Publications by authors named "Maria Grandinetti"

10 Publications

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Bicuspidized De Vega for functional tricuspid valve regurgitation: "De-Kay repair".

Ann Thorac Surg 2021 Apr 27. Epub 2021 Apr 27.

Department of Cardiovascular Science, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome.

Functional tricuspid valve regurgitation in the contest of mitral valve disease is a highly prevalent disease. We describe a ring-less technique that combines restrictive annuloplasty (De Vega) with posterior tricuspid leaflet obliteration (Kay) used for patients with less-than-severe functional tricuspid valve regurgitation undergoing mitral valve surgery. The technique has been in use at our centre since 2012, showing promising long-term echocardiographic results, with stable reduction of the annulus size and stable reduction of the degree of regurgitation.
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http://dx.doi.org/10.1016/j.athoracsur.2021.04.038DOI Listing
April 2021

Telemedicine for adult congenital heart disease patients during the first wave of COVID-19 era: a single center experience.

J Cardiovasc Med (Hagerstown) 2021 Apr 20. Epub 2021 Apr 20.

Dipartimento di Scienze Cardiovascolari e Toraciche, Fondazione Policlinico Universitario A. Gemelli IRCCS Catholic University of the Sacred Heart Department of Pediatric Cardiology and Cardiac Surgery - Bambino Gesù Hospital, Rome, Italy.

Aim: To summarize our experience on the implementation of a telemedicine service dedicated to adult congenital heart disease (ACHD) patients during the lockdown for the first wave of COVID-19.

Methods: This is a prospective study enrolling all ACHD patients who answered a questionnaire dedicated telematic cardiovascular examination.

Results: A total of 289 patients were enrolled, 133 (47%) were male, 25 (9%) were affected by a genetic syndrome. The median age was 38 (29-51) years, whereas the median time interval between the last visit and the telematic follow-up was 9.5 (7.5-11.5) months. Overall, 35 patients (12%) reported a worsening of fatigue in daily life activity, 17 (6%) experienced chest pain, 42 (15%) had presyncope and 2 (1%) syncope; in addition, 28 patients (10%) presented peripheral edema and 14 (5%) were orthopneic. A total of 116 (40%) patients reported palpitations and 12 had at least one episode of atrial fibrillation and underwent successful electrical (8) or pharmacological (4) cardioversion. One patient was admitted to the emergency department for uncontrolled arterial hypertension, five for chest pain, and one for heart failure. Two patients presented fever but both had negative COVID-19 nasal swab.

Conclusion: During the COVID-19 pandemic, the use of telemedicine dramatically increased and here we report a positive experience in ACHD patients. The postpandemic role of telemedicine will depend on permanent regulatory solutions and this early study might encourage a more systematic telematic approach for ACHD patients.
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http://dx.doi.org/10.2459/JCM.0000000000001195DOI Listing
April 2021

Infant miniaturized continuous-flow pumps and permanent support in Pediatrics.

Ann Cardiothorac Surg 2021 Mar;10(2):278-280

Heart Failure, Transplant and Mechanical Cardiocirculatory Support Unit, Department of Pediatric Cardiology and Cardiac Surgery, Heart Lung Transplantation, ERN GUARD HEART: Bambino Gesù Hospital and Research Institute, Rome, Italy.

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http://dx.doi.org/10.21037/acs-2020-cfmcs-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8033256PMC
March 2021

Heart valve critical pathway and heart valve clinic: novel benchmarks for modern management of valvular heart disease.

Crit Pathw Cardiol 2021 Mar 31. Epub 2021 Mar 31.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia Università Cattolica del Sacro Cuore, Roma, Italia.

The growing burden of Valvular Heart Disease (VHD) in Western countries represents a challenge for the daily clinical practice, especially in the light of the ever-increasing number of therapeutic options. The Euro Heart Survey showed that, among elderly subjects with severe, symptomatic valve dysfunction, surgery is denied for 33% of patients with aortic stenosis and for 50% of patients with mitral regurgitation. Current management (from diagnosis to follow-up) is often fragmented in multiple - sometimes unnecessary- steps. Such a "patchy" approach may translate into a suboptimal management, especially in the geriatric population. New healthcare models exist, that can coordinate care, reduce fragmentation, limit costs and, ultimately, improve outcomes: the clinical pathways.
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http://dx.doi.org/10.1097/HPC.0000000000000260DOI Listing
March 2021

Successful Transcatheter Treatment of Left Pulmonary Artery to Left Atrium Communication Diagnosed in Adulthood.

Circ Cardiovasc Imaging 2020 11 6;13(11):e010668. Epub 2020 Nov 6.

Department of Cardiovascular and Thoracic Sciences (R.L., F.G., F.B., G.L., C.A., E.R., M.G., E.P., R.S., F.I., M.M., C.T.) Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

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http://dx.doi.org/10.1161/CIRCIMAGING.120.010668DOI Listing
November 2020

Duchenne Dilated Cardiomyopathy: Cardiac Management from Prevention to Advanced Cardiovascular Therapies.

J Clin Med 2020 Oct 1;9(10). Epub 2020 Oct 1.

Heart Failure Clinic-Heart Failure, Heart Transplant, Mechanical Circulatory Support Unit, Department of Pediatric Cardiology and Cardiac Surgery, Heart and Lung Transplant, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.

Duchenne muscular dystrophy (DMD) cardiomyopathy (DCM) is characterized by a hypokinetic, dilated phenotype progressively increasing with age. Regular cardiac care is crucial in DMD care. Early recognition and prophylactic use of angiotensin converting enzyme inhibitors (ACEi) are the main stay therapeutic strategy to delay incidence of DMD-DCM. Pharmacological treatment to improve symptoms and left ventricle (LV) systolic function, have been widely implemented in the past years. Because of lack of DMD specific drugs, actual indications for established DCM include current treatment for heart failure (HF). This review focuses on current HF strategies to identify, characterize, and treat DMD-DCM.
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http://dx.doi.org/10.3390/jcm9103186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600130PMC
October 2020

Undiagnosed Severe Late Complications of Repaired Tetralogy of Fallot.

Circ Cardiovasc Imaging 2020 06;13(6):e010273

Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy (R.L., E.P., F.G., A.M.L., M.G., F.C., M.M.).

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http://dx.doi.org/10.1161/CIRCIMAGING.119.010273DOI Listing
June 2020

Results for tricuspid valve surgery in adults with congenital heart disease other than Ebstein's anomaly†.

Eur J Cardiothorac Surg 2019 Oct;56(4):706-713

Department of Congenital Cardiac Surgery, IRCCS Policlinico San Donato, San Donato Milanese, Italy.

Objectives: Tricuspid valve (TV) surgery in the adult with congenital heart disease (ACHD) is a frequently performed procedure. The aim of this study was to analyse postoperative and medium-term outcomes.

Methods: We conducted a single-centre retrospective study of patients with ACHD who underwent TV surgery (January 2000-December 2016); patients with Ebstein's anomalies were excluded. Operative and clinical records were reviewed. Outcomes considered were survival, grade of insufficiency/stenosis and TV reoperation at follow-up.

Results: A total of 128 patients with ACHD had TV surgery for functional regurgitation (n = 95), dysplasia (n = 23) and systemic TV (n = 10). Median age was 40.8 years [interquartile range (IQR) 25.3]; 55.5% were men. Preoperative regurgitation was classified as mild (n = 8), moderate (n = 47) and severe (n = 70). The TV was repaired in 109 as follows: ring annuloplasty (n = 43), de Vega annuloplasty (n = 29), Wooler annuloplasty (n = 13), commissural plasty (n = 9), Kay annuloplasty (n = 7) and others (n = 8). The TV was replaced in 19 patients with biological (n = 10) and mechanical (n = 9) prostheses. The median hospital stay was 12 days (IQR 10). The overall mortality rate was 8.6% (n = 11): 2 hospital deaths (1.6%) and 9 late deaths. Survival was 93% [95% confidence interval (CI) 85-97%] at 5 years and 83% (95% CI 70-91%) at 10 years. The median follow-up period was 4.95 years (IQR 7.7) with 1 TV reoperation. Echocardiographic assessment showed ≥moderate regurgitation in 34 (34.3%) patients. Suture plasty had a significantly higher incidence of TV regurgitation ≥moderate compared to ring annuloplasty (48.9% vs 26.3%; P = 0.033).

Conclusions: TV surgery in the ACHD is frequently associated with other main procedures. Stabilizing the TV annulus with a prosthetic ring guarantees lower recurrence of moderate to severe regurgitation compared to suture plasty repair.
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http://dx.doi.org/10.1093/ejcts/ezz093DOI Listing
October 2019

First Surgical Melody Valve-In-Valve Implantation for Early Degeneration in Mitral Position.

Ann Thorac Surg 2018 04;105(4):e169-e170

Department of Pediatric and Adult Congenital Cardiac Surgery, IRCCS Policlinico San Donato, Milan, Italy.

Congenital mitral valve disease is a real challenge in infants and small children. The implantation of expandable stented valves in mitral position has become one of the options of choice in consideration of their acceptable short-term expandable durability and subsequent feasibility of balloon expansion of these devices. We report the first case of a surgical Melody valve-in-valve procedure for early Melody valve degeneration in the mitral position. The result was good, and the procedure safe, rapid, and without an increased risk when a mechanical valve implantation will be necessary.
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http://dx.doi.org/10.1016/j.athoracsur.2017.10.024DOI Listing
April 2018

Back-to-school survival guide.

Nursing 2016 Nov;46(11):21-22

Maria Grandinetti is an assistant professor as well as retention and remediation coordinator at Wilkes University Passan School of Nursing in Wilkes-Barre, Pa. Amy Luckowski is an assistant professor at Neumann University in Aston, Pa., and a clinical nurse in the PACU at Chester County Hospital in West Chester, Pa.

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http://dx.doi.org/10.1097/01.NURSE.0000502768.58226.53DOI Listing
November 2016