Publications by authors named "Marcin Pekalski"

29Publications

A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease.

J Autoimmun 2018 12 13;95:1-14. Epub 2018 Nov 13.

JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK; JDRF/Wellcome Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, CB2 OXY, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411183042
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http://dx.doi.org/10.1016/j.jaut.2018.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284106PMC
December 2018

Macropinocytic entry of isolated mitochondria in epidermal growth factor-activated human osteosarcoma cells.

Sci Rep 2017 10 10;7(1):12886. Epub 2017 Oct 10.

MRC Mitochondrial Biology Unit, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.1038/s41598-017-13227-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634993PMC
October 2017

Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial.

Wellcome Open Res 2017 5;2:28. Epub 2017 Oct 5.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus,Cambridge, CB2 0XY, UK.

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https://wellcomeopenresearch.org/articles/2-28/v3
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http://dx.doi.org/10.12688/wellcomeopenres.11300.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531165PMC
October 2017

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

JCI Insight 2017 Aug 17;2(16). Epub 2017 Aug 17.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1172/jci.insight.93739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621870PMC
August 2017

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity.

J Autoimmun 2017 Nov 23;84:75-86. Epub 2017 Jul 23.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust/MRC Building, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Research Campus, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2017.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656572PMC
November 2017

In-depth immunophenotyping data of IL-6R on the human peripheral regulatory T cell (Treg) compartment.

Data Brief 2017 Jun 2;12:676-691. Epub 2017 May 2.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.dib.2017.04.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435581PMC
June 2017

Human IL-6RTIGIT CD4CD127CD25 T cells display potent in vitro suppressive capacity and a distinct Th17 profile.

Clin Immunol 2017 06 9;179:25-39. Epub 2017 Mar 9.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK; JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471606PMC
June 2017

Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study.

BMJ Open 2015 Dec 8;5(12):e009799. Epub 2015 Dec 8.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1136/bmjopen-2015-009799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679899PMC
December 2015

Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing.

Eur J Immunol 2015 Nov 1;45(11):3200-3. Epub 2015 Oct 1.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Research Campus, Cambridge, UK.

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http://dx.doi.org/10.1002/eji.201545646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832369PMC
November 2015

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping.

PLoS Genet 2015 Jun 24;11(6):e1005272. Epub 2015 Jun 24.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1005272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481316PMC
June 2015

Widespread seasonal gene expression reveals annual differences in human immunity and physiology.

Nat Commun 2015 May 12;6:7000. Epub 2015 May 12.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1038/ncomms8000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432600PMC
May 2015

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients.

Diabetologia 2015 Apr 6;58(4):781-90. Epub 2015 Feb 6.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, WT/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0XY, UK,

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http://dx.doi.org/10.1007/s00125-015-3509-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351433PMC
April 2015

Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells.

J Autoimmun 2015 Jan 30;56:66-80. Epub 2014 Oct 30.

JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge CB2 OXY, United Kingdom; Former Roche Site of Pharmaceutical Research and Early Development, Discovery Inflammation, Nutley, NJ 07110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2014.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298360PMC
January 2015

Investigation of soluble and transmembrane CTLA-4 isoforms in serum and microvesicles.

J Immunol 2014 Jul 13;193(2):889-900. Epub 2014 Jun 13.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom; National Institute for Health Research Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge CB2 0QQ, United Kingdom; and

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http://dx.doi.org/10.4049/jimmunol.1303389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082723PMC
July 2014

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.

PLoS Genet 2013 Apr 4;9(4):e1003444. Epub 2013 Apr 4.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1371/journal.pgen.1003444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617094PMC
April 2013

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.

J Immunol 2013 Mar 15;190(6):2554-66. Epub 2013 Feb 15.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1202914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614027PMC
March 2013

Renal allograft rejection: examination of delayed differentiation of Treg and Th17 effector T cells.

Immunobiology 2013 Mar 23;218(3):303-10. Epub 2012 May 23.

Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1016/j.imbio.2012.05.014DOI Listing
March 2013

Reduced expression of IFIH1 is protective for type 1 diabetes.

PLoS One 2010 Sep 9;5(9). Epub 2010 Sep 9.

Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936573PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012646PLOS
September 2010

The human mitochondrial ribosome recycling factor is essential for cell viability.

Nucleic Acids Res 2008 Oct 9;36(18):5787-99. Epub 2008 Sep 9.

Mitochondrial Research Group, Institute of Cellular Medicine, Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1093/nar/gkn576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566884PMC
October 2008

Renal allograft rejection: the contribution of chemokines to the adhesion and retention of alphaE(CD103)beta7 integrin-expressing intratubular T cells.

Mol Immunol 2008 Sep 22;45(15):4000-7. Epub 2008 Jul 22.

Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.molimm.2008.06.011DOI Listing
September 2008

Epithelial-mesenchymal transition contributes to portal tract fibrogenesis during human chronic liver disease.

Lab Invest 2008 Feb 3;88(2):112-23. Epub 2007 Dec 3.

Applied Immunobiology and Transplantation Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1038/labinvest.3700704DOI Listing
February 2008

Effect of culture conditions on the chemosensitivity of ovarian cancer cell lines.

Anticancer Drugs 2006 Sep;17(8):913-9

Translational Oncology Research Centre, Queen Alexandra Hospital, Portsmouth, UK.

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http://dx.doi.org/10.1097/01.cad.0000224445.23953.d9DOI Listing
September 2006