joshua Swamidass Donatella Taramelli Lauve R Y Tchokouaha Anjo Theron David Thomas Kathryn F Tonissen Simon Townson Abhai K Tripathi Valentin Trofimov Kenneth O Udenze Imran Ullah Cindy Vallieres Edgar Vigil Joseph M Vinetz Phat Voong Vinh Hoan Vu Nao-Aki Watanabe Kate Weatherby Pamela M White Andrew F Wilks Elizabeth A Winzeler Edward Wojcik Melanie Wree Wesley Wu Naoaki Yokoyama Paul H A Zollo Nada Abla Benjamin Blasco Jeremy Burrows Benoît Laleu Didier Leroy Thomas Spangenberg Timothy Wells Paul A Willis

PLoS Pathog 2016 07 28;12(7):e1005763. Epub 2016 Jul 28.

Medicines for Malaria Venture, Geneva, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1005763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965013PMC
July 2016

Structure-Based Virtual Screening for Dopamine D2 Receptor Ligands as Potential Antipsychotics.

ChemMedChem 2016 Apr 18;11(7):718-29. Epub 2016 Mar 18.

School of Pharmacy, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, 70211, Kuopio, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.201500599DOI Listing
April 2016

Synthesis and biological evaluation of a series of aminoalkyl-tetralones and tetralols as dual dopamine/serotonin ligands.

Eur J Med Chem 2014 Jan 20;71:237-49. Epub 2013 Nov 20.

Departamento de Farmacología, Facultad de Farmacia, Universidad de Santiago de Compostela, E-15782 Santiago de Compostela, Spain. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02235234130071
Publisher Site
http://dx.doi.org/10.1016/j.ejmech.2013.10.066DOI Listing
January 2014

Synthesis and binding affinity of new 1,4-disubstituted triazoles as potential dopamine D(3) receptor ligands.

Bioorg Med Chem Lett 2013 Oct 16;23(20):5586-91. Epub 2013 Aug 16.

Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2013.08.047DOI Listing
October 2013

A detailed proteomic analysis of rhodocytin-activated platelets reveals novel clues on the CLEC-2 signalosome: implications for CLEC-2 signaling regulation.

Blood 2012 Dec 10;120(26):e117-26. Epub 2012 Oct 10.

Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-09-456004DOI Listing
December 2012

New chromene scaffolds for adenosine A(2A) receptors: synthesis, pharmacology and structure-activity relationships.

Eur J Med Chem 2012 Aug 14;54:303-10. Epub 2012 May 14.

Center of Chemistry, Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2012.05.009DOI Listing
August 2012

A potential nanomedicine consisting of heparin-loaded polysaccharide nanocarriers for the treatment of asthma.

Macromol Biosci 2012 Feb 23;12(2):176-83. Epub 2011 Nov 23.

Department of Pharmacy, Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela, Santiago de Compostela, Spain.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/mabi.201100102
Publisher Site
http://dx.doi.org/10.1002/mabi.201100102DOI Listing
February 2012

Synthesis of novel chromene scaffolds for adenosine receptors.

Org Biomol Chem 2011 Jun 20;9(11):4242-9. Epub 2011 Apr 20.

Department of Chemistry, University of Minho, Campos de Gualtar, 4710-057, Braga, Portugal.

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=c1ob05305a
Publisher Site
http://dx.doi.org/10.1039/c1ob05305aDOI Listing
June 2011

In silico directed chemical probing of the adenosine receptor family.

Bioorg Med Chem 2010 May 27;18(9):3043-52. Epub 2010 Mar 27.

Center of Chemistry, Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2010.03.048DOI Listing
May 2010

Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif.

Bioorg Med Chem Lett 2009 Nov 17;19(21):6059-62. Epub 2009 Sep 17.

Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, E-15782, Santiago de Compostela, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2009.09.041DOI Listing
November 2009

Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands.

Bioorg Med Chem Lett 2009 Mar 27;19(6):1773-8. Epub 2009 Jan 27.

Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2009.01.067DOI Listing
March 2009

Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics.

J Med Chem 2008 Oct 11;51(19):6085-94. Epub 2008 Sep 11.

Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm800602wDOI Listing
October 2008

Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics.

Bioorg Med Chem Lett 2007 Sep 14;17(17):4873-7. Epub 2007 Jun 14.

Departamento de Química Orgánica, Laboratorio de Química Farmacéutica, Universidad de Santiago de Compostela, E-15782, Santiago de Compostela, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2007.06.045DOI Listing
September 2007

Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics.

Bioorg Med Chem Lett 2005 Jun;15(12):3063-6

Departamento de Química Orgánica, Laboratorio de Química Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela. E-15782, Santiago de Compostela, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2005.04.022DOI Listing
June 2005

Chemoenzymatic synthesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics.

Bioorg Med Chem Lett 2004 Feb;14(3):585-9

Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, E-15782, Santiago de Compostela, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2003.11.064DOI Listing
February 2004