Publications by authors named "Margaret C Frame"

91Publications

The autophagy protein Ambra1 regulates gene expression by supporting novel transcriptional complexes.

J Biol Chem 2020 Aug 2;295(34):12045-12057. Epub 2020 Jul 2.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

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http://dx.doi.org/10.1074/jbc.RA120.012565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7443501PMC
August 2020

A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen.

Mol Cancer Ther 2020 02 29;19(2):637-649. Epub 2019 Nov 29.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-19-0330DOI Listing
February 2020

Trafficking of Adhesion and Growth Factor Receptors and Their Effector Kinases.

Annu Rev Cell Dev Biol 2018 10 15;34:29-58. Epub 2018 Aug 15.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-cellbio-100617-062559DOI Listing
October 2018

Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase.

ACS Chem Biol 2018 08 22;13(8):2067-2073. Epub 2018 Jun 22.

Chemistry of RNA, Nucleosides, Peptides and Heterocycles, CNRS UMR8601 , Université Paris Descartes, PRES Sorbonne Paris Cité, UFR Biomédicale , 45 rue des Saints-Pères , 75270 Paris Cedex 06 , France.

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http://dx.doi.org/10.1021/acschembio.8b00250DOI Listing
August 2018

IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks.

Sci Signal 2017 Dec 5;10(508). Epub 2017 Dec 5.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1126/scisignal.aan8355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128400PMC
December 2017

Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth.

Cancer Res 2017 10 14;77(19):5301-5312. Epub 2017 Aug 14.

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126615PMC
October 2017

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks.

Elife 2017 03 31;6. Epub 2017 Mar 31.

Cancer Research United Kingdom Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.7554/eLife.23172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376188PMC
March 2017

Cellular functions of the ADF/cofilin family at a glance.

J Cell Sci 2016 09 9;129(17):3211-8. Epub 2016 Aug 9.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1242/jcs.187849DOI Listing
September 2016

FAK goes nuclear to control antitumor immunity-a new target in cancer immuno-therapy.

Oncoimmunology 2016 Apr 13;5(4):e1119356. Epub 2016 Jan 13.

Cancer Research UK Edinburgh Center, Institute of Genetics and Molecular Medicine, University of Edinburgh , Edinburgh, UK.

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http://dx.doi.org/10.1080/2162402X.2015.1119356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839353PMC
April 2016

Kindlin1 regulates microtubule function to ensure normal mitosis.

J Mol Cell Biol 2016 08 18;8(4):338-48. Epub 2016 Mar 18.

Edinburgh Cancer Research Centre, Institute of Genetics & Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK

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http://dx.doi.org/10.1093/jmcb/mjw009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991666PMC
August 2016

The ROCKs on which tumour cells thrive.

Elife 2016 03 7;5:e14511. Epub 2016 Mar 7.

CRUK Edinburgh Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.7554/eLife.14511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798958PMC
March 2016

Adhesion protein networks reveal functions proximal and distal to cell-matrix contacts.

Curr Opin Cell Biol 2016 Apr 27;39:93-100. Epub 2016 Feb 27.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1016/j.ceb.2016.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094910PMC
April 2016

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival.

Cell Rep 2015 Dec 19;13(9):1949-64. Epub 2015 Nov 19.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK. Electronic address:

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http://www.cell.com/cell-reports/pdf/S2211-1247(15)01245-0.p
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http://linkinghub.elsevier.com/retrieve/pii/S221112471501245
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http://dx.doi.org/10.1016/j.celrep.2015.10.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678118PMC
December 2015

p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy.

Cell Signal 2015 Sep 9;27(9):1816-23. Epub 2015 Jun 9.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2015.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508348PMC
September 2015

FAK to the rescue: activated stroma promotes a "safe haven" for BRAF-mutant melanoma cells by inducing FAK signaling.

Cancer Cell 2015 Apr;27(4):429-31

Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1016/j.ccell.2015.03.013DOI Listing
April 2015

Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells.

J Cell Sci 2014 Dec 29;127(Pt 24):5303-16. Epub 2014 Oct 29.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, EH4 2XR Edinburgh, UK

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http://dx.doi.org/10.1242/jcs.157560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265741PMC
December 2014

V-SRC informs integrin signalling.

Authors:
Margaret C Frame

Nat Rev Mol Cell Biol 2013 Sep 14;14(9):548. Epub 2013 Aug 14.

Edinburgh Cancer Research Centre, College of Medicine and Veterinary Medicine, University of Edinburgh, UK.

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http://dx.doi.org/10.1038/nrm3647DOI Listing
September 2013

Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1.

Nat Commun 2013 ;4:2056

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1038/ncomms3056DOI Listing
December 2013

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer.

Cancer Res 2013 Aug 7;73(15):4674-86. Epub 2013 Jun 7.

The Beatson Institute for Cancer Research, Glasgow; Section of Dermatology, School of Medicine, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-4545DOI Listing
August 2013

E-cadherin-integrin crosstalk in cancer invasion and metastasis.

J Cell Sci 2013 Jan 22;126(Pt 2):393-401. Epub 2013 Mar 22.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1242/jcs.100115DOI Listing
January 2013

Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion.

Curr Biol 2013 Jan 27;23(2):107-17. Epub 2012 Dec 27.

The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1016/j.cub.2012.11.059DOI Listing
January 2013

Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells.

EMBO Rep 2012 Aug 26;13(8):733-40. Epub 2012 Jun 26.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1038/embor.2012.92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410392PMC
August 2012

Diversity of matriptase expression level and function in breast cancer.

PLoS One 2012 13;7(4):e34182. Epub 2012 Apr 13.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034182PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325989PMC
August 2012

Combining imaging and pathway profiling: an alternative approach to cancer drug discovery.

Drug Discov Today 2012 Mar;17(5-6):203-14

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, UK.

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http://csmres.co.uk/cs.public.upd/article-downloads/Carraghe
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http://dx.doi.org/10.1016/j.drudis.2012.02.002DOI Listing
March 2012

Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo.

Breast Cancer Res 2012 Feb 28;14(1):R36. Epub 2012 Feb 28.

Goodman Cancer Centre, McGill University, 1160 Pine Ave, west, Montreal, QC, H3A 1A3, Canada.

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http://dx.doi.org/10.1186/bcr3131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496154PMC
February 2012

FAK and talin: who is taking whom to the integrin engagement party?

J Cell Biol 2012 Jan;196(2):185-7

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH2 4RX, Scotland, UK.

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http://dx.doi.org/10.1083/jcb.201112128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265951PMC
January 2012

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling.

Nat Cell Biol 2011 Dec 4;14(1):51-60. Epub 2011 Dec 4.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1038/ncb2386DOI Listing
December 2011

Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement: insights from in vivo imaging.

Cell Adh Migr 2011 Jul-Aug;5(4):360-5. Epub 2011 Jul 1.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210304PMC
http://dx.doi.org/10.4161/cam.5.4.17290DOI Listing
December 2011

The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells.

Int J Cancer 2012 Jul 30;131(2):287-97. Epub 2011 Aug 30.

Edinburgh Cancer Research Centre, Institute for Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1002/ijc.26351DOI Listing
July 2012

Signaling of the direction-sensing FAK/RACK1/PDE4D5 complex to the small GTPase Rap1.

Small GTPases 2011 Jan;2(1):54-61

Edinburgh Cancer Research UK Centre; Institute of Genetics and Molecular Medicine; University of Edinburgh; Western General Hospital; Edinburgh, UK.

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http://dx.doi.org/10.4161/sgtp.2.1.15137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116620PMC
January 2011

The calpain system and cancer.

Nat Rev Cancer 2011 May;11(5):364-74

University of Nottingham, School of Molecular Medical Sciences, Nottingham NG5 1PB, UK.

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http://dx.doi.org/10.1038/nrc3050DOI Listing
May 2011

Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics.

Cancer Res 2010 Nov 2;70(22):9413-22. Epub 2010 Nov 2.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079905PMC
November 2010

The FERM domain: organizing the structure and function of FAK.

Nat Rev Mol Cell Biol 2010 Nov;11(11):802-14

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1038/nrm2996DOI Listing
November 2010

mDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasion.

Mol Cell Biol 2010 Oct 2;30(19):4604-15. Epub 2010 Aug 2.

Department of Pharmacology, Kyoto University Faculty of Medicine, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.

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http://dx.doi.org/10.1128/MCB.00197-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950524PMC
October 2010

A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity.

Curr Biol 2010 Jun 20;20(12):1086-92. Epub 2010 May 20.

Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.1016/j.cub.2010.04.042DOI Listing
June 2010

Two-color photoactivatable probe for selective tracking of proteins and cells.

J Biol Chem 2010 Apr 5;285(15):11607-16. Epub 2010 Feb 5.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M110.102392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857038PMC
April 2010

Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo.

Cell Adh Migr 2009 Oct-Dec;3(4):351-4. Epub 2009 Oct 7.

Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802745PMC
http://dx.doi.org/10.4161/cam.3.4.9460DOI Listing
March 2010

Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development.

Cancer Res 2009 Apr 24;69(7):2714-9. Epub 2009 Mar 24.

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4308DOI Listing
April 2009

Visualization of Src activity at different compartments of the plasma membrane by FRET imaging.

Chem Biol 2009 Jan;16(1):48-57

Neuroscience Program, Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.chembiol.2008.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647969PMC
January 2009

A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model.

Carcinogenesis 2009 Feb 5;30(2):249-57. Epub 2008 Dec 5.

Institute of Genetics and Molecular Medicine, Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1093/carcin/bgn278DOI Listing
February 2009

NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediated adhesions via signaling modulation.

Dev Cell 2008 Oct;15(4):494-6

Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, United Kingdom.

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http://dx.doi.org/10.1016/j.devcel.2008.09.016DOI Listing
October 2008

Src and focal adhesion kinase as therapeutic targets in cancer.

Curr Opin Pharmacol 2008 Aug 22;8(4):427-32. Epub 2008 Jul 22.

Institute of Genetics & Molecular Medicine, Division of Cancer Biology, University of Edinburgh, Crewe Road South, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1016/j.coph.2008.06.012DOI Listing
August 2008

Focal adhesion kinase is not required for Src-induced formation of invadopodia in KM12C colon cancer cells and can interfere with their assembly.

Eur J Cell Biol 2008 Sep 17;87(8-9):569-79. Epub 2008 Jun 17.

The Beatson Institute for Cancer Research, Garscube Estate, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1016/j.ejcb.2008.04.002DOI Listing
September 2008

Endosomal trafficking of Src tyrosine kinase.

Trends Cell Biol 2008 Jul;18(7):322-9

Edinburgh Cancer Research Centre, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR, UK.

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http://dx.doi.org/10.1016/j.tcb.2008.05.004DOI Listing
July 2008

The multi-FERM-domain-containing protein FrmA is required for turnover of paxillin-adhesion sites during cell migration of Dictyostelium.

J Cell Sci 2008 Apr 18;121(Pt 8):1159-64. Epub 2008 Mar 18.

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1242/jcs.021725DOI Listing
April 2008

Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression.

Proc Natl Acad Sci U S A 2007 Dec 3;104(51):20302-7. Epub 2007 Dec 3.

Molecular Oncology Group, McGill University, Royal Victoria Hospital, Room H5.21, 687 Pine Avenue West, Montreal, QC, Canada H3A 1A1.

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http://keely.molbio.wisc.edu/sites/keely.molbio.wisc.edu/fil
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http://www.pnas.org/cgi/doi/10.1073/pnas.0710091104
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http://dx.doi.org/10.1073/pnas.0710091104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2154426PMC
December 2007

Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors.

EMBO Rep 2007 Dec 2;8(12):1162-9. Epub 2007 Nov 2.

Cancer Research UK Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/sj.embor.7401097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267225PMC
December 2007

Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex.

Nat Cell Biol 2007 Sep 26;9(9):1046-56. Epub 2007 Aug 26.

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/ncb1626DOI Listing
September 2007

An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells.

Exp Cell Res 2007 Sep 24;313(15):3175-88. Epub 2007 May 24.

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, Scotland, UK.

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http://dx.doi.org/10.1016/j.yexcr.2007.04.037DOI Listing
September 2007

The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements.

J Cell Sci 2007 Aug 10;120(Pt 15):2555-64. Epub 2007 Jul 10.

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1242/jcs.003657DOI Listing
August 2007

Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling.

Cell Signal 2007 May 29;19(5):1081-92. Epub 2006 Dec 29.

Lung Cancer Biology Group, Division of Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, United Kingdom.

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http://dx.doi.org/10.1016/j.cellsig.2006.12.003DOI Listing
May 2007

Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib.

Mol Cancer Ther 2006 Dec 5;5(12):3014-22. Epub 2006 Dec 5.

The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow, G61 1BD, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0382DOI Listing
December 2006

Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex.

Cell Motil Cytoskeleton 2006 Jan;63(1):6-13

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow G61 1BD, United Kingdom.

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http://dx.doi.org/10.1002/cm.20101DOI Listing
January 2006

Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition.

Curr Opin Cell Biol 2005 Oct;17(5):542-7

Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Glasgow G61 1BD, United Kingdom.

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http://dx.doi.org/10.1016/j.ceb.2005.08.007DOI Listing
October 2005

The role of focal-adhesion kinase in cancer - a new therapeutic opportunity.

Nat Rev Cancer 2005 Jul;5(7):505-15

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom.

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http://www.nature.com/articles/nrc1647
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http://dx.doi.org/10.1038/nrc1647DOI Listing
July 2005

The SRC-induced mesenchymal state in late-stage colon cancer cells.

Cells Tissues Organs 2005 ;179(1-2):73-80

Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, UK.

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http://dx.doi.org/10.1159/000084511DOI Listing
September 2005

N-cadherin differentially determines Schwann cell and olfactory ensheathing cell adhesion and migration responses upon contact with astrocytes.

Mol Cell Neurosci 2005 Feb;28(2):253-63

Division of Clinical Neuroscience, University of Glasgow, Beatson Institute, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1016/j.mcn.2004.09.009DOI Listing
February 2005

RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane.

Dev Cell 2004 Dec;7(6):855-69

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom.

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http://dx.doi.org/10.1016/j.devcel.2004.09.019DOI Listing
December 2004

Recruitment of phosphoinositide 3-kinase defines a positive contribution of tyrosine kinase signaling to E-cadherin function.

J Biol Chem 2005 Jan 19;280(4):3043-50. Epub 2004 Nov 19.

Division of Molecular Cell Biology, Institute for Molecular Bioscience and School for Biomedical Science, The University of Queensland, St. Lucia, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1074/jbc.M412148200DOI Listing
January 2005

Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis.

J Biol Chem 2004 Oct 23;279(44):46113-21. Epub 2004 Aug 23.

Cancer Research UK Paterson Institute for Cancer Research, Manchester, and School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M20 4BX, UK.

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http://dx.doi.org/10.1074/jbc.M408550200DOI Listing
October 2004

Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion.

Trends Cell Biol 2004 May;14(5):241-9

The Beatson Institute for Cancer Research, Cancer Research UK, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1016/j.tcb.2004.03.011DOI Listing
May 2004

PDE4-regulated cAMP degradation controls the assembly of integrin-dependent actin adhesion structures and REF52 cell migration.

J Cell Sci 2004 May;117(Pt 11):2377-88

Institute of Biological and Life Sciences, Davidson and Wolfson Buildings, University of Glasgow, Glasgow G12 8QQ, UK.

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http://dx.doi.org/10.1242/jcs.01096DOI Listing
May 2004

Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition.

Mol Biol Cell 2004 Jun 9;15(6):2794-803. Epub 2004 Apr 9.

Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow G61 1BD, United Kingdom.

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http://dx.doi.org/10.1091/mbc.e03-12-0879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC420103PMC
June 2004

Newest findings on the oldest oncogene; how activated src does it.

Authors:
Margaret C Frame

J Cell Sci 2004 Mar;117(Pt 7):989-98

Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK.

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http://dx.doi.org/10.1242/jcs.01111DOI Listing
March 2004

A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src.

Curr Biol 2003 Aug;13(16):1442-50

The Beatson Institute for Cancer Research, Cancer Research United Kingdom, Beatson Laboratories, Glasgow G61 1BD, Scotland, United Kingdom.

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http://dx.doi.org/10.1016/s0960-9822(03)00544-xDOI Listing
August 2003

Focal adhesion kinase as a potential target in oncology.

Expert Opin Pharmacother 2003 Feb;4(2):227-34

Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow, G61 1BD, Scotland, UK.

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http://dx.doi.org/10.1517/14656566.4.2.227DOI Listing
February 2003

Calpain: a role in cell transformation and migration.

Int J Biochem Cell Biol 2002 Dec;34(12):1539-43

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, G61 1BD Glasgow, Scotland, UK.

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http://dx.doi.org/10.1016/s1357-2725(02)00069-9DOI Listing
December 2002

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling.

Nat Cell Biol 2002 Aug;4(8):632-8

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/ncb829DOI Listing
August 2002

Src in cancer: deregulation and consequences for cell behaviour.

Authors:
Margaret C Frame

Biochim Biophys Acta 2002 Jun;1602(2):114-30

The Beatson Institute for Cancer Research and Institute of Biomedical and Life Sciences, CRC Beatson Laboratories (University of Glasgow), Glasgow, UK.

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http://dx.doi.org/10.1016/s0304-419x(02)00040-9DOI Listing
June 2002

v-Src's hold over actin and cell adhesions.

Nat Rev Mol Cell Biol 2002 Apr;3(4):233-45

The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1038/nrm779DOI Listing
April 2002

Advances in Rho-dependent actin regulation and oncogenic transformation.

Curr Opin Genet Dev 2002 Feb;12(1):36-43

The Beatson Institute for Cancer Research and Institute of Biomedical and Life Sciences, Cancer Research Campaign Beatson Laboratories, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.

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http://dx.doi.org/10.1016/s0959-437x(01)00261-1DOI Listing
February 2002