Publications by authors named "Marco Rusnati"

82Publications

Discovery of novel VX-809 hybrid derivatives as F508del-CFTR correctors by molecular modeling, chemical synthesis and biological assays.

Eur J Med Chem 2020 Dec 12;208:112833. Epub 2020 Sep 12.

Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Viale Benedetto XV 1, 16132, Genoa, Italy; Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV 9, 16132, Genoa, Italy. Electronic address:

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December 2020

The FGF/FGFR System in the Physiopathology of the Prostate Gland.

Physiol Rev 2020 Jul 30. Epub 2020 Jul 30.

Department of Molecular and Translational Medicine, University of Brescia, Italy.

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July 2020

Recent Strategic Advances in CFTR Drug Discovery: An Overview.

Int J Mol Sci 2020 Mar 31;21(7). Epub 2020 Mar 31.

Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genoa, 16132 Genoa, Italy.

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March 2020

Heparin and heparan sulfate proteoglycans promote HIV-1 p17 matrix protein oligomerization: computational, biochemical and biological implications.

Sci Rep 2019 10 31;9(1):15768. Epub 2019 Oct 31.

Section of Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, School of Medicine, University of Brescia, Brescia, Italy.

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October 2019

Sialic acid as a target for the development of novel antiangiogenic strategies.

Future Med Chem 2018 12 12;10(24):2835-2854. Epub 2018 Dec 12.

Section of Experimental Oncology & Immunology, Department of Molecular & Translational Medicine (DMTM), University of Brescia, Brescia 25123, Italy.

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December 2018

Identification of amino acid residues critical for the B cell growth-promoting activity of HIV-1 matrix protein p17 variants.

Biochim Biophys Acta Gen Subj 2019 01 21;1863(1):13-24. Epub 2018 Sep 21.

Department of Molecular and Translational Medicine, University of Brescia Medical School, Brescia, Italy. Electronic address:

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January 2019

Inhibition of Non Canonical HIV-1 Tat Secretion Through the Cellular Na,K-ATPase Blocks HIV-1 Infection.

EBioMedicine 2017 Jul 13;21:170-181. Epub 2017 Jun 13.

Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34149 Trieste, Italy. Electronic address:

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July 2017

Fibroblast growth factors (FGFs) in cancer: FGF traps as a new therapeutic approach.

Pharmacol Ther 2017 Nov 28;179:171-187. Epub 2017 May 28.

Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. Electronic address:

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November 2017

Surface Plasmon Resonance Analysis of Heparin-Binding Angiogenic Growth Factors.

Methods Mol Biol 2016 ;1464:73-84

Macromolecular Interaction Analysis Unit, Section of Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

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January 2018

Blocking the FGF/FGFR system as a "two-compartment" antiangiogenic/antitumor approach in cancer therapy.

Pharmacol Res 2016 05 22;107:172-185. Epub 2016 Mar 22.

Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. Electronic address:

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May 2016

Merging colloidal nanoplasmonics and surface plasmon resonance spectroscopy for enhanced profiling of multiple myeloma-derived exosomes.

Biosens Bioelectron 2016 Mar 3;77:518-24. Epub 2015 Oct 3.

Department of Molecular and Translational Medicine and INSTM, University of Brescia, Viale Europa, 11, 25132 Brescia, Italy. Electronic address:

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March 2016

The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis.

Expert Opin Ther Targets 2015 30;19(10):1361-77. Epub 2015 Jun 30.

a University of Brescia, Department of Molecular and Translational Medicine , Brescia, Italy +39 030 371 7311 ;

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May 2016

Heparin/Heparan sulfate proteoglycans glycomic interactome in angiogenesis: biological implications and therapeutical use.

Molecules 2015 Apr 10;20(4):6342-88. Epub 2015 Apr 10.

Section of Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Brescia 25123, Italy.

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April 2015

Angiogenic growth factors interactome and drug discovery: The contribution of surface plasmon resonance.

Cytokine Growth Factor Rev 2015 Jun 20;26(3):293-310. Epub 2014 Nov 20.

Section of Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, University of Brescia, Italy. Electronic address:

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June 2015

A CXCR1 haplotype hampers HIV-1 matrix protein p17 biological activity.

AIDS 2014 Oct;28(16):2355-64

aSection of Microbiology, Department of Molecular and Translational Medicine, School of Medicine, University of Brescia, Brescia bPediatrics Clinic and Institute for Molecular Medicine 'A. Nocivelli', Department of Clinical and Experimental Sciences, University of Brescia, Brescia cCancer Bio-Immunotherapy Unit, CRO-IRCCS, National Cancer Institute, Aviano (PN) dSection of Experimental Oncology and Immunology, Department of Molecular and Translational Medicine, School of Medicine, University of Brescia, Brescia, Italy.

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October 2014

Bridging the past and the future of virology: surface plasmon resonance as a powerful tool to investigate virus/host interactions.

Crit Rev Microbiol 2015 Jun 23;41(2):238-60. Epub 2013 Sep 23.

Department of Molecular and Translational Medicine, University of Brescia , Brescia , Italy.

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June 2015

Multispot, label-free biodetection at a phantom plastic-water interface.

Proc Natl Acad Sci U S A 2013 Jun 21;110(23):9350-5. Epub 2013 May 21.

Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, 20090 Segrate, Italy.

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June 2013

HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2.

Proc Natl Acad Sci U S A 2012 Sep 17;109(36):14580-5. Epub 2012 Aug 17.

Section of Microbiology, Department of Experimental and Applied Medicine, Medical School, University of Brescia, 25123 Brescia, Italy.

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September 2012

Inhibition of human respiratory syncytial virus infectivity by a dendrimeric heparan sulfate-binding peptide.

Antimicrob Agents Chemother 2012 Oct 30;56(10):5278-88. Epub 2012 Jul 30.

Department of Clinical and Biological Sciences, University of Turin, S. Luigi Gonzaga Medical School, Turin, Italy.

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October 2012

Sialic acid associated with αvβ3 integrin mediates HIV-1 Tat protein interaction and endothelial cell proangiogenic activation.

J Biol Chem 2012 Jun 23;287(24):20456-66. Epub 2012 Apr 23.

Unit of General Pathology and Immunology, School of Medicine, University of Brescia, 25123 Brescia, Italy.

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June 2012

Substrate-immobilized HIV-1 Tat drives VEGFR2/α(v)β(3)-integrin complex formation and polarization in endothelial cells.

Arterioscler Thromb Vasc Biol 2012 May 23;32(5):e25-34. Epub 2012 Feb 23.

Section of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy.

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May 2012

HIV-1 matrix protein p17 binds to the IL-8 receptor CXCR1 and shows IL-8-like chemokine activity on monocytes through Rho/ROCK activation.

Blood 2012 Mar 18;119(10):2274-83. Epub 2012 Jan 18.

Section of Microbiology, Department of Experimental and Applied Medicine, School of Medicine, University of Brescia, Italy.

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March 2012

Heparan sulfate proteoglycans mediate the angiogenic activity of the vascular endothelial growth factor receptor-2 agonist gremlin.

Arterioscler Thromb Vasc Biol 2011 Dec 15;31(12):e116-27. Epub 2011 Sep 15.

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Brescia, Italy.

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December 2011

Chemoselective surface immobilization of proteins through a cleavable peptide.

Bioconjug Chem 2011 Sep 11;22(9):1753-7. Epub 2011 Aug 11.

Department of Chemical Process Engineering, University of Padova, Via Marzolo 9, Padua, Italy.

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September 2011

Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors.

Oncotarget 2010 Nov;1(7):662-73

Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy.

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November 2010

Identification of a dendrimeric heparan sulfate-binding peptide that inhibits infectivity of genital types of human papillomaviruses.

Antimicrob Agents Chemother 2010 Oct 19;54(10):4290-9. Epub 2010 Jul 19.

Department of Clinical and Biological Sciences, University of Turin, S Luigi Gonzaga Hospital, Regione Gonzole 10, 10043 Orbassano, Turin, Italy.

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October 2010

Thrombospondin-1 as a Paradigm for the Development of Antiangiogenic Agents Endowed with Multiple Mechanisms of Action.

Pharmaceuticals (Basel) 2010 Apr 23;3(4):1241-1278. Epub 2010 Apr 23.

Tumor Angiogenesis Unit, Department of Oncology, Mario Negri Institute for Pharmacological Research, Bergamo, Italy.

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April 2010

Polysulfated/sulfonated compounds for the development of drugs at the crossroad of viral infection and oncogenesis.

Curr Pharm Des 2009 ;15(25):2946-57

Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy.

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November 2009

HIV-1 Tat and heparan sulfate proteoglycan interaction: a novel mechanism of lymphocyte adhesion and migration across the endothelium.

Blood 2009 Oct 6;114(15):3335-42. Epub 2009 Aug 6.

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, Medical School, University of Brescia, Brescia, Italy.

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October 2009

Sulfated K5 Escherichia coli polysaccharide derivatives: A novel class of candidate antiviral microbicides.

Pharmacol Ther 2009 Sep 14;123(3):310-22. Epub 2009 May 14.

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, 25123 Brescia, Italy.

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September 2009

Exploiting Surface Plasmon Resonance (SPR) Technology for the Identification of Fibroblast Growth Factor-2 (FGF2) Antagonists Endowed with Antiangiogenic Activity.

Sensors (Basel) 2009 20;9(8):6471-503. Epub 2009 Aug 20.

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Brescia, 25123, Italy; E-Mails: (M.R.); (A.B.); (S.M.); (D.L.);

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September 2012

Polyanionic drugs and viral oncogenesis: a novel approach to control infection, tumor-associated inflammation and angiogenesis.

Molecules 2008 Nov 6;13(11):2758-85. Epub 2008 Nov 6.

Department of Biomedical Sciences and Biotechnology, Unit of General Pathology and Immunology, School of Medicine, University of Brescia, Italy.

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November 2008

Sulfated K5 Escherichia coli polysaccharide derivatives as wide-range inhibitors of genital types of human papillomavirus.

Antimicrob Agents Chemother 2008 Apr 4;52(4):1374-81. Epub 2008 Feb 4.

Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Regione Gonzole 10, 10043 Orbassano, Turin, Italy.

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April 2008

Role of the soluble pattern recognition receptor PTX3 in vascular biology.

J Cell Mol Med 2007 Jul-Aug;11(4):723-38

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, viale Europa 11, 25123 Brescia, Italy.

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November 2007

Dendritic cell-endothelial cell cross-talk in angiogenesis.

Trends Immunol 2007 Sep 10;28(9):385-92. Epub 2007 Aug 10.

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.

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September 2007

The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and its role in haematological malignancies.

Cytokine Growth Factor Rev 2007 Jun-Aug;18(3-4):327-34. Epub 2007 May 29.

Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy.

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August 2007

Heparin-mimicking sulfonic acid polymers as multitarget inhibitors of human immunodeficiency virus type 1 Tat and gp120 proteins.

Antimicrob Agents Chemother 2007 Jul 23;51(7):2337-45. Epub 2007 Apr 23.

General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Brescia, Italy.

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July 2007

Identification of an antiangiogenic FGF2-binding site in the N terminus of the soluble pattern recognition receptor PTX3.

J Biol Chem 2006 Aug 12;281(32):22605-13. Epub 2006 Jun 12.

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, 25123 Brescia, Italy.

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August 2006

Extracellular angiogenic growth factor interactions: an angiogenesis interactome survey.

Endothelium 2006 Mar-Apr;13(2):93-111

Department of Biomedical Sciences and Biotechnology, Unit of General Pathology and Immunology, School of Medicine, University of Brescia, Italy.

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August 2006

Positively charged peptides can interact with each other, as revealed by solid phase binding assays.

Anal Biochem 2006 May 20;352(2):157-68. Epub 2006 Mar 20.

Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Safra Campus, Givat Ram, Jerusalem 91904, Israel.

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May 2006

Integrin alphavbeta3 as a target for blocking HIV-1 Tat-induced endothelial cell activation in vitro and angiogenesis in vivo.

Arterioscler Thromb Vasc Biol 2005 Nov 15;25(11):2315-20. Epub 2005 Sep 15.

Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy.

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November 2005

Cutting edge: proangiogenic properties of alternatively activated dendritic cells.

J Immunol 2005 Sep;175(5):2788-92

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy.

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September 2005

alpha(v)beta3-integrin-dependent activation of focal adhesion kinase mediates NF-kappaB activation and motogenic activity by HIV-1 Tat in endothelial cells.

J Cell Sci 2005 Sep 16;118(Pt 17):3949-58. Epub 2005 Aug 16.

General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, viale Europe 11, 25123 Brescia, Italy.

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September 2005

Biotechnological engineering of heparin/heparan sulphate: a novel area of multi-target drug discovery.

Curr Pharm Des 2005 ;11(19):2489-99

Unit of General Pathology & Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, 25123 Brescia, Italy.

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April 2006

Pentraxin 3 inhibits fibroblast growth factor 2-dependent activation of smooth muscle cells in vitro and neointima formation in vivo.

Arterioscler Thromb Vasc Biol 2005 Sep 14;25(9):1837-42. Epub 2005 Jul 14.

Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, 25123 Brescia, Italy.

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September 2005

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis.

Cytokine Growth Factor Rev 2005 Apr 2;16(2):159-78. Epub 2005 Feb 2.

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.

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April 2005

Chemically sulfated Escherichia coli K5 polysaccharide derivatives as extracellular HIV-1 Tat protein antagonists.

FEBS Lett 2004 Jun;568(1-3):171-7

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, viale Europa 11, 25123 Brescia, Italy.

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June 2004

Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.

Blood 2004 Jul 18;104(1):92-9. Epub 2004 Mar 18.

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy.

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July 2004

Inhibition of intra- and extra-cellular Tat function and HIV expression by pertussis toxin B-oligomer.

Eur J Immunol 2004 Feb;34(2):530-6

AIDS Immunopathogenesis Unit, Department of Immunology and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy.

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February 2004

Thrombospondin 1 as a scavenger for matrix-associated fibroblast growth factor 2.

Blood 2003 Dec 28;102(13):4399-406. Epub 2003 Aug 28.

Mario Negri Institute for Pharmacological Research, Via Gavazzeni 11, 24125 Bergamo, Italy.

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December 2003

HIV-1 Tat protein and endothelium: from protein/cell interaction to AIDS-associated pathologies.

Angiogenesis 2002 ;5(3):141-51

Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy.

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August 2003

Biological activity of substrate-bound basic fibroblast growth factor (FGF2): recruitment of FGF receptor-1 in endothelial cell adhesion contacts.

Oncogene 2002 May;21(24):3889-97

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Via Valsabbina 19, 25123 Brescia, Italy.

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May 2002

Cell membrane GM1 ganglioside is a functional coreceptor for fibroblast growth factor 2.

Proc Natl Acad Sci U S A 2002 Apr 26;99(7):4367-72. Epub 2002 Mar 26.

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, 25123 Brescia, Italy.

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April 2002

Fibroblast growth factors and their receptors in hematopoiesis and hematological tumors.

J Hematother Stem Cell Res 2002 Feb;11(1):19-32

Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Via Valsabbina 19, 25123 Brescia, Italy.

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February 2002