Margaret A Phillips

Margaret A Phillips

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Margaret A Phillips

Margaret A Phillips

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Toward a chemical vaccine for malaria.

Science 2018 12;362(6419):1112-1113

Division of Infectious Diseases, Department of Medicine and Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/science.aav7479DOI Listing
December 2018

Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs.

Structure 2018 11 6;26(11):1499-1512.e5. Epub 2018 Sep 6.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221947PMC
November 2018

Polyamines in protozoan pathogens.

J Biol Chem 2018 11 17;293(48):18746-18756. Epub 2018 Oct 17.

From the Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9038

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http://www.jbc.org/lookup/doi/10.1074/jbc.TM118.003342
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http://dx.doi.org/10.1074/jbc.TM118.003342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290135PMC
November 2018

A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei.

PLoS Pathog 2018 10 26;14(10):e1007404. Epub 2018 Oct 26.

Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Harry Hines Blvd, Dallas, TX, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1007404
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http://dx.doi.org/10.1371/journal.ppat.1007404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221367PMC
October 2018

Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.

J Med Chem 2018 02 5;61(3):1182-1203. Epub 2018 Jan 5.

Scynexis, Inc. (now Avista Pharma Solutions) , 3501 Tricenter Boulevard, Suite C, Durham, North Carolina 27713, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965259PMC
February 2018

Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.

J Med Chem 2018 02 5;61(3):1182-1203. Epub 2018 Jan 5.

Scynexis, Inc. (now Avista Pharma Solutions) , 3501 Tricenter Boulevard, Suite C, Durham, North Carolina 27713, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965259PMC
February 2018

Malaria.

Nat Rev Dis Primers 2017 Aug 3;3:17050. Epub 2017 Aug 3.

Medicines for Malaria Venture, Geneva, Switzerland.

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http://dx.doi.org/10.1038/nrdp.2017.50DOI Listing
August 2017

Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.

Elife 2016 12 15;5. Epub 2016 Dec 15.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States.

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http://dx.doi.org/10.7554/eLife.20198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201418PMC
December 2016

Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei.

PLoS Pathog 2016 Nov 7;12(11):e1006010. Epub 2016 Nov 7.

Department of Pharmacology University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098729PMC
November 2016

Improved Synthesis of MDL 73811 - a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound.

Synthesis (Stuttg) 2016 Jul;48(13):2065-2068

Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, United States.

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http://dx.doi.org/10.1055/s-0035-1561608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966539PMC
July 2016

A Teach-Discover-Treat Application of ZincPharmer: An Online Interactive Pharmacophore Modeling and Virtual Screening Tool.

PLoS One 2015 10;10(8):e0134697. Epub 2015 Aug 10.

Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134697PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530941PMC
May 2016

Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening.

J Chem Inf Model 2016 Mar 8;56(3):548-62. Epub 2016 Mar 8.

Departments of Pharmacology, University of Texas Southwestern Medical Center at Dallas , 6001 Forest Park Blvd, Dallas, Texas 75390-9041, United States.

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http://dx.doi.org/10.1021/acs.jcim.5b00680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871132PMC
March 2016

GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.

Mol Microbiol 2015 Sep 4;97(5):1006-20. Epub 2015 Jul 4.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Rd, Dallas, TX, 75390-9041, USA.

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http://dx.doi.org/10.1111/mmi.13083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550530PMC
September 2015

The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions.

Acta Crystallogr F Struct Biol Commun 2015 May 21;71(Pt 5):553-9. Epub 2015 Apr 21.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1107/S2053230X15000989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427164PMC
May 2015

Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor.

Antimicrob Agents Chemother 2015 Jan 20;59(1):686-9. Epub 2014 Oct 20.

Departments of Chemistry and Global Health, University of Washington, Seattle, Washington, USA

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http://dx.doi.org/10.1128/AAC.02347-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291421PMC
January 2015

Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.

J Med Chem 2014 Jun 13;57(12):5381-94. Epub 2014 Jun 13.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas , 6001 Forest Park Boulevard, Dallas, Texas 75390-9041, United States.

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http://dx.doi.org/10.1021/jm500481tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079327PMC
June 2014

Genetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme.

Eukaryot Cell 2014 May 7;13(5):614-24. Epub 2014 Mar 7.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.

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http://dx.doi.org/10.1128/EC.00015-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060477PMC
May 2014

Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei.

Eukaryot Cell 2014 Apr 21;13(4):504-16. Epub 2014 Feb 21.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1128/EC.00017-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4000095PMC
April 2014

A multiple aminoacyl-tRNA synthetase complex that enhances tRNA-aminoacylation in African trypanosomes.

Mol Cell Biol 2013 Dec 14;33(24):4872-88. Epub 2013 Oct 14.

Seattle Biomedical Research Institute, Seattle, Washington, USA.

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http://dx.doi.org/10.1128/MCB.00711-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3889560PMC
December 2013

Product feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozyme.

Mol Microbiol 2013 Jun 2;88(5):846-61. Epub 2013 May 2.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1111/mmi.12226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771639PMC
June 2013

SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity.

ACS Med Chem Lett 2013 Jun;4(6):517-521

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.

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http://dx.doi.org/10.1021/ml300464hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733392PMC
June 2013

Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog.

J Biol Chem 2013 May 21;288(21):15256-67. Epub 2013 Mar 21.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9041, USA.

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http://www.jbc.org/content/288/21/15256.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M113.461137
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http://dx.doi.org/10.1074/jbc.M113.461137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663545PMC
May 2013

Trypanosoma brucei S-adenosylmethionine decarboxylase N terminus is essential for allosteric activation by the regulatory subunit prozyme.

J Biol Chem 2013 Feb 3;288(7):5232-40. Epub 2013 Jan 3.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M112.442475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576127PMC
February 2013

Stoking the drug target pipeline for human African trypanosomiasis.

Mol Microbiol 2012 Oct 28;86(1):10-4. Epub 2012 Aug 28.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1111/mmi.12001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3456963PMC
October 2012

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.

J Med Chem 2012 May 18;55(9):4205-19. Epub 2012 Apr 18.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1021/jm201642zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349818PMC
May 2012

Regulation and function of polyamines in African trypanosomes.

Trends Parasitol 2012 Feb 20;28(2):66-72. Epub 2011 Dec 20.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1016/j.pt.2011.11.001DOI Listing
February 2012

Advanced molecular design of biopolymers for transmucosal and intracellular delivery of chemotherapeutic agents and biological therapeutics.

J Control Release 2011 Oct 14;155(2):119-27. Epub 2011 Jun 14.

Department of Chemical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.

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http://dx.doi.org/10.1016/j.jconrel.2011.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195952PMC
October 2011

State of the art in African trypanosome drug discovery.

Curr Top Med Chem 2011 ;11(10):1255-74

SCYNEXIS, Inc., Research Triangle Park, North Carolina 27709-2878, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101707PMC
http://dx.doi.org/10.2174/156802611795429167DOI Listing
August 2011

A Gateway® compatible vector for gene silencing in bloodstream form Trypanosoma brucei.

Mol Biochem Parasitol 2011 Jul-Aug;178(1-2):51-5. Epub 2011 Mar 21.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9041, United States.

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http://dx.doi.org/10.1016/j.molbiopara.2011.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101333PMC
August 2011

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

Mol Biochem Parasitol 2011 May 18;177(1):29-34. Epub 2011 Jan 18.

Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 W. Queen Lane, Philadelphia, PA 19129, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2011.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057331PMC
May 2011

Identification and assay of allosteric regulators of S-adenosylmethionine decarboxylase.

Methods Mol Biol 2011 ;720:219-35

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.

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http://dx.doi.org/10.1007/978-1-61779-034-8_14DOI Listing
May 2011

Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif.

Bioorg Med Chem Lett 2010 Aug 17;20(15):4364-6. Epub 2010 Jun 17.

Division of Biological Chemistry and Drug Discovery, College of Life Science, University of Dundee, Sir James Black Centre, Dundee, UK.

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http://dx.doi.org/10.1016/j.bmcl.2010.06.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935964PMC
August 2010

Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.

Infect Disord Drug Targets 2010 Jun;10(3):226-39

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Rd, Dallas, Texas 75390-9041, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883174PMC
http://dx.doi.org/10.2174/187152610791163336DOI Listing
June 2010

Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase.

J Biol Chem 2010 May 10;285(22):16771-81. Epub 2010 Mar 10.

Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1074/jbc.M109.081588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878083PMC
May 2010

Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes.

Assay Drug Dev Technol 2010 Apr;8(2):175-85

Graduate Program in Chemistry and Chemical Biology, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.1089/adt.2009.0249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098607PMC
April 2010

Targeted Nanodelivery of Drugs and Diagnostics.

Nano Today 2010 Apr;5(2):143-159

Department of Biomedical Engineering, Department of Chemical Engineering, Division of Pharmacy, The University of Texas at Austin, Austin, TX 78712.

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http://dx.doi.org/10.1016/j.nantod.2010.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882307PMC
April 2010

Cellular evaluation of synthesized insulin/transferrin bioconjugates for oral insulin delivery using intelligent complexation hydrogels.

Macromol Biosci 2010 Mar;10(3):299-306

Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, USA.

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http://dx.doi.org/10.1002/mabi.200900223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141299PMC
March 2010

Cross-species activation of trypanosome S-adenosylmethionine decarboxylase by the regulatory subunit prozyme.

Mol Biochem Parasitol 2009 Nov 10;168(1):1-6. Epub 2009 Jun 10.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2009.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730992PMC
November 2009

Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.

J Biol Chem 2009 Sep 28;284(39):26999-7009. Epub 2009 Jul 28.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9041, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.028589
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http://dx.doi.org/10.1074/jbc.M109.028589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785385PMC
September 2009

RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.

Eukaryot Cell 2009 May 20;8(5):747-55. Epub 2009 Mar 20.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1128/EC.00047-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681613PMC
May 2009

An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae.

J Biol Chem 2009 Apr 5;284(15):9899-907. Epub 2009 Feb 5.

Departments of Pharmacology, Microbiology, and Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M900110200
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http://dx.doi.org/10.1074/jbc.M900110200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665113PMC
April 2009

Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes.

PLoS Pathog 2008 Oct 24;4(10):e1000183. Epub 2008 Oct 24.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.

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http://dx.doi.org/10.1371/journal.ppat.1000183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562514PMC
October 2008

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

J Med Chem 2008 Jun 4;51(12):3649-53. Epub 2008 Jun 4.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Boulevard, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1021/jm8001026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2624570PMC
June 2008

Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase.

Biochemistry 2008 Feb 29;47(8):2466-75. Epub 2008 Jan 29.

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Boulevard, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1021/bi702218cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868338PMC
February 2008

Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases.

J Biol Chem 2007 Sep 11;282(37):27115-25. Epub 2007 Jul 11.

Departments of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M704066200
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http://dx.doi.org/10.1074/jbc.M704066200DOI Listing
September 2007

Phosphatidylinositol 4-kinase III-beta is required for Golgi maintenance and cytokinesis in Trypanosoma brucei.

Eukaryot Cell 2007 Jul 4;6(7):1108-18. Epub 2007 May 4.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1128/EC.00107-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951100PMC
July 2007

Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog.

Proc Natl Acad Sci U S A 2007 May 7;104(20):8275-80. Epub 2007 May 7.

Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1073/pnas.0701111104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895940PMC
May 2007

Detergent-dependent kinetics of truncated Plasmodium falciparum dihydroorotate dehydrogenase.

J Biol Chem 2007 Apr 28;282(17):12678-86. Epub 2007 Feb 28.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M609893200DOI Listing
April 2007

X-ray structure of Paramecium bursaria Chlorella virus arginine decarboxylase: insight into the structural basis for substrate specificity.

Biochemistry 2007 Mar 17;46(10):2831-41. Epub 2007 Feb 17.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi6023447
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http://dx.doi.org/10.1021/bi6023447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518046PMC
March 2007

Mechanisms of allosteric regulation of Trypanosoma cruzi S-adenosylmethionine decarboxylase.

Biochemistry 2006 Jun;45(25):7797-807

Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, 6001 Forest Park Boulevard, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1021/bi0603975DOI Listing
June 2006

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

J Biol Chem 2005 Jun 28;280(23):21847-53. Epub 2005 Mar 28.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M501100200DOI Listing
June 2005

Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase.

Biochemistry 2004 Oct;43(41):12990-9

Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1021/bi048933lDOI Listing
October 2004

The thrH gene product of Pseudomonas aeruginosa is a dual activity enzyme with a novel phosphoserine:homoserine phosphotransferase activity.

J Biol Chem 2004 Mar 29;279(13):13166-73. Epub 2003 Dec 29.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1074/jbc.M311393200DOI Listing
March 2004

Gene knockdown of gamma-glutamylcysteine synthetase by RNAi in the parasitic protozoa Trypanosoma brucei demonstrates that it is an essential enzyme.

J Biol Chem 2003 Oct 29;278(41):39794-800. Epub 2003 Jul 29.

Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M306306200DOI Listing
October 2003

X-ray structure determination of Trypanosoma brucei ornithine decarboxylase bound to D-ornithine and to G418: insights into substrate binding and ODC conformational flexibility.

J Biol Chem 2003 Jun 2;278(24):22037-43. Epub 2003 Apr 2.

Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, 5323 Harry Hines Boulevard, TX 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M300188200DOI Listing
June 2003

Prized malaria drug target nailed.

Nat Struct Biol 2003 May;10(5):316-8

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http://www.nature.com/articles/nsb0503-316
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http://dx.doi.org/10.1038/nsb0503-316DOI Listing
May 2003

Ornithine decarboxylase promotes catalysis by binding the carboxylate in a buried pocket containing phenylalanine 397.

Biochemistry 2003 Mar;42(10):2933-40

Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1021/bi026795zDOI Listing
March 2003

Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.

J Biol Chem 2002 Nov 19;277(44):41827-34. Epub 2002 Aug 19.

Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, 75390-9041, USA.

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http://dx.doi.org/10.1074/jbc.M206854200DOI Listing
November 2002

Putrescine activation of Trypanosoma cruzi S-adenosylmethionine decarboxylase.

Biochemistry 2002 Nov;41(44):13207-16

Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.1021/bi026541dDOI Listing
November 2002

Target validation for drug discovery in parasitic organisms.

Curr Top Med Chem 2002 May;2(5):425-38

Department of Pharmacology, UT Southwestern Medical Center at Dallas, Texas 75390-9041, USA.

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http://dx.doi.org/10.2174/1568026024607445DOI Listing
May 2002

Substrate binding determinants of Trypanosoma brucei gamma-glutamylcysteine synthetase.

Biochemistry 2002 Feb;41(8):2741-50

Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, 75390-9041, USA.

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http://dx.doi.org/10.1021/bi0159128DOI Listing
February 2002