Marco T Núñez

Marco T Núñez

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Marco T Núñez

Marco T Núñez

Publications by authors named "Marco T Núñez"

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New perspectives in iron chelation therapy for the treatment of Parkinson's disease.

Neural Regen Res 2019 Nov;14(11):1905-1906

Movement Disorders Center, Universidad de Santiago de Chile, Santiago, Chile.

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http://dx.doi.org/10.4103/1673-5374.259614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676885PMC
November 2019

Mathematical modeling of the relocation of the divalent metal transporter DMT1 in the intestinal iron absorption process.

PLoS One 2019 10;14(6):e0218123. Epub 2019 Jun 10.

Laboratory of Process Modeling and Distributed Computing, Department of Chemical Engineering, Biotechnology and Materials, University of Chile, Santiago, Chile.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0218123PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557526PMC
June 2019

New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases.

Pharmaceuticals (Basel) 2018 Oct 19;11(4). Epub 2018 Oct 19.

Center for the Treatment of Movement Disorders, Universidad de Santiago de Chile, Belisario Prat 1597, Santiago 83800000, Chile.

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http://www.mdpi.com/1424-8247/11/4/109
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http://dx.doi.org/10.3390/ph11040109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316457PMC
October 2018

Reactive oxygen species released from astrocytes treated with amyloid beta oligomers elicit neuronal calcium signals that decrease phospho-Ser727-STAT3 nuclear content.

Free Radic Biol Med 2018 03 5;117:132-144. Epub 2018 Jan 5.

Department of Biology, Faculty of Sciences,Universidad de Chile, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.01.006DOI Listing
March 2018

Oligodendrocytes: Functioning in a Delicate Balance Between High Metabolic Requirements and Oxidative Damage.

Adv Exp Med Biol 2016 ;949:167-181

Department of Biology, Faculty of Science, University of Chile, Santiago, Chile.

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http://dx.doi.org/10.1007/978-3-319-40764-7_8DOI Listing
September 2017

Cell death induced by mitochondrial complex I inhibition is mediated by Iron Regulatory Protein 1.

Biochim Biophys Acta Mol Basis Dis 2017 09 11;1863(9):2202-2209. Epub 2017 May 11.

Biology Department, Faculty of Sciences, Universidad de Chile, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.05.015DOI Listing
September 2017

Mathematical Modeling of Intestinal Iron Absorption Using Genetic Programming.

PLoS One 2017 10;12(1):e0169601. Epub 2017 Jan 10.

Laboratory of Process Modeling and Distributed Computing, Department of Chemical Engineering and Biotechnology, University of Chile, Santiago, Chile.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169601PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225013PMC
August 2017

Hepcidin attenuates amyloid beta-induced inflammatory and pro-oxidant responses in astrocytes and microglia.

J Neurochem 2017 07 4;142(1):140-152. Epub 2017 Apr 4.

Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile.

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http://dx.doi.org/10.1111/jnc.14005DOI Listing
July 2017

Neuroprotective Effect of a New 7,8-Dihydroxycoumarin-Based Fe/Cu Chelator in Cell and Animal Models of Parkinson's Disease.

ACS Chem Neurosci 2017 01 16;8(1):178-185. Epub 2016 Nov 16.

Biology Department, Faculty of Sciences, Universidad de Chile , Santiago 7800024, Chile.

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http://dx.doi.org/10.1021/acschemneuro.6b00309DOI Listing
January 2017

Parkinson's Disease: The Mitochondria-Iron Link.

Parkinsons Dis 2016 17;2016:7049108. Epub 2016 May 17.

Iron and Biology of Aging Laboratory, Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1155/2016/7049108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886095PMC
June 2016

Iron-induced reactive oxygen species mediate transporter DMT1 endocytosis and iron uptake in intestinal epithelial cells.

Am J Physiol Cell Physiol 2015 Oct 19;309(8):C558-67. Epub 2015 Aug 19.

Iron and Biology of Aging Laboratory, Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile;

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http://dx.doi.org/10.1152/ajpcell.00412.2014DOI Listing
October 2015

The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against mitochondrial-induced oxidative damage and neuronal death.

Biochem Biophys Res Commun 2015 Aug 5;463(4):787-92. Epub 2015 Jun 5.

Iron and Biology of Aging Laboratory, Department of Biology, Faculty of Sciences, University of Chile, Chile.

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http://dx.doi.org/10.1016/j.bbrc.2015.06.014DOI Listing
August 2015

Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders.

Mitochondrion 2015 Mar 8;21:92-105. Epub 2015 Feb 8.

Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile; Research Ring on Oxidative Stress in the Nervous System, Universidad de Chile, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.mito.2015.02.001DOI Listing
March 2015

The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders.

Front Pharmacol 2014 10;5:38. Epub 2014 Mar 10.

Department of Biology and Research Ring on Oxidative Stress in the Nervous System, Faculty of Sciences, University of Chile Santiago, Chile.

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http://dx.doi.org/10.3389/fphar.2014.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948003PMC
June 2014

Synthesis of coumarin derivatives as fluorescent probes for membrane and cell dynamics studies.

Eur J Med Chem 2014 Apr 11;76:79-86. Epub 2014 Feb 11.

Department of Chemistry, Faculty of Sciences, University of Chile, Santiago, Chile.

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http://dx.doi.org/10.1016/j.ejmech.2014.02.016DOI Listing
April 2014

Ryanodine receptor-mediated Ca(2+) release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca(2+) uptake in primary hippocampal neurons.

Front Mol Neurosci 2014 11;7:13. Epub 2014 Mar 11.

Center for Molecular Studies of the Cell, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile Santiago, Chile ; Biomedical Neuroscience Institute, Faculty of Medicine, Universidad de Chile Santiago, Chile ; Physiology and Biophysics Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile Santiago, Chile.

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http://dx.doi.org/10.3389/fnmol.2014.00013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949220PMC
March 2014

Design, synthesis and cellular dynamics studies in membranes of a new coumarin-based "turn-off" fluorescent probe selective for Fe2+.

Eur J Med Chem 2013 Sep 19;67:60-3. Epub 2013 Jun 19.

Department of Chemistry, Faculty of Sciences, University of Chile, Santiago, Chile; Departamento de Ciencias Químicas, Facultad de ciencias Exactas, Universidad Andrés Bello, Avenida República 275, Piso 3, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2013.06.022DOI Listing
September 2013

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells.

J Neurochem 2013 Aug 3;126(4):541-9. Epub 2013 Apr 3.

Department of Biology, Faculty of Sciences, Universidad de Chile and Research Ring on Oxidative Stress in the Nervous System, Santiago, Chile.

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http://dx.doi.org/10.1111/jnc.12244DOI Listing
August 2013

Endocytic pathway of exogenous iron-loaded ferritin in intestinal epithelial (Caco-2) cells.

Am J Physiol Gastrointest Liver Physiol 2013 Apr 31;304(7):G655-61. Epub 2013 Jan 31.

Facultad de Ciencias, Departamento de Biología, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1152/ajpgi.00472.2012DOI Listing
April 2013

The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1.

Biometals 2012 Aug;25(4):795-803

Department of Biology, Faculty of Sciences, Universidad de Chile and Cell Dynamics and Biotechnology Institute, Santiago, Chile.

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http://dx.doi.org/10.1007/s10534-012-9525-yDOI Listing
August 2012

Iron toxicity in neurodegeneration.

Biometals 2012 Aug 9;25(4):761-76. Epub 2012 Feb 9.

Department of Biology, Faculty of Sciences, Universidad de Chile and Cell Dynamics and Biotechnology Institute, Santiago, Chile.

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http://dx.doi.org/10.1007/s10534-012-9523-0DOI Listing
August 2012

Effect of mitochondrial complex I inhibition on Fe-S cluster protein activity.

Biochem Biophys Res Commun 2011 Jun 6;409(2):241-6. Epub 2011 May 6.

Department of Biology, Faculty of Sciences, Universidad de Chile, Las Palmeras 3425, Santiago, Chile.

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http://dx.doi.org/10.1016/j.bbrc.2011.04.137DOI Listing
June 2011

Iron mediates neuritic tree collapse in mesencephalic neurons treated with 1-methyl-4-phenylpyridinium (MPP+).

J Neural Transm (Vienna) 2011 Mar 2;118(3):421-31. Epub 2010 Oct 2.

Department of Biology, Faculty of Sciences, Cell Dynamics and Biotechnology Institute, Universidad de Chile, Santiago, Chile.

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http://link.springer.com/10.1007/s00702-010-0489-1
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http://dx.doi.org/10.1007/s00702-010-0489-1DOI Listing
March 2011

Mathematical modeling of the dynamic storage of iron in ferritin.

BMC Syst Biol 2010 Nov 3;4:147. Epub 2010 Nov 3.

Laboratory of Process Modeling and Distributed Computing, Department of Chemical Engineering and Biotechnology, University of Chile, Santiago, Chile.

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http://dx.doi.org/10.1186/1752-0509-4-147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992510PMC
November 2010

Regulatory mechanisms of intestinal iron absorption-uncovering of a fast-response mechanism based on DMT1 and ferroportin endocytosis.

Authors:
Marco T Núñez

Biofactors 2010 Mar-Apr;36(2):88-97

Department of Biology, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1002/biof.84DOI Listing
June 2010

Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1.

Am J Physiol Cell Physiol 2010 Mar 9;298(3):C477-85. Epub 2009 Dec 9.

Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Santiago, Chile.

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http://dx.doi.org/10.1152/ajpcell.00168.2009DOI Listing
March 2010

Iron induces protection and necrosis in cultured cardiomyocytes: Role of reactive oxygen species and nitric oxide.

Free Radic Biol Med 2010 Feb 4;48(4):526-34. Epub 2009 Dec 4.

Centro FONDAP de Estudios Moleculares de la Célula, Universidad de Chile, Santiago 838-0492, Chile .

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http://dx.doi.org/10.1016/j.freeradbiomed.2009.11.017DOI Listing
February 2010

Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene.

J Neurochem 2009 May 30;109(4):1067-78. Epub 2009 Mar 30.

Department of Pathology and Laboratory Medicine, Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06028.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696070PMC
May 2009

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease.

Proc Natl Acad Sci U S A 2008 Nov 14;105(47):18578-83. Epub 2008 Nov 14.

Institut National de la Santé et de la Recherche Médicale, Neurologie et Thérapeutique Expérimentale, Unité Mixte de Recherche S679, 47 Boulevard de l'Hôpital, 75013 Paris, France.

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http://dx.doi.org/10.1073/pnas.0804373105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2587621PMC
November 2008

Caco-2 intestinal epithelial cells absorb soybean ferritin by mu2 (AP2)-dependent endocytosis.

J Nutr 2008 Apr;138(4):659-66

Department of Biology, Faculty of Sciences, and Cell Dynamics and Biotechnology Institute, Universidad de Chile, Santiago, Chile.

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http://www.chori.org/Principal_Investigators/Theil_Elizabeth
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065195PMC
http://dx.doi.org/10.1093/jn/138.4.659DOI Listing
April 2008

Hepcidin inhibits apical iron uptake in intestinal cells.

Am J Physiol Gastrointest Liver Physiol 2008 Jan 25;294(1):G192-8. Epub 2007 Oct 25.

Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Santiago, Chile.

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http://dx.doi.org/10.1152/ajpgi.00122.2007DOI Listing
January 2008

Calcium, iron and neuronal function.

IUBMB Life 2007 Apr-May;59(4-5):280-5

Centro FONDAP de Estudios Moleculares de la Célula and Programa de Biologia Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1080/15216540701222906DOI Listing
December 2007

Upregulation of gamma-glutamate-cysteine ligase as part of the long-term adaptation process to iron accumulation in neuronal SH-SY5Y cells.

Am J Physiol Cell Physiol 2007 Jun 7;292(6):C2197-203. Epub 2007 Mar 7.

Department of Biology, University of Chile, Santiago, Chile.

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http://dx.doi.org/10.1152/ajpcell.00620.2006DOI Listing
June 2007

Inhibition of iron and copper uptake by iron, copper and zinc.

Biol Res 2006 ;39(1):95-102

Micronutrients Laboratory, Institute of Nutrition and Food Technology (INTA), Universidad de Chile.

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http://dx.doi.org/10.4067/s0716-97602006000100011DOI Listing
February 2007

Hereditary hemochromatosis: an opportunity for gene therapy.

Biol Res 2006 ;39(1):113-24

Millennium Institute for Advanced Studies in Cell Biology and Biotechnology, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.4067/s0716-97602006000100014DOI Listing
February 2007

Iron and glutathione at the crossroad of redox metabolism in neurons.

Biol Res 2006 ;39(1):157-65

Department of Biology, Faculty of Sciences and Cell Dynamic and Biotechnology Research Center, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.4067/s0716-97602006000100017DOI Listing
February 2007

Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells.

Biol Res 2006 ;39(1):189-90

PhD Program in Cell, Molecular and Neural Biology, Faculty of Sciences, Universidad de Chile.

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http://dx.doi.org/10.4067/s0716-97602006000100021DOI Listing
February 2007

Regulation of transepithelial transport of iron by hepcidin.

Biol Res 2006 ;39(1):191-3

Biology Department and Cell Dynamics and Biotechnology Research Center, Faculty of Sciences, Universidad de Chile, Santiago.

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http://dx.doi.org/10.4067/s0716-97602006000100022DOI Listing
February 2007

A role for reactive oxygen/nitrogen species and iron on neuronal synaptic plasticity.

Antioxid Redox Signal 2007 Feb;9(2):245-55

Centro FONDAP de Estudios Moleculares de la Célula, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1089/ars.2007.9.245DOI Listing
February 2007

Apical distribution of HFE-beta2-microglobulin is associated with inhibition of apical iron uptake in intestinal epithelia cells.

Biometals 2006 Aug;19(4):379-88

Micronutrients Laboratory, Institute of Nutrition and Food Technology, INTA, Universidad de Chile, Macul 5540, Macul, Santiago, Chile.

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http://dx.doi.org/10.1007/s10534-005-6687-xDOI Listing
August 2006

Quiescence induced by iron challenge protects neuroblastoma cells from oxidative stress.

J Neurochem 2006 Jul;98(1):11-9

Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile.

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http://dx.doi.org/10.1111/j.1471-4159.2006.03798.xDOI Listing
July 2006

Iron and copper metabolism.

Mol Aspects Med 2005 Aug-Oct;26(4-5):313-27

Nutrition and Food Technology Institute, University of Chile, Casilla 13811, Santiago, Chile.

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http://dx.doi.org/10.1016/j.mam.2005.07.010DOI Listing
November 2005

Iron homeostasis in neuronal cells: a role for IREG1.

BMC Neurosci 2005 Jan 24;6. Epub 2005 Jan 24.

Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile.

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http://dx.doi.org/10.1186/1471-2202-6-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC548319PMC
January 2005

Progressive iron accumulation induces a biphasic change in the glutathione content of neuroblastoma cells.

Free Radic Biol Med 2004 Oct;37(7):953-60

Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile.

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http://dx.doi.org/10.1016/j.freeradbiomed.2004.06.005DOI Listing
October 2004

Oxidative stress promotes tau dephosphorylation in neuronal cells: the roles of cdk5 and PP1.

Free Radic Biol Med 2004 Jun;36(11):1393-402

Laboratory of Cellular and Molecular Biology, Millennium Institute for Advanced Studies in Cell Biology and Biotechnology, and Department of Biology, Faculty of Sciences, University of Chile, Santiago, Chile.

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http://dx.doi.org/10.1016/j.freeradbiomed.2004.03.007DOI Listing
June 2004

Ethanol increases tumor necrosis factor-alpha receptor-1 (TNF-R1) levels in hepatic, intestinal, and cardiac cells.

Alcohol 2004 May;33(1):9-15

Millennium Institute for Advanced Studies in Cell Biology and Biotechnology, University of Chile, Santiago 6531057, Chile.

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http://dx.doi.org/10.1016/j.alcohol.2004.03.001DOI Listing
May 2004

The mechanisms for regulating absorption of Fe bis-glycine chelate and Fe-ascorbate in caco-2 cells are similar.

J Nutr 2004 Feb;134(2):395-8

Micronutrients Laboratory, Institute of Nutrition and Food Technology (INTA), Santiago, Chile.

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http://dx.doi.org/10.1093/jn/134.2.395DOI Listing
February 2004

DMT1, a physiologically relevant apical Cu1+ transporter of intestinal cells.

Am J Physiol Cell Physiol 2003 Jun;284(6):C1525-30

Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago, Chile.

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http://www.physiology.org/doi/10.1152/ajpcell.00480.2002
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http://dx.doi.org/10.1152/ajpcell.00480.2002DOI Listing
June 2003

Parallels and contrasts between iron and copper metabolism.

Biometals 2003 Mar;16(1):1-8

Department of Biochemistry, SUNY at Buffalo, NY 14214, USA.

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March 2003

An oxidative stress-mediated positive-feedback iron uptake loop in neuronal cells.

J Neurochem 2002 Jul;82(2):240-8

Department of Biology, Faculty of Sciences, University of Chile, Santiago.

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http://dx.doi.org/10.1046/j.1471-4159.2002.00971.xDOI Listing
July 2002