Publications by authors named "Marco Radici"

9 Publications

  • Page 1 of 1

Prevention of withdrawal symptoms in alcoholic patients with head and neck cancer.

Minerva Chir 2020 Dec 6;75(6):430-435. Epub 2020 Aug 6.

Department of Ear Nose and Throat, SS. Annunziata Hospital, G. D'Annunzio University, Chieti, Italy.

Background: The role of alcohol abuse is common in the onset of cancer of the upper aerodigestive tract, especially that affecting the tongue, floor of the mouth, palatine tonsil and piriform sinus. The consequences of the abuse of alcohol immediately after surgery in these patients are less known. But they are very important to achieve good final results.

Methods: To try to understand the best treatment for withdrawal symptoms in a group of Italian patient with head and neck cancers, we administered a 10-item questionnaire. Subsequently, we decided to send the questionnaire to the main Italian centers of head and neck oncology using the platform of online surveys SurveyMonkey.

Results: The results show clearly that it is not easy, within the Italian "latin" culture and lifestyle to correctly identify the alcoholic patient (patients in the last stage of the of the disease with a "behavioral dependency") and that the centers which address these problems mostly use a drug treatment, employing in particular two classes of drugs, associated or not with thiamine, with a varying quantity of other vitamins.

Conclusions: It is important to know the early withdrawal syndrome to assess the ideal treatment. We propose a personal protocol to present this complication.
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http://dx.doi.org/10.23736/S0026-4733.20.08316-9DOI Listing
December 2020

First Extraction of Transversity from a Global Analysis of Electron-Proton and Proton-Proton Data.

Phys Rev Lett 2018 May;120(19):192001

INFN Sezione di Pavia, Via Bassi 6, I-27100 Pavia, Italy.

We present the first extraction of the transversity distribution in the framework of collinear factorization based on the global analysis of pion-pair production in deep-inelastic scattering and in proton-proton collisions with a transversely polarized proton. The extraction relies on the knowledge of dihadron fragmentation functions, which are taken from the analysis of electron-positron annihilation data. For the first time, the transversity is extracted from a global analysis similar to what is usually done for the spin-averaged and helicity distributions. The knowledge of transversity is important for, among other things, detecting possible signals of new physics in high-precision low-energy experiments.
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http://dx.doi.org/10.1103/PhysRevLett.120.192001DOI Listing
May 2018

Steroid-Eluting Ethmoidal Stent Versus Antero-Posterior Ethmoidectomy: Comparison Of Efficacy And Safety In Allergic Patients.

Otolaryngol Pol 2016 Apr;70(2):6-12

Paediatric Allergology Unit, S. Pertini Hospital, Rome Italy.

Background: Allergic and chronic rhinosinusitis is a disabling pathological condition with an 8% prevalence in the European population and 5% in the Italian one. The ethmoidal sinus is the first one involved in the inflammation. The typical surgical procedure to manage ethmoidal sinusitis is an endoscopic antero-posterior ethmoidectomy. Recently introduced on the European market balloon called Relieva Stratus MicroFlow Spacer can be inserted within the ethmoid, with a local slow release of a steroid drug. This study had the aim to evaluate the efficacy and safety of the steroid-eluting ethmoidal stent in the management of allergic chronic rhinosinusitis in comparison with the traditional endoscopic ethmoidectomy. Methodos: 70 allergic patients who presented chronic rhinosinusitis were randomly divided into 2 groups and receive respectively the steroid-eluting ethmoidal stent or endoscopic ethmoidectomy.

Results: The most significant observation coming from the comparative analysis of the results is the substantial equivalence of the treatment with the steroid-eluting ethmoidal stent (SEES) compared with endoscopic ethmoidectomy in the management of ethmoid chronic rhinosinusitis with the exception of a reduction of overall discomfort and nasal secretion and better functional results at rhinomanometry in the steroid-eluting ethmoidal stent group.

Conclusion: in our experience, the SEES was efficacious in the treatment of allergic patients with ethmoidal CRS when conventional medical treatment had failed, or when wishing to avoid the classic endoscopic ethmoidectomy (EE). However, further long-term studies will be performed in order to confirm the safety and stability, over time, of the results obtained.
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http://dx.doi.org/10.5604/00306657.1199343DOI Listing
April 2016

TNM classification of the oral cavity carcinomas: some suggested modifications.

Otolaryngol Pol 2015 ;69(4):18-27

ENT Department, University "G. D'Annunzio" of Chieti-Pescara, Hospital "SS. Annunziata", Via dei Vestini, 66100, Chieti, Italy.

TNM system is a universally recognized cancer classification. It's based on the assessment of anatomical extent of tumor (T), nodal (N) and distant metastases (M). The first edition of TNM was published in 1968 and has since been updated several times. Relevant characteristics that affect prognosis prognosis, such as depth of invasion, tumor volume, surgical margin infiltration, and the number of involved nodes as well as the presence of extracapsular spread (such data should be determined by the pathologist and included in pTNM staging – ed. note) are not included in the TNM classification. Following a discussion on most recent classification updates we will discuss the factors, which in our opinion and in concordance with the most recent literature, deserve special consideration and influence management of oral carcinomas.
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http://dx.doi.org/10.5604/00306657.1160919DOI Listing
February 2017

Predictive Role of ERCC1 Expression in Head and Neck Squamous Cell Carcinoma Patients Treated with Surgery and Adjuvant Cisplatin-Based Chemoradiation.

Oncology 2015 9;89(4):227-34. Epub 2015 Jun 9.

Oncology Department, x2018;S. Giovanni Calibita' Fatebenefratelli Isola Tiberina Hospital, Rome, Italy.

Objective: ERCC1 (excision repair cross-complementation group 1) expression predicts survival in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) treated with chemoradiation. In order to evaluate the predictive role in the adjuvant setting, we investigated ERCC1 expression in radically resected HNSCC patients who underwent surgery and cisplatin chemoradiation.

Methods: ERCC1 expression levels were determined by immunohistochemistry in primary tumor tissues from 48 patients with stage III-IV cancers. The median follow-up was 38.5 months (range: 5-121).

Results: High ERCC1 expression was observed in 36 (75%) patients. Univariate analysis showed that patients with high levels of ERCC1 had significantly worse disease-free survival and overall survival (OS) than patients with low levels (HR = 7.15; 95% CI, 1.68-30.35; p = 0.008 and HR = 9.90; 95% CI, 1.33-73.96; p = 0.025, respectively). In the multivariate analysis, high ERCC1 expression (HR = 7.36; 95% CI, 1.72-31.4; p = 0.007) together with high-risk category (HR = 2.69; 95% CI, 1.01-7.18; p = 0.048) were the best predictors for relapse. High ERCC1 expression was the only unfavorable independent determinant for OS (HR = 9.53; 95% CI, 1.27-71.35; p = 0.028).

Conclusions: This investigation suggests that ERCC1 expression might be useful to predict prognosis in radically resected HNSCC patients treated with surgery and chemoradiation.
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http://dx.doi.org/10.1159/000430447DOI Listing
December 2015

Expression of E-cadherin and α-catenin in T1 N0 laryngeal cancer.

Anticancer Res 2012 Dec;32(12):5245-9

Department of Clinical and Molecular Medicine, Sapienza University, A.O. Sant'Andrea, Via di Grottarossa 1035, 00198 Rome, Italy.

Aim: To determine whether modulation of expression of cell adhesion molecules occurs in neoplastic transformation of laryngeal epithelium and to investigate their possible role in clinical outcome.

Materials And Methods: Fifty-five T1 N0 laryngeal biopsies were tested by immunohistochemistry for the E-cadherin/α-catenin adhesion complex.

Results: High immunohistochemical expression of E-cadherin and α-catenin was found in 18% and 53% cases, respectively. Expression of both adhesion molecules decreased according to histological grading; a significant relationship was particularly found between high E-cadherin expression and G1 cases (p=0.013). High E-cad-herin expression was statistically associated with in situ carcinoma (p=0.006). Non-statistical significance was evidenced between these adhesion molecules and tobacco use or site of occurence. Regarding clinical outcome, recurrence was associated with low expression of both adhesion molecules.

Conclusion: E-cadherin and α-catenin down-regulation might be associated with neoplastic transformation in laryngeal tissues and might be regarded as a risk factor for clinical recurrence.
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December 2012

Constraining quark angular momentum through semi-inclusive measurements.

Phys Rev Lett 2011 Nov 14;107(21):212001. Epub 2011 Nov 14.

Dipartimento di Fisica Nucleare e Teorica, Università di Pavia, Italy.

The determination of quark angular momentum requires the knowledge of the generalized parton distribution E in the forward limit. We assume a connection between this function and the Sivers transverse-momentum distribution, based on model calculations and theoretical considerations. Using this assumption, we show that it is possible to fit nucleon magnetic moments and semi-inclusive single-spin asymmetries at the same time. This imposes additional constraints on the Sivers function and opens a plausible way to quantifying quark angular momentum.
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http://dx.doi.org/10.1103/PhysRevLett.107.212001DOI Listing
November 2011

First glances at the transversity parton distribution through dihadron fragmentation functions.

Phys Rev Lett 2011 Jul 27;107(1):012001. Epub 2011 Jun 27.

Dipartimento di Fisica Nucleare e Teorica, Università di Pavia, Italy.

We present first observations of the transversity parton distribution based on an analysis of pion-pair production in deep-inelastic scattering off transversely polarized targets. The extraction of transversity relies on the knowledge of dihadron fragmentation functions, which we take from electron-positron annihilation measurements. This is the first attempt to determine the transversity distribution in the framework of collinear factorization.
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http://dx.doi.org/10.1103/PhysRevLett.107.012001DOI Listing
July 2011

Supracricoid partial laryngectomy as salvage surgery for radiation therapy failure.

Head Neck 2008 Aug;30(8):1064-71

Department of Otolaryngology-Head and Neck Surgery, University of Florence, Florence, Italy.

Background: The main concern in the treatment of laryngeal carcinomas is tumor control with preservation of laryngeal functions. We believe that salvage supracricoid partial laryngectomy (SPL) should be carefully considered in selected cases of radiotherapy failure, because it can offer the possibility of achieving adequate tumor control with preservation of laryngeal functions.

Methods: A series of 31 patients who underwent an SPL as salvage procedure after radiotherapy failure was reviewed.

Results: Locoregional control rate was 75%, with 60% 5-year overall survival; no patients were lost to follow-up, and a death-from-disease rate of 19.35% was recorded. Restoration of laryngeal functions was achieved in 89.29% of the patients. No statistically significant differences were found in locoregional control regarding anterior commissure involvement, elective neck dissection versus wait-and-see policy, pathologic positive neck disease, and restage I-II versus restage III-IV.

Conclusion: The oncologic and functional results indicate the consistency of salvage SPL, proposing this type of operation as a serious alternative to total laryngectomy in carefully selected cases.
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http://dx.doi.org/10.1002/hed.20837DOI Listing
August 2008