Dr Margherita Brindisi, PhD - University of Siena - Researcher

Dr Margherita Brindisi

PhD

University of Siena

Researcher

Siena, Tuscany | Italy

Main Specialties: Chemistry

Additional Specialties: Medicinal chemistry, Drug design

Dr Margherita Brindisi, PhD - University of Siena - Researcher

Dr Margherita Brindisi

PhD

Introduction

Primary Affiliation: University of Siena - Siena, Tuscany , Italy

Specialties:

Additional Specialties:

Publications

28Publications

700Reads

-Profile Views

153PubMed Central Citations

HCV-targeted antivirals: current status and future challenges.

Curr Pharm Des 2014 ;20(21):3445-64

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università di Siena, via Aldo Moro 2, 53100, Siena (Italy).

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http://dx.doi.org/10.2174/13816128113199990630DOI Listing
March 2015
10 Reads
4 Citations
3.452 Impact Factor

Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies.

J Med Chem 2014 Nov 7;57(22):9578-97. Epub 2014 Nov 7.

European Research Centre for Drug Discovery and Development, and ‡Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena , via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/jm501119jDOI Listing
November 2014
33 Reads
8 Citations
5.450 Impact Factor

A stereoselective approach to peptidomimetic BACE1 inhibitors.

Eur J Med Chem 2013 6;70:233-47. Epub 2013 Oct 6.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100 Siena, Italy; Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.ejmech.2013.09.056DOI Listing
September 2014
33 Reads
3 Citations
3.450 Impact Factor

Rational design of the first difluorostatone-based PfSUB1 inhibitors.

Bioorg Med Chem Lett 2014 Aug 23;24(15):3582-6. Epub 2014 May 23.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro 2, 53100 Siena, Italy; Dip. di Biotecnologie, Chimica e Farmacia, University of Siena, via Aldo Moro 2, 53100 Siena, Italy; Centro Interuniversitario di Ricerche sulla Malaria (CIRM), University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2014.05.044DOI Listing
August 2014
10 Reads
5 Citations
2.420 Impact Factor

Disease-modifying anti-Alzheimer's drugs: inhibitors of human cholinesterases interfering with β-amyloid aggregation.

CNS Neurosci Ther 2014 Jul;20(7):624-32

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Siena, Italy; Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1111/cns.12290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493034PMC
July 2014
10 Reads
4 Citations
3.931 Impact Factor

The structural evolution of β-secretase inhibitors: a focus on the development of small-molecule inhibitors.

Curr Top Med Chem 2013 ;13(15):1787-807

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034716PMC
http://dx.doi.org/10.2174/15680266113139990137DOI Listing
March 2014
4 Reads
4 Citations
3.402 Impact Factor

Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation.

ACS Med Chem Lett 2013 Dec 6;4(12):1178-82. Epub 2013 Oct 6.

European Research Centre for Drug Discovery and Development-NatSynDrugs and Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena , via Aldo Moro 2, 53100 Siena, Italy ; European Research Centre for Drug Discovery and Development-NatSynDrugs and Dipartimento di Biotecnologie, Chimica e Farmacia, University of Siena , via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/ml4002908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027481PMC
December 2013
43 Reads
3 Citations
3.120 Impact Factor

Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies.

Bioorg Med Chem Lett 2013 Jan 14;23(1):85-9. Epub 2012 Nov 14.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università degli Studi di Siena, Via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2012.11.011DOI Listing
January 2013
31 Reads
4 Citations
2.420 Impact Factor

Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.

Bioorg Med Chem Lett 2013 Jan 22;23(2):492-5. Epub 2012 Nov 22.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2012.11.035DOI Listing
January 2013
21 Reads
2.420 Impact Factor

Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.

Bioorg Med Chem Lett 2012 Aug 23;22(16):5317-21. Epub 2012 Jun 23.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Via A. Moro, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2012.06.023DOI Listing
August 2012
15 Reads
6 Citations
2.420 Impact Factor

Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.

J Med Chem 2012 Aug 26;55(15):6898-915. Epub 2012 Jul 26.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Università degli Studi di Siena , Via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/jm300689cDOI Listing
August 2012
12 Reads
3 Citations
5.450 Impact Factor

Developing β-secretase inhibitors for treatment of Alzheimer's disease.

J Neurochem 2012 Jan 28;120 Suppl 1:71-83. Epub 2011 Nov 28.

Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07476.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276244PMC
January 2012
23 Reads
58 Citations
4.281 Impact Factor

Synthesis and antiplasmodial activity of bicyclic dioxanes as simplified dihydroplakortin analogues.

J Med Chem 2011 Aug 29;54(16):5949-53. Epub 2011 Jul 29.

European Research Centre for Drug Discovery and Development (NatSynDrugs), 53100 Siena, Italy.

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http://dx.doi.org/10.1021/jm200686dDOI Listing
August 2011
27 Reads
5.450 Impact Factor

Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants.

Bioorg Med Chem Lett 2011 Jul 14;21(13):3935-8. Epub 2011 May 14.

European Research Centre for Drug Discovery and Development (NatSynDrugs), via Aldo Moro, 2-Università di Siena, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2011.05.020DOI Listing
July 2011
7 Reads
2.420 Impact Factor

Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils.

Org Biomol Chem 2011 Jul 1;9(14):5137-48. Epub 2011 Jun 1.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, via Aldo Moro, 53100, Siena, Italy.

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http://dx.doi.org/10.1039/c1ob05288hDOI Listing
July 2011
109 Reads
3 Citations
3.562 Impact Factor

Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase.

Bioorg Med Chem Lett 2011 May 6;21(9):2776-9. Epub 2010 Sep 6.

European Research Centre for Drug Discovery and Development, Università di Siena, via Aldo Moro, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2010.09.002DOI Listing
May 2011
7 Reads
6 Citations
2.420 Impact Factor

The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells.

Biochem Pharmacol 2009 Feb 30;77(3):310-21. Epub 2008 Oct 30.

School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland.

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http://dx.doi.org/10.1016/j.bcp.2008.10.008DOI Listing
February 2009
56 Reads
2 Citations
5.010 Impact Factor

An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds.

J Org Chem 2008 Nov 10;73(21):8458-68. Epub 2008 Oct 10.

European Research Centre for Drug Discovery and Development (NatSynDrugs), University of Siena, Banchi di Sotto 55, 53100 Siena, Italy.

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http://dx.doi.org/10.1021/jo8015456DOI Listing
November 2008
2 Reads
1 Citation
4.721 Impact Factor

Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity.

Bioorg Med Chem Lett 2008 Oct 26;18(19):5213-6. Epub 2008 Aug 26.

European Research Centre for Drug Discovery and Development (NatSynDrugs), Via Aldo Moro 2, 53100 Siena, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2008.08.076DOI Listing
October 2008
20 Reads
2.420 Impact Factor

Top co-authors

Stefania Butini
Stefania Butini

University of Siena

27
Giuseppe Campiani
Giuseppe Campiani

Trinity College

27
Sandra Gemma
Sandra Gemma

University of Siena

26
Ettore Novellino
Ettore Novellino

University of Naples Federico II

23
Isabella Fiorini
Isabella Fiorini

University of Siena

11
Simone Brogi
Simone Brogi

University of Siena

10
Samuele Maramai
Samuele Maramai

University of Siena

6
Luisa Savini
Luisa Savini

Università di Siena

6
Giovanni Maga
Giovanni Maga

Università degli Studi di Siena

6
Salvatore Sanna Coccone
Salvatore Sanna Coccone

Universita di Siena

6