Publications by authors named "Margaret Frame"

107Publications

FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs.

Authors:
Billie G C Griffith Rosanna Upstill-Goddard Holly Brunton Graeme R Grimes Andrew V Biankin Bryan Serrels Adam Byron Margaret C Frame

Sci Rep 2021 Jan 8;11(1):229. Epub 2021 Jan 8.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XR, UK.

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January 2021

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer.

Authors:
Stephan B Dreyer Rosie Upstill-Goddard Viola Paulus-Hock Clara Paris Eirini-Maria Lampraki Eloise Dray Bryan Serrels Giuseppina Caligiuri Selma Rebus Dennis Plenker Zachary Galluzzo Holly Brunton Richard Cunningham Mathias Tesson Craig Nourse Ulla-Maja Bailey Marc Jones Kim Moran-Jones Derek W Wright Fraser Duthie Karin Oien Lisa Evers Colin J McKay Grant A McGregor Aditi Gulati Rachel Brough Ilirjana Bajrami Stephan Pettitt Michele L Dziubinski Juliana Candido Frances Balkwill Simon T Barry Robert Grützmann Lola Rahib Amber Johns Marina Pajic Fieke E M Froeling Phillip Beer Elizabeth A Musgrove Gloria M Petersen Alan Ashworth Margaret C Frame Howard C Crawford Diane M Simeone Chris Lord Debabrata Mukhopadhyay Christian Pilarsky David A Tuveson Susanna L Cooke Nigel B Jamieson Jennifer P Morton Owen J Sansom Peter J Bailey Andrew V Biankin David K Chang

Gastroenterology 2021 Jan 9;160(1):362-377.e13. Epub 2020 Oct 9.

Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, United Kingdom; South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Liverpool, Australia. Electronic address:

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January 2021

Structural basis of Focal Adhesion Kinase activation on lipid membranes.

Authors:
Iván Acebrón Ricardo D Righetto Christina Schoenherr Svenja de Buhr Pilar Redondo Jayne Culley Carlos F Rodríguez Csaba Daday Nikhil Biyani Oscar Llorca Adam Byron Mohamed Chami Frauke Gräter Jasminka Boskovic Margaret C Frame Henning Stahlberg Daniel Lietha

EMBO J 2020 Oct 11;39(19):e104743. Epub 2020 Aug 11.

Structural Biology Programme, Spanish National Cancer Research Centre, Madrid, Spain.

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October 2020

The autophagy protein Ambra1 regulates gene expression by supporting novel transcriptional complexes.

Authors:
Christina Schoenherr Adam Byron Billie Griffith Alexander Loftus Jimi C Wills Alison F Munro Alex von Kriegsheim Margaret C Frame

J Biol Chem 2020 08 2;295(34):12045-12057. Epub 2020 Jul 2.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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August 2020

Novel roles of PRK1 and PRK2 in cilia and cancer biology.

Authors:
Hitesh Patel Jun Li Ana Herrero Jakob Kroboth Adam Byron Alex Von Kriegsheim Valerie Brunton Neil Carragher Toby Hurd Margaret Frame

Sci Rep 2020 03 3;10(1):3902. Epub 2020 Mar 3.

University of Edinburgh, Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, Edinburgh, United Kingdom.

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March 2020

A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen.

Authors:
John C Dawson Bryan Serrels Adam Byron Morwenna T Muir Ashraff Makda Amaya García-Muñoz Alex von Kriegsheim Daniel Lietha Neil O Carragher Margaret C Frame

Mol Cancer Ther 2020 02 29;19(2):637-649. Epub 2019 Nov 29.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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February 2020

Funding mechanisms risk promoting conscious bias.

Authors:
Wendy Bickmore Sarah Cunningham-Burley Margaret Frame

Nature 2018 10;562(7726):192

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October 2018

Trafficking of Adhesion and Growth Factor Receptors and Their Effector Kinases.

Authors:
Christina Schoenherr Margaret C Frame Adam Byron

Annu Rev Cell Dev Biol 2018 10 15;34:29-58. Epub 2018 Aug 15.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, United Kingdom; email:

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October 2018

Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase.

Authors:
Expédite Yen-Pon Bo Li Marta Acebrón-Garcia-de-Eulate Céline Tomkiewicz-Raulet John Dawson Daniel Lietha Margaret C Frame Xavier Coumoul Christiane Garbay Mélanie Etheve-Quelquejeu Huixiong Chen

ACS Chem Biol 2018 08 22;13(8):2067-2073. Epub 2018 Jun 22.

Chemistry of RNA, Nucleosides, Peptides and Heterocycles, CNRS UMR8601 , Université Paris Descartes, PRES Sorbonne Paris Cité, UFR Biomédicale , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France.

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August 2018

Rapid Polymer Conjugation Strategies for the Generation of pH-Responsive, Cancer Targeting, Polymeric Nanoparticles.

Authors:
Weishuo Li Jin Geng Helen Titmarsh Alicia Megia-Fernandez Kev Dhaliwal Margaret Frame Mark Bradley

Biomacromolecules 2018 07 17;19(7):2721-2730. Epub 2018 May 17.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine , University of Edinburgh, Western General Hospital , Crewe Road South , Edinburgh , U.K.

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July 2018

IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks.

Authors:
Bryan Serrels Niamh McGivern Marta Canel Adam Byron Sarah C Johnson Henry J McSorley Niall Quinn David Taggart Alex Von Kreigsheim Stephen M Anderton Alan Serrels Margaret C Frame

Sci Signal 2017 Dec 5;10(508). Epub 2017 Dec 5.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.

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December 2017

Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth.

Authors:
Marta Canel Adam Byron Andrew H Sims Jessy Cartier Hitesh Patel Margaret C Frame Valerie G Brunton Bryan Serrels Alan Serrels

Cancer Res 2017 10 14;77(19):5301-5312. Epub 2017 Aug 14.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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October 2017

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks.

Authors:
Christina Schoenherr Adam Byron Emma Sandilands Ketevan Paliashvili George S Baillie Amaya Garcia-Munoz Cristina Valacca Francesco Cecconi Bryan Serrels Margaret C Frame

Elife 2017 03 31;6. Epub 2017 Mar 31.

Cancer Research United Kingdom Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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March 2017

Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma.

Authors:
Maria Romina Girotti Filipa Lopes Natasha Preece Dan Niculescu-Duvaz Alfonso Zambon Lawrence Davies Steven Whittaker Grazia Saturno Amaya Viros Malin Pedersen Bart M J M Suijkerbuijk Delphine Menard Robert McLeary Louise Johnson Laura Fish Sarah Ejiama Berta Sanchez-Laorden Juliane Hohloch Neil Carragher Kenneth Macleod Garry Ashton Anna A Marusiak Alberto Fusi John Brognard Margaret Frame Paul Lorigan Richard Marais Caroline Springer

Cancer Cell 2017 03;31(3):466

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March 2017

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.

Authors:
Lindsay C Spender G John Ferguson Sijia Liu Chao Cui Maria Romina Girotti Gary Sibbet Ellen B Higgs Morven K Shuttleworth Tom Hamilton Paul Lorigan Michael Weller David F Vincent Owen J Sansom Margaret Frame Peter Ten Dijke Richard Marais Gareth J Inman

Oncotarget 2016 Dec;7(50):81995-82012

Growth Factor Signalling Laboratory, The Beatson Institute for Cancer Research, Bearsden, Glasgow, United Kingdom.

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December 2016

Cellular functions of the ADF/cofilin family at a glance.

Authors:
Georgios Kanellos Margaret C Frame

J Cell Sci 2016 09 9;129(17):3211-8. Epub 2016 Aug 9.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK.

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September 2016

FAK goes nuclear to control antitumor immunity-a new target in cancer immuno-therapy.

Authors:
Alan Serrels Margaret C Frame

Oncoimmunology 2016 Apr 13;5(4):e1119356. Epub 2016 Jan 13.

Cancer Research UK Edinburgh Center, Institute of Genetics and Molecular Medicine, University of Edinburgh , Edinburgh, UK.

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April 2016

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.

Authors:
Craig Fraser John C Dawson Reece Dowling Douglas R Houston Jason T Weiss Alison F Munro Morwenna Muir Lea Harrington Scott P Webster Margaret C Frame Valerie G Brunton E Elizabeth Patton Neil O Carragher Asier Unciti-Broceta

J Med Chem 2016 05 4;59(10):4697-710. Epub 2016 May 4.

University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh , Edinburgh EH16 4TJ, United Kingdom.

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May 2016

Kindlin1 regulates microtubule function to ensure normal mitosis.

Authors:
Hitesh Patel Ifigeneia Stavrou Roshan L Shrestha Viji Draviam Margaret C Frame Valerie G Brunton

J Mol Cell Biol 2016 08 18;8(4):338-48. Epub 2016 Mar 18.

Edinburgh Cancer Research Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK

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August 2016

Corrigendum: Translation Microscopy (TRAM) for super-resolution imaging.

Authors:
Zhen Qiu Rhodri S Wilson Yuewei Liu Alison R Dun Rebecca S Saleeb Dongsheng Liu Colin Rickman Margaret Frame Rory R Duncan Weiping Lu

Sci Rep 2016 Mar 18;6:22313. Epub 2016 Mar 18.

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March 2016