Marco Bugliani

Marco Bugliani

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Marco Bugliani

Marco Bugliani

Publications by authors named "Marco Bugliani"

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The microRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells.

J Mol Endocrinol 2019 Jul 1. Epub 2019 Jul 1.

D Eizirik, ULB, Center for Diabetes Research, ULB, Anderlecht, Belgium.

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http://dx.doi.org/10.1530/JME-19-0066DOI Listing
July 2019

Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors.

Cell Metab 2018 12 2;28(6):946-960.e6. Epub 2018 Aug 2.

INSERM, U1016, Cochin Institute, 75014 Paris, France; CNRS, UMR8104, Cochin Institute, 75014 Paris, France; Paris Descartes University, Sorbonne Paris Cité, 75014 Paris, France; Assistance Publique Hôpitaux de Paris, Service de Diabétologie, Cochin Hospital, 75014 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.07.007DOI Listing
December 2018

Probing the light scattering properties of insulin secretory granules in single live cells.

Biochem Biophys Res Commun 2018 09 14;503(4):2710-2714. Epub 2018 Aug 14.

NEST - Scuola Normale Superiore, Istituto Nanoscienze - CNR (CNR NANO), Pisa, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183170
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http://dx.doi.org/10.1016/j.bbrc.2018.08.029DOI Listing
September 2018

Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets.

Diabetologia 2018 08 12;61(8):1780-1793. Epub 2018 May 12.

Unité Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, Équipe Régulation de la glycémie par le système nerveux central, Université Paris Diderot, 4 rue Marie-Andrée-Lagroua-Weill-Hallé, 75205, Paris CEDEX 13, France.

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http://dx.doi.org/10.1007/s00125-018-4629-8DOI Listing
August 2018

The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic β-Cell Survival and Insulin Secretion.

Diabetes 2017 11 19;66(11):2849-2856. Epub 2017 Jul 19.

Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy

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http://dx.doi.org/10.2337/db17-0002DOI Listing
November 2017

Ultrastructural alterations of pancreatic beta cells in human diabetes mellitus.

Diabetes Metab Res Rev 2017 09 18;33(6). Epub 2017 Apr 18.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

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http://doi.wiley.com/10.1002/dmrr.2894
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http://dx.doi.org/10.1002/dmrr.2894DOI Listing
September 2017

Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes.

Front Cell Dev Biol 2017 23;5:55. Epub 2017 May 23.

Department of Clinical and Experimental Medicine, University of PisaPisa, Italy.

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http://dx.doi.org/10.3389/fcell.2017.00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440564PMC
May 2017

Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway.

Cell Death Differ 2016 12 2;23(12):1995-2006. Epub 2016 Sep 2.

ULB Center for Diabetes Research, Université Libre de Bruxelles, 1070 Brussels, Belgium.

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http://dx.doi.org/10.1038/cdd.2016.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136495PMC
December 2016

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.

Cell Metab 2016 09 21;24(3):389-401. Epub 2016 Jul 21.

Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London W12 0NN, UK; Institute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham B15 2TT, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham B15 2TH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031557PMC
September 2016

Mast cells infiltrate pancreatic islets in human type 1 diabetes.

Diabetologia 2015 Nov 15;58(11):2554-62. Epub 2015 Aug 15.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126, Pisa, Italy.

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http://dx.doi.org/10.1007/s00125-015-3734-1DOI Listing
November 2015

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms.

Diabetologia 2015 Oct 23;58(10):2307-16. Epub 2015 Jun 23.

ULB-Center for Diabetes Research, Universitè Libre de Bruxelles (ULB), Route de Lennik, 808-CP618, 1070, Brussels, Belgium.

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http://dx.doi.org/10.1007/s00125-015-3669-6DOI Listing
October 2015

The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.

Diabetologia 2015 Jun 26;58(6):1260-71. Epub 2015 Mar 26.

Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Piazza Giulio Cesare, 11, 70124, Bari, Italy.

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http://link.springer.com/10.1007/s00125-015-3563-2
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http://dx.doi.org/10.1007/s00125-015-3563-2DOI Listing
June 2015

In vitro use of free fatty acids bound to albumin: A comparison of protocols.

Biotechniques 2015 May 1;58(5):228-33. Epub 2015 May 1.

ULB Center for Diabetes Research, Université Libre de Bruxelles (ULB), Brussels, Belgium.

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http://dx.doi.org/10.2144/000114285DOI Listing
May 2015

Optical control of insulin release using a photoswitchable sulfonylurea.

Nat Commun 2014 Oct 14;5:5116. Epub 2014 Oct 14.

Department of Chemistry, Ludwig-Maximilians-Universität München, and Munich Center for Integrated Protein Science, Butenandtstrasse 5-13, 81377 München, Germany.

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http://www.nature.com/articles/ncomms6116
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http://dx.doi.org/10.1038/ncomms6116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208094PMC
October 2014

Mitochondrial and ER-targeted eCALWY probes reveal high levels of free Zn2+.

ACS Chem Biol 2014 Sep 17;9(9):2111-20. Epub 2014 Jul 17.

Section of Cell Biology, Division of Medicine, and ‡National Heart and Lung Institute, Imperial College London , London, United Kingdom.

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http://dx.doi.org/10.1021/cb5004064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101202PMC
September 2014

Incretin-modulated beta cell energetics in intact islets of Langerhans.

Mol Endocrinol 2014 Jun 25;28(6):860-71. Epub 2014 Apr 25.

Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine (D.J.H, A.I.T., S.G.B., R.K.M., N.R.J., S.H., M.C.C., G.A.R.), Imperial College London, London W12 0NN, United Kingdom; Department of Endocrinology and Metabolism (M.B., P.M.), University of Pisa, 56126 Pisa, Italy; Cell Isolation and Transplantation Center, Department of Surgery (D.B.), Geneva University Hospitals and University of Geneva, 1205 Geneva, Switzerland; Oxford Centre for Diabetes, Endocrinology, & Metabolism (P.R.J., S.J.H.), University of Oxford, Oxford OX3 7LE, United Kingdom; NIHR Oxford Biomedical Research Centre (P.R.J., S.J.H.), Churchill Hospital, Oxford OX3 7LE, United Kingdom; and Nuffield Department of Surgical Sciences (P.R.J., S.J.H.), University of Oxford, Oxford OX3 9DU, United Kingdom.

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http://dx.doi.org/10.1210/me.2014-1038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042069PMC
June 2014

Direct effects of rosuvastatin on pancreatic human beta cells.

Acta Diabetol 2013 Dec 17;50(6):983-5. Epub 2013 Mar 17.

Islet Cell Laboratory, Department of Clinical and Experimental Medicine, University of Pisa, Via Paradisa, 2, 56124, Pisa, PI, Italy,

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http://dx.doi.org/10.1007/s00592-013-0465-yDOI Listing
December 2013

Glucagon-like peptide-1 protects human islets against cytokine-mediated β-cell dysfunction and death: a proteomic study of the pathways involved.

J Proteome Res 2013 Sep 26;12(9):4193-206. Epub 2013 Aug 26.

Laboratory for Clinical and Experimental Endocrinology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1021/pr400527qDOI Listing
September 2013

From genotype to human β cell phenotype and beyond.

Islets 2012 Sep-Oct;4(5):323-32. Epub 2012 Sep 1.

Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.4161/isl.22282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524138PMC
June 2013

The pancreatic beta cells in human type 2 diabetes.

Adv Exp Med Biol 2012 ;771:288-309

Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1007/978-1-4614-5441-0_22DOI Listing
March 2013

Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetes.

Acta Diabetol 2012 Dec 25;49 Suppl 1:S247-52. Epub 2012 Nov 25.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, Scuola Medica, 56126 Pisa, Italy.

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http://dx.doi.org/10.1007/s00592-012-0446-6DOI Listing
December 2012

Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes.

J Mol Cell Biol 2012 Aug 19;4(4):221-30. Epub 2012 May 19.

Institute of Metabolic Physiology, Heinrich-Heine University, D-40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1093/jmcb/mjs025DOI Listing
August 2012

A role for autophagy in β-cell life and death.

Islets 2009 Sep-Oct;1(2):157-9

Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.4161/isl.1.2.9372DOI Listing
March 2011

Class II phosphoinositide 3-kinase regulates exocytosis of insulin granules in pancreatic beta cells.

J Biol Chem 2011 Feb 2;286(6):4216-25. Epub 2010 Dec 2.

From the Queen Mary University of London, Barts and The London School of Medicine and Dentistry, Blizard Institute of Cell and Molecular Science, Centre for Diabetes, London E1 2AT, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.200295
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http://dx.doi.org/10.1074/jbc.M110.200295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039383PMC
February 2011

The beta-cell in human type 2 diabetes.

Adv Exp Med Biol 2010 ;654:501-14

Department of Endocrinology and Metabolism, Cisanello Hospital, 56124 Pisa, Italy.

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http://dx.doi.org/10.1007/978-90-481-3271-3_22DOI Listing
June 2010

Enhanced signaling downstream of ribonucleic Acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets.

J Clin Endocrinol Metab 2010 Mar 15;95(3):1442-9. Epub 2010 Jan 15.

Laboratory of Experimental Medicine, Université Libre de Bruxelles CP-618, Route de Lennik 808, 1070 Brussels, Belgium.

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http://dx.doi.org/10.1210/jc.2009-2322DOI Listing
March 2010

Apoptotic, regenerative, and immune-related signaling in human islets from type 2 diabetes individuals.

J Proteome Res 2009 Dec;8(12):5650-6

Department of Medical Cell Biology, Uppsala University, 75123 Uppsala, Sweden.

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http://dx.doi.org/10.1021/pr9006816DOI Listing
December 2009

Effects of C-peptide on isolated human pancreatic islet cells.

Diabetes Metab Res Rev 2007 Mar;23(3):215-9

Department of Endocrinology and Metabolism - Metabolic Unit, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1002/dmrr.674DOI Listing
March 2007

The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets.

Eur J Endocrinol 2006 Feb;154(2):355-61

Metabolic Unit, Department of Endocrinology and Metabolism, University of Pisa, Ospedale Cisanello, via Paradisa 2, 56100 Pisa, Italy.

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http://dx.doi.org/10.1530/eje.1.02086DOI Listing
February 2006

Hepatitis C virus infection and human pancreatic beta-cell dysfunction.

Diabetes Care 2005 Apr;28(4):940-1

Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa and Pisa University Hospital, Via Paradisa 2, 56124 Pisa, Italy.

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http://dx.doi.org/10.2337/diacare.28.4.940DOI Listing
April 2005

Functional and molecular defects of pancreatic islets in human type 2 diabetes.

Diabetes 2005 Mar;54(3):727-35

Department of Endocrinology and Metabolism, Metabolic Unit, Ospedale Cisanello, Via Paradisa 2, 56124 Pisa, Italy.

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http://dx.doi.org/10.2337/diabetes.54.3.727DOI Listing
March 2005

Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.

J Clin Endocrinol Metab 2004 Nov;89(11):5535-41

Department of Endocrinology and Metabolism and Diabetes, Transplant Unit, University of Pisa, Italy.

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http://dx.doi.org/10.1210/jc.2004-0150DOI Listing
November 2004