Margaret G Ehm

Margaret G Ehm

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Margaret G Ehm

Margaret G Ehm

Publications by authors named "Margaret G Ehm"

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Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenet Genomics 2017 03;27(3):89-100

aGlaxoSmithKline Research and Development, Durham, North Carolina bGlaxoSmithKline Research and Development, King of Prussia, Pennsylvania cDepartment of Biostatistics and/or Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA dGlaxoSmithKline Research and Development, Sydney, New South Wales, Australia eSeoul National University fDNA Link Inc., Seoul, Korea gKyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1097/FPC.0000000000000260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287433PMC
March 2017

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.

Authors:
Robert A Scott Daniel F Freitag Li Li Audrey Y Chu Praveen Surendran Robin Young Niels Grarup Alena Stancáková Yuning Chen Tibor V Varga Hanieh Yaghootkar Jian'an Luan Jing Hua Zhao Sara M Willems Jennifer Wessel Shuai Wang Nisa Maruthur Kyriaki Michailidou Ailith Pirie Sven J van der Lee Christopher Gillson Ali Amin Al Olama Philippe Amouyel Larraitz Arriola Dominique Arveiler Iciar Aviles-Olmos Beverley Balkau Aurelio Barricarte Inês Barroso Sara Benlloch Garcia Joshua C Bis Stefan Blankenberg Michael Boehnke Heiner Boeing Eric Boerwinkle Ingrid B Borecki Jette Bork-Jensen Sarah Bowden Carlos Caldas Muriel Caslake L Adrienne Cupples Carlos Cruchaga Jacek Czajkowski Marcel den Hoed Janet A Dunn Helena M Earl Georg B Ehret Ele Ferrannini Jean Ferrieres Thomas Foltynie Ian Ford Nita G Forouhi Francesco Gianfagna Carlos Gonzalez Sara Grioni Louise Hiller Jan-Håkan Jansson Marit E Jørgensen J Wouter Jukema Rudolf Kaaks Frank Kee Nicola D Kerrison Timothy J Key Jukka Kontto Zsofia Kote-Jarai Aldi T Kraja Kari Kuulasmaa Johanna Kuusisto Allan Linneberg Chunyu Liu Gaëlle Marenne Karen L Mohlke Andrew P Morris Kenneth Muir Martina Müller-Nurasyid Patricia B Munroe Carmen Navarro Sune F Nielsen Peter M Nilsson Børge G Nordestgaard Chris J Packard Domenico Palli Salvatore Panico Gina M Peloso Markus Perola Annette Peters Christopher J Poole J Ramón Quirós Olov Rolandsson Carlotta Sacerdote Veikko Salomaa María-José Sánchez Naveed Sattar Stephen J Sharp Rebecca Sims Nadia Slimani Jennifer A Smith Deborah J Thompson Stella Trompet Rosario Tumino Daphne L van der A Yvonne T van der Schouw Jarmo Virtamo Mark Walker Klaudia Walter Jean E Abraham Laufey T Amundadottir Jennifer L Aponte Adam S Butterworth Josée Dupuis Douglas F Easton Rosalind A Eeles Jeanette Erdmann Paul W Franks Timothy M Frayling Torben Hansen Joanna M M Howson Torben Jørgensen Jaspal Kooner Markku Laakso Claudia Langenberg Mark I McCarthy James S Pankow Oluf Pedersen Elio Riboli Jerome I Rotter Danish Saleheen Nilesh J Samani Heribert Schunkert Peter Vollenweider Stephen O'Rahilly Panos Deloukas John Danesh Mark O Goodarzi Sekar Kathiresan James B Meigs Margaret G Ehm Nicholas J Wareham Dawn M Waterworth

Sci Transl Med 2016 06;8(341):341ra76

Genetics, PCPS, GlaxoSmithKline, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scitranslmed.aad3744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219001PMC
June 2016

Comparing variant calling algorithms for target-exon sequencing in a large sample.

BMC Bioinformatics 2015 Mar 7;16:75. Epub 2015 Mar 7.

Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1186/s12859-015-0489-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359451PMC
March 2015

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.

Authors:
Jennifer Wessel Audrey Y Chu Sara M Willems Shuai Wang Hanieh Yaghootkar Jennifer A Brody Marco Dauriz Marie-France Hivert Sridharan Raghavan Leonard Lipovich Bertha Hidalgo Keolu Fox Jennifer E Huffman Ping An Yingchang Lu Laura J Rasmussen-Torvik Niels Grarup Margaret G Ehm Li Li Abigail S Baldridge Alena Stančáková Ravinder Abrol Céline Besse Anne Boland Jette Bork-Jensen Myriam Fornage Daniel F Freitag Melissa E Garcia Xiuqing Guo Kazuo Hara Aaron Isaacs Johanna Jakobsdottir Leslie A Lange Jill C Layton Man Li Jing Hua Zhao Karina Meidtner Alanna C Morrison Mike A Nalls Marjolein J Peters Maria Sabater-Lleal Claudia Schurmann Angela Silveira Albert V Smith Lorraine Southam Marcus H Stoiber Rona J Strawbridge Kent D Taylor Tibor V Varga Kristine H Allin Najaf Amin Jennifer L Aponte Tin Aung Caterina Barbieri Nathan A Bihlmeyer Michael Boehnke Cristina Bombieri Donald W Bowden Sean M Burns Yuning Chen Yii-DerI Chen Ching-Yu Cheng Adolfo Correa Jacek Czajkowski Abbas Dehghan Georg B Ehret Gudny Eiriksdottir Stefan A Escher Aliki-Eleni Farmaki Mattias Frånberg Giovanni Gambaro Franco Giulianini William A Goddard Anuj Goel Omri Gottesman Megan L Grove Stefan Gustafsson Yang Hai Göran Hallmans Jiyoung Heo Per Hoffmann Mohammad K Ikram Richard A Jensen Marit E Jørgensen Torben Jørgensen Maria Karaleftheri Chiea C Khor Andrea Kirkpatrick Aldi T Kraja Johanna Kuusisto Ethan M Lange I T Lee Wen-Jane Lee Aaron Leong Jiemin Liao Chunyu Liu Yongmei Liu Cecilia M Lindgren Allan Linneberg Giovanni Malerba Vasiliki Mamakou Eirini Marouli Nisa M Maruthur Angela Matchan Roberta McKean-Cowdin Olga McLeod Ginger A Metcalf Karen L Mohlke Donna M Muzny Ioanna Ntalla Nicholette D Palmer Dorota Pasko Andreas Peter Nigel W Rayner Frida Renström Ken Rice Cinzia F Sala Bengt Sennblad Ioannis Serafetinidis Jennifer A Smith Nicole Soranzo Elizabeth K Speliotes Eli A Stahl Kathleen Stirrups Nikos Tentolouris Anastasia Thanopoulou Mina Torres Michela Traglia Emmanouil Tsafantakis Sundas Javad Lisa R Yanek Eleni Zengini Diane M Becker Joshua C Bis James B Brown L Adrienne Cupples Torben Hansen Erik Ingelsson Andrew J Karter Carlos Lorenzo Rasika A Mathias Jill M Norris Gina M Peloso Wayne H-H Sheu Daniela Toniolo Dhananjay Vaidya Rohit Varma Lynne E Wagenknecht Heiner Boeing Erwin P Bottinger George Dedoussis Panos Deloukas Ele Ferrannini Oscar H Franco Paul W Franks Richard A Gibbs Vilmundur Gudnason Anders Hamsten Tamara B Harris Andrew T Hattersley Caroline Hayward Albert Hofman Jan-Håkan Jansson Claudia Langenberg Lenore J Launer Daniel Levy Ben A Oostra Christopher J O'Donnell Stephen O'Rahilly Sandosh Padmanabhan James S Pankow Ozren Polasek Michael A Province Stephen S Rich Paul M Ridker Igor Rudan Matthias B Schulze Blair H Smith André G Uitterlinden Mark Walker Hugh Watkins Tien Y Wong Eleftheria Zeggini Markku Laakso Ingrid B Borecki Daniel I Chasman Oluf Pedersen Bruce M Psaty E Shyong Tai Cornelia M van Duijn Nicholas J Wareham Dawn M Waterworth Eric Boerwinkle W H Linda Kao Jose C Florez Ruth J F Loos James G Wilson Timothy M Frayling David S Siscovick Josée Dupuis Jerome I Rotter James B Meigs Robert A Scott Mark O Goodarzi

Nat Commun 2015 Jan 29;6:5897. Epub 2015 Jan 29.

1] Department of Medicine and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA [2] Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1038/ncomms6897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311266PMC
January 2015

Analysis of rare variant population structure in Europeans explains differential stratification of gene-based tests.

Eur J Hum Genet 2014 Sep 8;22(9):1137-44. Epub 2014 Jan 8.

1] Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA [2] Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1038/ejhg.2013.297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135410PMC
September 2014

Comparison of association methods for dense marker data.

Genet Epidemiol 2008 Dec;32(8):791-9

GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1002/gepi.20347DOI Listing
December 2008

Use of whole-genome association scans in disease gene identification, drug discovery and development.

IDrugs 2007 Nov;10(11):797-804

Duke University, R David Thomas Center, 1 Towerview Drive, Suite 343, Box 90120, Durham, NC 27708, USA.

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November 2007

Contrasting linkage-disequilibrium patterns between cases and controls as a novel association-mapping method.

Am J Hum Genet 2006 May 13;78(5):737-746. Epub 2006 Mar 13.

Department of Genetics Research, GlaxoSmithKline, Research Triangle Park, NC.

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http://dx.doi.org/10.1086/503710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474029PMC
May 2006

On the utility of data from the International HapMap Project for Australian association studies.

Hum Genet 2006 Mar 11;119(1-2):220-2. Epub 2006 Jan 11.

Division of Genetics and Bioinformatics, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 3050 Parkville, Victoria, Australia.

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http://dx.doi.org/10.1007/s00439-005-0120-yDOI Listing
March 2006

Guidelines for conducting and reporting whole genome/large-scale association studies.

Hum Mol Genet 2005 Sep 21;14(17):2485-8. Epub 2005 Jul 21.

Design and Standards, GlaxoSmithKline, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1093/hmg/ddi252DOI Listing
September 2005

Case-control single-marker and haplotypic association analysis of pedigree data.

Genet Epidemiol 2005 Feb;28(2):110-22

Genetics Research, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1002/gepi.20051DOI Listing
February 2005

Effect of two- and three-locus linkage disequilibrium on the power to detect marker/phenotype associations.

Genetics 2004 Oct;168(2):1029-40

Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695-7566, USA.

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http://dx.doi.org/10.1534/genetics.103.022335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448814PMC
October 2004

Selection of genetic markers for association analyses, using linkage disequilibrium and haplotypes.

Am J Hum Genet 2003 Jul 5;73(1):115-30. Epub 2003 Jun 5.

Bioinformatics Research Center, Campus Box 7566, North Carolina State University, Raleigh, NC 27695-7566, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180574PMC
http://dx.doi.org/10.1086/376561DOI Listing
July 2003

Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals.

Hum Hered 2002 ;53(2):79-91

GlaxoSmithKline Inc., Discovery Genetics, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1159/000057986DOI Listing
October 2002