Publications by authors named "Marco Gandolfi"

50 Publications

Discrimination of nano-objects via cluster analysis techniques applied to time-resolved thermo-acoustic microscopy.

Ultrasonics 2021 Jul 28;114:106403. Epub 2021 Feb 28.

Interdisciplinary Laboratories for Advanced Materials Physics (I-LAMP), Università Cattolica del Sacro Cuore, I-25121 Brescia, Italy; Dipartimento di Matematica e Fisica, Università Cattolica del Sacro Cuore, I-25121 Brescia, Italy. Electronic address:

Time-effective, unsupervised clustering techniques are exploited to discriminate nanometric metal disks patterned on a dielectric substrate. The discrimination relies on cluster analysis applied to time-resolved optical traces obtained from thermo-acoustic microscopy based on asynchronous optical sampling. The analysis aims to recognize similarities among nanopatterned disks and to cluster them accordingly. Each cluster is characterized by a fingerprint time-resolved trace, synthesizing the common features of the thermo-acoustics response of the composing elements. The protocol is robust and widely applicable, not relying on any specific knowledge of the physical mechanisms involved. The present route constitutes an alternative diagnostic tool for on-chip non-destructive testing of individual nano-objects.
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http://dx.doi.org/10.1016/j.ultras.2021.106403DOI Listing
July 2021

Temperonic Crystal: A Superlattice for Temperature Waves in Graphene.

Phys Rev Lett 2020 Dec;125(26):265901

FemtoNanoOptics group, Université de Lyon, CNRS, Université Claude Bernard Lyon 1, Institut Lumière Matière, F-69622 Villeurbanne, France.

The temperonic crystal, a periodic structure with a unit cell made of two slabs sustaining temperature wavelike oscillations on short timescales, is introduced. The complex-valued dispersion relation for the temperature scalar field is investigated for the case of a localized temperature pulse. The dispersion discloses frequency gaps, tunable upon varying the slabs' thermal properties. Results are shown for the paradigmatic case of a graphene-based temperonic crystal. The temperonic crystal extends the concept of superlattices to the realm of temperature waves, allowing for coherent control of ultrafast temperature pulses in the hydrodynamic regime at above liquid nitrogen temperatures.
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http://dx.doi.org/10.1103/PhysRevLett.125.265901DOI Listing
December 2020

Efficacy and tolerability of short contact therapy with tretinoin, clindamycin, and glycolic acid gel in acne: A randomized, controlled, assessor-blinded two-center trial: The MASCOTTE study.

Dermatol Ther 2021 Jan 6;34(1):e14724. Epub 2021 Jan 6.

Section of Dermatology, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Retinoids and antibiotics topical treatments are commonly used as first line therapy in mild to moderate acne. However, irritant contact dermatitis is a common side effect of topical retinoids. A strategy to increase local tolerability is the "short contact therapy" (SCT) approach, consisting in the application of the product with the complete removal after 30 to 60 minutes using a non-aggressive cleanser. A gel containing tretinoin 0.02%, clindamycin 0.8%, and glycolic acid 4% in polyvinyl alcohol (MP-gel) has shown to be effective as monotherapy in mild to moderate acne with a tolerability profile similar to other topical retinoids. So far, no trials have been performed with this gel comparing the tolerability profile of SCT with standard application therapy (SAT). We conducted a 2-center randomized parallel groups, controlled, assessor-blinded study, comparing MP-gel applied as SCT in comparison with MP-gel used as SAT (The "MASCOTTE" trial). Forty-six subjects (nine men and 37 women, mean age 23 ± 4 years, range 18-31 years) with mild-to-moderate acne were enrolled, after their written informed consent in a randomized, parallel groups controlled, assessor-blinded 8-week trial. Twenty-three were assigned to MP-gel once daily (evening application) using the SCT approach (ie, complete removal of product after 1 hour using a gentle cleanser), and 23 were randomized to the SAT approach with the same gel. The primary endpoint was the evolution of the tolerability score (TS) assessed evaluating four items: erythema, dryness, stinging, and burning, using a 4-point score scale (from 0: no symptom to 3: severe symptom). Secondary endpoints were the evolution of global acne grading system (GAGS) score (range: from 0 to >39) and the investigator global assessment (IGA of acne severity) score (range from 0 to 4). TS was evaluated at 2, 4, and 8 weeks. GAGS and IGA scores were evaluated at baseline and at week eight. At week eight, an efficacy global score (EGS) (from 1: no efficacy to 4: very good efficacy) and a tolerability global score (TGS) (from 1: very low tolerability to 3: very good tolerability) evaluation were also done. All the evaluations were performed by an investigator unaware of treatment groups allocation (SCT or SAT). Thirty-eight subjects (83%) completed the 8-week treatment period. Eight subjects (two in the SCT group and six in the SAT group) dropped out prematurely due to low skin tolerability. In the SCT the TS at week two was 1.3 ± 1.7, in the SAT group TS was significantly higher (3.1 ± 1.7) (P = .028). TS was significantly lower in SCT group vs SAT also at weeks four and eight (P = .01; ANOVA test). The GAGS score at baseline was 19 ± 7 in the SCT group and 23 ± 4 in the SAT group (NS). At week 8 the GAGS score in SCT was significantly reduced to 8.5 ± 2.8 (-55%) (P = .001 vs baseline) and was also significantly lower in comparison with SAT group (8.5 vs 15; P = .0054). The IGA scores at baseline were 1.9 ± 0.6 in SCT and 2.4 ± 0.7 in SAT group. At week eight, in comparison with baseline values IGA score was reduced significantly by 48% in SCT and by 30% in SAT. EGS and TGS were significantly higher (better clinical efficacy and better tolerability) in SCT in comparison with SAT (3.6 ± 0.5 and 2.9 ± 0.3 vs 2.7 ± 0.6 and 1.5 ± 0.7; respectively). This tretinoin, clindamycin, glycolic acid gel, applied as SCT, has shown a better skin tolerability and at least a comparable clinical efficacy in comparison with the standard application modality in the treatment of mild-to-moderate acne. The SCT therefore could be an effective treatment strategy which could improve subjects' compliance and adherence.
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http://dx.doi.org/10.1111/dth.14724DOI Listing
January 2021

Optical wavelength dependence of photoacoustic signal of gold nanofluid.

Photoacoustics 2020 Dec 12;20:100199. Epub 2020 Aug 12.

Laboratory of Soft Matter and Biophysics, Department of Physics and Astronomy, KU Leuven, Celestijnenlaan 200D, B-3001 Leuven, Belgium.

We investigate the optical wavelength dependence of the photoacoustic (PA) signal, detected with bandwidth (BW) in the MHz range, of gold nanospheres (NSs) immersed in water upon illumination with ns laser pulses. We compare the wavelength dependence of the PA signal (within the MHz BW) with the one of the optical absorption coefficient as determined from optical transmission measurements. Thermal boundary conductance (TBC) at the gold-water interface is taken into account, as well as the temperature dependence of the thermal expansion coefficient of water. The effects of NS size and laser pulse duration on the PA signal are also explored. The PA signal is investigated with an opto-thermo-acoustic model considering light absorption in gold NS and in a surrounding water shell.
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http://dx.doi.org/10.1016/j.pacs.2020.100199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452055PMC
December 2020

Blue nevus of the nail: A case report and review.

Dermatol Ther 2020 07 16;33(4):e13763. Epub 2020 Jul 16.

Department of Dermatology, University of Parma, Parma, Italy.

Blue nevus (BN), in all its clinical variants, rarely affects the nail bed. This leads to difficulty in the diagnosis of BN within the nail bed as well as to challenges with regard to its treatment and follow-up management, not solely attributed to the intrinsic difficulty of the anatomical site. We present the first case in the literature of an acquired cellular BN entirely confined within the nail bed, in a female Caucasian patient. We propose diagnostic and therapeutic options based on personal clinical and surgical experience.
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http://dx.doi.org/10.1111/dth.13763DOI Listing
July 2020

Generalized verrucosis: A therapeutic challenge: Efficacy of topical sinecatechins (Veregen) 10.

Dermatol Ther 2019 07 5;32(4):e12986. Epub 2019 Jul 5.

Section of Dermatology, University of Parma, Parma, Italy.

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http://dx.doi.org/10.1111/dth.12986DOI Listing
July 2019

Topical sinecatechins in the treatment of verrucae planae of the face.

Dermatol Ther 2019 05 29;32(3):e12891. Epub 2019 Apr 29.

Section of Dermatology, University of Parma, Parma, Italy.

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http://dx.doi.org/10.1111/dth.12891DOI Listing
May 2019

Simplified Removal of the Donati Stitch.

Dermatol Surg 2020 02;46(2):281-282

Department of Medicine and Surgery, Section of Dermatology, University of Parma, Parma, Italy.

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http://dx.doi.org/10.1097/DSS.0000000000001864DOI Listing
February 2020

Quality of Life in Psoriasis Vietnamese Patients Treated with Metformin in Combination with Methotrexate.

Open Access Maced J Med Sci 2019 Jan 27;7(2):302-303. Epub 2019 Jan 27.

University of Rome G. Marconi, Rome, Italy.

A cross-sectional study was performed on 48 psoriasis Vietnamese patients treated with metformin as an add-on for methotrexate and 48 psoriasis patients treated methotrexate alone. The mean PASI scores were 5.25 ± 5.72. Total QOL scores had a slight difference between patients treated metformin combined with methotrexate and methotrexate alone (62.32 ± 18.1 vs 60.91 ± 19.63). Combined therapy with metformin and methotrexate contributes to significantly improve the quality of life for patients with psoriasis.
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http://dx.doi.org/10.3889/oamjms.2019.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364721PMC
January 2019

The Relationship between HLA-B27, HLA-Cw06, HLA-DR7 and Psoriatic Arthritis in Vietnamese Patients: Disease Progression and Therapeutic Burden.

Open Access Maced J Med Sci 2019 Jan 27;7(2):300-301. Epub 2019 Jan 27.

University of Rome G. Marconi, Rome, Italy.

We conducted a prospective, cross-sectional study at Ho Chi Minh City Hospital of Dermato Venereology from January 2016 to March 2017 in 40 psoriatic arthritis (PsA) patients to evaluate the disease progression and therapeutic burden about the HLA patterns. Based upon our results, PsA with HLA-B27 (+) had a threat of severe arthritis. PsA with HLA-Cw06 (+) had a higher risk of earlier onset and shorter duration for plaque psoriasis to transform into PsA. HLA-DR7 (+) in PsA delayed the time for conversion from plaque psoriasis into PsA. These findings are quite similar to other studies in the literature.
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http://dx.doi.org/10.3889/oamjms.2019.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364717PMC
January 2019

Successful Treatment of Intralesional Bleomycin in Keloids of Vietnamese Population.

Open Access Maced J Med Sci 2019 Jan 29;7(2):298-299. Epub 2019 Jan 29.

University of Rome G. Marconi, Rome, Italy.

Background: Keloid is an overactive condition of the skin tissue to early lesions characterised by proliferation of fibroblasts, excessive collagen production in the lesion. Treatment of keloids is a big challenge because of the poor response rate and high risk of recurrence after treatment. We found that bleomycin offers promise in the treatment of keloids.

Aim: To evaluate the efficacy of bleomycin injected in the injury for keloids treatment.

Methods: The treatment was carried out in 55 patients having 120 keloids of different sizes and locations. Average treatments were 4 times.

Results: Complete flattening was 70.8%, highly significant flattening was 8.3%, no patient of minimal flattening. Systemic side-effects of bleomycin were not evaluated, but local side-effects were mainly pains (100%), blisters (78.3%), ulceration (5.8%), and hyperpigmentation (56.7%).

Conclusion: The percentage of patients recurring 6, 12, 15, 18 months after the last treatment were 3.8, 15.4, 45.5, 50%, respectively.
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http://dx.doi.org/10.3889/oamjms.2019.099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364735PMC
January 2019

Microneedling Therapy for Atrophic Acne Scar: Effectiveness and Safety in Vietnamese Patients.

Open Access Maced J Med Sci 2019 Jan 29;7(2):293-297. Epub 2019 Jan 29.

University of Rome G. Marconi, Rome, Italy.

Aim: To evaluate the effectiveness and safety of micro-needling therapy in atrophic acne scar treatment.

Method: A prospective, single centred study was implemented in a total of 31 patients suffering from atrophic acne scar grade 2 to 4 of Goodman and Baron scaring grading system was recruited. They were treated by microneedle derma roller every week in 3 months. The scars were evaluated by a magic system camera and by dermatologists clinically using Goodman and Baron scaring grading system, and Lipper and Perez score at baseline, at final treatment, 1 month and 2 months after the final treatment.

Results: The results showed improvement in all patients. The mean of Goodman and Barron's grade was decreased from 3.29 ± 0.59 at baseline, 2.23 ± 0.56 at final treatment, 1.93 ± 0.58 one month after the completion of therapy and to 1.77 ± 0.57 two months after the completion of therapy (with the p-value < 0.05). Similarly, Lipper and Perez score also dropped significantly from 36.48 ± 12.07 at baseline to 23.16 ± 15.01 at final treatment, to 17.83 ± 7.00 one month after the final treatment and to 16.37 ± 7.29 at two months after the final treatment (p-value < 0.05). Skin roughness and hyperpigmented spots got improved significantly. History of having nodular-cystic or vulgaris acne did not affect the effectiveness of the therapy. Side effects of the therapy were burning sensation, erythema but they were very mild and recovered in 1-2 days. No severe complication and post-inflammatory hyperpigmentation were noted. 83.3% of the patients satisfied after the completion of the therapy.

Conclusion: Skin needling is an effective and safe method for the treatment of atrophic acne scars.
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http://dx.doi.org/10.3889/oamjms.2019.098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364723PMC
January 2019

The Effectiveness of Oral Mini-Pulse Methylprednisolonein - the Treatment of Alopecia Areata in Vietnam.

Open Access Maced J Med Sci 2019 Jan 29;7(2):291-292. Epub 2019 Jan 29.

University of Rome G. Marconi, Rome, Italy.

Background: Systemic corticosteroid is used to treat alopecia areata, but it is associated with side effects. Mini-pulse therapy is thought to be effective but able to reduce side effects.

Aim: The study aimed to evaluate the effectiveness of oral mini-pulse methylprednisolone in the treatment of alopecia areata.

Methods: Patients received methylprednisolone 16 mg orally for 2 consecutive days every week.

Results: After 3 months, among patients, 40% recovered well, and 55.6% recovered fairly. After 6 months, 82.2% recovered well, 17.8% recovered fairly. No adverse events were detected, and the recurrence rate was low (2.2%).

Conclusion: Oral mini-pulse methylprednisolone therapy is an effective and safe therapeutic option for alopecia areata without side effects, and the time of the treatment is short.
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http://dx.doi.org/10.3889/oamjms.2019.097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364712PMC
January 2019

Successful Treatment of Freckles by Alex Trivantage Laser Wavelight 755 nm in Vietnamese Patients.

Open Access Maced J Med Sci 2019 Jan 29;7(2):287-290. Epub 2019 Jan 29.

University of Rome G. Marconi, Rome, Italy.

Objectives: This study aims to evaluate the effectiveness of Alex Trivantage laser wavelength 755 nm (ATL) in the treatment of freckles at Hanoi Hospital of Dermatology and Venereology, Vietnam.

Patients And Methods: A group of 30 patients with freckles were treated by ATL (Alex Trivantage-Candela Co America) with spots size 3 mm, wavelength 755 mm, and energy 5-6 j/cm. All the patients were treated 2 times with 4-weeks interval. The results were evaluated at 4, 8, and 12 weeks after treatment. The colour of the lesions was evaluated by using Von-Luchan's chromatic scale and Visia® complex analysis system. Brown spot index (BSI) was calculated by the VISA complexion analysis system devices. The data was analysed by SPSS 16.0.

Results: After 2 times of treatment, the lesion colour of all of the patients had been improved. The good and very good levels of improvement were noted in 63.3% of patients; there was 26.7% of them had partial improvement. Brown spots index was significantly improved (39.13 ± 20.66 before and 54.23 ± 16.78 after treatment; p < 0.001). Hyperpigmentation was noted in 6.7% of patients.

Conclusion: freckles have been improved by treatment with Alex trivantage laser wavelength 755 nm with safety.
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http://dx.doi.org/10.3889/oamjms.2019.096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364722PMC
January 2019

Successful Treatment of Vitiligo Vietnamese Patients with Vitilinex® Herbal Bio-Actives in Combination with Phototherapy.

Open Access Maced J Med Sci 2019 Jan 29;7(2):283-286. Epub 2019 Jan 29.

University of Rome G. Marconi, Rome, Italy.

Background: Vitiligo is an acquired pigmentary disease, that causes progressive loss of melanocytes, resulting in hypopigmented skin patches. Current treatments aim at stopping the disease progression and achieving repigmentation of the amelanotic areas. Corticosteroids, surgery, topical immunomodulators, total depigmentation of normal pigmented skin and phototherapy are current treatment options for vitiligo although phototherapy remains the treatment of choice. There is no documented evidence that herbal bio-active products may also be effective treatment options for vitiligo.

Aim: This study aimed to investigate the efficacy and safety of Vitilinex® (herbal bio- actives) alone and in combination with UVB narrowband (311 nm) phototherapy, in the treatment of localised stable or active forms of vitiligo.

Material And Methods: Sixty two subjects with mean age 34.5 years (range: 18-58 years) with mild to moderate vitiligo, consisting of 36 females and 26 males were randomly divided into three treatment groups - Group A (13 females, 10 males) treated with Vitilinex® alone; Group B (12 females, 11 males) were treated with Vitilinex® in combination with narrowband UVB (311 nm) phototherapy for 15 seconds, using a handheld lamp and Group C (8 females, 8 males) were treated with nbUVB (311 nm) phototherapy alone, for 15 seconds over a 12-week period.

Results: In Group A, 9 patients (39%) achieved outstanding improvement with a re-pigmentation rate higher than 75%, with 2 patients experiencing total repigmentation. 6 patients (26%) had marked improvement with a repigmentation rate between 50-75% while 5 patients (22%) showed a moderate response between 25-50% re-pigmentation rate. 3 patients (13%) had minimal or no improvement. In Group B, 16 patients (69.5%) achieved outstanding improvement with a re-pigmentation rate higher than 75%, with 12 patients experiencing total re-pigmentation. 4 patients (17.5 %) achieved a marked improvement with a re-pigmentation rate between 50-75%; 2 patients (8.7%) showed a moderate response with a re-pigmentation rate between 25-50%. 1 (4.3%) patient had minimal or no improvement. In Group C, 6 patients (37.5%) achieved a re-pigmentation rate higher than 75%, with 2 patients experiencing total re-pigmentation. 4 patients (25%) achieved marked improvement with a re-pigmentation rate between 50-75% while 3 patients (18.75%) had a re-pigmentation rate between 25-50%. 3 patients (18.75%) had minimal or no improvement.

Conclusion: Vitilinex® herbal bio-actives in combination with nbUVB is a more effective treatment option for vitiligo with 87% of the patients achieving a re-pigmentation rate higher than 50%, compared to Vitilinex® alone (65%) or nbUVB alone (62.5%).
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http://dx.doi.org/10.3889/oamjms.2019.095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364738PMC
January 2019

Efficacy of Oral Low-Dose Isotretinoin in the Treatment of Acne Vulgaris in Vietnam.

Open Access Maced J Med Sci 2019 Jan 20;7(2):279-282. Epub 2019 Jan 20.

University of Rome G. Marconi, Rome, Italy.

Background: Oral isotretinoin is an effective therapy for acne. However, isotretinoin can induce hyperhomocysteinemia and decreased serum folic acid level, which may be a risk for cardiovascular disease and thrombosis, as well as psychoses. Besides, many recent types of research emphasise the safety and effects of the low dose isotretinoin therapy.

Aim: The aim of our study was to evaluate the effect of the low-dose isotretinoin on the plasma homocysteine and serum folic acid level in the Vietnamese population.

Methods: We conducted a longitudinal study to evaluate the effectiveness of the low-dose therapy on the plasma homocysteine and serum folic acid level of 52 acne patients after 6-8-week treatment at University Medical Center Ho Chi Minh City, Viet Nam. Patients had moderate-severe acne with the prolonged course, and most of them had a scar.

Results: With a low dose of oral isotretinoin (0.37 ± 0.11 mg/kg/day), after 6-8-week treatment, patients dropped the severity of disease, increased the plasma homocysteine level and decreased the serum folic acid level with significant differences in comparison to those before treatment. However, these changes do not exceed the normal range.

Conclusion: In overall, low dose isotretinoin treatment had effectiveness in decrease the severity of disease and no increasing the plasma homocysteine level as well as the serum folic acid level.
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http://dx.doi.org/10.3889/oamjms.2019.094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364726PMC
January 2019

Successful Treatment of Intralesional Triamcilonon Acetonide Injection in Keloid Patients.

Open Access Maced J Med Sci 2019 Jan 28;7(2):275-278. Epub 2019 Jan 28.

University of Rome G. Marconi, Rome, Italy.

Aim: Evaluation the effect of intralesional corticosteroid injection on keloid, at the National Hospital of Dermatology and Venereology from 1/2009 to 12/2009.

Methods: A group of 65 patients with keloid were randomly assigned into three groups. In the studied group, 33 patients were intralesionally injected 7.5 mg/1 cm of TCA. In the control group, TAC 32 patients were intralesionally injected 15 mg/1 cm of TCA. The result was evaluated basing on the criteria of Henderson (1998) and El-Tonsy (1996).

Results: In comparison between 2 groups, good to excellent improvement in the studied group was statistically higher than the control group (90.7% versus 68.7%; p < 0.05). After each injection, the thickness of the scar was reduced 1.24 ± 0.53 mm in the studied group and 0.81 ± 0.39 mm in the control group. The disappearance of pain and itching after treatment were 86.6% and 95.5% in the studied group and 78.1% and 80% in the control group (p > 0.05). Ulceration, acne and troublesome with menstrual cycles were sometimes were noted more frequently in the control group than in the studied group.

Conclusion: Intralesional triamcinolone acetonide injection had a good result, and 7.5 mg/1 cm scar is the best dose for treatment of keloid.
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http://dx.doi.org/10.3889/oamjms.2019.093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364710PMC
January 2019

Efficacy of Azole Antifungal in Treatment of Pityriasis Versicolor.

Open Access Maced J Med Sci 2019 Jan 28;7(2):272-274. Epub 2019 Jan 28.

Psoriasis Eczema Clinic, Melbourne, Australia.

Aim: Compare itraconazole alone, fluconazole combined with ketoconazole and ketoconazole in the treatment of patients with pityriasis versicolor.

Material And Methods: A group of 240 pityriasis versicolor patients (confirmed with KOH and culture) were classified into 3 groups: Fluconazole 300 mg a week and 2% ketoconazole foam twice a week for 2 weeks (Category I), Itraconazole 200 mg daily for one week (category II); Ketoconazole 2% foam daily for 2 weeks (Category 3). Clinical (colour of macule, scale, pruritus) and mycological assessment were done after 4 weeks of therapy.

Results: After 4 weeks of treatment, clinical cure was observed in 62.4% (Category I), 36.3% (Category II) and 37.5% (Category III).

Conclusion: It was reported in our study that the most effective regimen for PV patients is fluconazole 300 mg per week combined with ketoconazole 2% twice a week for 2 weeks.
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http://dx.doi.org/10.3889/oamjms.2019.092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364740PMC
January 2019

Efficacy of 10% Potassium Hydroxide Solution Versus 10% Salicylic Acid Ointment in Treatment of Molluscum Contagiosum - the Low - Cost Dermatologic Therapy in Vietnam.

Open Access Maced J Med Sci 2019 Jan 28;7(2):269-271. Epub 2019 Jan 28.

University of Rome G. Marconi, Rome, Italy.

Background: Molluscum contagiosum is a common viral disease primarily affecting children.

Aim: The objective is to compare the efficacy of 10% potassium hydroxide (KOH) solution versus 10% salicylic pomade in the treatment of molluscum contagiosum.

Methods: Clinical trials on 70 patients were randomised into 2 groups: 39 patients treated with 10% KOH solution and 31 patients treated with 10% salicylic pomade. The evaluation was based on the complete clearance of lesions, side effects and complications of the drug.

Results: The clearance of all lesions after 2, 4, 6, 8 weeks of treatment in both groups were 7.7%; 23.1%; 53.8%; 79.5% and 0%; 3.2%, 9.7% 22.6%, respectively (p < 0.05). Side effects were seen in both groups include burning (76.9% versus 19.4%; p < 0.05); redness (59% versus 14%; p < 0.01); desquamation (12.8% versus 19.3%; p < 0.05).

Conclusion: The efficacy of KOH solution in the treatment of MC was better than that of salicylic pomade and both products are safe, effective, and easy to apply at home.
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http://dx.doi.org/10.3889/oamjms.2019.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364743PMC
January 2019

Efficacy of BAFF in Monitoring Treatment Response in Early Vietnamese Systemic Sclerosis Patients.

Open Access Maced J Med Sci 2019 Jan 28;7(2):264-268. Epub 2019 Jan 28.

University of Rome G. Marconi, Rome, Italy.

Background: B-cell activating factor (BAFF) is considered to have a role in the pathogenesis of systemic sclerosis (SSc).

Aim: We conducted a longitudinal study on early SSc patients to determine the change in BAFF serum level after treatment and its association with organ involvements.

Methods: A total of 46 patients (32 diffuse, 14 limited) were recruited, among which 35 patients (24 diffuse, 11 limited) completed 12-month follow-up.

Results: Higher pretreatment BAFF levels were observed in patients with positive anti-topoisomerase antibody (ATA) (2252.1 ± 899.7 pg/ml versus 1475.5 ± 697.6 pg/ml in ATA-negative patients; p = 0.01) and muscular involvement (2741.9 ± 1039.9 pg/ml versus 1897.2 ± 762.9 pg/ml in patients without muscular involvement; p = 0.005). Lower levels were observed in patients with interstitial lung disease (ILD) (1926.7 ± 757.9 pg/ml versus 2721.6 ± 1131.4 pg/ml in non-ILD patients; p = 0.01). After treatment, BAFF level reduced significantly in diffuse SSc patients (1652.2 ± 892.7 pg/ml versus 2147.6 ± 945.5 pg/ml before treatment; p = 0.03).

Conclusion: Patients with worsening outcome had the highest pretreatment BAFF level and was associated with increased BAFF level after treatment. BAFF can be used to predict and monitor patients' response to therapy.
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http://dx.doi.org/10.3889/oamjms.2019.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364724PMC
January 2019

The Efficacy of a Two-Fold Increase of H1-Antihistamine in the Treatment of Chronic Urticaria - the Vietnamese Experience.

Open Access Maced J Med Sci 2019 Jan 28;7(2):259-263. Epub 2019 Jan 28.

University of Rome G. Marconi, Rome, Italy.

Background: Chronic urticaria, a mast cell-driven condition, is common, debilitating and hard to treat. H1-antihistamines are the first line treatment of chronic urticaria, but often patients do not get satisfactory relief with the recommended dose. European guidelines recommend increased antihistamine doses up to four-fold.

Aim: We conducted this study to evaluate the efficacy of increased H1-antihistamine doses up to two-fold in Vietnamese chronic urticaria patients.

Methods: One hundred and two patients with chronic urticaria were recruited for treatment with levocetirizine (n = 52) or fexofenadine (n = 50). Treatment started at the conventional daily dose of 5 mg levocetirizine or 180 mg fexofenadine for 2 weeks and then increased to 10 mg levocetirizine or 360 mg fexofenadine for 2 weeks if patients did not have an improvement in symptoms. At week 0, week 2 and week 4 wheal, pruritus, size of the wheal, total symptom scores, and associated side-effects were assessed.

Results: With the conventional dose, the total symptom scores after week 2 decreased significantly in both groups compared to baseline figures, i.e. 7.4 vs 2.3 for levocetirizine group and 8.0 vs 2.6 for fexofenadine group (p < 0.05). However, there were still 26 patients in each group who did not have improvements. Of these 26 patients, after having a two-fold increase of the conventional dose, 11.5% and 38.5% became symptom-free at week 4 in levocetirizine group and fexofenadine group, respectively. At week 4 in both groups, the total symptom scores had significantly decreased when compared with those at week 2 (2.8 ± 1.5 versus 4.7 ± 1.6 in levocetirizine group; 2.1 ± 1.9 versus 5.1 ± 1.4 in fexofenadine group). In both groups, there was no difference in the rate of negative side effects between the conventional dose and the double dose.

Conclusion: This study showed that increasing the dosages of levocetirizine and fexofenadine by two-fold improved chronic urticaria symptoms without increasing the rate of negative side effects.
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http://dx.doi.org/10.3889/oamjms.2019.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364734PMC
January 2019

The Decline of PUVA Therapy in Vietnam: Effective Treatment of Narrow Band UVB in Vietnamese Vitiligo Patients.

Open Access Maced J Med Sci 2019 Jan 28;7(2):256-258. Epub 2019 Jan 28.

University of Rome G. Marconi, Rome, Italy.

Aim: To examine the efficacy and safety of Narrowband ultraviolet B (NB-UVB) in Vietnamese vitiligo patients.

Methods: We recruited thirty-one patients (14 males, 17 females), aged from 7 to 67 years, with both segmental vitiligo (SV) and non-segmental vitiligo (NSV), treated three times weekly with NB-UVB. The starting dose for adults from 15 years old and children less than 15 years old was 200 mJ/cm and 150 mJ/cm, respectively, with 50 mJ/cm and 20 mJ/cm dose increments at each subsequent visit, respectively, until mild erythema lasting less than 24 hrs reported by patient, given for a period of 6 months. Response to therapy was assessed based on VASI score changes.

Results: Based upon our results, 38.7% (12/31) of patients achieved a very good response of more than 50% VASI changes, 41.9% (13/31) obtained a good response (VASI changed from 25 to 50%). Total good and very good response to therapy significantly increased with prolonged treatment, increasing from 19.4% to 64.5% and 80.6% after 2, 4 and 6 months, respectively. Localised NSV patients obtained good and very good response significantly more frequently than generalised NSV (55.6% versus 18.2%). Adverse effects were minimal, of which one case developed herpes simplex, and 4 cases reported mild photo burn reaction which completely disappeared after adjusting the dose.

Conclusion: NB-UVB therapy is an effective and safe tool in the management of Vietnamese vitiligo patients.
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http://dx.doi.org/10.3889/oamjms.2019.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364711PMC
January 2019

Successful Psoriasis Treatment Using NB-UVB with Methotrexate: The Vietnamese Experience.

Open Access Maced J Med Sci 2019 Jan 27;7(2):253-255. Epub 2019 Jan 27.

University of Rome G. Marconi, Rome, Italy.

Aim: To compare the effectiveness of narrowband ultraviolet B (NBUVB) and oral methotrexate (MTX) to oral MTX alone in Vietnamese psoriasis patients, from May 2016 to May 2018.

Methods: We conducted a non-randomized trial on 70 patients with plaque-type psoriasis of moderate to severe. Thirty-five patients apply NBUVB once/day in 5 days/week for 4 weeks plus oral MTX 7.5 mg/week and 35 patients oral MTX 7.5 mg/week and both two groups treatment for 3 months. The extent of the lesion was assessed by the Psoriasis Area and Severity Index (PASI).

Results: The proportion of decreasing PASI was comparable (68.49% in NBUVB and MTX versus 57.62% in MTX alone); p < 0.05. Inside, good 28.58%, moderate 68.57% and poor 2.85% in NBUVB and MTX better than good 2.85%, moderate 71.4% and poor 25.72% in MTX alone; p < 0.05. The recurrence rate after 24 months of the NBUVB and MTX group (42.9%) was lower than the MTX alone group (71.4%); p < 0.05.

Conclusion: NBUVB and oral MTX have affected treatment with chronic plaque psoriasis better than oral MTX alone.
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http://dx.doi.org/10.3889/oamjms.2019.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364742PMC
January 2019

Effectiveness, Safety and Tolerance of Methotrexate in Vietnamese Psoriatic Arthritis Patients.

Open Access Maced J Med Sci 2019 Jan 27;7(2):250-252. Epub 2019 Jan 27.

University of Rome G. Marconi, Rome, Italy.

Aim: To access the effectiveness, safety and tolerance of methotrexate (MTX) in psoriatic arthritis (PsA) treatment.

Methods: We recruit 37 patients, admitted at HCMC Hospital of Dermato-Venereology from 1/2016 to 3/2017, with MTX dosage ranging from 10 mg to 15 mg per week.

Results: Skin lesion response after 12 weeks improved PASI 50: 40.5%, PASI 75: 24.3%. Disease activity score decreased after 12 weeks with ∆DAS28 = -1.43 + 0.79, 37.8% PsA achieved complete remission. Nausea and vomiting were 8.1%. These symptoms were mild and transient. We did not stop MTX usage. The rate of elevating SGPT 2-3 times as much as the upper limit of the normal range was 2.7%.

Conclusion: We finally demonstrated that the rate of treatment response in Vietnam is the same as demonstrated by foreign authors in other countries.
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http://dx.doi.org/10.3889/oamjms.2019.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364709PMC
January 2019

Antifungal Susceptibility of Dermatophytes Isolated From Cutaneous Fungal Infections: The Vietnamese Experience.

Open Access Maced J Med Sci 2019 Jan 27;7(2):247-249. Epub 2019 Jan 27.

University of Rome G. Marconi, Rome, Italy.

Aim: Evaluate the resistance of dermatophytes to systemic antifungal drugs in the Vietnamese population.

Methods: We enrolled 101 patients with cutaneous dermatophytosis at the Dermato-Venereology hospital in HCMC from August 2016 to March 2017. All the specimens were subjected to direct examination (10% KOH mount) and culture on Sabouraud dextrose agar. In vitro antifungal sensitivity testing was done on species isolated from a culture with broth microdilution method.

Results: Direct microscopy was positive for dermatophytes in all patients. However this pathogen was found in fungal cultures in only 61.38% of patients. The main causative agent isolated was . (90.3%), followed by . (8%) and . (1.7%). . Has shown resistance to fluconazole, griseofulvin, ketoconazole, and itraconazole in 92.9%, 46.4%, 5.4% and 1.8% of strains, respectively. All Microsporum spp. Strains were found resistant to fluconazole and griseofulvin while resistance to ketoconazole was demonstrated in only 20% of strains and none of them was resistant to itraconazole. strains were all resistant to fluconazole, griseofulvin, ketoconazole while none of them was resistant to itraconazole.

Conclusion: Based upon our results, Itraconazole shows the greatest probability of efficacy in the treatment of cutaneous dermatophytosis in Vietnamese patients.
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http://dx.doi.org/10.3889/oamjms.2019.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364716PMC
January 2019

Superantigens of Colonization in Atopic Dermatitis and Treatment Efficacy of Oral Cefuroxim in Vietnamese Patients.

Open Access Maced J Med Sci 2019 Jan 20;7(2):243-246. Epub 2019 Jan 20.

University of Rome G. Marconi, Rome, Italy.

Background: Atopic dermatitis (AD) is a common, chronic, relapsing, genetically determined inflammatory skin disorder. Staphylococcus aureus (S. aureus) plays an important role in the pathogenesis of AD. Atopic skin is susceptible to infection with .

Aim: This study was aimed to compare the skin colonisation status and its secretion of superantigens in adult AD and healthy subjects and to evaluate the efficacy of two treatment regimens (oral cefuroxime plus topical betamethasone dipropionate 0.05% versus topical betamethasone dipropionate 0.05%) in AD patients.

Methods: A group of 128 AD and 40 healthy subjects were recruited in this study and treatment efficacy was assessed by the SCORAD score.

Results: was found in skin lesions in 83.8% of AD patients while only 37.5% of healthy subjects possessed this kind of bacteria in the external nares (p < 0.001). Superantigen production was more common in strains isolated from AD than the control group (58.6% versus 6.6%, p = 0.0006) and staphylococcal enterotoxin B was predominant (88.89%). 68 AD patients who had positive cultures with were included in a clinical therapeutic trial. The isolated bacteria were all sensitive to cefuroxime. Patients were randomised to receive either oral cefuroxime 500 mg b.i.d. Plus topical betamethasone dipropionate 0.05% twice daily for 2 weeks (so-called group 1, 36 patients) or only topical betamethasone dipropionate 0.05% twice daily for 2 weeks (so-called group 2, 32 patients). The mean SCORAD scores of group 1 at baseline and after 1 and 2 weeks of treatment were 44.61, 26.69 and 16.61, respectively. The corresponding values for group 2 were 43.03, 32.53 and 23.41, respectively.

Conclusion: The reduction in SCORAD scores was significantly higher in group 1 than group 2 in comparison to the baseline value of each study group (p = 0.003 after 1 week and p < 0.001 at the end of treatment).
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http://dx.doi.org/10.3889/oamjms.2019.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364715PMC
January 2019

Efficacy of Adding Oral Simvastatin to Topical Therapy for Treatment of Psoriasis: The Vietnamese Experience.

Open Access Maced J Med Sci 2019 Jan 27;7(2):237-242. Epub 2019 Jan 27.

University of Rome G. Marconi, Rome, Italy.

Background: Psoriasis, the prevalence of which ranges from 2% to 3% of the general population, has been recently recognised as not only a chronic inflammatory skin disorder but also an immunometabolic systemic disease. Dyslipidemia is one of the most important comorbidities of psoriasis. Statins, frequently used as anti-hyperlipidemic agents, may be beneficial in the treatment of several autoimmune diseases, including psoriasis, due to their anti-inflammatory and immunomodulatory characteristics. Hence, we hypothesised that using this medication was not only beneficial for reducing hyperlipidemia but also improving psoriatic conditions.

Aim: We conducted a study to determine the prevalence of dyslipidemia in psoriatic patients as well as whether the addition of statins (simvastatin prescribed forms) to standard topical antipsoriatic treatment can improve skin lesions in psoriatic patients.

Methods: A group of 128 psoriatic patients and 128 healthy controls who were matched with the patients regarding ethnicity, age, and sex were enrolled, and their lipid concentrations were determined. Furthermore, sixty patients were randomly selected from the former group and divided into two treatment subgroups to evaluate the effect of statins on the severity of psoriasis using the PASI score.

Results: We found that the rate of dyslipidemia in the patient group was significantly higher than in the healthy group (53.9% versus 21.9%, p < 0.001), particularly the triglyceride concentration (1.86 ± 1.17 versus 1.43 ± 0.79 mg/dL, p < 0.001). Also, the PASI score reduction in the simvastatin-treated subgroup was significantly different from that in the placebo-treated one after eight weeks of therapy (8.63 ± 4.78 versus 5.34 ± 3.59, p < 0.01).

Conclusion: This study showed that simvastatin might play a role in controlling hyperlipidemia and in turn decrease the PASI score in psoriatic patients.
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http://dx.doi.org/10.3889/oamjms.2019.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364708PMC
January 2019

The Efficacy and Safety of Hyaluronic Acid Microinjection for Skin Rejuvenation in Vietnam.

Open Access Maced J Med Sci 2019 Jan 26;7(2):234-236. Epub 2019 Jan 26.

University of Rome G. Marconi, Rome, Italy.

Background: Aging is an increasing concern of modern society, particularly facial ageing. In recent years, the microinjection technique has increasingly been emphasised as a skin rejuvenation strategy. Hyaluronic acid (HA) plays an important role in the hydration of the extracellular space and can thus improve skin hydration, firmness and viscoelastic properties.

Aim: To evaluate the efficacy and safety of HA microinjection in skin rejuvenation.

Methods: We enrolled thirty participants underwent three sessions of HA microinjection involving multiple injections in the face or back of the hands at 2-week intervals. The aesthetic outcomes were assessed at baseline and after 2, 4 and 8 weeks. Clinical evaluation was based on the Global Aesthetic Improvement Scale (GAIS) and the Wrinkle Severity Rating Scale (WSRS).

Results: Evaluation of photographs from 2, 4 and 8 weeks revealed significant clinical improvement in the brightness, texture and wrinkling of the skin. Analysis of the GAIS and WSRS scores revealed statistically significant results after 2 months.

Conclusion: Most of the participants felt satisfied with the treatment (93.3%).
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http://dx.doi.org/10.3889/oamjms.2019.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364739PMC
January 2019

Serial Excision for the Treatment of Giant Congenital Melanocytic Nevus: The Vietnamese Way.

Open Access Maced J Med Sci 2019 Jan 26;7(2):231-233. Epub 2019 Jan 26.

University of Rome G. Marconi, Rome, Italy.

Aim: To investigate the efficacy of plastic surgery in the treatment of giant congenital melanocytic nevus (GCMN).

Methods: We enrolled 20 patients with 44 lesions and performed one of the following procedures: serial excision, skin grafting, tissue expansion, primary skin closure, distant flap, and adjacent flap. We assessed the outcome at 10 days and 6 months after surgery.

Results: Of 44 surgical sites, the most commonly used reconstruction surgeries were serial excision (16), skin grafting (16), and tissue expansion (6). Other types were rarely used. All patients with serial excision had good outcome. A total of 81% and 19% of the patients with skin grafting had good and fair outcome, respectively. Around 83% and 17% of the patients with tissue expansion had good and fair outcome. No cases had bad outcome.

Conclusion: In conclusion plastic surgery is effective in the treatment of GCMN. There are different techniques but serial excision, skin grafts, and tissue expansion are most commonly used.
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http://dx.doi.org/10.3889/oamjms.2019.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364729PMC
January 2019

Efficacy of Narrow - Band UVB Phototherapy versus PUVA Chemophototherapy for Psoriasis in Vietnamese Patients.

Open Access Maced J Med Sci 2019 Jan 25;7(2):227-230. Epub 2019 Jan 25.

University of Rome G. Marconi, Rome, Italy.

Background: Psoralen UVA (PUVA) and narrow-band UVB (NBUVB) chemophototherapy are treatment options for psoriasis.

Aim: To compare the effectiveness of NBUVB with PUVA in Vietnamese psoriasis patients.

Methods: We conducted a non-randomized trial on 60 patients with plaque-type psoriasis (30 NBUVB, 30 PUVA). Both regimens were thrice-weekly. The extent of lesion was assessed by the Psoriasis Area Severity Index (PASI). Clearance was defined as a ≥ 75% reduction in a follow-up PASI score from baseline. Patients with clearance were followed-up until 6 months after stopping treatment. Relapse was defined as 50% or more of the original extent.

Results: The proportion of patients achieving PASI75 was comparable (76.7% in NBUVB versus 80% in PUVA; p > 0.05). Patients in both groups had a similar number of sessions to achieve clearance but patients in the PUVA group exposed to a significantly higher cumulative UV dose. After six months, the relapse rate was higher in the NBUVB group compared with in the PUVA group (p > 0.05).

Conclusion: Thrice weekly NBUVB is as effective as thrice weekly PUVA in treating psoriasis for Vietnamese patients.
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http://dx.doi.org/10.3889/oamjms.2019.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364720PMC
January 2019