Margarita Garcia-Calvo

Margarita Garcia-Calvo

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Margarita Garcia-Calvo

Margarita Garcia-Calvo

Publications by authors named "Margarita Garcia-Calvo"

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32Publications

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Moderate to high throughput in vitro binding kinetics for drug discovery.

Front Biosci (Schol Ed) 2016 06 1;8:278-97. Epub 2016 Jun 1.

In vitro Pharmacology, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey, USA.

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http://dx.doi.org/10.2741/s462DOI Listing
June 2016

Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors.

J Med Chem 2015 Dec 20;58(23):9345-53. Epub 2015 Nov 20.

Department of Discovery Chemistry, ‡Chemistry Modeling, and Informatics, §In Vitro Pharmacology, ∥In Vivo Pharmacology, ⊥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, #Basic Pharmaceutical Sciences, and ○Atherosclerosis, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01345DOI Listing
December 2015

Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors.

Bioorg Med Chem Lett 2014 Apr 6;24(7):1657-60. Epub 2014 Mar 6.

Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.

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http://dx.doi.org/10.1016/j.bmcl.2014.02.070DOI Listing
April 2014

Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension.

Bioorg Med Chem Lett 2013 Jun 22;23(12):3650-3. Epub 2013 Mar 22.

Department of Medicinal Chemistry, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/j.bmcl.2013.03.011DOI Listing
June 2013

Concerted antigen processing of a short viral antigen by human caspase-5 and -10.

J Biol Chem 2011 May 28;286(19):16910-3. Epub 2011 Mar 28.

Centro Nacional de Microbiología, Instituto de Salud Carlos III, E-28220 Madrid, Spain.

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http://dx.doi.org/10.1074/jbc.M111.234658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089534PMC
May 2011

Spiroimidazolidinone NPC1L1 inhibitors. Part 2: structure-activity studies and in vivo efficacy.

Bioorg Med Chem Lett 2010 Dec 8;20(23):6929-32. Epub 2010 Oct 8.

Department of Medicinal Chemistry, Merck & Co., Inc., Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.09.138DOI Listing
December 2010

Caspases in virus-infected cells contribute to recognition by CD8+ T lymphocytes.

J Immunol 2010 May 26;184(9):5193-9. Epub 2010 Mar 26.

Centro Nacional de Microbiología, Instituto de Salud Carlos III, Spain.

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http://dx.doi.org/10.4049/jimmunol.1000050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202692PMC
May 2010

Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand.

Bioorg Med Chem Lett 2009 Sep 22;19(17):5033-6. Epub 2009 Jul 22.

Department of Process Research, Merck Research Laboratories, Rahway, NJ 07065-0900, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.07.051DOI Listing
September 2009

Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening.

Bioorg Med Chem Lett 2009 Jun 17;19(11):2965-8. Epub 2009 Apr 17.

Department of Chemistry Modeling & Informatics, Merck & Co, Inc, NJ 07065, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0900552
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http://dx.doi.org/10.1016/j.bmcl.2009.04.031DOI Listing
June 2009

Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.

J Biol Chem 2007 Feb 19;282(7):4545-52. Epub 2006 Dec 19.

Departments of Medicine, Cell Biology, and Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1074/jbc.M606564200DOI Listing
February 2007

Antigen processing of a short viral antigen by proteasomes.

J Biol Chem 2006 Oct 21;281(41):30315-8. Epub 2006 Jul 21.

Unidad de Proteómica, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Madrid, Spain.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M605973200
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http://dx.doi.org/10.1074/jbc.M605973200DOI Listing
October 2006

Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis.

Bioorg Med Chem Lett 2002 Aug;12(16):2197-200

Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/s0960-894x(02)00363-3DOI Listing
August 2002