Margaret A Knowles

Margaret A Knowles

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Margaret A Knowles

Margaret A Knowles

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ETV5 links the FGFR3 and Hippo signalling pathways in bladder cancer.

Authors:
Erica di Martino Olivia Alder Carolyn D Hurst Margaret A Knowles

Sci Rep 2019 Apr 5;9(1):5740. Epub 2019 Apr 5.

University of Leeds, Leeds Institute of Medical Research at St James's, St. James's University Hospital, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.1038/s41598-018-36456-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450944PMC
April 2019

FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation.

Authors:
Mona Foth Nur Faezah Binti Ismail Jeng Sum Charmaine Kung Darren Tomlinson Margaret A Knowles Pontus Eriksson Gottfrid Sjödahl Jonathan M Salmond Owen J Sansom Tomoko Iwata

J Pathol 2018 11 19;246(3):331-343. Epub 2018 Sep 19.

School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1002/path.5143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334176PMC
November 2018

Mutational landscape of non-muscle-invasive bladder cancer.

Authors:
Carolyn D Hurst Margaret A Knowles

Urol Oncol 2018 Nov 13. Epub 2018 Nov 13.

Section of Molecular Oncology, Leeds Institute of Cancer and Pathology, St James's University Hospital, Leeds, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10781439183039
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http://dx.doi.org/10.1016/j.urolonc.2018.10.015DOI Listing
November 2018

Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation.

Authors:
Paul Mellor Jeremy D S Marshall Xuan Ruan Dielle E Whitecross Rebecca L Ross Margaret A Knowles Stanley A Moore Deborah H Anderson

Sci Rep 2018 05 8;8(1):7108. Epub 2018 May 8.

Cancer Research Group, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, S7N 5E5, Canada.

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http://dx.doi.org/10.1038/s41598-018-25487-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940657PMC
May 2018

Bladder cancer: Multi-omic profiling refines the molecular view.

Authors:
Carolyn D Hurst Margaret A Knowles

Nat Rev Clin Oncol 2018 04 19;15(4):203-204. Epub 2017 Dec 19.

Leeds Institute of Cancer and Pathology, St James's University Hospital, Beckett Street, University of Leeds, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1038/nrclinonc.2017.195DOI Listing
April 2018

Identification of an Indazole-Based Pharmacophore for the Inhibition of FGFR Kinases Using Fragment-Led Design.

Authors:
Lewis D Turner Abbey J Summers Laura O Johnson Margaret A Knowles Colin W G Fishwick

ACS Med Chem Lett 2017 Dec 11;8(12):1264-1268. Epub 2017 Nov 11.

School of Chemistry and Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, LS2 9JT, U.K.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733262PMC
December 2017

Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency.

Authors:
Carolyn D Hurst Olivia Alder Fiona M Platt Alastair Droop Lucy F Stead Julie E Burns George J Burghel Sunjay Jain Leszek J Klimczak Helen Lindsay Jo-An Roulson Claire F Taylor Helene Thygesen Angus J Cameron Anne J Ridley Helen R Mott Dmitry A Gordenin Margaret A Knowles

Cancer Cell 2017 11;32(5):701-715.e7

Section of Molecular Oncology, Leeds Institute of Cancer and Pathology, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108173034
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http://dx.doi.org/10.1016/j.ccell.2017.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774674PMC
November 2017

Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis.

Authors:
Benedetta Lombardi Paul Ashford Aurelio A Moya-Garcia Aleksander Rust Mark Crawford Sarah V Williams Margaret A Knowles Matilda Katan Christine Orengo Jasminka Godovac-Zimmermann

Oncotarget 2017 Nov 25;8(61):102898-102911. Epub 2017 Oct 25.

Proteomics and Molecular Cell Dynamics, Center for Nephrology, School of Life and Medical Sciences, University College London, London NW3 2PF, United Kingdom.

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http://dx.doi.org/10.18632/oncotarget.22048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732698PMC
November 2017

TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p.

Authors:
Jonathan Berrout Eleni Kyriakopoulou Lavanya Moparthi Alexandra S Hogea Liza Berrout Cristina Ivan Mihaela Lorger John Boyle Chris Peers Stephen Muench Jacobo Elies Gomez Xin Hu Carolyn Hurst Thomas Hall Sujanitha Umamaheswaran Laura Wesley Mihai Gagea Michael Shires Iain Manfield Margaret A Knowles Simon Davies Klaus Suhling Yurema Teijeiro Gonzalez Neil Carragher Kenneth Macleod N Joan Abbott George A Calin Nikita Gamper Peter M Zygmunt Zahra Timsah

Nat Commun 2017 10 16;8(1):947. Epub 2017 Oct 16.

School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK.

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http://www.nature.com/articles/s41467-017-00983-w
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http://dx.doi.org/10.1038/s41467-017-00983-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643494PMC
October 2017

Bladder cancer.

Authors:
Oner Sanli Jakub Dobruch Margaret A Knowles Maximilian Burger Mehrdad Alemozaffar Matthew E Nielsen Yair Lotan

Nat Rev Dis Primers 2017 Apr 13;3:17022. Epub 2017 Apr 13.

Department of Urology, UT Southwestern Medical Center at Dallas, Moss Building, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9110, USA.

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http://dx.doi.org/10.1038/nrdp.2017.22DOI Listing
April 2017

Fibroblast growth factor receptor (FGFR) alterations in squamous differentiated bladder cancer: a putative therapeutic target for a small subgroup.

Authors:
Philipp H Baldia Angela Maurer Timon Heide Michael Rose Robert Stoehr Arndt Hartmann Sarah V Williams Margaret A Knowles Ruth Knuechel Nadine T Gaisa

Oncotarget 2016 Nov;7(44):71429-71439

Institute of Pathology, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.18632/oncotarget.12198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342089PMC
November 2016

A place for precision medicine in bladder cancer: targeting the FGFRs.

Authors:
Erica di Martino Darren C Tomlinson Sarah V Williams Margaret A Knowles

Future Oncol 2016 Oct 6;12(19):2243-63. Epub 2016 Jul 6.

Section of Molecular Oncology, Leeds Institute of Cancer & Pathology, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.2217/fon-2016-0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066128PMC
October 2016

Towards a Next-Generation Sequencing Diagnostic Service for Tumour Genotyping: A Comparison of Panels and Platforms.

Authors:
George J Burghel Carolyn D Hurst Christopher M Watson Phillip A Chambers Helen Dickinson Paul Roberts Margaret A Knowles

Biomed Res Int 2015 17;2015:478017. Epub 2015 Aug 17.

Leeds Institute of Cancer & Pathology, University of Leeds, St. James's University Hospital, Leeds LS9 7TF, UK.

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http://www.hindawi.com/journals/bmri/2015/478017/
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http://dx.doi.org/10.1155/2015/478017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553307PMC
June 2016

Frequency of TERT Promoter Mutations in Prostate Cancer.

Authors:
Robert Stoehr Helge Taubert Ulrike Zinnall Johannes Giedl Nadine T Gaisa Maximilian Burger Petra Ruemmele Carolyn D Hurst Margaret A Knowles Bernd Wullich Arndt Hartmann

Pathobiology 2015 21;82(2):53-7. Epub 2015 May 21.

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

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https://www.karger.com/Article/FullText/381903
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http://dx.doi.org/10.1159/000381903DOI Listing
May 2016

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use.

Authors:
Harshnira Patani Tom D Bunney Nethaji Thiyagarajan Richard A Norman Derek Ogg Jason Breed Paul Ashford Andrew Potterton Mina Edwards Sarah V Williams Gary S Thomson Camilla S M Pang Margaret A Knowles Alexander L Breeze Christine Orengo Chris Phillips Matilda Katan

Oncotarget 2016 Apr;7(17):24252-68

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower St, London WC1E 6BT, UK.

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http://dx.doi.org/10.18632/oncotarget.8132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029699PMC
April 2016

Polycomb Repressor Complex 1 Member, BMI1 Contributes to Urothelial Tumorigenesis through p16-Independent Mechanisms.

Authors:
Lia E De Faveri Carolyn D Hurst Jo-An Roulson Henry Wood Marta Sanchez-Carbayo Margaret A Knowles Emma J Chapman

Transl Oncol 2015 Oct;8(5):387-99

Leeds Institute of Cancer and Pathology, St James's University Hospital, Beckett Street, Leeds, LS97TF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2015.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631094PMC
October 2015

Use of Lectin Affinity Chromatography to Enrich Candidate Biomarkers from the Urine of Patients with Bladder Cancer.

Authors:
Sarah R Ambrose Naheema S Gordon James C Goldsmith Wenbin Wei Maurice P Zeegers Nicholas D James Margaret A Knowles Richard T Bryan Douglas G Ward

Proteomes 2015 Sep 3;3(3):266-282. Epub 2015 Sep 3.

School of Cancer Sciences, University of Birmingham, Birmingham B15 2TT, UK.

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http://dx.doi.org/10.3390/proteomes3030266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217382PMC
September 2015

The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study.

Authors:
Tom D Bunney Shunzhou Wan Nethaji Thiyagarajan Ludovico Sutto Sarah V Williams Paul Ashford Hans Koss Margaret A Knowles Francesco L Gervasio Peter V Coveney Matilda Katan

EBioMedicine 2015 Mar;2(3):194-204

Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower St., London WC1E 6BT, UK.

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http://dx.doi.org/10.1016/j.ebiom.2015.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471147PMC
March 2015

FGFR3 expression in primary invasive bladder cancers and matched lymph node metastases.

Authors:
Rafal Turo Patricia Harnden Helene Thygesen Achim Fleischmann George N Thalmann Roland Seiler William R Cross Margaret A Knowles

J Urol 2015 Jan 13;193(1):325-30. Epub 2014 Jun 13.

Leeds Institute of Cancer and Pathology, St. James's University Hospital, Leeds, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2014.06.026DOI Listing
January 2015

Alteration of cell-cell and cell-matrix adhesion in urothelial cells: an oncogenic mechanism for mutant FGFR3.

Authors:
Erica di Martino Gavin Kelly Jo-An Roulson Margaret A Knowles

Mol Cancer Res 2015 Jan 15;13(1):138-48. Epub 2014 Sep 15.

Section of Experimental Oncology, Leeds Institute of Cancer and Pathology, St. James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0022DOI Listing
January 2015

Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity.

Authors:
Margaret A Knowles Carolyn D Hurst

Nat Rev Cancer 2015 Jan;15(1):25-41

Section of Experimental Oncology, Leeds Institute of Cancer and Pathology, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.1038/nrc3817DOI Listing
January 2015

Identification of mutations in distinct regions of p85 alpha in urothelial cancer.

Authors:
Rebecca L Ross Julie E Burns Claire F Taylor Paul Mellor Deborah H Anderson Margaret A Knowles

PLoS One 2013 18;8(12):e84411. Epub 2013 Dec 18.

Section of Experimental Oncology, Leeds Institute of Cancer and Pathology, St James's University Hospital, Leeds, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084411PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867501PMC
October 2014

Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer.

Authors:
Thorunn Rafnar Patrick Sulem Gudmar Thorleifsson Sita H Vermeulen Hannes Helgason Jona Saemundsdottir Sigurjon A Gudjonsson Asgeir Sigurdsson Simon N Stacey Julius Gudmundsson Hrefna Johannsdottir Kristin Alexiusdottir Vigdis Petursdottir Sigfus Nikulasson Gudmundur Geirsson Thorvaldur Jonsson Katja K H Aben Anne J Grotenhuis Gerald W Verhaegh Aleksandra M Dudek J Alfred Witjes Antoine G van der Heijden Alina Vrieling Tessel E Galesloot Ana De Juan Angeles Panadero Fernando Rivera Carolyn Hurst D Timothy Bishop Sei C Sak Ananya Choudhury Mark T W Teo Cecilia Arici Angela Carta Elena Toninelli Petra de Verdier Peter Rudnai Eugene Gurzau Kvetoslava Koppova Kirstin A van der Keur Irene Lurkin Mieke Goossens Eliane Kellen Simonetta Guarrera Alessia Russo Rossana Critelli Carlotta Sacerdote Paolo Vineis Clémentine Krucker Maurice P Zeegers Holger Gerullis Daniel Ovsiannikov Frank Volkert Jan G Hengstler Silvia Selinski Olafur T Magnusson Gisli Masson Augustine Kong Daniel Gudbjartsson Annika Lindblom Ellen Zwarthoff Stefano Porru Klaus Golka Frank Buntinx Giuseppe Matullo Rajiv Kumar José I Mayordomo D Gunnar Steineck Anne E Kiltie Eirikur Jonsson François Radvanyi Margaret A Knowles Unnur Thorsteinsdottir Lambertus A Kiemeney Kari Stefansson

Hum Mol Genet 2014 Oct 26;23(20):5545-57. Epub 2014 May 26.

deCODE Genetics/AMGEN, Reykjavik 101, Iceland Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland

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http://dx.doi.org/10.1093/hmg/ddu264DOI Listing
October 2014

Assessing the quality of studies on the diagnostic accuracy of tumor markers.

Authors:
Peter J Goebell Ashish M Kamat Richard J Sylvester Peter Black Michael Droller Guilherme Godoy M'Liss A Hudson Kerstin Junker Wassim Kassouf Margaret A Knowles Wolfgang A Schulz Roland Seiler Bernd J Schmitz-Dräger

Urol Oncol 2014 Oct 20;32(7):1051-60. Epub 2014 Aug 20.

Schön Klinik Nürnberg Fürth, Fürth, Germany; Urologie 24, Nürnberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.urolonc.2013.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524775PMC
October 2014

FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism.

Authors:
Jaime Acquaviva Suqin He Chaohua Zhang John-Paul Jimenez Masazumi Nagai Jim Sang Manuel Sequeira Donald L Smith Luisa Shin Ogawa Takayo Inoue Noriaki Tatsuta Margaret A Knowles Richard C Bates David A Proia

Mol Cancer Res 2014 Jul 30;12(7):1042-54. Epub 2014 Apr 30.

Authors' Affiliations: Synta Pharmaceuticals Corp., Lexington, Massachusetts; and

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0004DOI Listing
July 2014

Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes.

Authors:
Claire F Taylor Fiona M Platt Carolyn D Hurst Helene H Thygesen Margaret A Knowles

Hum Mol Genet 2014 Apr 22;23(8):1964-74. Epub 2013 Nov 22.

Cancer Research UK Centre Genomics Facility.

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http://dx.doi.org/10.1093/hmg/ddt589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959811PMC
April 2014

Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine.

Authors:
Carolyn D Hurst Fiona M Platt Margaret A Knowles

Eur Urol 2014 Feb 3;65(2):367-9. Epub 2013 Sep 3.

Section of Experimental Oncology, Leeds Institute of Cancer and Pathology, St James's University Hospital, Leeds, UK. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2013.08.057DOI Listing
February 2014

Molecular subtyping of invasive bladder cancer: time to divide and rule?

Authors:
Carolyn D Hurst Margaret A Knowles

Cancer Cell 2014 Feb;25(2):135-6

Section of Experimental Oncology, Leeds Institute of Cancer and Pathology, University of Leeds, St. James's University Hospital, Beckett Street, Leeds, West Yorkshire LS9 7TF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.01.026DOI Listing
February 2014

Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer.

Authors:
Maria Teresa Herrera-Abreu Alex Pearson James Campbell Steve D Shnyder Margaret A Knowles Alan Ashworth Nicholas C Turner

Cancer Discov 2013 Sep 6;3(9):1058-71. Epub 2013 Jun 6.

1The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research; 2Breast Unit, Royal Marsden Hospital, London; 3Institute of Cancer Therapeutics, University of Bradford, Bradford; and 4Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770512PMC
September 2013

An integrated genomic, transcriptional and protein investigation of FGFRL1 as a putative 4p16.3 deletion target in bladder cancer.

Authors:
Erica di Martino Claire F Taylor Jo-An Roulson Margaret A Knowles

Genes Chromosomes Cancer 2013 Sep 14;52(9):860-71. Epub 2013 Jun 14.

Section of Experimental Oncology, Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1002/gcc.22082DOI Listing
September 2013

Expression of Engrailed-2 (EN2) protein in bladder cancer and its potential utility as a urinary diagnostic biomarker.

Authors:
Richard Morgan Richard T Bryan Saqib Javed Francesca Launchbury Maurice P Zeegers K K Cheng Nicholas D James D Michael A Wallace Carolyn D Hurst Douglas G Ward Margaret A Knowles Hardev Pandha

Eur J Cancer 2013 Jun 21;49(9):2214-22. Epub 2013 Feb 21.

Oncology, Faculty of Health and Medical Sciences, Leggett Building, University of Surrey, Surrey GU2 7WG, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S09598049130008
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http://dx.doi.org/10.1016/j.ejca.2013.01.019DOI Listing
June 2013

Proteomic studies of urinary biomarkers for prostate, bladder and kidney cancers.

Authors:
Steven L Wood Margaret A Knowles Douglas Thompson Peter J Selby Rosamonde E Banks

Nat Rev Urol 2013 Apr 26;10(4):206-18. Epub 2013 Feb 26.

Wolfson Molecular Imaging Centre, 27 Palatine Road, Withington, Manchester M20 3LJ, UK.

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http://www.nature.com/articles/nrurol.2013.24
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http://dx.doi.org/10.1038/nrurol.2013.24DOI Listing
April 2013

Imatinib radiosensitizes bladder cancer by targeting homologous recombination.

Authors:
Boling Qiao Martin Kerr Blaz Groselj Mark T W Teo Margaret A Knowles Robert G Bristow Roger M Phillips Anne E Kiltie

Cancer Res 2013 Mar 9;73(5):1611-20. Epub 2013 Jan 9.

Sections of Experimental Oncology and Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds, UK.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590104PMC
March 2013

Oncogenic FGFR3 gene fusions in bladder cancer.

Authors:
Sarah V Williams Carolyn D Hurst Margaret A Knowles

Hum Mol Genet 2013 Feb 21;22(4):795-803. Epub 2012 Nov 21.

Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James’s University Hospital, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1093/hmg/dds486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554204PMC
February 2013

FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms.

Authors:
Darren C Tomlinson Euan W Baxter Paul M Loadman Mark A Hull Margaret A Knowles

PLoS One 2012 12;7(6):e38972. Epub 2012 Jun 12.

Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038972PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373505PMC
November 2012

Novel tumor subgroups of urothelial carcinoma of the bladder defined by integrated genomic analysis.

Authors:
Carolyn D Hurst Fiona M Platt Claire F Taylor Margaret A Knowles

Clin Cancer Res 2012 Nov 29;18(21):5865-5877. Epub 2012 Aug 29.

Cancer Research UK Centre, Leeds Institute of Molecular Medicine, St James's University Hospital, Beckett Street, Leeds, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081094PMC
http://dx.doi.org/10.1158/1078-0432.CCR-12-1807DOI Listing
November 2012

A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges.

Authors:
Erica di Martino Darren C Tomlinson Margaret A Knowles

Adv Urol 2012 31;2012:429213. Epub 2012 Jul 31.

Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1155/2012/429213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415141PMC
August 2012

A meckelin-filamin A interaction mediates ciliogenesis.

Authors:
Matthew Adams Roslyn J Simms Zakia Abdelhamed Helen R Dawe Katarzyna Szymanska Clare V Logan Gabrielle Wheway Eva Pitt Keith Gull Margaret A Knowles Edward Blair Sally H Cross John A Sayer Colin A Johnson

Hum Mol Genet 2012 Mar 25;21(6):1272-86. Epub 2011 Nov 25.

Ciliopathy Research Group, Section of Ophthalmology and Neurosciences, Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1093/hmg/ddr557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284117PMC
March 2012

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.

Authors:
Thorunn Rafnar Sita H Vermeulen Patrick Sulem Gudmar Thorleifsson Katja K Aben J Alfred Witjes Anne J Grotenhuis Gerald W Verhaegh Christina A Hulsbergen-van de Kaa Soren Besenbacher Daniel Gudbjartsson Simon N Stacey Julius Gudmundsson Hrefna Johannsdottir Hjordis Bjarnason Carlo Zanon Hafdis Helgadottir Jon Gunnlaugur Jonasson Laufey Tryggvadottir Eirikur Jonsson Gudmundur Geirsson Sigfus Nikulasson Vigdis Petursdottir D Timothy Bishop Sei Chung-Sak Ananya Choudhury Faye Elliott Jennifer H Barrett Margaret A Knowles Petra J de Verdier Charlotta Ryk Annika Lindblom Peter Rudnai Eugene Gurzau Kvetoslava Koppova Paolo Vineis Silvia Polidoro Simonetta Guarrera Carlotta Sacerdote Angeles Panadero José I Sanz-Velez Manuel Sanchez Gabriel Valdivia Maria D Garcia-Prats Jan G Hengstler Silvia Selinski Holger Gerullis Daniel Ovsiannikov Abdolaziz Khezri Alireza Aminsharifi Mahyar Malekzadeh Leonard H van den Berg Roel A Ophoff Jan H Veldink Maurice P Zeegers Eliane Kellen Jacopo Fostinelli Daniele Andreoli Cecilia Arici Stefano Porru Frank Buntinx Abbas Ghaderi Klaus Golka José I Mayordomo Giuseppe Matullo Rajiv Kumar Gunnar Steineck Anne E Kiltie Augustine Kong Unnur Thorsteinsdottir Kari Stefansson Lambertus A Kiemeney

Hum Mol Genet 2011 Nov 12;20(21):4268-81. Epub 2011 Jul 12.

deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland.

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http://dx.doi.org/10.1093/hmg/ddr303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188988PMC
November 2011

Structure-function studies of an engineered scaffold protein derived from Stefin A. II: Development and applications of the SQT variant.

Authors:
Lukas Kurt Josef Stadler Toni Hoffmann Darren Charles Tomlinson Qifeng Song Tracy Lee Michael Busby Yvonne Nyathi Elisenda Gendra Christian Tiede Keith Flanagan Simon J Cockell Anil Wipat Colin Harwood Simon D Wagner Margaret A Knowles Jason J Davis Neil Keegan Paul Ko Ferrigno

Protein Eng Des Sel 2011 Sep 25;24(9):751-63. Epub 2011 May 25.

Section of Experimental Therapeutics, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, UK.

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http://dx.doi.org/10.1093/protein/gzr019DOI Listing
September 2011

Functional assays to determine the significance of two common XPC 3'UTR variants found in bladder cancer patients.

Authors:
Boling Qiao Gina B Scott Faye Elliott Laurence Vaslin Johanne Bentley Janet Hall D Timothy Bishop Margaret A Knowles Anne E Kiltie

BMC Med Genet 2011 Jun 20;12:84. Epub 2011 Jun 20.

Section of Experimental Oncology, Leeds Institute of Molecular Medicine, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1186/1471-2350-12-84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142493PMC
June 2011

In vitro functional effects of XPC gene rare variants from bladder cancer patients.

Authors:
Boling Qiao Abdul-Haq Ansari Gina B Scott Sei C Sak Philip A Chambers Faye Elliott Mark T W Teo Johanne Bentley Michael Churchman Janet Hall Claire F Taylor Timothy D Bishop Margaret A Knowles Anne E Kiltie

Carcinogenesis 2011 Apr 27;32(4):516-21. Epub 2011 Jan 27.

Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James’s University Hospital, Beckett St, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1093/carcin/bgr005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066418PMC
April 2011

Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium.

Authors:
Peter J Goebell Margaret A Knowles

Urol Oncol 2010 Jul-Aug;28(4):409-28

Department of Urology, University Clinic of Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1016/j.urolonc.2010.04.003DOI Listing
November 2010

Patterns of expression of DNA repair genes and relapse from melanoma.

Authors:
Rosalyn Jewell Caroline Conway Angana Mitra Juliette Randerson-Moor Samira Lobo Jérémie Nsengimana Mark Harland Maria Marples Sara Edward Martin Cook Barry Powell Andy Boon Floor de Kort Katharine A Parker Ian A Cree Jennifer H Barrett Margaret A Knowles D Timothy Bishop Julia Newton-Bishop

Clin Cancer Res 2010 Nov 12;16(21):5211-21. Epub 2010 Aug 12.

Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-1521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972254PMC
November 2010

Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.

Authors:
Darren C Tomlinson Margaret A Knowles

Am J Pathol 2010 Nov 1;177(5):2379-86. Epub 2010 Oct 1.

Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, LS9 7TF, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S000294401060290
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http://dx.doi.org/10.2353/ajpath.2010.100354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966796PMC
November 2010

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

Authors:
Nathaniel Rothman Montserrat Garcia-Closas Nilanjan Chatterjee Nuria Malats Xifeng Wu Jonine D Figueroa Francisco X Real David Van Den Berg Giuseppe Matullo Dalsu Baris Michael Thun Lambertus A Kiemeney Paolo Vineis Immaculata De Vivo Demetrius Albanes Mark P Purdue Thorunn Rafnar Michelle A T Hildebrandt Anne E Kiltie Olivier Cussenot Klaus Golka Rajiv Kumar Jack A Taylor Jose I Mayordomo Kevin B Jacobs Manolis Kogevinas Amy Hutchinson Zhaoming Wang Yi-Ping Fu Ludmila Prokunina-Olsson Laurie Burdett Meredith Yeager William Wheeler Adonina Tardón Consol Serra Alfredo Carrato Reina García-Closas Josep Lloreta Alison Johnson Molly Schwenn Margaret R Karagas Alan Schned Gerald Andriole Robert Grubb Amanda Black Eric J Jacobs W Ryan Diver Susan M Gapstur Stephanie J Weinstein Jarmo Virtamo Victoria K Cortessis Manuela Gago-Dominguez Malcolm C Pike Mariana C Stern Jian-Min Yuan David J Hunter Monica McGrath Colin P Dinney Bogdan Czerniak Meng Chen Hushan Yang Sita H Vermeulen Katja K Aben J Alfred Witjes Remco R Makkinje Patrick Sulem Soren Besenbacher Kari Stefansson Elio Riboli Paul Brennan Salvatore Panico Carmen Navarro Naomi E Allen H Bas Bueno-de-Mesquita Dimitrios Trichopoulos Neil Caporaso Maria Teresa Landi Federico Canzian Borje Ljungberg Anne Tjonneland Francoise Clavel-Chapelon David T Bishop Mark T W Teo Margaret A Knowles Simonetta Guarrera Silvia Polidoro Fulvio Ricceri Carlotta Sacerdote Alessandra Allione Geraldine Cancel-Tassin Silvia Selinski Jan G Hengstler Holger Dietrich Tony Fletcher Peter Rudnai Eugen Gurzau Kvetoslava Koppova Sophia C E Bolick Ashley Godfrey Zongli Xu José I Sanz-Velez María D García-Prats Manuel Sanchez Gabriel Valdivia Stefano Porru Simone Benhamou Robert N Hoover Joseph F Fraumeni Debra T Silverman Stephen J Chanock

Nat Genet 2010 Nov 24;42(11):978-84. Epub 2010 Oct 24.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/ng.687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049891PMC
November 2010

Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors.

Authors:
Christian Hafner Agustí Toll Alejandro Fernández-Casado Julie Earl Miriam Marqués Francesco Acquadro Marinela Méndez-Pertuz Miguel Urioste Núria Malats Julie E Burns Margaret A Knowles Juan C Cigudosa Arndt Hartmann Thomas Vogt Michael Landthaler Ramón M Pujol Francisco X Real

Proc Natl Acad Sci U S A 2010 Nov 15;107(48):20780-5. Epub 2010 Nov 15.

Department of Dermatology, University of Regensburg, 93042 Regensburg, Germany.

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http://dx.doi.org/10.1073/pnas.1008365107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996414PMC
November 2010

MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer.

Authors:
Ananya Choudhury Louisa D Nelson Mark T W Teo Sameer Chilka Selina Bhattarai Colin F Johnston Faye Elliott Johanna Lowery Claire F Taylor Michael Churchman Johanne Bentley Margaret A Knowles Patricia Harnden Robert G Bristow D Timothy Bishop Anne E Kiltie

Cancer Res 2010 Sep;70(18):7017-26

Sections of Experimental Oncology and Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Cancer Research UK Genome Variation Laboratory Service, Leeds, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941719PMC
September 2010

High-resolution analysis of genomic alteration on chromosome arm 8p in urothelial carcinoma.

Authors:
Sarah V Williams Fiona M Platt Carolyn D Hurst Jo S Aveyard Claire F Taylor Jessica C M Pole Maria J Garcia Margaret A Knowles

Genes Chromosomes Cancer 2010 Jul;49(7):642-59

Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, UK.

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http://dx.doi.org/10.1002/gcc.20775DOI Listing
July 2010

Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma.

Authors:
Caroline Conway Samantha Beswick Faye Elliott Yu-Mei Chang Juliette Randerson-Moor Mark Harland Paul Affleck Jerry Marsden D Scott Sanders Andy Boon Margaret A Knowles D Timothy Bishop Julia A Newton-Bishop

Genes Chromosomes Cancer 2010 May;49(5):425-38

Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, St. James's University Hospital, Leeds, UK.

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http://doi.wiley.com/10.1002/gcc.20753
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948432PMC
May 2010

A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.

Authors:
Lambertus A Kiemeney Patrick Sulem Soren Besenbacher Sita H Vermeulen Asgeir Sigurdsson Gudmar Thorleifsson Daniel F Gudbjartsson Simon N Stacey Julius Gudmundsson Carlo Zanon Jelena Kostic Gisli Masson Hjordis Bjarnason Stefan T Palsson Oskar B Skarphedinsson Sigurjon A Gudjonsson J Alfred Witjes Anne J Grotenhuis Gerald W Verhaegh D Timothy Bishop Sei Chung Sak Ananya Choudhury Faye Elliott Jennifer H Barrett Carolyn D Hurst Petra J de Verdier Charlotta Ryk Peter Rudnai Eugene Gurzau Kvetoslava Koppova Paolo Vineis Silvia Polidoro Simonetta Guarrera Carlotta Sacerdote Marcello Campagna Donatella Placidi Cecilia Arici Maurice P Zeegers Eliane Kellen Berta Saez Gutierrez José I Sanz-Velez Manuel Sanchez-Zalabardo Gabriel Valdivia Maria D Garcia-Prats Jan G Hengstler Meinolf Blaszkewicz Holger Dietrich Roel A Ophoff Leonard H van den Berg Kristin Alexiusdottir Kristleifur Kristjansson Gudmundur Geirsson Sigfus Nikulasson Vigdis Petursdottir Augustine Kong Thorgeir Thorgeirsson N Aydin Mungan Annika Lindblom Michael A van Es Stefano Porru Frank Buntinx Klaus Golka José I Mayordomo Rajiv Kumar Giuseppe Matullo Gunnar Steineck Anne E Kiltie Katja K H Aben Eirikur Jonsson Unnur Thorsteinsdottir Margaret A Knowles Thorunn Rafnar Kari Stefansson

Nat Genet 2010 May 28;42(5):415-9. Epub 2010 Mar 28.

Department of Epidemiology, Biostatistics and Health Technology Assessment, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/ng.558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923020PMC
May 2010

Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease.

Authors:
Neil V Morgan Mark R Morris Hakan Cangul Diane Gleeson Anna Straatman-Iwanowska Nicholas Davies Stephen Keenan Shanaz Pasha Fatimah Rahman Dean Gentle Maaike P G Vreeswijk Peter Devilee Margaret A Knowles Serdar Ceylaner Richard C Trembath Carlos Dalence Erol Kismet Vedat Köseoğlu Hans-Christoph Rossbach Paul Gissen David Tannahill Eamonn R Maher

PLoS Genet 2010 Feb 5;6(2):e1000833. Epub 2010 Feb 5.

Wellchild Paediatric Research Centre and Department of Medical and Molecular Genetics, University of Birmingham College of Medical and Dental Sciences, Edgbaston, Birmingham, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1000833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816679PMC
February 2010

Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes.

Authors:
Irene Lurkin Robert Stoehr Carolyn D Hurst Angela A G van Tilborg Margaret A Knowles Arndt Hartmann Ellen C Zwarthoff

PLoS One 2010 Jan 21;5(1):e8802. Epub 2010 Jan 21.

Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008802PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809099PMC
January 2010

Analysis of VHL Gene Alterations and their Relationship to Clinical Parameters in Sporadic Conventional Renal Cell Carcinoma.

Authors:
Alison C Young Rachel A Craven Dena Cohen Claire Taylor Christopher Booth Patricia Harnden David A Cairns Dewi Astuti Walter Gregory Eamonn R Maher Margaret A Knowles Adrian Joyce Peter J Selby Rosamonde E Banks

Clin Cancer Res 2009 Dec;15(24):7582-7592

Authors' Affiliations: Cancer Research UK Clinical Centre, Cancer Research UK Mutation Detection Facility, and Pyrah Department of Urology, St James's University Hospital, and Clinical Trials Research Unit, University of Leeds, Leeds, United Kingdom; and Cancer Research UK Renal Molecular Oncology Group, University of Birmingham, Edgbaston, United Kingdom.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-09-2131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795746PMC
December 2009

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer.

Authors:
Margaret A Knowles Fiona M Platt Rebecca L Ross Carolyn D Hurst

Cancer Metastasis Rev 2009 Dec;28(3-4):305-16

Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1007/s10555-009-9198-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797439PMC
December 2009

Necdin: a multi functional protein with potential tumor suppressor role?

Authors:
Emma J Chapman Margaret A Knowles

Mol Carcinog 2009 Nov;48(11):975-81

Cancer Research UK Clinical Centre, Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1002/mc.20567DOI Listing
November 2009

Distinct microRNA alterations characterize high- and low-grade bladder cancer.

Authors:
James W F Catto Saiful Miah Helen C Owen Helen Bryant Katie Myers Ewa Dudziec Stéphane Larré Marta Milo Ishtiaq Rehman Derek J Rosario Erica Di Martino Margaret A Knowles Mark Meuth Adrian L Harris Freddie C Hamdy

Cancer Res 2009 Nov 20;69(21):8472-81. Epub 2009 Oct 20.

Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-09-0744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871298PMC
November 2009

Gene expression profiling of paraffin-embedded primary melanoma using the DASL assay identifies increased osteopontin expression as predictive of reduced relapse-free survival.

Authors:
Caroline Conway Angana Mitra Rosalyn Jewell Juliette Randerson-Moor Samira Lobo Jérémie Nsengimana Sara Edward D Scott Sanders Martin Cook Barry Powell Andy Boon Faye Elliott Floor de Kort Margaret A Knowles D Timothy Bishop Julia Newton-Bishop

Clin Cancer Res 2009 Nov 3;15(22):6939-46. Epub 2009 Nov 3.

Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, United Kingdom.

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http://clincancerres.aacrjournals.org/content/15/22/6939.ful
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-09-1631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778654PMC
November 2009

Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer.

Authors:
Fiona M Platt Carolyn D Hurst Claire F Taylor Walter M Gregory Patricia Harnden Margaret A Knowles

Clin Cancer Res 2009 Oct 29;15(19):6008-17. Epub 2009 Sep 29.

Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-0898DOI Listing
October 2009

Integrated genomic and transcriptional analysis of the in vitro evolution of telomerase-immortalized urothelial cells (TERT-NHUC).

Authors:
Emma J Chapman Sarah V Williams Fiona M Platt Carolyn D Hurst Philip Chambers Paul Roberts Margaret A Knowles

Genes Chromosomes Cancer 2009 Aug;48(8):694-710

Cancer Research UK Clinical Centre, St James's University Hospital, Leeds LS97TF, UK.

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http://dx.doi.org/10.1002/gcc.20672DOI Listing
August 2009

Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer.

Authors:
Darren C Tomlinson Fiona R Lamont Steve D Shnyder Margaret A Knowles

Cancer Res 2009 Jun 19;69(11):4613-20. Epub 2009 May 19.

Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737316PMC
June 2009

Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities.

Authors:
Johanne Bentley Corine L'Hôte Fiona Platt Carolyn D Hurst Johanna Lowery Claire Taylor Sei C Sak Patricia Harnden Margaret A Knowles Anne E Kiltie

Genes Chromosomes Cancer 2009 Apr;48(4):310-21

Cancer Research UK Clinical Centre, Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, UK.

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http://dx.doi.org/10.1002/gcc.20641DOI Listing
April 2009

A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene.

Authors:
Carolyn D Hurst Tahlita C M Zuiverloon Christian Hafner Ellen C Zwarthoff Margaret A Knowles

BMC Res Notes 2009 Apr 29;2:66. Epub 2009 Apr 29.

Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, UK.

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http://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0
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http://dx.doi.org/10.1186/1756-0500-2-66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683860PMC
April 2009

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer.

Authors:
Lambertus A Kiemeney Steinunn Thorlacius Patrick Sulem Frank Geller Katja K H Aben Simon N Stacey Julius Gudmundsson Margret Jakobsdottir Jon T Bergthorsson Asgeir Sigurdsson Thorarinn Blondal J Alfred Witjes Sita H Vermeulen Christina A Hulsbergen-van de Kaa Dorine W Swinkels Martine Ploeg Erik B Cornel Henk Vergunst Thorgeir E Thorgeirsson Daniel Gudbjartsson Sigurjon A Gudjonsson Gudmar Thorleifsson Kari T Kristinsson Magali Mouy Steinunn Snorradottir Donatella Placidi Marcello Campagna Cecilia Arici Kvetoslava Koppova Eugene Gurzau Peter Rudnai Eliane Kellen Silvia Polidoro Simonetta Guarrera Carlotta Sacerdote Manuel Sanchez Berta Saez Gabriel Valdivia Charlotta Ryk Petra de Verdier Annika Lindblom Klaus Golka D Timothy Bishop Margaret A Knowles Sigfus Nikulasson Vigdis Petursdottir Eirikur Jonsson Gudmundur Geirsson Baldvin Kristjansson Jose I Mayordomo Gunnar Steineck Stefano Porru Frank Buntinx Maurice P Zeegers Tony Fletcher Rajiv Kumar Giuseppe Matullo Paolo Vineis Anne E Kiltie Jeffrey R Gulcher Unnur Thorsteinsdottir Augustine Kong Thorunn Rafnar Kari Stefansson

Nat Genet 2008 Nov 14;40(11):1307-12. Epub 2008 Sep 14.

Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/ng.229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539560PMC
November 2008

Genomics: a preview of genomic medicine.

Authors:
Jose A Karam Shahrokh F Shariat Jer-Tsong Hsieh Margaret A Knowles

BJU Int 2008 Nov;102(9 Pt B):1221-7

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1111/j.1464-410X.2008.07963.xDOI Listing
November 2008

Bladder cancer subtypes defined by genomic alterations.

Authors:
Margaret A Knowles

Scand J Urol Nephrol Suppl 2008 Sep(218):116-30

Cancer Research UK Clinical Centre, Leeds Institute for Molecular Medicine, St James's University Hospital, Beckett Street, Leeds, UK.

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http://dx.doi.org/10.1080/03008880802284605DOI Listing
September 2008

Molecular pathogenesis of bladder cancer.

Authors:
Margaret A Knowles

Int J Clin Oncol 2008 Aug 15;13(4):287-97. Epub 2008 Aug 15.

Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St James's University Hospital, Beckett Street, Leeds, UK.

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http://dx.doi.org/10.1007/s10147-008-0812-0DOI Listing
August 2008

Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms.

Authors:
Louis S Pymar Fiona M Platt Jon M Askham Ewan E Morrison Margaret A Knowles

Hum Mol Genet 2008 Jul 7;17(13):2006-17. Epub 2008 Apr 7.

Cancer Research UK Clinical Centre in Leeds, Leeds Institute for Molecular Medicine, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1093/hmg/ddn098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427143PMC
July 2008

Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells.

Authors:
Emma J Chapman Gavin Kelly Margaret A Knowles

Mol Cancer Res 2008 Jul;6(7):1154-68

Cancer Research UK Clinical Centre, St. James's University Hospital, Leeds LS97TF, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-2168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437422PMC
July 2008

Novel therapeutic targets in bladder cancer: mutation and expression of FGF receptors.

Authors:
Margaret A Knowles

Future Oncol 2008 Feb;4(1):71-83

Cancer Research UK Clinical Centre, Section of Oncology, Leeds Institute of Molecular Medicine, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK.

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https://www.futuremedicine.com/doi/10.2217/14796694.4.1.71
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February 2008

Role of FGFR3 in urothelial cell carcinoma: biomarker and potential therapeutic target.

Authors:
Margaret A Knowles

World J Urol 2007 Dec 3;25(6):581-93. Epub 2007 Oct 3.

Cancer Research UK Clinical Centre, Section of Oncology, Leeds Institute of Molecular Medicine, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.1007/s00345-007-0213-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876910PMC
December 2007

Tumor suppressor loci in bladder cancer.

Authors:
Margaret A Knowles

Front Biosci 2007 Jan 1;12:2233-51. Epub 2007 Jan 1.

Cancer Research UK Clinical Centre, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, United Kingdom.

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http://dx.doi.org/10.2741/2226DOI Listing
January 2007

Urinary biomarker profiling in transitional cell carcinoma.

Authors:
Nicholas P Munro David A Cairns Paul Clarke Mark Rogers Anthea J Stanley Jennifer H Barrett Patricia Harnden Douglas Thompson Ian Eardley Rosamonde E Banks Margaret A Knowles

Int J Cancer 2006 Dec;119(11):2642-50

Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street, Leeds, United Kingdom.

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http://dx.doi.org/10.1002/ijc.22238DOI Listing
December 2006

Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?

Authors:
Margaret A Knowles

Carcinogenesis 2006 Mar 13;27(3):361-73. Epub 2005 Dec 13.

Cancer Research UK Clinical Centre, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1093/carcin/bgi310DOI Listing
March 2006

Prevalence of 9p21 deletions in UK melanoma families.

Authors:
Sushila H Mistry Claire Taylor Juliette A Randerson-Moor Mark Harland Faye Turner Jennifer H Barrett Linda Whitaker Robert B Jenkins Margaret A Knowles Julia A Newton Bishop D Timothy Bishop

Genes Chromosomes Cancer 2005 Nov;44(3):292-300

Genetic Epidemiology Division, Cancer Research UK Clinical Centre in Leeds, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1002/gcc.20238DOI Listing
November 2005

Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines.

Authors:
Darren C Tomlinson Corine G L'Hôte Wendy Kennedy Eva Pitt Margaret A Knowles

Cancer Res 2005 Nov;65(22):10441-9

Cancer Research UK Clinical Centre, St. James's University Hospital, Leeds, United Kingdom.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-1718DOI Listing
November 2005

Assessment by M-FISH of karyotypic complexity and cytogenetic evolution in bladder cancer in vitro.

Authors:
Sarah V Williams Jacqui Adams Jane Coulter Brenda M Summersgill Janet Shipley Margaret A Knowles

Genes Chromosomes Cancer 2005 Aug;43(4):315-28

Cancer Research UK Clinical Centre, St. James's University Hospital, Leeds, UK.

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http://dx.doi.org/10.1002/gcc.20166DOI Listing
August 2005

FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma.

Authors:
Adel H Jebar Carolyn D Hurst Darren C Tomlinson Colin Johnston Claire F Taylor Margaret A Knowles

Oncogene 2005 Aug;24(33):5218-25

Cancer Research UK Clinical Centre, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1038/sj.onc.1208705DOI Listing
August 2005

Comprehensive analysis of CDKN2A status in microdissected urothelial cell carcinoma reveals potential haploinsufficiency, a high frequency of homozygous co-deletion and associations with clinical phenotype.

Authors:
Emma J Chapman Patricia Harnden Philip Chambers Colin Johnston Margaret A Knowles

Clin Cancer Res 2005 Aug;11(16):5740-7

Cancer Research UK Clinical Centre, St. James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-0411DOI Listing
August 2005

Mutation analysis of the 8p candidate tumour suppressor genes DBC2 (RHOBTB2) and LZTS1 in bladder cancer.

Authors:
Margaret A Knowles Joanne S Aveyard Claire F Taylor Patricia Harnden Sylvia Bass

Cancer Lett 2005 Jul 10;225(1):121-30. Epub 2004 Dec 10.

Cancer Research UK Clinical Centre, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1016/j.canlet.2004.10.047DOI Listing
July 2005

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis.

Authors:
Corine G M L'Hôte Margaret A Knowles

Exp Cell Res 2005 Apr 16;304(2):417-31. Epub 2004 Dec 16.

Cancer Research UK Clinical Centre, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S001448270400686
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http://dx.doi.org/10.1016/j.yexcr.2004.11.012DOI Listing
April 2005

Infrequent mutation of TRAIL receptor 2 (TRAIL-R2/DR5) in transitional cell carcinoma of the bladder with 8p21 loss of heterozygosity.

Authors:
Jacqui Adams Darren Cuthbert-Heavens Sylvia Bass Margaret A Knowles

Cancer Lett 2005 Apr;220(2):137-44

Cancer Research UK Clinical Centre, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1016/j.canlet.2004.06.052DOI Listing
April 2005

Loss of heterozygosity analysis and DNA copy number measurement on 8p in bladder cancer reveals two mechanisms of allelic loss.

Authors:
Jacqui Adams Sarah V Williams Joanne S Aveyard Margaret A Knowles

Cancer Res 2005 Jan;65(1):66-75

Cancer Research UK Clinical Centre, St. James' University Hospital, Leeds, United Kingdom.

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January 2005

Measurement of relative copy number of CDKN2A/ARF and CDKN2B in bladder cancer by real-time quantitative PCR and multiplex ligation-dependent probe amplification.

Authors:
Joanne S Aveyard Margaret A Knowles

J Mol Diagn 2004 Nov;6(4):356-65

Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street, Leeds, LS9 7TF UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867481PMC
http://dx.doi.org/10.1016/S1525-1578(10)60532-6DOI Listing
November 2004

DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining.

Authors:
Johanne Bentley Christine P Diggle Patricia Harnden Margaret A Knowles Anne E Kiltie

Nucleic Acids Res 2004 5;32(17):5249-59. Epub 2004 Oct 5.

Cancer Research UK Clinical Centre, St James's University Hospital, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.1093/nar/gkh842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC521655PMC
October 2004

High-resolution analysis of genomic copy number alterations in bladder cancer by microarray-based comparative genomic hybridization.

Authors:
Carolyn D Hurst Heike Fiegler Philippa Carr Sarah Williams Nigel P Carter Margaret A Knowles

Oncogene 2004 Mar;23(12):2250-63

Cancer Research UK Clinical Centre, St James's University Hospital, Beckett St, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1038/sj.onc.1207260DOI Listing
March 2004

Mutation spectrum of the 9q34 tuberous sclerosis gene TSC1 in transitional cell carcinoma of the bladder.

Authors:
Margaret A Knowles Tomonori Habuchi Wendy Kennedy Darren Cuthbert-Heavens

Cancer Res 2003 Nov;63(22):7652-6

Division of Cancer Medicine Research, Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street, Leeds, West Yorkshire LS9 7TF, U.K.

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November 2003

High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder.

Authors:
Rachael Natrajan Jari Louhelainen Sarah Williams Jonathan Laye Margaret A Knowles

Cancer Res 2003 Nov;63(22):7657-62

Division of Cancer Medicine Research, Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street, Leeds, West Yorkshire LS9 7TF, U.K.

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November 2003

Identification of genes up-regulated in urothelial tumors: the 67-kd laminin receptor and tumor-associated trypsin inhibitor.

Authors:
Christine P Diggle Sheena Cruickshank Jonathon D Olsburgh Stephanie Pellegrin Barbara Smith Rosamonde E Banks Peter J Selby Margaret A Knowles Jennifer Southgate Patricia Harnden

Am J Pathol 2003 Aug;163(2):493-504

Cancer Research United Kingdom Clinical Centre, St. James's University Hospital, Leeds, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868207PMC
http://dx.doi.org/10.1016/S0002-9440(10)63678-4DOI Listing
August 2003

Can p53 staining be used to identify patients with aggressive superficial bladder cancer?

Authors:
John R W Masters Urvi D Vani Kenneth M Grigor Gareth O Griffiths Angela Crook Mahesh K B Parmar Margaret A Knowles

J Pathol 2003 May;200(1):74-81

Institute of Urology, University College London, 3rd Floor, 67 Riding House Street, London W1W 7EJ, UK.

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http://dx.doi.org/10.1002/path.1293DOI Listing
May 2003

Fibroblast growth factors and their receptors in transitional cell carcinoma.

Authors:
Nicholas P Munro Margaret A Knowles

J Urol 2003 Feb;169(2):675-82

Cancer Research United Kingdom Clinical Centre in Leeds, St James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1097/01.ju.0000042721.63319.1dDOI Listing
February 2003

Molecular genetic analysis of chromosome 9 candidate tumor-suppressor loci in bladder cancer cell lines.

Authors:
Sarah V Williams Kathryn D Sibley Alison M Davies Hiroyuki Nishiyama Nick Hornigold Jane Coulter Wendy J Kennedy Amy Skilleter Tomonori Habuchi Margaret A Knowles

Genes Chromosomes Cancer 2002 May;34(1):86-96

Imperial Cancer Research Fund Clinical Centre, St. James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1002/gcc.10050DOI Listing
May 2002