Publications by authors named "Maria Grazia Roncarolo"

100Publications

Engineered type 1 regulatory T cells designed for clinical use kill primary pediatric acute myeloid leukemia cells.

Haematologica 2020 Sep 28;Online ahead of print. Epub 2020 Sep 28.

Department of Pediatrics, Division of Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, CA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford.

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http://dx.doi.org/10.3324/haematol.2020.263129DOI Listing
September 2020

Celebrating 20 years of FOCIS.

Sci Immunol 2020 Oct;5(52)

Maria Grazia Roncarolo is the past president of FOCIS and the George D. Smith professor of pediatrics and medicine, the director of the Center for Definitive and Curative Medicine, and the co-director of the Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. Email:

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http://dx.doi.org/10.1126/sciimmunol.abe8102DOI Listing
October 2020

Gene therapy for Wiskott-Aldrich syndrome: History, new vectors, future directions.

J Allergy Clin Immunol 2020 Aug 2;146(2):262-265. Epub 2020 Jul 2.

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2020.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453879PMC
August 2020

Graft Engineering and Adoptive Immunotherapy: New Approaches to Promote Immune Tolerance After Hematopoietic Stem Cell Transplantation.

Front Immunol 2019 10;10:1342. Epub 2019 Jul 10.

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2019.01342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635579PMC
June 2020

Gene therapy for primary immunodeficiency.

Hum Mol Genet 2019 10;28(R1):R15-R23

Molecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, UK.

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http://dx.doi.org/10.1093/hmg/ddz170DOI Listing
October 2019

Driving Medical Innovation Through Interdisciplinarity: Unique Opportunities and Challenges.

Front Med (Lausanne) 2019 26;6:35. Epub 2019 Feb 26.

Department of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital Utrecht, Utrecht, Netherlands.

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https://www.frontiersin.org/article/10.3389/fmed.2019.00035/
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http://dx.doi.org/10.3389/fmed.2019.00035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400109PMC
February 2019

Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10).

Cell Mol Immunol 2020 01 6;17(1):95-107. Epub 2019 Mar 6.

San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), San Raffaele Scientific Institute (IRCCS), Milan, Italy.

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http://dx.doi.org/10.1038/s41423-019-0218-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952411PMC
January 2020

Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome.

Cell Stem Cell 2019 02 10;24(2):309-317.e7. Epub 2019 Jan 10.

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183059
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http://dx.doi.org/10.1016/j.stem.2018.12.003DOI Listing
February 2019

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases.

Immunity 2018 12;49(6):1004-1019

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institute, 17176 Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S10747613183052
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http://dx.doi.org/10.1016/j.immuni.2018.12.001DOI Listing
December 2018

Tregopathies: Monogenic diseases resulting in regulatory T-cell deficiency.

J Allergy Clin Immunol 2018 12;142(6):1679-1695

Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine, Stanford School of Medicine, Stanford, Calif; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford School of Medicine, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.10.026DOI Listing
December 2018

APVO210: A Bispecific Anti-CD86-IL-10 Fusion Protein (ADAPTIR™) to Induce Antigen-Specific T Regulatory Type 1 Cells.

Front Immunol 2018 25;9:881. Epub 2018 May 25.

Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine, Stanford University, Stanford, CA, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2018.00881
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http://dx.doi.org/10.3389/fimmu.2018.00881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980965PMC
July 2019

Role of human forkhead box P3 in early thymic maturation and peripheral T-cell homeostasis.

J Allergy Clin Immunol 2018 12 27;142(6):1909-1921.e9. Epub 2018 Apr 27.

San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy; Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford School of Medicine, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.03.015DOI Listing
December 2018

Engineered T Regulatory Type 1 Cells for Clinical Application.

Front Immunol 2018 15;9:233. Epub 2018 Feb 15.

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, ISCBRM, Stanford School of Medicine, Stanford, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2018.00233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818395PMC
March 2019

Gene Therapy for Adenosine Deaminase Deficiency: A Comprehensive Evaluation of Short- and Medium-Term Safety.

Mol Ther 2018 03 4;26(3):917-931. Epub 2018 Jan 4.

San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan, Italy, 20132; Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 20132; Vita-Salute San Raffaele University, Milan, Italy, 20132. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016183000
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http://dx.doi.org/10.1016/j.ymthe.2017.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5910668PMC
March 2018

Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study.

J Allergy Clin Immunol 2018 03 11;141(3):1036-1049.e5. Epub 2017 Dec 11.

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050203PMC
March 2018

Identity and Diversity of Human Peripheral Th and T Regulatory Cells Defined by Single-Cell Mass Cytometry.

J Immunol 2018 01 27;200(1):336-346. Epub 2017 Nov 27.

Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA 94305;

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http://dx.doi.org/10.4049/jimmunol.1701025DOI Listing
January 2018

IL-10-Engineered Human CD4 Tr1 Cells Eliminate Myeloid Leukemia in an HLA Class I-Dependent Mechanism.

Mol Ther 2017 10 5;25(10):2254-2269. Epub 2017 Jul 5.

San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan 20132, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15250016173031
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http://dx.doi.org/10.1016/j.ymthe.2017.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628869PMC
October 2017

Peanut-specific type 1 regulatory T cells induced in vitro from allergic subjects are functionally impaired.

J Allergy Clin Immunol 2018 01 6;141(1):202-213.e8. Epub 2017 Jul 6.

Division of Stem Cell Transplantation and Regenerative Medicine at Stanford University, and Department of Pediatrics, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.05.045DOI Listing
January 2018

Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial.

Lancet 2016 Jul 8;388(10043):476-87. Epub 2016 Jun 8.

San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy; Pediatric Immunohematology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Bone Marrow Transplantation Program, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita Salute San Raffaele University, Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(16)30374-9DOI Listing
July 2016

In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution Phases.

Cell Stem Cell 2016 07 26;19(1):107-19. Epub 2016 May 26.

San Raffaele Telethon Institute for Gene Therapy (TIGET), 20132 Milan, Italy; Pediatric Immunohematology and Bone Marrow Transplant Unit, San Raffaele Scientific Institute, 20132 Milan, Italy; Vita-Salute San Raffaele University, 20132 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942697PMC
July 2016

From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation.

Ann N Y Acad Sci 2018 04 25;1417(1):5-22. Epub 2016 Feb 25.

Department of Pediatrics, Division of Pediatric Stem Cells, Transplantation and Regenerative Medicine, Stanford University Medical School, Stanford, California.

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http://dx.doi.org/10.1111/nyas.13011DOI Listing
April 2018

Concise Review: Cell-Based Therapies and Other Non-Traditional Approaches for Type 1 Diabetes.

Stem Cells 2016 Apr 9;34(4):809-19. Epub 2016 Feb 9.

Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine Stanford, CA, USA.

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http://dx.doi.org/10.1002/stem.2290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021120PMC
April 2016

Mixed chimerism evolution is associated with T regulatory type 1 (Tr1) cells in a β-thalassemic patient after haploidentical haematopoietic stem cell transplantation.

Chimerism 2014 9;5(3-4):75-9. Epub 2015 Dec 9.

b San Raffaele Telethon Institute for Gene Therapy (TIGET); Division of Regenerative Medicine; Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute ; Milan , Italy.

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http://dx.doi.org/10.1080/19381956.2015.1103423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063086PMC
August 2016

Clinical Outlook for Type-1 and FOXP3(+) T Regulatory Cell-Based Therapy.

Front Immunol 2015 25;6:593. Epub 2015 Nov 25.

Department of Pediatric Stem Cell Transplantation and Regenerative Medicine, Stanford School of Medicine , Palo Alto, CA , USA.

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http://dx.doi.org/10.3389/fimmu.2015.00593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658444PMC
December 2015

Insulin B chain 9-23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs.

Sci Transl Med 2015 May;7(289):289ra81

San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy. Vita-Salute San Raffaele University, Milan 20132, Italy. Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa3032DOI Listing
May 2015

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.

Blood 2015 Jun 1;125(25):3886-95. Epub 2015 Apr 1.

Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; Division of Gastroenterology, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1182/blood-2014-12-618363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473116PMC
June 2015

HLA-G expression levels influence the tolerogenic activity of human DC-10.

Haematologica 2015 Apr 6;100(4):548-57. Epub 2015 Feb 6.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy

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http://dx.doi.org/10.3324/haematol.2014.113803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380729PMC
April 2015

In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells.

Sci Transl Med 2015 Feb;7(273):273ra13

Department of Pediatrics, Ospedale Pediatrico Bambino Gesù and University of Rome "Tor Vergata," Rome 00165, Italy. TIGET, Pediatric Immunohematology and Stem Cell Programme, San Raffaele Scientific Institute, Milan 20132, Italy.

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http://dx.doi.org/10.1126/scitranslmed.3010314DOI Listing
February 2015

BAT2 and BAT3 polymorphisms as novel genetic risk factors for rejection after HLA-related SCT.

Bone Marrow Transplant 2014 Nov 11;49(11):1400-1404. Epub 2014 Aug 11.

San Raffaele Telethon Institute for Gene Therapy (HSRTIGET), Division of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1038/bmt.2014.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222814PMC
November 2014

Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications.

Curr Top Microbiol Immunol 2014 ;380:39-68

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy,

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http://dx.doi.org/10.1007/978-3-662-43492-5_3DOI Listing
November 2014

Forkhead box P3: the peacekeeper of the immune system.

Int Rev Immunol 2014 Mar 19;33(2):129-45. Epub 2013 Dec 19.

1Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.3109/08830185.2013.863303DOI Listing
March 2014

CD4⁺ T cells from IPEX patients convert into functional and stable regulatory T cells by FOXP3 gene transfer.

Sci Transl Med 2013 Dec;5(215):215ra174

San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan 20132, Italy.

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http://stm.sciencemag.org/cgi/doi/10.1126/scitranslmed.30073
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http://dx.doi.org/10.1126/scitranslmed.3007320DOI Listing
December 2013

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells.

Nat Med 2013 Jun 28;19(6):739-46. Epub 2013 Apr 28.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1038/nm.3179DOI Listing
June 2013

Immune responses in liver-directed lentiviral gene therapy.

Transl Res 2013 Apr 26;161(4):230-40. Epub 2013 Jan 26.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1016/j.trsl.2012.12.018DOI Listing
April 2013

HLA-G expressing DC-10 and CD4(+) T cells accumulate in human decidua during pregnancy.

Hum Immunol 2013 Apr 10;74(4):406-11. Epub 2012 Dec 10.

San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1016/j.humimm.2012.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610019PMC
April 2013

Enforced IL-10 expression confers type 1 regulatory T cell (Tr1) phenotype and function to human CD4(+) T cells.

Mol Ther 2012 Sep 12;20(9):1778-90. Epub 2012 Jun 12.

San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1038/mt.2012.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437582PMC
September 2012

The cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory T cells.

Front Immunol 2012 29;3:30. Epub 2012 Feb 29.

Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), San Raffaele Scientific Institute Milan, Italy.

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http://dx.doi.org/10.3389/fimmu.2012.00030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342353PMC
August 2012

Manipulating Immune Tolerance with Micro-RNA Regulated Gene Therapy.

Front Microbiol 2011 14;2:221. Epub 2011 Nov 14.

San Raffaele Telethon Institute for Gene Therapy, Department of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Institute Milan, Italy.

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http://journal.frontiersin.org/article/10.3389/fmicb.2011.00
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http://dx.doi.org/10.3389/fmicb.2011.00221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229161PMC
October 2012

Immune intervention with T regulatory cells: past lessons and future perspectives for type 1 diabetes.

Semin Immunol 2011 Jun 9;23(3):182-94. Epub 2011 Aug 9.

San Raffaele Diabetes Research Institute, via Olgettina 58, 20132 Milan, Italy.

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http://dx.doi.org/10.1016/j.smim.2011.07.007DOI Listing
June 2011

Clinical tolerance in allogeneic hematopoietic stem cell transplantation.

Immunol Rev 2011 May;241(1):145-63

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells, Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1111/j.1600-065X.2011.01010.xDOI Listing
May 2011

Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells.

Eur J Immunol 2011 Jun 13;41(6):1652-62. Epub 2011 May 13.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://doi.wiley.com/10.1002/eji.201041120
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http://dx.doi.org/10.1002/eji.201041120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116154PMC
June 2011

Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells.

J Allergy Clin Immunol 2010 Dec 30;126(6):1242-51. Epub 2010 Oct 30.

Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S009167491001342
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http://dx.doi.org/10.1016/j.jaci.2010.09.001DOI Listing
December 2010

Bone marrow as a source of hematopoietic stem cells for human gene therapy of β-thalassemia.

Hum Gene Ther 2011 Apr 4;22(4):507-13. Epub 2011 Mar 4.

Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, 20132 Milan, Italy.

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http://dx.doi.org/10.1089/hum.2010.045DOI Listing
April 2011

Granulocyte-colony stimulating factor drives the in vitro differentiation of human dendritic cells that induce anergy in naïve T cells.

Eur J Immunol 2010 Nov 19;40(11):3097-106. Epub 2010 Oct 19.

San Raffaele Telethon Institute for Gene Therapy, Department of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1002/eji.201040659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997328PMC
November 2010

Methods for in vitro generation of human type 1 regulatory T cells.

Methods Mol Biol 2011 ;677:31-46

Department of Regenerative Medicine, San Raffaele Telethon Institute for Gene Therapy HSR, Milan, Italy.

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http://dx.doi.org/10.1007/978-1-60761-869-0_3DOI Listing
February 2011

HIV-1-derived lentiviral vectors directly activate plasmacytoid dendritic cells, which in turn induce the maturation of myeloid dendritic cells.

Hum Gene Ther 2011 Feb 14;22(2):177-88. Epub 2011 Jan 14.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET) , Department of Regenerative Medicine, Stem Cells and Gene Therapy, Via Olgettina 58, Milan, Italy.

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http://www.liebertpub.com/doi/10.1089/hum.2010.085
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http://dx.doi.org/10.1089/hum.2010.085DOI Listing
February 2011

Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.

Blood 2010 Aug 6;116(6):935-44. Epub 2010 May 6.

Department of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy, Via Olgettina 58, Milan, Italy.

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http://dx.doi.org/10.1182/blood-2009-07-234872DOI Listing
August 2010

Induction of anergic allergen-specific suppressor T cells using tolerogenic dendritic cells derived from children with allergies to house dust mites.

J Allergy Clin Immunol 2010 Mar 11;125(3):727-36. Epub 2010 Feb 11.

Department of Pediatric Medicine, Immuno-Infectivology Unit, Bambino Gesu' Children's Hospital, Rome, Italy.

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http://dx.doi.org/10.1016/j.jaci.2009.12.004DOI Listing
March 2010

Ten years of gene therapy for primary immune deficiencies.

Hematology Am Soc Hematol Educ Program 2009 :682-9

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1182/asheducation-2009.1.682DOI Listing
March 2010

The Tregs' world according to GARP.

Eur J Immunol 2009 Dec;39(12):3296-300

San Raffaele Telethon Institute for Gene Therapy, Milano, Italy.

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http://dx.doi.org/10.1002/eji.200940117DOI Listing
December 2009

Wild-type FOXP3 is selectively active in CD4+CD25(hi) regulatory T cells of healthy female carriers of different FOXP3 mutations.

Blood 2009 Nov 8;114(19):4138-41. Epub 2009 Sep 8.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, 58-20132 Milan, Italy.

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http://dx.doi.org/10.1182/blood-2009-04-214593DOI Listing
November 2009

Role of human leukocyte antigen-G in the induction of adaptive type 1 regulatory T cells.

Hum Immunol 2009 Dec 4;70(12):966-9. Epub 2009 Aug 4.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Milan, Italy.

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http://dx.doi.org/10.1016/j.humimm.2009.07.022DOI Listing
December 2009

Autoimmune diabetic patients undergoing allogeneic islet transplantation: are we ready for a regulatory T-cell therapy?

Immunol Lett 2009 Dec 28;127(1):1-7. Epub 2009 Jul 28.

San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), 20132 Milano, Italy.

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http://dx.doi.org/10.1016/j.imlet.2009.07.007DOI Listing
December 2009