Publications by authors named "Marcia C Haigis"

78Publications

The effects of age and systemic metabolism on anti-tumor T cell responses.

Elife 2020 11 10;9. Epub 2020 Nov 10.

Department of Cell Biology, Blavatnik Institute and Ludwig Center at Harvard, Harvard Medical School, Boston, United States.

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http://dx.doi.org/10.7554/eLife.62420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655106PMC
November 2020

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance.

Cell Metab 2020 Sep 6;32(3):391-403.e6. Epub 2020 Aug 6.

Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2020.07.009DOI Listing
September 2020

The human mitochondrial 12S rRNA mC methyltransferase METTL15 is required for mitochondrial function.

J Biol Chem 2020 Jun 5;295(25):8505-8513. Epub 2020 May 5.

Division of Newborn Medicine and Epigenetics Program, Department of Medicine, Boston Children's Hospital, Boston, Massachusetts, USA

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http://dx.doi.org/10.1074/jbc.RA119.012127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307190PMC
June 2020

Nitrogen Metabolism in Cancer and Immunity.

Trends Cell Biol 2020 05 10;30(5):408-424. Epub 2020 Mar 10.

Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA; Ludwig Center, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2020.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386658PMC
May 2020

Sweet Temptation: From Sugar Metabolism to Gene Regulation.

Immunity 2019 12;51(6):980-981

Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.11.008DOI Listing
December 2019

T Cell Activation Depends on Extracellular Alanine.

Cell Rep 2019 09;28(12):3011-3021.e4

Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193107
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http://dx.doi.org/10.1016/j.celrep.2019.08.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934407PMC
September 2019

Chemical and Physiological Features of Mitochondrial Acylation.

Mol Cell 2018 11;72(4):610-624

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Ludwig Center for Cancer Research at Harvard, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183088
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http://dx.doi.org/10.1016/j.molcel.2018.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498146PMC
November 2018

The multifaceted contributions of mitochondria to cellular metabolism.

Nat Cell Biol 2018 07 27;20(7):745-754. Epub 2018 Jun 27.

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41556-018-0124-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541229PMC
July 2018

Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass.

Science 2017 11 12;358(6365):941-946. Epub 2017 Oct 12.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.aam9305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748897PMC
November 2017

An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues.

Sci Rep 2017 09 4;7(1):10304. Epub 2017 Sep 4.

Department of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41598-017-09993-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583358PMC
September 2017

Strength in numbers: Phosphofructokinase polymerization prevails in the liver.

J Cell Biol 2017 08 17;216(8):2239-2241. Epub 2017 Jul 17.

Department of Cell Biology, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.1083/jcb.201706005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551721PMC
August 2017

SIRT4 Is a Regulator of Insulin Secretion.

Cell Chem Biol 2017 Jun;24(6):656-658

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.06.002DOI Listing
June 2017

Mitochondrial Sirtuins and Molecular Mechanisms of Aging.

Trends Mol Med 2017 04 10;23(4):320-331. Epub 2017 Mar 10.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2017.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713479PMC
April 2017

Mitochondria and Cancer.

Cell 2016 Jul;166(3):555-566

Department of Cell Biology, Ludwig Center at Harvard, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036969PMC
July 2016

Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism.

Mol Cells 2015 Sep 18;38(9):750-8. Epub 2015 Sep 18.

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.14348/molcells.2015.0167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588717PMC
September 2015

Sirtuins and the Metabolic Hurdles in Cancer.

Curr Biol 2015 Jun;25(13):R569-83

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2015.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748939PMC
June 2015

Nuclear respiratory factor 2 induces SIRT3 expression.

Aging Cell 2015 Oct 24;14(5):818-25. Epub 2015 Jun 24.

Department of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1111/acel.12360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568969PMC
October 2015

Intersections between mitochondrial sirtuin signaling and tumor cell metabolism.

Crit Rev Biochem Mol Biol 2015 21;50(3):242-55. Epub 2015 Apr 21.

a Department of Cell Biology , Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.3109/10409238.2015.1031879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5889941PMC
April 2016

Mitochondrial metabolism in T cell activation and senescence: a mini-review.

Gerontology 2015 13;61(2):131-8. Epub 2014 Nov 13.

Department of Cell Biology, Harvard Medical School, Boston, Mass., USA.

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http://dx.doi.org/10.1159/000362502DOI Listing
November 2015

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis.

Nat Cell Biol 2014 Oct 21;16(10):992-1003, 1-15. Epub 2014 Sep 21.

1] Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA [2] Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncb3039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369153PMC
October 2014

Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.

Proc Natl Acad Sci U S A 2014 Jul 30;111(28):10299-304. Epub 2014 Jun 30.

Stem Cell Program, Boston Children's Hospital, Boston MA 02115;Harvard Stem Cell Institute, Cambridge, MA 02138;Department of Genetics, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1404399111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104911PMC
July 2014

Luciferase-based reporter to monitor the transcriptional activity of the SIRT3 promoter.

Methods Enzymol 2014 ;543:141-63

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-801329-8.00007-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748892PMC
February 2015

SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma.

J Biol Chem 2014 Feb 24;289(7):4135-44. Epub 2013 Dec 24.

From the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M113.525949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924279PMC
February 2014

The protein deacetylase SIRT3 prevents oxidative stress-induced keratinocyte differentiation.

J Biol Chem 2013 Dec 5;288(51):36484-91. Epub 2013 Nov 5.

From the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M113.472324
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http://dx.doi.org/10.1074/jbc.M113.472324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868761PMC
December 2013

SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation.

Mol Cell Biol 2013 Nov 16;33(22):4552-61. Epub 2013 Sep 16.

Department of Cell Biology, The Paul F. Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/MCB.00087-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838178PMC
November 2013

HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS.

Mol Cancer Res 2013 Sep 30;11(9):1072-7. Epub 2013 May 30.

Molecular Pathology Unit, Center for Cancer Research, and Center for Systems Biology, Massachusetts General Hospital, 149 13 Street, Charlestown, MA 02129.

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0040-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778089PMC
September 2013

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels.

Cell Mol Life Sci 2013 Jun 3;70(11):2015-29. Epub 2013 Jan 3.

Laboratory of Signal-dependent Transcription, Department of Translational Pharmacology DTP, Consorzio Mario Negri Sud, 66030, Santa Maria Imbaro Ch, Italy.

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http://dx.doi.org/10.1007/s00018-012-1244-6DOI Listing
June 2013

From sirtuin biology to human diseases: an update.

J Biol Chem 2012 Dec 18;287(51):42444-52. Epub 2012 Oct 18.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1074/jbc.R112.402768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3522245PMC
December 2012

SIRT3 regulation of mitochondrial oxidative stress.

Exp Gerontol 2013 Jul 31;48(7):634-9. Epub 2012 Aug 31.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.exger.2012.08.007DOI Listing
July 2013

A metabolic prosurvival role for PML in breast cancer.

J Clin Invest 2012 Sep 13;122(9):3088-100. Epub 2012 Aug 13.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Harvard Medical School, and Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA.

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http://dx.doi.org/10.1172/JCI62129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433768PMC
September 2012

Metabolic regulation by SIRT3: implications for tumorigenesis.

Trends Mol Med 2012 Sep 27;18(9):516-23. Epub 2012 Jun 27.

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.molmed.2012.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765807PMC
September 2012

Regulation of RAS oncogenicity by acetylation.

Proc Natl Acad Sci U S A 2012 Jul 18;109(27):10843-8. Epub 2012 Jun 18.

Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1073/pnas.1201487109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390846PMC
July 2012

Short-term calorie restriction enhances skeletal muscle stem cell function.

Cell Stem Cell 2012 May;10(5):515-9

Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, 7 Divinity Avenue, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.stem.2012.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561899PMC
May 2012

Role of sirtuins and calorie restriction in neuroprotection: implications in Alzheimer's and Parkinson's diseases.

Curr Pharm Des 2011 ;17(31):3418-33

The Paul F. Glenn Labs for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.2174/138161211798072526DOI Listing
March 2012

Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.

PLoS One 2011 17;6(8):e23295. Epub 2011 Aug 17.

Department of Pathology, The Paul F. Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023295PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3157345PMC
February 2012

The aging stress response.

Mol Cell 2010 Oct;40(2):333-44

Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987618PMC
October 2010

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.

Trends Biochem Sci 2010 Dec 20;35(12):669-75. Epub 2010 Sep 20.

Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09680004100013
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http://dx.doi.org/10.1016/j.tibs.2010.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992946PMC
December 2010

Mammalian sirtuins: biological insights and disease relevance.

Annu Rev Pathol 2010 ;5:253-95

Glenn Laboratories for the Molecular Biology of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1146/annurev.pathol.4.110807.092250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866163PMC
March 2010

Sirtuins regulate key aspects of lipid metabolism.

Biochim Biophys Acta 2010 Aug 2;1804(8):1652-7. Epub 2009 Dec 2.

Department of Pathology and Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.bbapap.2009.11.021DOI Listing
August 2010

The coordination of nuclear and mitochondrial communication during aging and calorie restriction.

Ageing Res Rev 2009 Jul 27;8(3):173-88. Epub 2009 Mar 27.

The Paul F. Glenn Labs for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.arr.2009.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702504PMC
July 2009

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.

Cell 2009 May;137(3):560-70

Department of Biology, Massachusetts Institute of Technology, Cambridge, 02139, USA.

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http://dx.doi.org/10.1016/j.cell.2009.02.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698666PMC
May 2009

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction.

Genes Dev 2006 Nov;20(21):2913-21

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1467506
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http://dx.doi.org/10.1101/gad.1467506DOI Listing
November 2006

Ribonuclease inhibitor: structure and function.

Prog Nucleic Acid Res Mol Biol 2005 ;80:349-74

Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1016/S0079-6603(05)80009-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811166PMC
January 2006

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria.

Biochem J 2004 Nov;383(Pt. 3):439-46

Center for Neurologic Diseases, Department of Neurology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://biochemj.org/lookup/doi/10.1042/BJ20041081
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http://dx.doi.org/10.1042/BJ20041081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1133736PMC
November 2004

Ribonuclease inhibitor as an intracellular sentry.

Nucleic Acids Res 2003 Feb;31(3):1024-32

Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706-1544, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149185PMC
http://dx.doi.org/10.1093/nar/gkg163DOI Listing
February 2003

Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway.

J Cell Sci 2003 Jan;116(Pt 2):313-24

Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812863PMC
http://dx.doi.org/10.1242/jcs.00214DOI Listing
January 2003

Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein.

Anal Biochem 2002 Jul;306(1):100-7

Department of Biochemistry, University of Wisconsin at Madison, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1006/abio.2002.5678DOI Listing
July 2002

KFERQ sequence in ribonuclease A-mediated cytotoxicity.

J Biol Chem 2002 Mar 18;277(13):11576-81. Epub 2002 Jan 18.

Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1074/jbc.M112227200DOI Listing
March 2002

Translocation of a beta-peptide across cell membranes.

J Am Chem Soc 2002 Jan;124(3):368-9

Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1021/ja017283vDOI Listing
January 2002