Publications by authors named "Marcia Belvin"

52Publications

Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable.

PLoS One 2016 6;11(10):e0164166. Epub 2016 Oct 6.

Department of Translational Oncology, Genentech Inc. South San Francisco, California, United States of America.

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June 2017

Is all cancer therapy immunotherapy?

Sci Transl Med 2015 Nov;7(315):315fs48

Department of Cancer Immunology, Genentech, South San Francisco, CA 94080, USA.

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November 2015

Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors.

J Med Chem 2014 Feb 4;57(3):1033-45. Epub 2014 Feb 4.

Department of Discovery Chemistry, ‡Department of Translational Oncology, △Department of Pathology, §Department of Drug Metabolism and Pharmacokinetics, ∥Department of Biochemical and Cellular Pharmacology, and ⊥Department of Structural Biology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.

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February 2014

Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition.

Proc Natl Acad Sci U S A 2013 Nov 11;110(48):19426-31. Epub 2013 Nov 11.

Departments of Protein Chemistry, Translational Oncology, Nonclinical Biostatistics, and Bioinformatics and Computational Biology, Genentech, Inc., South San Francisco, CA 94080.

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November 2013

Systems-wide analysis of K-Ras, Cdc42, and PAK4 signaling by quantitative phosphoproteomics.

Mol Cell Proteomics 2013 Aug 22;12(8):2070-80. Epub 2013 Apr 22.

Department of Bioinformatics and Computational Biology, Genentech, Inc., South San Francisco, California 94080, USA.

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August 2013

PK-PD modeling of combination efficacy effect from administration of the MEK inhibitor GDC-0973 and PI3K inhibitor GDC-0941 in A2058 xenografts.

Cancer Chemother Pharmacol 2013 Jan 7;71(1):133-43. Epub 2012 Oct 7.

Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, CA 94080, USA.

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January 2013

mTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations.

Cancer Lett 2012 Dec 16;326(2):168-75. Epub 2012 Aug 16.

Department of Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, CA 94080, United States.

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December 2012

p21-activated kinase 1: PAK'ed with potential.

Oncotarget 2011 Jun;2(6):491-6

Department of Translational Oncology, Genentech, Inc., South San Francisco, CA 94080, USA.

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June 2011

Pharmacokinetic-pharmacodynamic modeling of tumor growth inhibition and biomarker modulation by the novel phosphatidylinositol 3-kinase inhibitor GDC-0941.

Drug Metab Dispos 2010 Sep 10;38(9):1436-42. Epub 2010 Jun 10.

Departments of Drug Metabolism and Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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September 2010

Isoform-specific phosphoinositide 3-kinase inhibitors exert distinct effects in solid tumors.

Cancer Res 2010 Feb 26;70(3):1164-72. Epub 2010 Jan 26.

Cancer Signaling and Translational Oncology, Genentech, Inc., South San Francisco, California 94080, USA.

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February 2010

Dual activation of the Drosophila toll pathway by two pattern recognition receptors.

Science 2003 Dec;302(5653):2126-30

Unité Propre de Recherche 9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, F67084 Strasbourg Cedex, France.

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December 2003

DmMyD88 controls dorsoventral patterning of the Drosophila embryo.

EMBO Rep 2003 Jan;4(1):64-9

Institut de Biologie Moléculaire et Cellulaire, UPR 9022 du CNRS, 15, rue René Descartes, 67084 Strasbourg Cedex, France.

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January 2003

A serpin mutant links Toll activation to melanization in the host defence of Drosophila.

EMBO J 2002 Dec;21(23):6330-7

Institut de Biologie Moléculaire and Cellulaire, UPR 9022 du CNRS, 15, rue René Descartes, F-67084 Strasbourg Cedex, France.

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December 2002

The Drosophila immune defense against gram-negative infection requires the death protein dFADD.

Immunity 2002 Nov;17(5):575-81

Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15 Rue René Descartes, 67084 Cedex, Strasbourg, France.

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November 2002

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein.

Nature 2002 Apr 24;416(6881):640-4. Epub 2002 Mar 24.

UPR 9022 du Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, F67084 Strasbourg, Cedex, France.

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April 2002