Marcus Conrad

Marcus Conrad

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Marcus Conrad

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Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion.

Nat Rev Cancer 2019 07;19(7):405-414

Institute of Developmental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41568-019-0149-1DOI Listing
July 2019

Broken hearts: Iron overload, ferroptosis and cardiomyopathy.

Cell Res 2019 Apr;29(4):263-264

Helmholtz Zentrum München, Institute of Developmental Genetics, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41422-019-0150-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461867PMC
April 2019

Role of GPX4 in ferroptosis and its pharmacological implication.

Free Radic Biol Med 2019 03 13;133:144-152. Epub 2018 Sep 13.

Helmholtz Zentrum München, Institute of Developmental Genetics, 85764 Neuherberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08915849183159
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http://dx.doi.org/10.1016/j.freeradbiomed.2018.09.014DOI Listing
March 2019

Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4.

J Med Chem 2019 01 2;62(1):266-275. Epub 2018 May 2.

Rudolf Virchow Center for Experimental Biomedicine , University of Würzburg , 97080 Würzburg , Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00315DOI Listing
January 2019

Ferroptosis and necroinflammation, a yet poorly explored link.

Cell Death Differ 2019 01 6;26(1):14-24. Epub 2018 Aug 6.

Institute of Developmental Genetics, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany.

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http://dx.doi.org/10.1038/s41418-018-0173-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294786PMC
January 2019

Selenium and GPX4, a vital symbiosis.

Free Radic Biol Med 2018 11 6;127:153-159. Epub 2018 Mar 6.

Institute of Developmental Genetics, Helmholtz Zentrum München, 85764 Neuherberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08915849183010
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http://dx.doi.org/10.1016/j.freeradbiomed.2018.03.001DOI Listing
November 2018

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues.

Antioxid Redox Signal 2018 07 30;29(1):61-74. Epub 2017 May 30.

1 Department of Molecular Medicine, University of Padova , Padova, Italy .

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http://dx.doi.org/10.1089/ars.2017.7115DOI Listing
July 2018

Regulation of lipid peroxidation and ferroptosis in diverse species.

Genes Dev 2018 05;32(9-10):602-619

Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

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http://dx.doi.org/10.1101/gad.314674.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004068PMC
May 2018

Modulation of Glutathione Hemostasis by Inhibition of 12/15-Lipoxygenase Prevents ROS-Mediated Cell Death after Hepatic Ischemia and Reperfusion.

Oxid Med Cell Longev 2017 24;2017:8325754. Epub 2017 Jul 24.

Department of General, Visceral, Vascular and Transplant Surgery, University Hospital Munich, Ludwig-Maximilians University of Munich, Campus Großhadern, Munich, Germany.

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https://www.hindawi.com/journals/omcl/2017/8325754/
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http://dx.doi.org/10.1155/2017/8325754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546123PMC
April 2018

Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe.

J Am Chem Soc 2018 04 23;140(13):4712-4720. Epub 2018 Mar 23.

Institute of Developmental Genetics , Helmholtz Zentrum Munchen , Munchen , Germany.

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http://pubs.acs.org/doi/10.1021/jacs.8b01462
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http://dx.doi.org/10.1021/jacs.8b01462DOI Listing
April 2018

Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System.

Front Neurosci 2018 20;12:214. Epub 2018 Apr 20.

Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, United States.

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http://dx.doi.org/10.3389/fnins.2018.00214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920049PMC
April 2018

Selenium and iron, two elemental rivals in the ferroptotic death process.

Oncotarget 2018 Apr 27;9(32):22241-22242. Epub 2018 Apr 27.

Helmholtz Zentrum München, Institute of Developmental Genetics, Neuherberg, Germany.

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http://dx.doi.org/10.18632/oncotarget.25295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976460PMC
April 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Lipoxygenases-Killers against Their Will?

ACS Cent Sci 2018 Mar 16;4(3):312-314. Epub 2018 Mar 16.

Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1021/acscentsci.8b00077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879469PMC
March 2018

The ferroptosis inducer erastin irreversibly inhibits system x- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells.

Sci Rep 2018 01 17;8(1):968. Epub 2018 Jan 17.

Laboratory of Biochemistry and Molecular Biology, Department of Medical Technology, Faculty of Medicine, Niigata University, 746-2 Asahimachi-dori, Chuo-ku, Niigata, 951-8518, Japan.

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http://dx.doi.org/10.1038/s41598-018-19213-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772355PMC
January 2018

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

Authors:
Javier Egea Isabel Fabregat Yves M Frapart Pietro Ghezzi Agnes Görlach Thomas Kietzmann Kateryna Kubaichuk Ulla G Knaus Manuela G Lopez Gloria Olaso-Gonzalez Andreas Petry Rainer Schulz Jose Vina Paul Winyard Kahina Abbas Opeyemi S Ademowo Catarina B Afonso Ioanna Andreadou Haike Antelmann Fernando Antunes Mutay Aslan Markus M Bachschmid Rui M Barbosa Vsevolod Belousov Carsten Berndt David Bernlohr Esther Bertrán Alberto Bindoli Serge P Bottari Paula M Brito Guia Carrara Ana I Casas Afroditi Chatzi Niki Chondrogianni Marcus Conrad Marcus S Cooke João G Costa Antonio Cuadrado Pham My-Chan Dang Barbara De Smet Bilge Debelec-Butuner Irundika H K Dias Joe Dan Dunn Amanda J Edson Mariam El Assar Jamel El-Benna Péter Ferdinandy Ana S Fernandes Kari E Fladmark Ulrich Förstermann Rashid Giniatullin Zoltán Giricz Anikó Görbe Helen Griffiths Vaclav Hampl Alina Hanf Jan Herget Pablo Hernansanz-Agustín Melanie Hillion Jingjing Huang Serap Ilikay Pidder Jansen-Dürr Vincent Jaquet Jaap A Joles Balaraman Kalyanaraman Danylo Kaminskyy Mahsa Karbaschi Marina Kleanthous Lars-Oliver Klotz Bato Korac Kemal Sami Korkmaz Rafal Koziel Damir Kračun Karl-Heinz Krause Vladimír Křen Thomas Krieg João Laranjinha Antigone Lazou Huige Li Antonio Martínez-Ruiz Reiko Matsui Gethin J McBean Stuart P Meredith Joris Messens Verónica Miguel Yuliya Mikhed Irina Milisav Lidija Milković Antonio Miranda-Vizuete Miloš Mojović María Monsalve Pierre-Alexis Mouthuy John Mulvey Thomas Münzel Vladimir Muzykantov Isabel T N Nguyen Matthias Oelze Nuno G Oliveira Carlos M Palmeira Nikoletta Papaevgeniou Aleksandra Pavićević Brandán Pedre Fabienne Peyrot Marios Phylactides Gratiela G Pircalabioru Andrew R Pitt Henrik E Poulsen Ignacio Prieto Maria Pia Rigobello Natalia Robledinos-Antón Leocadio Rodríguez-Mañas Anabela P Rolo Francis Rousset Tatjana Ruskovska Nuno Saraiva Shlomo Sasson Katrin Schröder Khrystyna Semen Tamara Seredenina Anastasia Shakirzyanova Geoffrey L Smith Thierry Soldati Bebiana C Sousa Corinne M Spickett Ana Stancic Marie José Stasia Holger Steinbrenner Višnja Stepanić Sebastian Steven Kostas Tokatlidis Erkan Tuncay Belma Turan Fulvio Ursini Jan Vacek Olga Vajnerova Kateřina Valentová Frank Van Breusegem Lokman Varisli Elizabeth A Veal A Suha Yalçın Olha Yelisyeyeva Neven Žarković Martina Zatloukalová Jacek Zielonka Rhian M Touyz Andreas Papapetropoulos Tilman Grune Santiago Lamas Harald H H W Schmidt Fabio Di Lisa Andreas Daiber

Redox Biol 2017 10 18;13:94-162. Epub 2017 May 18.

Molecular Cardiology, Center for Cardiology, Cardiology 1, University Medical Center Mainz, Mainz, Germany; DZHK (German Centre for Cardiovascular Research), partner site Rhine-Main, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458069PMC
October 2017

Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency.

Neuroscience 2017 08 13;357:241-254. Epub 2017 Jun 13.

Research Unit NeuroBiology of Diabetes, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg 85764, Germany; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg 85764, Germany; German Center for Diabetes Research (DZD), Neuherberg 85764, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2017.05.050DOI Listing
August 2017

Iron and ferroptosis: A still ill-defined liaison.

IUBMB Life 2017 06 9;69(6):423-434. Epub 2017 Mar 9.

Helmholtz Zentrum München, Institute of Developmental Genetics, Neuherberg, Germany.

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http://dx.doi.org/10.1002/iub.1616DOI Listing
June 2017

Ferroptosis Inhibition: Mechanisms and Opportunities.

Trends Pharmacol Sci 2017 05 28;38(5):489-498. Epub 2017 Mar 28.

Helmholtz Zentrum München, Institute of Developmental Genetics, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2017.02.005DOI Listing
May 2017

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death.

ACS Cent Sci 2017 Mar 7;3(3):232-243. Epub 2017 Mar 7.

Department of Chemistry and Biomolecular Sciences, University of Ottawa , Ottawa, Ontario K1N 6N5, Canada.

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http://dx.doi.org/10.1021/acscentsci.7b00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364454PMC
March 2017

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration.

Redox Biol 2016 10 26;9:22-31. Epub 2016 May 26.

Helmholtz Zentrum München, Institute for Developmental Genetics, Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2016.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900515PMC
October 2016

Endothelial Dysfunction, and A Prothrombotic, Proinflammatory Phenotype Is Caused by Loss of Mitochondrial Thioredoxin Reductase in Endothelium.

Arterioscler Thromb Vasc Biol 2016 09 7;36(9):1891-9. Epub 2016 Jul 7.

From the Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-University, Munich, Germany (J.K., H.S., J.-I.P., M.R., M.S., J.H., O.C., K.M.S., J.Q., K.P., P.K., B.U., J.P., E.D., U.P., H.B.); Stress and Immunity Lab, Department of Anesthesiology, Ludwig-Maximilians-University Hospital of Munich, Munich, Germany (J.-I.P.); Munich Cluster for Systems Neurology (SyNergy), Munich, Germany (U.P.); Partner site Munich Heart Alliance, Munich, Germany (U.P.); Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany (S.M., T.K.); and Helmholtz Zentrum München, Institute of Developmental Genetics, Neuherberg, Munich, Germany (M.C.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307843DOI Listing
September 2016

Glutathione peroxidase 4 (Gpx4) and ferroptosis: what's so special about it?

Mol Cell Oncol 2015 Jul-Sep;2(3):e995047. Epub 2015 Jan 30.

Institute of Developmental Genetics; Helmholtz Zentrum München; , München, Germany.

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http://dx.doi.org/10.4161/23723556.2014.995047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905320PMC
June 2016

Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness.

Sci Rep 2016 06 27;6:28080. Epub 2016 Jun 27.

Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1038/srep28080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921861PMC
June 2016

Regulated necrosis: disease relevance and therapeutic opportunities.

Nat Rev Drug Discov 2016 05 18;15(5):348-66. Epub 2016 Jan 18.

Department of Biological Sciences and Department of Chemistry, Howard Hughes Medical Institute, Columbia University, 550 West 120th Street, Northwest Corner Building, MC 4846, New York, New York 10027, USA.

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http://dx.doi.org/10.1038/nrd.2015.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531857PMC
May 2016

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming.

Cell Stem Cell 2016 Mar 31;18(3):396-409. Epub 2015 Dec 31.

Physiological Genomics, Biomedical Center Ludwig-Maximilians-University Munich, 80336 Munich, Germany; Institute for Stem Cell Research, Helmholtz Center Munich, 85764 Neuherberg, Germany; Excellence Cluster of Systems Neurology (SYNERGY), 80336 Munich, Germany. Electronic address:

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http://www.cell.com/cell-stem-cell/pdf/S1934-5909(15)00548-2
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http://linkinghub.elsevier.com/retrieve/pii/S193459091500548
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http://dx.doi.org/10.1016/j.stem.2015.12.003DOI Listing
March 2016

A Glutathione-Nrf2-Thioredoxin Cross-Talk Ensures Keratinocyte Survival and Efficient Wound Repair.

PLoS Genet 2016 Jan 25;12(1):e1005800. Epub 2016 Jan 25.

Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland.

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http://dx.plos.org/10.1371/journal.pgen.1005800
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http://dx.doi.org/10.1371/journal.pgen.1005800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4726503PMC
January 2016

ROS, thiols and thiol-regulating systems in male gametogenesis.

Biochim Biophys Acta 2015 Aug 23;1850(8):1566-74. Epub 2014 Oct 23.

Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.bbagen.2014.10.020DOI Listing
August 2015

The antioxidant requirement for plasma membrane repair in skeletal muscle.

Free Radic Biol Med 2015 Jul 3;84:246-253. Epub 2015 Apr 3.

Department of Cellular Biology and Anatomy, Georgia Regents University, Augusta, GA 30912, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072523PMC
http://dx.doi.org/10.1016/j.freeradbiomed.2015.03.016DOI Listing
July 2015

Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility.

J Biol Chem 2015 Jun 28;290(23):14668-78. Epub 2015 Apr 28.

From the Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Developmental Genetics, Ingolstädter Landstrassse 1, 85764 Neuherberg, Germany,

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http://dx.doi.org/10.1074/jbc.M115.656363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505533PMC
June 2015

Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function.

J Biol Chem 2015 Apr 20;290(14):8778-88. Epub 2015 Feb 20.

From the Department of Food and Applied Life Sciences, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan, the Department of Functional Genomics and Biotechnology, United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan, the Laboratory of Biochemistry and Molecular Biology, Department of Medical Technology, Faculty of Medicine, Niigata University, Chuo-ku, Niigata 951-8518, Japan

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http://dx.doi.org/10.1074/jbc.M114.625053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423669PMC
April 2015

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

J Exp Med 2015 Apr 30;212(4):555-68. Epub 2015 Mar 30.

Molecular Biomedicine, Institute of Molecular Health Science, Department of Biology, ETH Zurich, 8093 Zurich, Switzerland

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http://jem.rupress.org/content/212/4/555.full.pdf
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http://www.jem.org/lookup/doi/10.1084/jem.20140857
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http://dx.doi.org/10.1084/jem.20140857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387287PMC
April 2015

Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons.

Biol Trace Elem Res 2014 May 6;158(2):203-10. Epub 2014 Mar 6.

Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

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http://dx.doi.org/10.1007/s12011-014-9920-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984410PMC
May 2014

Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice.

Circ Res 2013 Aug 14;113(4):408-17. Epub 2013 Jun 14.

Walter Brendel Centre of Experimental Medicine, Munich Heart Alliance, Munich Cluster for Systems Neurology, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1161/CIRCRESAHA.113.279984DOI Listing
August 2013

Selective activation of oxidized PTP1B by the thioredoxin system modulates PDGF-β receptor tyrosine kinase signaling.

Proc Natl Acad Sci U S A 2013 Aug 30;110(33):13398-403. Epub 2013 Jul 30.

Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institutet, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1073/pnas.1302891110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746926PMC
August 2013

Disruption of thioredoxin reductase 1 protects mice from acute acetaminophen-induced hepatotoxicity through enhanced NRF2 activity.

Chem Res Toxicol 2013 Jul 7;26(7):1088-96. Epub 2013 Jun 7.

Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/tx4001013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334300PMC
July 2013

Glutathione and thioredoxin dependent systems in neurodegenerative disease: what can be learned from reverse genetics in mice.

Neurochem Int 2013 Apr 18;62(5):738-49. Epub 2013 Jan 18.

Helmholtz Zentrum München, Institute of Developmental Genetics, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.neuint.2013.01.010DOI Listing
April 2013

The nuclear form of glutathione peroxidase 4 is associated with sperm nuclear matrix and is required for proper paternal chromatin decondensation at fertilization.

J Cell Physiol 2012 Apr;227(4):1420-7

DAHFMO, Section of Histology & Medical Embryology, University of Rome La Sapienza, Rome, Italy.

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http://dx.doi.org/10.1002/jcp.22857DOI Listing
April 2012

Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability.

J Androl 2011 Nov-Dec;32(6):641-50. Epub 2011 Mar 25.

CNRS 6247-INSERM U931-Clermont Université, 24 avenue des Landais, Aubière cedex, France.

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http://dx.doi.org/10.2164/jandrol.110.012823DOI Listing
February 2012

The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-) : cystine supplier and beyond.

Amino Acids 2012 Jan 16;42(1):231-46. Epub 2011 Mar 16.

DZNE, German Center for Neurodegenerative Diseases, Munich, 80336, Munich, Germany.

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http://dx.doi.org/10.1007/s00726-011-0867-5DOI Listing
January 2012

Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages.

Mol Immunol 2011 Oct 22;49(1-2):311-6. Epub 2011 Sep 22.

Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.molimm.2011.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205301PMC
October 2011

Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation.

Proteomics 2011 Aug;11(16):3299-311

Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Radiation Biology, Neuherberg, Germany.

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http://dx.doi.org/10.1002/pmic.201100178DOI Listing
August 2011

Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.

FASEB J 2011 Jul 14;25(7):2135-44. Epub 2011 Mar 14.

Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Clinical Molecular Biology and Tumor Genetics, Munich, Germany.

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http://www.fasebj.org/doi/10.1096/fj.10-177147
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July 2011

Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.

FASEB J 2011 Apr 29;25(4):1359-69. Epub 2010 Dec 29.

Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.

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http://www.fasebj.org/doi/10.1096/fj.10-177212
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April 2011

Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation.

Cancer Res 2010 Nov 2;70(22):9505-14. Epub 2010 Nov 2.

Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1509DOI Listing
November 2010

System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency.

J Biol Chem 2010 Jul 12;285(29):22244-53. Epub 2010 May 12.

Institute of Clinical Molecular Biology and Tumor Genetics, German Research Center for Environmental Health, 81377 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M110.121327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903358PMC
July 2010

Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin.

Exp Cell Res 2010 Jun 17;316(10):1662-80. Epub 2010 Mar 17.

Biozentrum, Department of Biology II, Ludwig-Maximilians-University, Grosshadernerstrasse 2, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/j.yexcr.2010.03.008DOI Listing
June 2010

Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studies.

Antioxid Redox Signal 2010 Apr;12(7):851-65

Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Marchioninistrasse 25, Munich, Germany.

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http://dx.doi.org/10.1089/ars.2009.2912DOI Listing
April 2010

Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4.

Authors:
Marcus Conrad

Biochim Biophys Acta 2009 Nov 9;1790(11):1575-85. Epub 2009 May 9.

Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Marchioninistr. 25, 81377 Munich, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S030441650900120
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November 2009

Mitochondrial glutathione peroxidase 4 disruption causes male infertility.

FASEB J 2009 Sep 5;23(9):3233-42. Epub 2009 May 5.

Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

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http://dx.doi.org/10.1096/fj.09-132795DOI Listing
September 2009

EpCAM is involved in maintenance of the murine embryonic stem cell phenotype.

Stem Cells 2009 Aug;27(8):1782-91

Clinical Cooperation Group Molecular Oncology, Helmholtz-Zentrum München, German Research Center for Environmental Health, and Head and Neck Research Department, Ludwig-Maximilians-University of Munich, Munich, Germany.

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http://dx.doi.org/10.1002/stem.97DOI Listing
August 2009

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.

Cell Metab 2008 Sep;8(3):237-48

Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Marchioninistrasse 25, 81377 Munich, Germany.

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http://dx.doi.org/10.1016/j.cmet.2008.07.005DOI Listing
September 2008

The role of thioredoxin reductases in brain development.

PLoS One 2008 Mar 19;3(3):e1813. Epub 2008 Mar 19.

Department of Comparative Medicine, Helmholtz Zentrum München German Research Center for Environmental Health, Neuherberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001813PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2263137PMC
March 2008

Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals.

Biol Chem 2007 Oct;388(10):1019-25

Institute of Clinical Molecular Biology and Tumour Genetics, GSF-National Research Center for Environment and Health, Marchioninistr. 25, D-81377 Munich, Germany.

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October 2007

B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance.

Biol Chem 2007 Oct;388(10):1083-90

Department of Comparative Medicine, GSF Research Centre for Environment and Health, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany.

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http://dx.doi.org/10.1515/BC.2007.131DOI Listing
October 2007

Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate.

Genesis 2007 Jan;45(1):11-6

Department of Comparative Medicine, GSF Research Center for Environment and Health, Neuherberg, Germany.

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http://doi.wiley.com/10.1002/dvg.20244
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January 2007

Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase.

Gene Expr Patterns 2006 Jun 2;6(5):489-94. Epub 2006 Feb 2.

Department of Comparative Medicine, GSF Research Centre for Environment and Health, Ingolstaedter Landstr. 1, D-85764 Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.modgep.2005.11.002DOI Listing
June 2006

Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferation.

Mol Cell Biol 2005 Sep;25(17):7665-74

GSF-Research Centre for Environment and Health, Institute for Clinical Molecular Biology and Tumour Genetics, Munich, Germany.

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http://dx.doi.org/10.1128/MCB.25.17.7665-7674.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1190292PMC
September 2005

Optimized vector for conditional gene targeting in mouse embryonic stem cells.

Biotechniques 2003 Jun;34(6):1136-8, 1140

Institute of Clinical Molecular Biology and Tumour Genetics, GSF Research Centre for Environment and Health, Marchioninistr. 25, D-81377, Munich, Germany.

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http://dx.doi.org/10.2144/03346bm03DOI Listing
June 2003

Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx).

Biol Chem 2003 Apr;384(4):635-43

Institute of Clinical Molecular Biology and Tumor Genetics, GSF Research Centre for Environment and Health, Marchioninistr. 25, D-81377 Munich, Germany.

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http://dx.doi.org/10.1515/BC.2003.070DOI Listing
April 2003