Marella De Bruijn

Marella De Bruijn

UNVERIFIED PROFILE

Are you Marella De Bruijn?   Register this Author

Register author
Marella De Bruijn

Marella De Bruijn

Publications by authors named "Marella De Bruijn"

Are you Marella De Bruijn?   Register this Author

51Publications

1175Reads

35Profile Views

Microhomologies are prevalent at Cas9-induced larger deletions.

Nucleic Acids Res 2019 Aug;47(14):7402-7417

MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkz459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698657PMC
August 2019

Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium.

Nat Commun 2019 Aug 8;10(1):3577. Epub 2019 Aug 8.

Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-11423-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687740PMC
August 2019

Kit ligand has a critical role in mouse yolk sac and aorta-gonad-mesonephros hematopoiesis.

EMBO Rep 2018 10 30;19(10). Epub 2018 Aug 30.

MRC Molecular Hematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embr.201745477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172468PMC
October 2018

Disruption of the aortic wall by coelomic lining-derived mesenchymal cells accompanies the onset of aortic hematopoiesis.

Int J Dev Biol 2017 ;61(3-4-5):329-335

Department of Genetics and Developmental Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1387/ijdb.170012tsDOI Listing
June 2018

The Role of Runx1 in Embryonic Blood Cell Formation.

Adv Exp Med Biol 2017 ;962:47-64

Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19103, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-981-10-3233-2_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813695PMC
September 2017

Runx transcription factors in the development and function of the definitive hematopoietic system.

Blood 2017 04 8;129(15):2061-2069. Epub 2017 Feb 8.

MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2016-12-689109DOI Listing
April 2017

Transcriptional regulation of Hhex in hematopoiesis and hematopoietic stem cell ontogeny.

Dev Biol 2017 04 9;424(2):236-245. Epub 2017 Feb 9.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK; Stem Cell Laboratory, UCL Cancer Institute, University College London, London WC1E 6DD, UK. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00121606163063
Publisher Site
http://dx.doi.org/10.1016/j.ydbio.2016.12.021DOI Listing
April 2017

Turning it down a Notch.

Blood 2016 09;128(12):1541-2

UNIVERSITY OF OXFORD.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2016-08-729483DOI Listing
September 2016

Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells.

Dev Cell 2016 Mar;36(5):525-39

Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1496, New York, NY 10029, USA; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1496, New York, NY 10029, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2016.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785845PMC
March 2016

The Origin of Tissue-Resident Macrophages: When an Erythro-myeloid Progenitor Is an Erythro-myeloid Progenitor.

Immunity 2015 Dec;43(6):1023-4

King's College London, Great Maze Pond, SE1 1UL London, UK; Memorial Sloan Kettering Cancer Center, 417 East 68(th) Street, New York, NY 10065, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2015.11.022DOI Listing
December 2015

SMAD1 and SMAD5 Expression Is Coordinately Regulated by FLI1 and GATA2 during Endothelial Development.

Mol Cell Biol 2015 Jun 13;35(12):2165-72. Epub 2015 Apr 13.

Lowy Cancer Research Centre and the Prince of Wales Clinical School, The University of New South Wales, Sydney, NSW, Australia Department of Haematology, Prince of Wales Hospital, Sydney, NSW, Australia

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.00239-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438244PMC
June 2015

A comparative encyclopedia of DNA elements in the mouse genome.

Authors:
Feng Yue Yong Cheng Alessandra Breschi Jeff Vierstra Weisheng Wu Tyrone Ryba Richard Sandstrom Zhihai Ma Carrie Davis Benjamin D Pope Yin Shen Dmitri D Pervouchine Sarah Djebali Robert E Thurman Rajinder Kaul Eric Rynes Anthony Kirilusha Georgi K Marinov Brian A Williams Diane Trout Henry Amrhein Katherine Fisher-Aylor Igor Antoshechkin Gilberto DeSalvo Lei-Hoon See Meagan Fastuca Jorg Drenkow Chris Zaleski Alex Dobin Pablo Prieto Julien Lagarde Giovanni Bussotti Andrea Tanzer Olgert Denas Kanwei Li M A Bender Miaohua Zhang Rachel Byron Mark T Groudine David McCleary Long Pham Zhen Ye Samantha Kuan Lee Edsall Yi-Chieh Wu Matthew D Rasmussen Mukul S Bansal Manolis Kellis Cheryl A Keller Christapher S Morrissey Tejaswini Mishra Deepti Jain Nergiz Dogan Robert S Harris Philip Cayting Trupti Kawli Alan P Boyle Ghia Euskirchen Anshul Kundaje Shin Lin Yiing Lin Camden Jansen Venkat S Malladi Melissa S Cline Drew T Erickson Vanessa M Kirkup Katrina Learned Cricket A Sloan Kate R Rosenbloom Beatriz Lacerda de Sousa Kathryn Beal Miguel Pignatelli Paul Flicek Jin Lian Tamer Kahveci Dongwon Lee W James Kent Miguel Ramalho Santos Javier Herrero Cedric Notredame Audra Johnson Shinny Vong Kristen Lee Daniel Bates Fidencio Neri Morgan Diegel Theresa Canfield Peter J Sabo Matthew S Wilken Thomas A Reh Erika Giste Anthony Shafer Tanya Kutyavin Eric Haugen Douglas Dunn Alex P Reynolds Shane Neph Richard Humbert R Scott Hansen Marella De Bruijn Licia Selleri Alexander Rudensky Steven Josefowicz Robert Samstein Evan E Eichler Stuart H Orkin Dana Levasseur Thalia Papayannopoulou Kai-Hsin Chang Arthur Skoultchi Srikanta Gosh Christine Disteche Piper Treuting Yanli Wang Mitchell J Weiss Gerd A Blobel Xiaoyi Cao Sheng Zhong Ting Wang Peter J Good Rebecca F Lowdon Leslie B Adams Xiao-Qiao Zhou Michael J Pazin Elise A Feingold Barbara Wold James Taylor Ali Mortazavi Sherman M Weissman John A Stamatoyannopoulos Michael P Snyder Roderic Guigo Thomas R Gingeras David M Gilbert Ross C Hardison Michael A Beer Bing Ren

Nature 2014 Nov;515(7527):355-64

Ludwig Institute for Cancer Research and University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature13992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266106PMC
November 2014

The hemangioblast revisited.

Blood 2014 Oct;124(16):2472-3

UNIVERSITY OF OXFORD.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-09-597674DOI Listing
October 2014

A short history of hemogenic endothelium.

Blood Cells Mol Dis 2013 Dec 4;51(4):206-12. Epub 2013 Oct 4.

MRC Molecular Haematology Unit, MRC Weatherall Institute of Medicine, John Radcliffe Hospital, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DS, United Kingdom.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10799796130020
Publisher Site
http://dx.doi.org/10.1016/j.bcmd.2013.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700588PMC
December 2013

Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis.

Nat Cell Biol 2013 Apr 24;15(4):363-72. Epub 2013 Mar 24.

Department of Haematology, Wellcome Trust and MRC Cambridge Stem Cell Institute and Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb2709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3796878PMC
April 2013

Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells.

Haematologica 2013 Feb 16;98(2):163-71. Epub 2012 Jul 16.

Department of Haematology, Cambridge Institute for Medical Research, Wellcome Trust & MRC Stem Cell Institute, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2012.070789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561421PMC
February 2013

Isolation and analysis of hematopoietic stem cells from mouse embryos.

Methods Mol Med 2002 ;63:1-14

Department of Cell Biology and Genetics, Erasmus University, Rotterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1385/1-59259-140-X:001DOI Listing
October 2012

Hematopoietic stem cell emergence in the conceptus and the role of Runx1.

Int J Dev Biol 2010 ;54(6-7):1151-63

Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://www.intjdevbiol.com/paper.php?doi=103106gs
Publisher Site
http://dx.doi.org/10.1387/ijdb.103106gsDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512753PMC
February 2011

Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis.

Blood 2010 Apr 4;115(15):3042-50. Epub 2010 Feb 4.

Medical Research Council Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2009-08-238626DOI Listing
April 2010

Visualizing blood cell emergence from aortic endothelium.

Cell Stem Cell 2010 Apr;6(4):289-90

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2010.03.007DOI Listing
April 2010

Alternative Runx1 promoter usage in mouse developmental hematopoiesis.

Blood Cells Mol Dis 2009 Jul-Aug;43(1):35-42. Epub 2009 May 21.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcmd.2009.03.011DOI Listing
September 2009

Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development.

Development 2009 Aug 1;136(15):2613-21. Epub 2009 Jul 1.

Erasmus Stem Cell Institute, Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.034728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709067PMC
August 2009

Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.

Blood 2007 Dec 6;110(13):4188-97. Epub 2007 Sep 6.

Medical Research Council (MRC) Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2007-07-100883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234795PMC
December 2007

The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity.

Proc Natl Acad Sci U S A 2007 Jan 9;104(3):840-5. Epub 2007 Jan 9.

Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0607196104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783401PMC
January 2007

From hemangioblast to hematopoietic stem cell: an endothelial connection?

Exp Hematol 2005 Sep;33(9):1029-40

Developmental Biology Laboratory, UPMC, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2005.06.005DOI Listing
September 2005

Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells.

Stem Cells 2004 ;22(2):158-68

Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, USA. (Current address for Dr. de Bruijn) MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1634/stemcells.22-2-158
Publisher Site
http://dx.doi.org/10.1634/stemcells.22-2-158DOI Listing
November 2004

Core-binding factors in hematopoiesis and immune function.

Oncogene 2004 May;23(24):4238-48

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1207763DOI Listing
May 2004

Developmental stages of myeloid dendritic cells in mouse bone marrow.

Int Immunol 2003 Apr;15(4):515-24

Department of Immunology, Erasmus MC, University Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands. t.nikolic@erasmusmc

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/intimm/dxg050DOI Listing
April 2003

Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta.

Immunity 2002 May;16(5):673-83

Department of Cell Biology and Genetics, Erasmus University, Rotterdam, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1074-7613(02)00313-8DOI Listing
May 2002

Expression of the Ly-6A (Sca-1) lacZ transgene in mouse haematopoietic stem cells and embryos.

Br J Haematol 2002 Feb;116(2):401-8

Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1365-2141.2002.03250.xDOI Listing
February 2002