Publications by authors named "Marcia Triunfol"

11 Publications

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What's not in the news headlines or titles of Alzheimer disease articles? #InMice.

PLoS Biol 2021 Jun 15;19(6):e3001260. Epub 2021 Jun 15.

Casa de Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil.

There is increasing scrutiny around how science is communicated to the public. For instance, a Twitter account @justsaysinmice (with 70.4K followers in January 2021) was created to call attention to news headlines that omit that mice, not humans, are the ones for whom the study findings apply. This is the case of many headlines reporting on Alzheimer disease (AD) research. AD is characterized by a degeneration of the human brain, loss of cognition, and behavioral changes, for which no treatment is available. Around 200 rodent models have been developed to study AD, even though AD is an exclusively human condition that does not occur naturally in other species and appears impervious to reproduction in artificial animal models, an information not always disclosed. It is not known what prompts writers of news stories to either omit or acknowledge, in the story's headlines, that the study was done in mice and not in humans. Here, we raised the hypothesis that how science is reported by scientists plays a role on the news reporting. To test this hypothesis, we investigated whether an association exists between articles' titles and news' headlines regarding the omission, or not, of mice. To this end, we analyzed a sample of 623 open-access scientific papers indexed in PubMed in 2018 and 2019 that used mice either as models or as the biological source for experimental studies in AD research. We found a significant association (p < 0.01) between articles' titles and news stories' headlines, revealing that when authors omit the species in the paper's title, writers of news stories tend to follow suit. We also found that papers not mentioning mice in their titles are more newsworthy and significantly more tweeted than papers that do. Our study shows that science reporting may affect media reporting and asks for changes in the way we report about findings obtained with animal models used to study human diseases.
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http://dx.doi.org/10.1371/journal.pbio.3001260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8205157PMC
June 2021

Patient-Derived Xenograft vs. Organoids: A Preliminary Analysis of Cancer Research Output, Funding and Human Health Impact in 2014-2019.

Animals (Basel) 2020 Oct 20;10(10). Epub 2020 Oct 20.

Humane Society International, Washington, DC, 20037, USA.

Cancer remains a major threat to mortality and morbidity globally, despite intense research and generous funding. Patient-derived xenograft (PDX) models-where tumor biopsies are injected into an animal-were developed to improve the predictive capacity of preclinical animal models. However, recent observations have called into question the clinical relevance, and therefore the translational accuracy, of these. Patient-derived organoids (PDO) use patient tumor samples to create in vitro models that maintain aspects of tumor structure and heterogeneity. We undertook a preliminary analysis of the number of breast, colorectal, and lung cancer research studies using PDX or PDO published worldwide between 2014-2019. We looked for evidence of impacts of this research on human health. The number of publications that focused on PDO is gradually increasing over time, but is still very low compared to publications using PDX models. Support for new research projects using PDO is gradually increasing, a promising indicator of a shift towards more human-relevant approaches to understanding human disease. Overall, increases in total funding for these three major cancer types does not appear to be translating to any consequential increase in outputs, defined for this purpose as publications associated with clinical trials. With increasing public discomfort in research using animals and demands for 'alternative' methods, it is timely to consider how to implement non-animal methods more effectively.
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http://dx.doi.org/10.3390/ani10101923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593921PMC
October 2020

Human-specific approaches to brain research for the 21st century: a South American perspective.

Drug Discov Today 2018 12 13;23(12):1929-1935. Epub 2018 Jun 13.

Research & Toxicology Department, Humane Society International, Toronto, Canada.

The 21st century paradigm in toxicology, which emphasizes mechanistic understanding and species-relevant modeling of human biology and pathophysiology, is gaining traction in the wider biosciences through a global workshop series organized by the BioMed21 Collaboration. The second of this series, entitled Emerging Technology Toward Pathway-Based Human Brain Research, was held in Brazil in 2017, bringing together leading South American and international scientists, research funders and other stakeholders. The aims were to foster strategic scientific dialogue and identify actionable consensus recommendations as a first step toward a roadmap for 21st century, human-specific health research and funding in the region.
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http://dx.doi.org/10.1016/j.drudis.2018.06.001DOI Listing
December 2018

New data back early hypothesis for infectious microcephaly.

Authors:
Marcia Triunfol

Lancet Infect Dis 2016 09;16(9):1008-1009

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http://dx.doi.org/10.1016/S1473-3099(16)30281-XDOI Listing
September 2016

Microcephaly in Brazil: confidence builds in Zika connection.

Authors:
Marcia Triunfol

Lancet Infect Dis 2016 05 18;16(5):527-528. Epub 2016 Apr 18.

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http://dx.doi.org/10.1016/S1473-3099(16)30015-9DOI Listing
May 2016

Concern over Zika virus grips the world.

Lancet 2016 Feb;387(10018):521-524

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http://dx.doi.org/10.1016/S0140-6736(16)00257-9DOI Listing
February 2016

A new mosquito-borne threat to pregnant women in Brazil.

Authors:
Marcia Triunfol

Lancet Infect Dis 2016 Feb 24;16(2):156-7. Epub 2015 Dec 24.

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http://dx.doi.org/10.1016/S1473-3099(15)00548-4DOI Listing
February 2016

Latin American science moves into the spotlight.

Cell 2007 Dec;131(7):1213-6

PetrĂ³polis, Brazil.

With new incentives, some governments in Latin America are starting to increase investment in basic and applied research. Although the news is encouraging, scientists in this region still face many challenges ahead.
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http://dx.doi.org/10.1016/j.cell.2007.12.008DOI Listing
December 2007

Dynamics of list-server discussion on genetically modified foods.

Public Underst Sci 2004 Apr;13(2):155-75

Associate editor at the American Assocation for the Advancement of Science (AAAS).

Computer-mediated discussion lists, or list-servers, are popular tools in settings ranging from professional to personal to educational. A discussion list on genetically modified food (GMF) was created in September 2000 as part of the Forum on Genetically Modified Food developed by Science Controversies: Online Partnerships in Education (SCOPE), an educational project that uses computer resources to aid research and learning around unresolved scientific questions. The discussion list "GMF-Science" was actively supported from January 2001 to May 2002. The GMF-Science list welcomed anyone interested in discussing the controversies surrounding GMF. Here, we analyze the dynamics of the discussions and how the GMF-Science list may contribute to learning. Activity on the GMF-Science discussion list reflected some but not all the controversies that were appearing in more traditional publication formats, broached other topics not well represented in the published literature, and tended to leave undiscussed the more technical research developments.
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http://dx.doi.org/10.1177/0963662504044110DOI Listing
April 2004
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