Publications by authors named "Marcia Belvin"

52Publications

Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

Authors:
Mark Merchant John Moffat Gabriele Schaefer Jocelyn Chan Xi Wang Christine Orr Jason Cheng Thomas Hunsaker Lily Shao Stephanie J Wang Marie-Claire Wagle Eva Lin Peter M Haverty Sheerin Shahidi-Latham Hai Ngu Margaret Solon Jeffrey Eastham-Anderson Hartmut Koeppen Shih-Min A Huang Jacob Schwarz Marcia Belvin Daniel Kirouac Melissa R Junttila

PLoS One 2018 25;13(1):e0192059. Epub 2018 Jan 25.

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January 2018

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors.

Authors:
Mark Merchant John Moffat Gabriele Schaefer Jocelyn Chan Xi Wang Christine Orr Jason Cheng Thomas Hunsaker Lily Shao Stephanie J Wang Marie-Claire Wagle Eva Lin Peter M Haverty Sheerin Shahidi-Latham Hai Ngu Margaret Solon Jeffrey Eastham-Anderson Hartmut Koeppen Shih-Min A Huang Jacob Schwarz Marcia Belvin Daniel Kirouac Melissa R Junttila

PLoS One 2017 5;12(10):e0185862. Epub 2017 Oct 5.

Department of Translational Oncology, Genentech, Inc., South San Francisco, California, United States of America.

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October 2017

Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.

Authors:
Taner Dogan Florian Gnad Jocelyn Chan Lilian Phu Amy Young Mark J Chen Sophia Doll Matthew P Stokes Marcia Belvin Lori S Friedman Donald S Kirkpatrick Klaus P Hoeflich Georgia Hatzivassiliou

J Biol Chem 2017 09 27;292(35):14311-14324. Epub 2017 Jun 27.

From the Departments of Translational Oncology,

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September 2017

Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice.

Authors:
Janet Lau Jeanne Cheung Armando Navarro Steve Lianoglou Benjamin Haley Klara Totpal Laura Sanders Hartmut Koeppen Patrick Caplazi Jacqueline McBride Henry Chiu Rebecca Hong Jane Grogan Vincent Javinal Robert Yauch Bryan Irving Marcia Belvin Ira Mellman Jeong M Kim Maike Schmidt

Nat Commun 2017 02 21;8:14572. Epub 2017 Feb 21.

Department of Cancer Immunology, Genentech, Inc., South San Francisco, California 94080, USA.

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February 2017

Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable.

Authors:
Yang Xiao Mandy Kwong Anneleen Daemen Marcia Belvin Xiaorong Liang Georgia Hatzivassiliou Thomas O'Brien

PLoS One 2016 6;11(10):e0164166. Epub 2016 Oct 6.

Department of Translational Oncology, Genentech Inc. South San Francisco, California, United States of America.

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June 2017

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.

Authors:
Aaron Boudreau Hans E Purkey Anna Hitz Kirk Robarge David Peterson Sharada Labadie Mandy Kwong Rebecca Hong Min Gao Christopher Del Nagro Raju Pusapati Shuguang Ma Laurent Salphati Jodie Pang Aihe Zhou Tommy Lai Yingjie Li Zhongguo Chen Binqing Wei Ivana Yen Steve Sideris Mark McCleland Ron Firestein Laura Corson Alex Vanderbilt Simon Williams Anneleen Daemen Marcia Belvin Charles Eigenbrot Peter K Jackson Shiva Malek Georgia Hatzivassiliou Deepak Sampath Marie Evangelista Thomas O'Brien

Nat Chem Biol 2016 10 1;12(10):779-86. Epub 2016 Aug 1.

Translational Oncology, Genentech, South San Francisco, California, USA.

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October 2016

Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network.

Authors:
Florian Gnad Jeffrey Wallin Kyle Edgar Sophia Doll David Arnott Liliane Robillard Donald S Kirkpatrick Matthew P Stokes Ulka Vijapurkar Georgia Hatzivassiliou Lori S Friedman Marcia Belvin

Proteomics 2016 07 8;16(14):1992-7. Epub 2016 Jul 8.

Department of Translational Oncology, Genentech Inc, South San Francisco, CA, USA.

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July 2016

Phosphoproteome analysis of the MAPK pathway reveals previously undetected feedback mechanisms.

Authors:
Florian Gnad Sophia Doll Kyung Song Matthew P Stokes John Moffat Bonnie Liu David Arnott Jeffrey Wallin Lori S Friedman Georgia Hatzivassiliou Marcia Belvin

Proteomics 2016 07;16(14):1998-2004

Department of Translational Oncology, Genentech Inc, South San Francisco, CA, USA.

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July 2016

Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.

Authors:
James F Blake Michael Burkard Jocelyn Chan Huifen Chen Kang-Jye Chou Dolores Diaz Danette A Dudley John J Gaudino Stephen E Gould Jonas Grina Thomas Hunsaker Lichuan Liu Matthew Martinson David Moreno Lars Mueller Christine Orr Patricia Pacheco Ann Qin Kevin Rasor Li Ren Kirk Robarge Sheerin Shahidi-Latham Jeffrey Stults Francis Sullivan Weiru Wang Jianping Yin Aihe Zhou Marcia Belvin Mark Merchant John Moffat Jacob B Schwarz

J Med Chem 2016 06 7;59(12):5650-60. Epub 2016 Jun 7.

Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.

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June 2016

MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade.

Authors:
Peter J R Ebert Jeanne Cheung Yagai Yang Erin McNamara Rebecca Hong Marina Moskalenko Stephen E Gould Heather Maecker Bryan A Irving Jeong M Kim Marcia Belvin Ira Mellman

Immunity 2016 Mar 2;44(3):609-621. Epub 2016 Mar 2.

Genentech, 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:

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March 2016

Is all cancer therapy immunotherapy?

Authors:
Marcia Belvin Ira Mellman

Sci Transl Med 2015 Nov;7(315):315fs48

Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.

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November 2015

PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition.

Authors:
Wei Zhou Adrian M Jubb Karen Lyle Qian Xiao Christy C Ong Rupal Desai Ling Fu Florian Gnad Qinghua Song Peter M Haverty Daniela Aust Robert Grützmann Mally Romero Klara Totpal Richard M Neve Yibing Yan William F Forrest Yulei Wang Rajiv Raja Christian Pilarsky Ana de Jesus-Acosta Marcia Belvin Lori S Friedman Mark Merchant Elizabeth M Jaffee Lei Zheng Hartmut Koeppen Klaus P Hoeflich

J Pathol 2014 Dec 6;234(4):502-13. Epub 2014 Oct 6.

Department of Translational Oncology, Genentech, Inc, South San Francisco, CA 94080, USA.

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December 2014

Amphiregulin and PTEN evoke a multimodal mechanism of acquired resistance to PI3K inhibition.

Authors:
Kyle A Edgar Lisa Crocker Eric Cheng Marie-Claire Wagle Matthew Wongchenko Yibing Yan Timothy R Wilson Nicholas Dompe Richard M Neve Marcia Belvin Deepak Sampath Lori S Friedman Jeffrey J Wallin

Genes Cancer 2014 Mar;5(3-4):113-26

Departments of Translational Oncology, South San Francisco, CA, USA.

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March 2014

Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors.

Authors:
Steven T Staben Jianwen A Feng Karen Lyle Marcia Belvin Jason Boggs Jason D Burch Ching-ching Chua Haifeng Cui Antonio G DiPasquale Lori S Friedman Christopher Heise Hartmut Koeppen Adrian Kotey Robert Mintzer Angela Oh David Allen Roberts Lionel Rouge Joachim Rudolph Christine Tam Weiru Wang Yisong Xiao Amy Young Yamin Zhang Klaus P Hoeflich

J Med Chem 2014 Feb 4;57(3):1033-45. Epub 2014 Feb 4.

Department of Discovery Chemistry, ‡Department of Translational Oncology, △Department of Pathology, §Department of Drug Metabolism and Pharmacokinetics, ∥Department of Biochemical and Cellular Pharmacology, and ⊥Department of Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.

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February 2014

Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition.

Authors:
Donald S Kirkpatrick Daisy J Bustos Taner Dogan Jocelyn Chan Lilian Phu Amy Young Lori S Friedman Marcia Belvin Qinghua Song Corey E Bakalarski Klaus P Hoeflich

Proc Natl Acad Sci U S A 2013 Nov 11;110(48):19426-31. Epub 2013 Nov 11.

Departments of Protein Chemistry, Translational Oncology, Nonclinical Biostatistics, and Bioinformatics and Computational Biology, Genentech, Inc., South San Francisco, CA 94080.

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November 2013

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.

Authors:
Georgia Hatzivassiliou Jacob R Haling Huifen Chen Kyung Song Steve Price Robert Heald Joanne F M Hewitt Mark Zak Ariana Peck Christine Orr Mark Merchant Klaus P Hoeflich Jocelyn Chan Shiuh-Ming Luoh Daniel J Anderson Mary J C Ludlam Christian Wiesmann Mark Ultsch Lori S Friedman Shiva Malek Marcia Belvin

Nature 2013 Sep 11;501(7466):232-6. Epub 2013 Aug 11.

Department of Translational Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA.

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September 2013

Systems-wide analysis of K-Ras, Cdc42, and PAK4 signaling by quantitative phosphoproteomics.

Authors:
Florian Gnad Amy Young Wei Zhou Karen Lyle Christy C Ong Matthew P Stokes Jeffrey C Silva Marcia Belvin Lori S Friedman Hartmut Koeppen Audrey Minden Klaus P Hoeflich

Mol Cell Proteomics 2013 Aug 22;12(8):2070-80. Epub 2013 Apr 22.

Department of Bioinformatics and Computational Biology, Genentech, Inc., South San Francisco, California 94080, USA.

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August 2013

Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinase β isoform.

Authors:
Steven T Staben Chudi Ndubaku Nicole Blaquiere Marcia Belvin Richard J Bull Danette Dudley Kyle Edgar Daniel Gray Robert Heald Timothy P Heffron Graham E Jones Mark Jones Aleks Kolesnikov Leslie Lee John Lesnick Cristina Lewis Jeremy Murray Neville J McLean Jim Nonomiya Alan G Olivero Rachel Ord Jodie Pang Stephen Price Wei Wei Prior Lionel Rouge Laurent Salphati Deepak Sampath Jeff Wallin Lan Wang BinQing Wei Christian Weismann Ping Wu

Bioorg Med Chem Lett 2013 May 7;23(9):2606-13. Epub 2013 Mar 7.

Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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May 2013

P21-activated kinase 1 (PAK1) as a therapeutic target in BRAF wild-type melanoma.

Authors:
Christy C Ong Adrian M Jubb Diana Jakubiak Wei Zhou Joachim Rudolph Peter M Haverty Marcin Kowanetz Yibing Yan Jarrod Tremayne Richard Lisle Adrian L Harris Lori S Friedman Marcia Belvin Mark R Middleton Elizabeth M Blackwood Hartmut Koeppen Klaus P Hoeflich

J Natl Cancer Inst 2013 May 27;105(9):606-7. Epub 2013 Mar 27.

Department of Translational Oncology Genentech, MS 50, 1 DNA Way, South San Francisco, CA 94080, USA.

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May 2013

Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349.

Authors:
Zhonghua Pei Elizabeth Blackwood Lichuan Liu Shiva Malek Marcia Belvin Michael F T Koehler Daniel F Ortwine Huifen Chen Frederick Cohen Jane R Kenny Philippe Bergeron Kevin Lau Cuong Ly Xianrui Zhao Anthony A Estrada Tom Truong Jennifer A Epler Jim Nonomiya Lan Trinh Steve Sideris John Lesnick Linda Bao Ulka Vijapurkar Sophie Mukadam Suzanne Tay Gauri Deshmukh Yung-Hsiang Chen Xiao Ding Lori S Friedman Joseph P Lyssikatos

ACS Med Chem Lett 2013 Jan 29;4(1):103-7. Epub 2012 Nov 29.

Departments of Discovery Chemistry, Translational Oncology, DMPK, Biochemical and Cellular Pharmacology, and Pharmaceutics, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.

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January 2013

Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models.

Authors:
Jie Lin Deepak Sampath Michelle A Nannini Brian B Lee Michael Degtyarev Jason Oeh Heidi Savage Zhengyu Guan Rebecca Hong Robert Kassees Leslie B Lee Tyler Risom Stefan Gross Bianca M Liederer Hartmut Koeppen Nicholas J Skelton Jeffrey J Wallin Marcia Belvin Elizabeth Punnoose Lori S Friedman Kui Lin

Clin Cancer Res 2013 Apr 3;19(7):1760-72. Epub 2013 Jan 3.

Genentech, South San Francisco, CA 94080, USA.

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April 2013

An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer.

Authors:
Mark L McCleland Adam S Adler Yonglei Shang Thomas Hunsaker Tom Truong David Peterson Eric Torres Li Li Benjamin Haley Jean-Philippe Stephan Marcia Belvin Georgia Hatzivassiliou Elizabeth M Blackwood Laura Corson Marie Evangelista Jiping Zha Ron Firestein

Cancer Res 2012 Nov 8;72(22):5812-23. Epub 2012 Nov 8.

Departments of Pathology, Genentech, Inc, South San Francisco, California 94080, USA.

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November 2012

PK-PD modeling of combination efficacy effect from administration of the MEK inhibitor GDC-0973 and PI3K inhibitor GDC-0941 in A2058 xenografts.

Authors:
Edna F Choo Chee M Ng Leanne Berry Marcia Belvin Nicholas Lewin-Koh Mark Merchant Laurent Salphati

Cancer Chemother Pharmacol 2013 Jan 7;71(1):133-43. Epub 2012 Oct 7.

Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA 94080, USA.

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January 2013

mTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations.

Authors:
Ulka Vijapurkar Liliane Robillard Siqun Zhou Michael Degtyarev Kui Lin Tom Truong Jarrod Tremayne Leanne Berry Ross Zhonghua Pei Lori S Friedman Elizabeth M Blackwood Marcia Belvin

Cancer Lett 2012 Dec 16;326(2):168-75. Epub 2012 Aug 16.

Department of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, CA 94080, United States.

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December 2012

GDC-0941, a novel class I selective PI3K inhibitor, enhances the efficacy of docetaxel in human breast cancer models by increasing cell death in vitro and in vivo.

Authors:
Jeffrey J Wallin Jane Guan Wei Wei Prior Leslie B Lee Leanne Berry Lisa D Belmont Hartmut Koeppen Marcia Belvin Lori S Friedman Deepak Sampath

Clin Cancer Res 2012 Jul 14;18(14):3901-11. Epub 2012 May 14.

Department of Translational Oncology, Genentech, Inc., San Francisco, CA, USA.

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July 2012

Active PI3K pathway causes an invasive phenotype which can be reversed or promoted by blocking the pathway at divergent nodes.

Authors:
Jeffrey J Wallin Jane Guan Kyle A Edgar Wei Zhou Ross Francis Anthony C Torres Peter M Haverty Jeffrey Eastham-Anderson Sabrina Arena Alberto Bardelli Sue Griffin John E Goodall Kyla M Grimshaw Klaus P Hoeflich Christopher Torrance Marcia Belvin Lori S Friedman

PLoS One 2012 3;7(5):e36402. Epub 2012 May 3.

Department of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California, USA.

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January 2013

Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions.

Authors:
Robert A Heald Philip Jackson Pascal Savy Mark Jones Emanuela Gancia Brenda Burton Richard Newman Jason Boggs Emily Chan Jocelyn Chan Edna Choo Mark Merchant Patrick Rudewicz Mark Ultsch Christian Wiesmann Qin Yue Marcia Belvin Steve Price

J Med Chem 2012 May 3;55(10):4594-604. Epub 2012 May 3.

Argenta, 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, UK.

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May 2012

Bridging the gap between preclinical and clinical studies using pharmacokinetic-pharmacodynamic modeling: an analysis of GDC-0973, a MEK inhibitor.

Authors:
Harvey Wong Laurent Vernillet Amy Peterson Joseph A Ware Lillian Lee Jean-Francois Martini Peiwen Yu Congfen Li Geoffrey Del Rosario Edna F Choo Klaus P Hoeflich Yongchang Shi Blake T Aftab Ron Aoyama Sanh Tan Lam Marcia Belvin John Prescott

Clin Cancer Res 2012 Jun 10;18(11):3090-9. Epub 2012 Apr 10.

Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, MS 412a, South San Francisco, CA 94080, USA.

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June 2012

ERK inhibition overcomes acquired resistance to MEK inhibitors.

Authors:
Georgia Hatzivassiliou Bonnie Liu Carol O'Brien Jill M Spoerke Klaus P Hoeflich Peter M Haverty Robert Soriano William F Forrest Sherry Heldens Huifen Chen Karen Toy Connie Ha Wei Zhou Kyung Song Lori S Friedman Lukas C Amler Garret M Hampton John Moffat Marcia Belvin Mark R Lackner

Mol Cancer Ther 2012 May 8;11(5):1143-54. Epub 2012 Mar 8.

Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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May 2012

Preclinical disposition of GDC-0973 and prospective and retrospective analysis of human dose and efficacy predictions.

Authors:
Edna F Choo Marcia Belvin Jason Boggs Yuzhong Deng Klaus P Hoeflich Justin Ly Mark Merchant Christine Orr Emile Plise Kirk Robarge Jean F Martini Robert Kassees Ron G Aoyama Atulkumar Ramaiya Stuart H Johnston

Drug Metab Dispos 2012 May 7;40(5):919-27. Epub 2012 Feb 7.

Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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May 2012

Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition.

Authors:
Klaus P Hoeflich Mark Merchant Christine Orr Jocelyn Chan Doug Den Otter Leanne Berry Ian Kasman Hartmut Koeppen Ken Rice Nai-Ying Yang Stefan Engst Stuart Johnston Lori S Friedman Marcia Belvin

Cancer Res 2012 Jan 14;72(1):210-9. Epub 2011 Nov 14.

Genentech, Inc and Exelixis, Inc, South San Francisco, California 94080, USA.

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January 2012

GDC-0980 is a novel class I PI3K/mTOR kinase inhibitor with robust activity in cancer models driven by the PI3K pathway.

Authors:
Jeffrey J Wallin Kyle A Edgar Jane Guan Megan Berry Wei Wei Prior Leslie Lee John D Lesnick Cristina Lewis Jim Nonomiya Jodie Pang Laurent Salphati Alan G Olivero Daniel P Sutherlin Carol O'Brien Jill M Spoerke Sonal Patel Letitia Lensun Robert Kassees Leanne Ross Mark R Lackner Deepak Sampath Marcia Belvin Lori S Friedman

Mol Cancer Ther 2011 Dec 13;10(12):2426-36. Epub 2011 Oct 13.

Department of Translational Oncology, Genentech, Inc., South San Francisco, California 94080, USA.

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December 2011

p21-activated kinase 1: PAK'ed with potential.

Authors:
Christy C Ong Adrian M Jubb Wei Zhou Peter M Haverty Adrian L Harris Marcia Belvin Lori S Friedman Hartmut Koeppen Klaus P Hoeflich

Oncotarget 2011 Jun;2(6):491-6

Department of Translational Oncology, Genentech, Inc., South San Francisco, CA 94080, USA.

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June 2011

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.

Authors:
Christy C Ong Adrian M Jubb Peter M Haverty Wei Zhou Victoria Tran Tom Truong Helen Turley Tom O'Brien Domagoj Vucic Adrian L Harris Marcia Belvin Lori S Friedman Elizabeth M Blackwood Hartmut Koeppen Klaus P Hoeflich

Proc Natl Acad Sci U S A 2011 Apr 11;108(17):7177-82. Epub 2011 Apr 11.

Department of Translational Oncology, Genentech, Inc, South San Francisco, CA 94080, USA.

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April 2011

Preclinical disposition and pharmacokinetics-pharmacodynamic modeling of biomarker response and tumour growth inhibition in xenograft mouse models of G-573, a MEK inhibitor.

Authors:
Edna F Choo Marcia Belvin Jocelyn Chan Klaus Hoeflich Christine Orr Kirk Robarge Xiaoye Yang Mark Zak Jason Boggs

Xenobiotica 2010 Nov;40(11):751-62

Department of Drug Metabolism and Pharmacokinetics, South San Francisco, CA 94080, USA.

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November 2010

Nuclear phospho-Akt increase predicts synergy of PI3K inhibition and doxorubicin in breast and ovarian cancer.

Authors:
Jeffrey J Wallin Jane Guan Wei Wei Prior Kyle A Edgar Robert Kassees Deepak Sampath Marcia Belvin Lori S Friedman

Sci Transl Med 2010 Sep;2(48):48ra66

Cancer Signaling, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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September 2010

Pharmacokinetic-pharmacodynamic modeling of tumor growth inhibition and biomarker modulation by the novel phosphatidylinositol 3-kinase inhibitor GDC-0941.

Authors:
Laurent Salphati Harvey Wong Marcia Belvin Delia Bradford Kyle A Edgar Wei Wei Prior Deepak Sampath Jeffrey J Wallin

Drug Metab Dispos 2010 Sep 10;38(9):1436-42. Epub 2010 Jun 10.

Departments of Drug Metabolism and Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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September 2010

Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.

Authors:
Carol O'Brien Jeffrey J Wallin Deepak Sampath Debraj GuhaThakurta Heidi Savage Elizabeth A Punnoose Jane Guan Leanne Berry Wei Wei Prior Lukas C Amler Marcia Belvin Lori S Friedman Mark R Lackner

Clin Cancer Res 2010 Jul 7;16(14):3670-83. Epub 2010 May 7.

Department of Development Oncology Diagnostics, Genentech, Inc., South San Francisco, California 94080, USA.

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July 2010

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

Authors:
Georgia Hatzivassiliou Kyung Song Ivana Yen Barbara J Brandhuber Daniel J Anderson Ryan Alvarado Mary J C Ludlam David Stokoe Susan L Gloor Guy Vigers Tony Morales Ignacio Aliagas Bonnie Liu Steve Sideris Klaus P Hoeflich Bijay S Jaiswal Somasekar Seshagiri Hartmut Koeppen Marcia Belvin Lori S Friedman Shiva Malek

Nature 2010 Mar 3;464(7287):431-5. Epub 2010 Feb 3.

Genentech, South San Francisco, California 94080, USA.

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March 2010

Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors.

Authors:
Kyle A Edgar Jeffrey J Wallin Megan Berry Leslie B Lee Wei Wei Prior Deepak Sampath Lori S Friedman Marcia Belvin

Cancer Res 2010 Feb 26;70(3):1164-72. Epub 2010 Jan 26.

Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California 94080, USA.

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February 2010

In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models.

Authors:
Klaus P Hoeflich Carol O'Brien Zachary Boyd Guy Cavet Steve Guerrero Kenneth Jung Tom Januario Heidi Savage Elizabeth Punnoose Tom Truong Wei Zhou Leanne Berry Lesley Murray Lukas Amler Marcia Belvin Lori S Friedman Mark R Lackner

Clin Cancer Res 2009 Jul 30;15(14):4649-64. Epub 2009 Jun 30.

Translational Oncology, Genentech, Inc., South San Francisco, California 94080, USA.

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July 2009

Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab.

Authors:
Evelyn Yao Wei Zhou Si Tuen Lee-Hoeflich Tom Truong Peter M Haverty Jeffrey Eastham-Anderson Nicholas Lewin-Koh Bert Gunter Marcia Belvin Lesley J Murray Lori S Friedman Mark X Sliwkowski Klaus P Hoeflich

Clin Cancer Res 2009 Jun 9;15(12):4147-56. Epub 2009 Jun 9.

Department of Cancer Signaling, Genentech, Inc, South San Francisco, California, USA.

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June 2009

Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.

Authors:
Klaus P Hoeflich Sylvia Herter Janet Tien Leo Wong Leanne Berry Jocelyn Chan Carol O'Brien Zora Modrusan Somasekar Seshagiri Mark Lackner Howard Stern Edna Choo Lesley Murray Lori S Friedman Marcia Belvin

Cancer Res 2009 Apr 10;69(7):3042-51. Epub 2009 Mar 10.

Department of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California 94080, USA.

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April 2009

Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy.

Authors:
Harvey Wong Marcia Belvin Sylvia Herter Klaus P Hoeflich Lesley J Murray Leo Wong Edna F Choo

J Pharmacol Exp Ther 2009 Apr 15;329(1):360-7. Epub 2009 Jan 15.

Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., San Francisco, CA 94080, USA.

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April 2009

Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors.

Authors:
Marie Gottar Vanessa Gobert Alexey A Matskevich Jean-Marc Reichhart Chengshu Wang Tariq M Butt Marcia Belvin Jules A Hoffmann Dominique Ferrandon

Cell 2006 Dec;127(7):1425-37

UPR 9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, F67084 Strasbourg Cedex, France.

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December 2006

Synthetic lethality of retinoblastoma mutant cells in the Drosophila eye by mutation of a novel peptidyl prolyl isomerase gene.

Authors:
Kyle A Edgar Marcia Belvin Annette L Parks Kellie Whittaker Matt B Mahoney Monique Nicoll Christopher C Park Christopher G Winter Feng Chen Kim Lickteig Ferhad Ahmad Hanife Esengil Matthew V Lorenzi Amanda Norton Brent A Rupnow Laleh Shayesteh Mariano Tabios Lynn M Young Pamela M Carroll Casey Kopczynski Gregory D Plowman Lori S Friedman Helen L Francis-Lang

Genetics 2005 May 2;170(1):161-71. Epub 2005 Mar 2.

Exelixis, South San Francisco, California 94083, USA.

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May 2005

Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome.

Authors:
Annette L Parks Kevin R Cook Marcia Belvin Nicholas A Dompe Robert Fawcett Kari Huppert Lory R Tan Christopher G Winter Kevin P Bogart Jennifer E Deal Megan E Deal-Herr Deanna Grant Marie Marcinko Wesley Y Miyazaki Stephanie Robertson Kenneth J Shaw Mariano Tabios Valentina Vysotskaia Lora Zhao Rachel S Andrade Kyle A Edgar Elizabeth Howie Keith Killpack Brett Milash Amanda Norton Doua Thao Kellie Whittaker Millicent A Winner Lori Friedman Jonathan Margolis Matthew A Singer Casey Kopczynski Daniel Curtis Thomas C Kaufman Gregory D Plowman Geoffrey Duyk Helen L Francis-Lang

Nat Genet 2004 Mar 22;36(3):288-92. Epub 2004 Feb 22.

Exelixis, 170 Harbor Way, South San Francisco, California 94083-0511, USA.

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March 2004

Dual activation of the Drosophila toll pathway by two pattern recognition receptors.

Authors:
Vanessa Gobert Marie Gottar Alexey A Matskevich Sophie Rutschmann Julien Royet Marcia Belvin Jules A Hoffmann Dominique Ferrandon

Science 2003 Dec;302(5653):2126-30

Unité Propre de Recherche 9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, F67084 Strasbourg Cedex, France.

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December 2003

DmMyD88 controls dorsoventral patterning of the Drosophila embryo.

Authors:
Zakaria Kambris Hana Bilak Rosalba D'Alessandro Marcia Belvin Jean-Luc Imler Maria Capovilla

EMBO Rep 2003 Jan;4(1):64-9

Institut de Biologie Moléculaire et Cellulaire, UPR 9022 du CNRS, 15, rue René Descartes, 67084 Strasbourg Cedex, France.

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January 2003

A serpin mutant links Toll activation to melanization in the host defence of Drosophila.

Authors:
Petros Ligoxygakis Nadège Pelte Chuanyi Ji Vincent Leclerc Bernard Duvic Marcia Belvin Haobo Jiang Jules A Hoffmann Jean-Marc Reichhart

EMBO J 2002 Dec;21(23):6330-7

Institut de Biologie Moléculaire and Cellulaire, UPR 9022 du CNRS, 15, rue René Descartes, F-67084 Strasbourg Cedex, France.

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December 2002

The Drosophila immune defense against gram-negative infection requires the death protein dFADD.

Authors:
Silvia Naitza Carine Rossé Christine Kappler Philippe Georgel Marcia Belvin David Gubb Jacques Camonis Jules A Hoffmann Jean Marc Reichhart

Immunity 2002 Nov;17(5):575-81

Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15 Rue René Descartes, 67084 Cedex, Strasbourg, France.

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November 2002

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein.

Authors:
Marie Gottar Vanessa Gobert Tatiana Michel Marcia Belvin Geoffrey Duyk Jules A Hoffmann Dominique Ferrandon Julien Royet

Nature 2002 Apr 24;416(6881):640-4. Epub 2002 Mar 24.

UPR 9022 du Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, F67084 Strasbourg, Cedex, France.

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April 2002