Publications by authors named "Margaret Frame"

107Publications

FAK regulates IL-33 expression by controlling chromatin accessibility at c-Jun motifs.

Sci Rep 2021 Jan 8;11(1):229. Epub 2021 Jan 8.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XR, UK.

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January 2021

The autophagy protein Ambra1 regulates gene expression by supporting novel transcriptional complexes.

J Biol Chem 2020 08 2;295(34):12045-12057. Epub 2020 Jul 2.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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August 2020

Novel roles of PRK1 and PRK2 in cilia and cancer biology.

Sci Rep 2020 03 3;10(1):3902. Epub 2020 Mar 3.

University of Edinburgh, Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, Crewe Road South, Edinburgh, United Kingdom.

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March 2020

A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen.

Mol Cancer Ther 2020 02 29;19(2):637-649. Epub 2019 Nov 29.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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February 2020

Trafficking of Adhesion and Growth Factor Receptors and Their Effector Kinases.

Annu Rev Cell Dev Biol 2018 10 15;34:29-58. Epub 2018 Aug 15.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, United Kingdom; email:

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October 2018

Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase.

ACS Chem Biol 2018 08 22;13(8):2067-2073. Epub 2018 Jun 22.

Chemistry of RNA, Nucleosides, Peptides and Heterocycles, CNRS UMR8601 , Université Paris Descartes, PRES Sorbonne Paris Cité, UFR Biomédicale , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France.

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August 2018

Rapid Polymer Conjugation Strategies for the Generation of pH-Responsive, Cancer Targeting, Polymeric Nanoparticles.

Biomacromolecules 2018 07 17;19(7):2721-2730. Epub 2018 May 17.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine , University of Edinburgh, Western General Hospital , Crewe Road South , Edinburgh , U.K.

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July 2018

IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks.

Sci Signal 2017 Dec 5;10(508). Epub 2017 Dec 5.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.

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December 2017

Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth.

Cancer Res 2017 10 14;77(19):5301-5312. Epub 2017 Aug 14.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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October 2017

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks.

Elife 2017 03 31;6. Epub 2017 Mar 31.

Cancer Research United Kingdom Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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March 2017

Cellular functions of the ADF/cofilin family at a glance.

J Cell Sci 2016 09 9;129(17):3211-8. Epub 2016 Aug 9.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK.

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September 2016

FAK goes nuclear to control antitumor immunity-a new target in cancer immuno-therapy.

Oncoimmunology 2016 Apr 13;5(4):e1119356. Epub 2016 Jan 13.

Cancer Research UK Edinburgh Center, Institute of Genetics and Molecular Medicine, University of Edinburgh , Edinburgh, UK.

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April 2016

Kindlin1 regulates microtubule function to ensure normal mitosis.

J Mol Cell Biol 2016 08 18;8(4):338-48. Epub 2016 Mar 18.

Edinburgh Cancer Research Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK

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August 2016