Publications by authors named "Margrit Urbanek"

42Publications

Distinct subtypes of polycystic ovary syndrome with novel genetic associations: An unsupervised, phenotypic clustering analysis.

PLoS Med 2020 06 23;17(6):e1003132. Epub 2020 Jun 23.

Division of Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1003132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310679PMC
June 2020

Hyperandrogenemia is Common in Asymptomatic Women and is Associated with Increased Metabolic Risk.

Obesity (Silver Spring) 2020 01 14;28(1):106-113. Epub 2019 Nov 14.

Division of Endocrinology, Diabetes, and Bone Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1002/oby.22659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925332PMC
January 2020

Scaffold-Free Endometrial Organoids Respond to Excess Androgens Associated With Polycystic Ovarian Syndrome.

J Clin Endocrinol Metab 2020 03;105(3)

Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, US.

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http://dx.doi.org/10.1210/clinem/dgz100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7112974PMC
March 2020

Family-based quantitative trait meta-analysis implicates rare noncoding variants in DENND1A in polycystic ovary syndrome.

J Clin Endocrinol Metab 2019 Apr 30. Epub 2019 Apr 30.

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.

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http://dx.doi.org/10.1210/jc.2018-02496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660913PMC
April 2019

Functional Genetic Variation in the Anti-Müllerian Hormone Pathway in Women With Polycystic Ovary Syndrome.

J Clin Endocrinol Metab 2019 07;104(7):2855-2874

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1210/jc.2018-02178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543512PMC
July 2019

Pathogenic Anti-Müllerian Hormone Variants in Polycystic Ovary Syndrome.

J Clin Endocrinol Metab 2017 08;102(8):2862-2872

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.

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http://dx.doi.org/10.1210/jc.2017-00612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546867PMC
August 2017

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.

Nat Commun 2015 Aug 18;6:7502. Epub 2015 Aug 18.

1] Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA [2] Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1038/ncomms8502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557132PMC
August 2015

Genetic risk score for prediction of newborn adiposity and large-for-gestational-age birth.

J Clin Endocrinol Metab 2014 Nov 19;99(11):E2377-86. Epub 2014 Aug 19.

Division of Pediatric Endocrinology, Ann & Robert H. Lurie Children's Hospital of Chicago (R.C.), Department of Preventive Medicine (S.E.B., J.R., A.C.R., L.P.L., D.M.S.), Division of Endocrinology, Metabolism & Molecular Medicine (L.L.A., M.U., B.E.M., M.G.H., W.L.L.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; and PhD (cand) (S.B.), University of Washington, Seattle, Washington 355852.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2013-4221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223445PMC
November 2014

Parent-of-origin effects on glucose homeostasis in polycystic ovary syndrome.

J Clin Endocrinol Metab 2014 Aug 30;99(8):2961-6. Epub 2014 May 30.

Division of Endocrinology, Metabolism, and Molecular Medicine (K.K., P.V., R.K.S., L.A., J.Y.L., M.G.H., M.U., A.D.), Department of Medicine, and Department of Preventive Medicine (J.L.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; and Department of Obstetrics and Gynecology (R.S.L.), Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033.

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http://dx.doi.org/10.1210/jc.2013-4338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121025PMC
August 2014

The inflammatory gene pathway is not a major contributor to polycystic ovary snydrome.

J Clin Endocrinol Metab 2014 Mar 1;99(3):E567-71. Epub 2014 Jan 1.

Division of Endocrinology, Metabolism, and Molecular Medicine (S.B., P.M., O.A.G., A.D., M.U.) and Center for Genetic Medicine (N.J.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; and Department of Obstetrics and Gynecology (R.S.L.), Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033.

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http://dx.doi.org/10.1210/jc.2013-2342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942235PMC
March 2014

The role of TGF-β in polycystic ovary syndrome.

Reprod Sci 2014 Jan 12;21(1):20-31. Epub 2013 Apr 12.

1Division of Endocrinology, Diabetes, and Metabolism, Pennsylvania State University College of Medicine, M.S. Hershey Medical Center, Hershey, PA, USA.

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http://journals.sagepub.com/doi/10.1177/1933719113485294
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http://dx.doi.org/10.1177/1933719113485294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933191PMC
January 2014

Accumulation of cadmium in insulin-producing β cells.

Islets 2012 Nov-Dec;4(6):405-16. Epub 2012 Nov 1.

Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://www.biomedsearch.com/attachments/00/23/46/68/23466887
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http://www.tandfonline.com/doi/abs/10.4161/isl.23101
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http://dx.doi.org/10.4161/isl.23101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605169PMC
September 2013

Evidence for chromosome 2p16.3 polycystic ovary syndrome susceptibility locus in affected women of European ancestry.

J Clin Endocrinol Metab 2013 Jan 1;98(1):E185-90. Epub 2012 Nov 1.

Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1210/jc.2012-2471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537106PMC
January 2013

Genetics of the polycystic ovary syndrome.

Mol Cell Endocrinol 2013 Jul 16;373(1-2):29-38. Epub 2012 Oct 16.

Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, United States.

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http://dx.doi.org/10.1016/j.mce.2012.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609918PMC
July 2013

The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy.

PLoS One 2012 30;7(3):e32958. Epub 2012 Mar 30.

Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032958PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316547PMC
August 2012

Association of fibrillin-3 and transcription factor-7-like 2 gene variants with metabolic phenotypes in PCOS.

Obesity (Silver Spring) 2012 Jun 2;20(6):1273-8. Epub 2012 Feb 2.

Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/oby.2011.400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346885PMC
June 2012

Ethnic variation in allele distribution of the androgen receptor (AR) (CAG)n repeat.

J Androl 2012 Mar-Apr;33(2):210-5. Epub 2011 May 19.

Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL 60611, USA.

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http://dx.doi.org/10.2164/jandrol.111.013391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833274PMC
May 2012

Family-based analysis of candidate genes for polycystic ovary syndrome.

J Clin Endocrinol Metab 2010 May 3;95(5):2306-15. Epub 2010 Mar 3.

Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1210/jc.2009-2703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869537PMC
May 2010

The role of genetic variation in the lamin a/c gene in the etiology of polycystic ovary syndrome.

J Clin Endocrinol Metab 2009 Jul 28;94(7):2665-9. Epub 2009 Apr 28.

Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 15-717, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1210/jc.2008-2704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708953PMC
July 2009

Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2.

J Clin Endocrinol Metab 2009 Jul 7;94(7):2617-25. Epub 2009 Apr 7.

Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1210/jc.2008-1664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708958PMC
July 2009

Associations of serum sex hormone binding globulin (SHBG) levels with SHBG gene polymorphisms in the CARDIA Male Hormone Study.

Am J Epidemiol 2008 Feb 4;167(4):412-8. Epub 2007 Dec 4.

Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1093/aje/kwm332DOI Listing
February 2008

Identification of a polycystic ovary syndrome susceptibility variant in fibrillin-3 and association with a metabolic phenotype.

J Clin Endocrinol Metab 2007 Nov 4;92(11):4191-8. Epub 2007 Sep 4.

Division of Endocrinology, Metabolism, and Molecular Medicine, 303 East Chicago Avenue, Tarry 15-717, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1210/jc.2007-0761DOI Listing
November 2007

The genetics of the polycystic ovary syndrome.

Authors:
Margrit Urbanek

Nat Clin Pract Endocrinol Metab 2007 Feb;3(2):103-11

Division of Endocrinology, Metabolism, and Molecular Medicine and the Center for Genetic Medicine, Northwestern University Medical School, Chicago, IL, USA.

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http://dx.doi.org/10.1038/ncpendmet0400DOI Listing
February 2007

The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis.

J Biol Chem 2003 Jul 6;278(29):26380-90. Epub 2003 May 6.

Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M300688200DOI Listing
July 2003

Variation in resistin gene promoter not associated with polycystic ovary syndrome.

Diabetes 2003 Jan;52(1):214-7

Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.2337/diabetes.52.1.214DOI Listing
January 2003

Evidence for a hereditary neuroblastoma predisposition locus at chromosome 16p12-13.

Cancer Res 2002 Nov;62(22):6651-8

Department of Pediatrics, University of Pennsylvania School of Medicine and Children's Hospital of Philadelphia, Abramson Pediatric Research Center, Philadelphia, Pennsylvania 19104-4318, USA.

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November 2002

Self-selected women with polycystic ovary syndrome are reproductively and metabolically abnormal and undertreated.

Fertil Steril 2002 Jul;78(1):51-7

M.S. Hershey Medical Center, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1016/s0015-0282(02)03153-9DOI Listing
July 2002

A single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter influences amnion cell MMP-1 expression and risk for preterm premature rupture of the fetal membranes.

J Biol Chem 2002 Feb 11;277(8):6296-302. Epub 2001 Dec 11.

Center for Research on Reproduction and Women's Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M107865200DOI Listing
February 2002