Publications by authors named "Marcin Imielinski"

54Publications

Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers.

Mol Cell 2020 11;80(4):562-577

Pathology and Laboratory Medicine and Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.molcel.2020.10.033DOI Listing
November 2020

Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.

Nature 2020 02 5;578(7793):102-111. Epub 2020 Feb 5.

The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41586-020-1965-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054214PMC
February 2020

Fusion oncogenes-genetic musical chairs.

Science 2018 08;361(6405):848-849

Department of Pathology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aau8231
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http://dx.doi.org/10.1126/science.aau8231DOI Listing
August 2018

Deep Convolutional Neural Networks Enable Discrimination of Heterogeneous Digital Pathology Images.

EBioMedicine 2018 Jan 28;27:317-328. Epub 2017 Dec 28.

Institute for Computational Biomedicine, Weill Cornell Medical College, NY, USA; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medical College, NY, USA; The Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

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http://dx.doi.org/10.1016/j.ebiom.2017.12.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828543PMC
January 2018

Modeling cancer rearrangement landscapes.

Curr Opin Syst Biol 2017 Feb 14;1:54-61. Epub 2016 Dec 14.

New York Genome Center, New York, USA.

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http://dx.doi.org/10.1016/j.coisb.2016.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699513PMC
February 2017

Prostate cancer: Clinical hallmarks in whole cancer genomes.

Nat Rev Clin Oncol 2017 05 4;14(5):265-266. Epub 2017 Apr 4.

The Englander Institute for Precision Medicine, The Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College-New York Presbyterian Hospital, Department of Pathology and Laboratory Medicine, 413 East 69th Street, 14th floor, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nrclinonc.2017.45DOI Listing
May 2017

Insertions and Deletions Target Lineage-Defining Genes in Human Cancers.

Cell 2017 01 12;168(3):460-472.e14. Epub 2017 Jan 12.

Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564321PMC
January 2017

Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers.

Nat Genet 2016 Feb 14;48(2):176-82. Epub 2015 Dec 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4857881PMC
February 2016

Genetic modifiers of EGFR dependence in non-small cell lung cancer.

Proc Natl Acad Sci U S A 2014 Dec 15;111(52):18661-6. Epub 2014 Dec 15.

Broad Institute of Harvard and MIT, Cambridge, MA 02142; Departments of Pathology and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115; and

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http://dx.doi.org/10.1073/pnas.1412228112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284598PMC
December 2014

A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events.

PLoS One 2014 31;9(1):e87361. Epub 2014 Jan 31.

Cancer Program, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America ; Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087361PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909098PMC
October 2014

Signatures of mutational processes in human cancer.

Nature 2013 Aug 14;500(7463):415-21. Epub 2013 Aug 14.

Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

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http://dx.doi.org/10.1038/nature12477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776390PMC
August 2013

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Authors:
Carl A Anderson Gabrielle Boucher Charlie W Lees Andre Franke Mauro D'Amato Kent D Taylor James C Lee Philippe Goyette Marcin Imielinski Anna Latiano Caroline Lagacé Regan Scott Leila Amininejad Suzannah Bumpstead Leonard Baidoo Robert N Baldassano Murray Barclay Theodore M Bayless Stephan Brand Carsten Büning Jean-Frédéric Colombel Lee A Denson Martine De Vos Marla Dubinsky Cathryn Edwards David Ellinghaus Rudolf S N Fehrmann James A B Floyd Timothy Florin Denis Franchimont Lude Franke Michel Georges Jürgen Glas Nicole L Glazer Stephen L Guthery Talin Haritunians Nicholas K Hayward Jean-Pierre Hugot Gilles Jobin Debby Laukens Ian Lawrance Marc Lémann Arie Levine Cecile Libioulle Edouard Louis Dermot P McGovern Monica Milla Grant W Montgomery Katherine I Morley Craig Mowat Aylwin Ng William Newman Roel A Ophoff Laura Papi Orazio Palmieri Laurent Peyrin-Biroulet Julián Panés Anne Phillips Natalie J Prescott Deborah D Proctor Rebecca Roberts Richard Russell Paul Rutgeerts Jeremy Sanderson Miquel Sans Philip Schumm Frank Seibold Yashoda Sharma Lisa A Simms Mark Seielstad A Hillary Steinhart Stephan R Targan Leonard H van den Berg Morten Vatn Hein Verspaget Thomas Walters Cisca Wijmenga David C Wilson Harm-Jan Westra Ramnik J Xavier Zhen Z Zhao Cyriel Y Ponsioen Vibeke Andersen Leif Torkvist Maria Gazouli Nicholas P Anagnou Tom H Karlsen Limas Kupcinskas Jurgita Sventoraityte John C Mansfield Subra Kugathasan Mark S Silverberg Jonas Halfvarson Jerome I Rotter Christopher G Mathew Anne M Griffiths Richard Gearry Tariq Ahmad Steven R Brant Mathias Chamaillard Jack Satsangi Judy H Cho Stefan Schreiber Mark J Daly Jeffrey C Barrett Miles Parkes Vito Annese Hakon Hakonarson Graham Radford-Smith Richard H Duerr Séverine Vermeire Rinse K Weersma John D Rioux

Nat Genet 2011 Mar 6;43(3):246-52. Epub 2011 Feb 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084597PMC
March 2011

Deep epistasis in human metabolism.

Chaos 2010 Jun;20(2):026104

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1063/1.3456056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909311PMC
June 2010

Common variants at five new loci associated with early-onset inflammatory bowel disease.

Authors:
Marcin Imielinski Robert N Baldassano Anne Griffiths Richard K Russell Vito Annese Marla Dubinsky Subra Kugathasan Jonathan P Bradfield Thomas D Walters Patrick Sleiman Cecilia E Kim Aleixo Muise Kai Wang Joseph T Glessner Shehzad Saeed Haitao Zhang Edward C Frackelton Cuiping Hou James H Flory George Otieno Rosetta M Chiavacci Robert Grundmeier Massimo Castro Anna Latiano Bruno Dallapiccola Joanne Stempak Debra J Abrams Kent Taylor Dermot McGovern Gary Silber Iwona Wrobel Antonio Quiros Jeffrey C Barrett Sarah Hansoul Dan L Nicolae Judy H Cho Richard H Duerr John D Rioux Steven R Brant Mark S Silverberg Kent D Taylor M Michael Barmuda Alain Bitton Themistocles Dassopoulos Lisa Wu Datta Todd Green Anne M Griffiths Emily O Kistner Michael T Murtha Miguel D Regueiro Jerome I Rotter L Philip Schumm A Hillary Steinhart Stephen R Targan Ramnik J Xavier Cécile Libioulle Cynthia Sandor Mark Lathrop Jacques Belaiche Olivier Dewit Ivo Gut Simon Heath Debby Laukens Myriam Mni Paul Rutgeerts André Van Gossum Diana Zelenika Denis Franchimont J P Hugot Martine de Vos Severine Vermeire Edouard Louis Lon R Cardon Carl A Anderson Hazel Drummond Elaine Nimmo Tariq Ahmad Natalie J Prescott Clive M Onnie Sheila A Fisher Jonathan Marchini Jilur Ghori Suzannah Bumpstead Rhian Gwillam Mark Tremelling Panos Delukas John Mansfield Derek Jewell Jack Satsangi Christopher G Mathew Miles Parkes Michel Georges Mark J Daly Melvin B Heyman George D Ferry Barbara Kirschner Jessica Lee Jonah Essers Richard Grand Michael Stephens Arie Levine David Piccoli John Van Limbergen Salvatore Cucchiara Dimitri S Monos Stephen L Guthery Lee Denson David C Wilson Straun F A Grant Mark Daly Mark S Silverberg Jack Satsangi Hakon Hakonarson

Nat Genet 2009 Dec 15;41(12):1335-40. Epub 2009 Nov 15.

Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267927PMC
December 2009

Association of the BANK 1 R61H variant with systemic lupus erythematosus in Americans of European and African ancestry.

Appl Clin Genet 2009 9;2:1-5. Epub 2009 Dec 9.

Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA, USA ; Department of Pediatrics and Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA ; Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681036PMC
http://dx.doi.org/10.2147/tacg.s4089DOI Listing
June 2013

Exploiting the pathway structure of metabolism to reveal high-order epistasis.

BMC Syst Biol 2008 Apr 30;2:40. Epub 2008 Apr 30.

Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, USA.

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http://dx.doi.org/10.1186/1752-0509-2-40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2390508PMC
April 2008

Systematic analysis of conservation relations in Escherichia coli genome-scale metabolic network reveals novel growth media.

Biophys J 2006 Apr 3;90(8):2659-72. Epub 2006 Feb 3.

Genomics and Computational Biology Graduate Group, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000634950672450
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http://dx.doi.org/10.1529/biophysj.105.069278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414550PMC
April 2006

Investigating metabolite essentiality through genome-scale analysis of Escherichia coli production capabilities.

Bioinformatics 2005 May 25;21(9):2008-16. Epub 2005 Jan 25.

Genomics and Computational Biology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/bti245DOI Listing
May 2005

Persistent parity-induced changes in growth factors, TGF-beta3, and differentiation in the rodent mammary gland.

Mol Endocrinol 2002 Sep;16(9):2034-51

Departments of Cancer Biology, of Cell and Developmental Biology, and of Medicine, and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6160, USA.

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http://dx.doi.org/10.1210/me.2002-0073DOI Listing
September 2002