Margaret A Knowles

Margaret A Knowles

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Margaret A Knowles

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ETV5 links the FGFR3 and Hippo signalling pathways in bladder cancer.

Sci Rep 2019 Apr 5;9(1):5740. Epub 2019 Apr 5.

University of Leeds, Leeds Institute of Medical Research at St James's, St. James's University Hospital, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.1038/s41598-018-36456-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450944PMC
April 2019

FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation.

J Pathol 2018 11 19;246(3):331-343. Epub 2018 Sep 19.

School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

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http://dx.doi.org/10.1002/path.5143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334176PMC
November 2018

Mutational landscape of non-muscle-invasive bladder cancer.

Urol Oncol 2018 Nov 13. Epub 2018 Nov 13.

Section of Molecular Oncology, Leeds Institute of Cancer and Pathology, St James's University Hospital, Leeds, United Kingdom. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10781439183039
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http://dx.doi.org/10.1016/j.urolonc.2018.10.015DOI Listing
November 2018

Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation.

Sci Rep 2018 05 8;8(1):7108. Epub 2018 May 8.

Cancer Research Group, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, S7N 5E5, Canada.

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http://dx.doi.org/10.1038/s41598-018-25487-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940657PMC
May 2018

Bladder cancer: Multi-omic profiling refines the molecular view.

Nat Rev Clin Oncol 2018 04 19;15(4):203-204. Epub 2017 Dec 19.

Leeds Institute of Cancer and Pathology, St James's University Hospital, Beckett Street, University of Leeds, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1038/nrclinonc.2017.195DOI Listing
April 2018

Identification of an Indazole-Based Pharmacophore for the Inhibition of FGFR Kinases Using Fragment-Led Design.

ACS Med Chem Lett 2017 Dec 11;8(12):1264-1268. Epub 2017 Nov 11.

School of Chemistry and Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, LS2 9JT, U.K.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733262PMC
December 2017

Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis.

Oncotarget 2017 Nov 25;8(61):102898-102911. Epub 2017 Oct 25.

Proteomics and Molecular Cell Dynamics, Center for Nephrology, School of Life and Medical Sciences, University College London, London NW3 2PF, United Kingdom.

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http://dx.doi.org/10.18632/oncotarget.22048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732698PMC
November 2017

Bladder cancer.

Nat Rev Dis Primers 2017 Apr 13;3:17022. Epub 2017 Apr 13.

Department of Urology, UT Southwestern Medical Center at Dallas, Moss Building, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9110, USA.

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http://dx.doi.org/10.1038/nrdp.2017.22DOI Listing
April 2017

A place for precision medicine in bladder cancer: targeting the FGFRs.

Future Oncol 2016 Oct 6;12(19):2243-63. Epub 2016 Jul 6.

Section of Molecular Oncology, Leeds Institute of Cancer & Pathology, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.2217/fon-2016-0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066128PMC
October 2016

Frequency of TERT Promoter Mutations in Prostate Cancer.

Pathobiology 2015 21;82(2):53-7. Epub 2015 May 21.

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

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https://www.karger.com/Article/FullText/381903
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http://dx.doi.org/10.1159/000381903DOI Listing
May 2016

Polycomb Repressor Complex 1 Member, BMI1 Contributes to Urothelial Tumorigenesis through p16-Independent Mechanisms.

Transl Oncol 2015 Oct;8(5):387-99

Leeds Institute of Cancer and Pathology, St James's University Hospital, Beckett Street, Leeds, LS97TF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2015.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631094PMC
October 2015

FGFR3 expression in primary invasive bladder cancers and matched lymph node metastases.

J Urol 2015 Jan 13;193(1):325-30. Epub 2014 Jun 13.

Leeds Institute of Cancer and Pathology, St. James's University Hospital, Leeds, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.juro.2014.06.026DOI Listing
January 2015

Alteration of cell-cell and cell-matrix adhesion in urothelial cells: an oncogenic mechanism for mutant FGFR3.

Mol Cancer Res 2015 Jan 15;13(1):138-48. Epub 2014 Sep 15.

Section of Experimental Oncology, Leeds Institute of Cancer and Pathology, St. James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0022DOI Listing
January 2015

Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity.

Nat Rev Cancer 2015 Jan;15(1):25-41

Section of Experimental Oncology, Leeds Institute of Cancer and Pathology, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.1038/nrc3817DOI Listing
January 2015

Identification of mutations in distinct regions of p85 alpha in urothelial cancer.

PLoS One 2013 18;8(12):e84411. Epub 2013 Dec 18.

Section of Experimental Oncology, Leeds Institute of Cancer and Pathology, St James's University Hospital, Leeds, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084411PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3867501PMC
October 2014

Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer.

Hum Mol Genet 2014 Oct 26;23(20):5545-57. Epub 2014 May 26.

deCODE Genetics/AMGEN, Reykjavik 101, Iceland Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland

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http://dx.doi.org/10.1093/hmg/ddu264DOI Listing
October 2014

Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine.

Eur Urol 2014 Feb 3;65(2):367-9. Epub 2013 Sep 3.

Section of Experimental Oncology, Leeds Institute of Cancer and Pathology, St James's University Hospital, Leeds, UK. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2013.08.057DOI Listing
February 2014

Molecular subtyping of invasive bladder cancer: time to divide and rule?

Cancer Cell 2014 Feb;25(2):135-6

Section of Experimental Oncology, Leeds Institute of Cancer and Pathology, University of Leeds, St. James's University Hospital, Beckett Street, Leeds, West Yorkshire LS9 7TF, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.01.026DOI Listing
February 2014

Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer.

Cancer Discov 2013 Sep 6;3(9):1058-71. Epub 2013 Jun 6.

1The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research; 2Breast Unit, Royal Marsden Hospital, London; 3Institute of Cancer Therapeutics, University of Bradford, Bradford; and 4Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770512PMC
September 2013

An integrated genomic, transcriptional and protein investigation of FGFRL1 as a putative 4p16.3 deletion target in bladder cancer.

Genes Chromosomes Cancer 2013 Sep 14;52(9):860-71. Epub 2013 Jun 14.

Section of Experimental Oncology, Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1002/gcc.22082DOI Listing
September 2013

Proteomic studies of urinary biomarkers for prostate, bladder and kidney cancers.

Nat Rev Urol 2013 Apr 26;10(4):206-18. Epub 2013 Feb 26.

Wolfson Molecular Imaging Centre, 27 Palatine Road, Withington, Manchester M20 3LJ, UK.

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http://www.nature.com/articles/nrurol.2013.24
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http://dx.doi.org/10.1038/nrurol.2013.24DOI Listing
April 2013

Imatinib radiosensitizes bladder cancer by targeting homologous recombination.

Cancer Res 2013 Mar 9;73(5):1611-20. Epub 2013 Jan 9.

Sections of Experimental Oncology and Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds, UK.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590104PMC
March 2013

Oncogenic FGFR3 gene fusions in bladder cancer.

Hum Mol Genet 2013 Feb 21;22(4):795-803. Epub 2012 Nov 21.

Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James’s University Hospital, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1093/hmg/dds486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554204PMC
February 2013

FGFR1-induced epithelial to mesenchymal transition through MAPK/PLCγ/COX-2-mediated mechanisms.

PLoS One 2012 12;7(6):e38972. Epub 2012 Jun 12.

Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0038972PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373505PMC
November 2012

Novel tumor subgroups of urothelial carcinoma of the bladder defined by integrated genomic analysis.

Clin Cancer Res 2012 Nov 29;18(21):5865-5877. Epub 2012 Aug 29.

Cancer Research UK Centre, Leeds Institute of Molecular Medicine, St James's University Hospital, Beckett Street, Leeds, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081094PMC
http://dx.doi.org/10.1158/1078-0432.CCR-12-1807DOI Listing
November 2012

A Decade of FGF Receptor Research in Bladder Cancer: Past, Present, and Future Challenges.

Adv Urol 2012 31;2012:429213. Epub 2012 Jul 31.

Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1155/2012/429213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415141PMC
August 2012

A meckelin-filamin A interaction mediates ciliogenesis.

Hum Mol Genet 2012 Mar 25;21(6):1272-86. Epub 2011 Nov 25.

Ciliopathy Research Group, Section of Ophthalmology and Neurosciences, Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1093/hmg/ddr557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3284117PMC
March 2012

European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.

Hum Mol Genet 2011 Nov 12;20(21):4268-81. Epub 2011 Jul 12.

deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland.

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http://dx.doi.org/10.1093/hmg/ddr303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188988PMC
November 2011

In vitro functional effects of XPC gene rare variants from bladder cancer patients.

Carcinogenesis 2011 Apr 27;32(4):516-21. Epub 2011 Jan 27.

Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James’s University Hospital, Beckett St, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1093/carcin/bgr005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3066418PMC
April 2011

Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium.

Urol Oncol 2010 Jul-Aug;28(4):409-28

Department of Urology, University Clinic of Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1016/j.urolonc.2010.04.003DOI Listing
November 2010

Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.

Am J Pathol 2010 Nov 1;177(5):2379-86. Epub 2010 Oct 1.

Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, LS9 7TF, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S000294401060290
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http://dx.doi.org/10.2353/ajpath.2010.100354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966796PMC
November 2010

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

Authors:
Nathaniel Rothman Montserrat Garcia-Closas Nilanjan Chatterjee Nuria Malats Xifeng Wu Jonine D Figueroa Francisco X Real David Van Den Berg Giuseppe Matullo Dalsu Baris Michael Thun Lambertus A Kiemeney Paolo Vineis Immaculata De Vivo Demetrius Albanes Mark P Purdue Thorunn Rafnar Michelle A T Hildebrandt Anne E Kiltie Olivier Cussenot Klaus Golka Rajiv Kumar Jack A Taylor Jose I Mayordomo Kevin B Jacobs Manolis Kogevinas Amy Hutchinson Zhaoming Wang Yi-Ping Fu Ludmila Prokunina-Olsson Laurie Burdett Meredith Yeager William Wheeler Adonina Tardón Consol Serra Alfredo Carrato Reina García-Closas Josep Lloreta Alison Johnson Molly Schwenn Margaret R Karagas Alan Schned Gerald Andriole Robert Grubb Amanda Black Eric J Jacobs W Ryan Diver Susan M Gapstur Stephanie J Weinstein Jarmo Virtamo Victoria K Cortessis Manuela Gago-Dominguez Malcolm C Pike Mariana C Stern Jian-Min Yuan David J Hunter Monica McGrath Colin P Dinney Bogdan Czerniak Meng Chen Hushan Yang Sita H Vermeulen Katja K Aben J Alfred Witjes Remco R Makkinje Patrick Sulem Soren Besenbacher Kari Stefansson Elio Riboli Paul Brennan Salvatore Panico Carmen Navarro Naomi E Allen H Bas Bueno-de-Mesquita Dimitrios Trichopoulos Neil Caporaso Maria Teresa Landi Federico Canzian Borje Ljungberg Anne Tjonneland Francoise Clavel-Chapelon David T Bishop Mark T W Teo Margaret A Knowles Simonetta Guarrera Silvia Polidoro Fulvio Ricceri Carlotta Sacerdote Alessandra Allione Geraldine Cancel-Tassin Silvia Selinski Jan G Hengstler Holger Dietrich Tony Fletcher Peter Rudnai Eugen Gurzau Kvetoslava Koppova Sophia C E Bolick Ashley Godfrey Zongli Xu José I Sanz-Velez María D García-Prats Manuel Sanchez Gabriel Valdivia Stefano Porru Simone Benhamou Robert N Hoover Joseph F Fraumeni Debra T Silverman Stephen J Chanock

Nat Genet 2010 Nov 24;42(11):978-84. Epub 2010 Oct 24.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1038/ng.687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049891PMC
November 2010

High-resolution analysis of genomic alteration on chromosome arm 8p in urothelial carcinoma.

Genes Chromosomes Cancer 2010 Jul;49(7):642-59

Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, UK.

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http://dx.doi.org/10.1002/gcc.20775DOI Listing
July 2010

A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.

Nat Genet 2010 May 28;42(5):415-9. Epub 2010 Mar 28.

Department of Epidemiology, Biostatistics and Health Technology Assessment, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/ng.558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923020PMC
May 2010

Analysis of VHL Gene Alterations and their Relationship to Clinical Parameters in Sporadic Conventional Renal Cell Carcinoma.

Clin Cancer Res 2009 Dec;15(24):7582-7592

Authors' Affiliations: Cancer Research UK Clinical Centre, Cancer Research UK Mutation Detection Facility, and Pyrah Department of Urology, St James's University Hospital, and Clinical Trials Research Unit, University of Leeds, Leeds, United Kingdom; and Cancer Research UK Renal Molecular Oncology Group, University of Birmingham, Edgbaston, United Kingdom.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-09-2131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795746PMC
December 2009

Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer.

Cancer Metastasis Rev 2009 Dec;28(3-4):305-16

Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1007/s10555-009-9198-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2797439PMC
December 2009

Necdin: a multi functional protein with potential tumor suppressor role?

Mol Carcinog 2009 Nov;48(11):975-81

Cancer Research UK Clinical Centre, Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1002/mc.20567DOI Listing
November 2009

Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer.

Clin Cancer Res 2009 Oct 29;15(19):6008-17. Epub 2009 Sep 29.

Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-0898DOI Listing
October 2009

Integrated genomic and transcriptional analysis of the in vitro evolution of telomerase-immortalized urothelial cells (TERT-NHUC).

Genes Chromosomes Cancer 2009 Aug;48(8):694-710

Cancer Research UK Clinical Centre, St James's University Hospital, Leeds LS97TF, UK.

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http://dx.doi.org/10.1002/gcc.20672DOI Listing
August 2009

Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer.

Cancer Res 2009 Jun 19;69(11):4613-20. Epub 2009 May 19.

Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St. James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737316PMC
June 2009

Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities.

Genes Chromosomes Cancer 2009 Apr;48(4):310-21

Cancer Research UK Clinical Centre, Section of Experimental Oncology, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, UK.

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http://dx.doi.org/10.1002/gcc.20641DOI Listing
April 2009

A SNaPshot assay for the rapid and simple detection of four common hotspot codon mutations in the PIK3CA gene.

BMC Res Notes 2009 Apr 29;2:66. Epub 2009 Apr 29.

Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, UK.

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http://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0
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http://dx.doi.org/10.1186/1756-0500-2-66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683860PMC
April 2009

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer.

Nat Genet 2008 Nov 14;40(11):1307-12. Epub 2008 Sep 14.

Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/ng.229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539560PMC
November 2008

Genomics: a preview of genomic medicine.

BJU Int 2008 Nov;102(9 Pt B):1221-7

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1111/j.1464-410X.2008.07963.xDOI Listing
November 2008

Bladder cancer subtypes defined by genomic alterations.

Scand J Urol Nephrol Suppl 2008 Sep(218):116-30

Cancer Research UK Clinical Centre, Leeds Institute for Molecular Medicine, St James's University Hospital, Beckett Street, Leeds, UK.

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http://dx.doi.org/10.1080/03008880802284605DOI Listing
September 2008

Molecular pathogenesis of bladder cancer.

Int J Clin Oncol 2008 Aug 15;13(4):287-97. Epub 2008 Aug 15.

Cancer Research UK Clinical Centre, Leeds Institute of Molecular Medicine, St James's University Hospital, Beckett Street, Leeds, UK.

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http://dx.doi.org/10.1007/s10147-008-0812-0DOI Listing
August 2008

Bladder tumour-derived somatic TSC1 missense mutations cause loss of function via distinct mechanisms.

Hum Mol Genet 2008 Jul 7;17(13):2006-17. Epub 2008 Apr 7.

Cancer Research UK Clinical Centre in Leeds, Leeds Institute for Molecular Medicine, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1093/hmg/ddn098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427143PMC
July 2008

Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells.

Mol Cancer Res 2008 Jul;6(7):1154-68

Cancer Research UK Clinical Centre, St. James's University Hospital, Leeds LS97TF, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-07-2168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437422PMC
July 2008

Novel therapeutic targets in bladder cancer: mutation and expression of FGF receptors.

Future Oncol 2008 Feb;4(1):71-83

Cancer Research UK Clinical Centre, Section of Oncology, Leeds Institute of Molecular Medicine, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK.

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https://www.futuremedicine.com/doi/10.2217/14796694.4.1.71
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http://dx.doi.org/10.2217/14796694.4.1.71DOI Listing
February 2008

Role of FGFR3 in urothelial cell carcinoma: biomarker and potential therapeutic target.

World J Urol 2007 Dec 3;25(6):581-93. Epub 2007 Oct 3.

Cancer Research UK Clinical Centre, Section of Oncology, Leeds Institute of Molecular Medicine, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.1007/s00345-007-0213-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876910PMC
December 2007

Tumor suppressor loci in bladder cancer.

Front Biosci 2007 Jan 1;12:2233-51. Epub 2007 Jan 1.

Cancer Research UK Clinical Centre, St James's University Hospital, Beckett Street, Leeds, LS9 7TF, United Kingdom.

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http://dx.doi.org/10.2741/2226DOI Listing
January 2007

Urinary biomarker profiling in transitional cell carcinoma.

Int J Cancer 2006 Dec;119(11):2642-50

Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street, Leeds, United Kingdom.

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http://dx.doi.org/10.1002/ijc.22238DOI Listing
December 2006

Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?

Carcinogenesis 2006 Mar 13;27(3):361-73. Epub 2005 Dec 13.

Cancer Research UK Clinical Centre, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1093/carcin/bgi310DOI Listing
March 2006

Prevalence of 9p21 deletions in UK melanoma families.

Genes Chromosomes Cancer 2005 Nov;44(3):292-300

Genetic Epidemiology Division, Cancer Research UK Clinical Centre in Leeds, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1002/gcc.20238DOI Listing
November 2005

Assessment by M-FISH of karyotypic complexity and cytogenetic evolution in bladder cancer in vitro.

Genes Chromosomes Cancer 2005 Aug;43(4):315-28

Cancer Research UK Clinical Centre, St. James's University Hospital, Leeds, UK.

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http://dx.doi.org/10.1002/gcc.20166DOI Listing
August 2005

FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma.

Oncogene 2005 Aug;24(33):5218-25

Cancer Research UK Clinical Centre, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1038/sj.onc.1208705DOI Listing
August 2005

Mutation analysis of the 8p candidate tumour suppressor genes DBC2 (RHOBTB2) and LZTS1 in bladder cancer.

Cancer Lett 2005 Jul 10;225(1):121-30. Epub 2004 Dec 10.

Cancer Research UK Clinical Centre, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1016/j.canlet.2004.10.047DOI Listing
July 2005

Cell responses to FGFR3 signalling: growth, differentiation and apoptosis.

Exp Cell Res 2005 Apr 16;304(2):417-31. Epub 2004 Dec 16.

Cancer Research UK Clinical Centre, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S001448270400686
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http://dx.doi.org/10.1016/j.yexcr.2004.11.012DOI Listing
April 2005

Infrequent mutation of TRAIL receptor 2 (TRAIL-R2/DR5) in transitional cell carcinoma of the bladder with 8p21 loss of heterozygosity.

Cancer Lett 2005 Apr;220(2):137-44

Cancer Research UK Clinical Centre, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1016/j.canlet.2004.06.052DOI Listing
April 2005

Loss of heterozygosity analysis and DNA copy number measurement on 8p in bladder cancer reveals two mechanisms of allelic loss.

Cancer Res 2005 Jan;65(1):66-75

Cancer Research UK Clinical Centre, St. James' University Hospital, Leeds, United Kingdom.

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January 2005

Measurement of relative copy number of CDKN2A/ARF and CDKN2B in bladder cancer by real-time quantitative PCR and multiplex ligation-dependent probe amplification.

J Mol Diagn 2004 Nov;6(4):356-65

Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street, Leeds, LS9 7TF UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867481PMC
http://dx.doi.org/10.1016/S1525-1578(10)60532-6DOI Listing
November 2004

DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining.

Nucleic Acids Res 2004 5;32(17):5249-59. Epub 2004 Oct 5.

Cancer Research UK Clinical Centre, St James's University Hospital, Leeds, LS9 7TF, UK.

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http://dx.doi.org/10.1093/nar/gkh842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC521655PMC
October 2004

High-resolution analysis of genomic copy number alterations in bladder cancer by microarray-based comparative genomic hybridization.

Oncogene 2004 Mar;23(12):2250-63

Cancer Research UK Clinical Centre, St James's University Hospital, Beckett St, Leeds LS9 7TF, UK.

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http://dx.doi.org/10.1038/sj.onc.1207260DOI Listing
March 2004

Mutation spectrum of the 9q34 tuberous sclerosis gene TSC1 in transitional cell carcinoma of the bladder.

Cancer Res 2003 Nov;63(22):7652-6

Division of Cancer Medicine Research, Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street, Leeds, West Yorkshire LS9 7TF, U.K.

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November 2003

High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder.

Cancer Res 2003 Nov;63(22):7657-62

Division of Cancer Medicine Research, Cancer Research UK Clinical Centre, St. James's University Hospital, Beckett Street, Leeds, West Yorkshire LS9 7TF, U.K.

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November 2003

Can p53 staining be used to identify patients with aggressive superficial bladder cancer?

J Pathol 2003 May;200(1):74-81

Institute of Urology, University College London, 3rd Floor, 67 Riding House Street, London W1W 7EJ, UK.

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http://dx.doi.org/10.1002/path.1293DOI Listing
May 2003

Fibroblast growth factors and their receptors in transitional cell carcinoma.

J Urol 2003 Feb;169(2):675-82

Cancer Research United Kingdom Clinical Centre in Leeds, St James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1097/01.ju.0000042721.63319.1dDOI Listing
February 2003

Molecular genetic analysis of chromosome 9 candidate tumor-suppressor loci in bladder cancer cell lines.

Genes Chromosomes Cancer 2002 May;34(1):86-96

Imperial Cancer Research Fund Clinical Centre, St. James's University Hospital, Leeds, United Kingdom.

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http://dx.doi.org/10.1002/gcc.10050DOI Listing
May 2002