Marcel Verbeek

Marcel Verbeek

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Marcel Verbeek

Publications by authors named "Marcel Verbeek"

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Valuing biomarker diagnostics for dementia care: enhancing the reflection of patients, their care-givers and members of the wider public.

Med Health Care Philos 2019 Sep;22(3):439-451

Department of Laboratory Medicine, Radboud University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s11019-018-09883-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710218PMC
September 2019

Aβ43 in human Alzheimer's disease: effects of active Aβ42 immunization.

Acta Neuropathol Commun 2019 Sep 2;7(1):141. Epub 2019 Sep 2.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1186/s40478-019-0791-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717966PMC
September 2019

Cerebrospinal Fluid Galectin-1 Levels Discriminate Patients with Parkinsonism from Controls.

Mol Neurobiol 2019 Jul 21;56(7):5067-5074. Epub 2018 Nov 21.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s12035-018-1426-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647396PMC
July 2019

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.

JAMA Neurol 2019 Jun 17. Epub 2019 Jun 17.

UCL Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1001/jamaneurol.2019.1534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580449PMC
June 2019

α-Synuclein real-time quaking-induced conversion in the cerebrospinal fluid of uncertain cases of parkinsonism.

Ann Neurol 2019 May 25;85(5):777-781. Epub 2019 Mar 25.

The Department of Neurology, Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1002/ana.25447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593725PMC
May 2019

Serum NFL discriminates Parkinson disease from atypical parkinsonisms.

Neurology 2019 Mar 27;92(13):e1479-e1486. Epub 2019 Feb 27.

From the Department of Neurology (T.M.M., A.v.R., H.B.K., R.A.J.E., B.R.B., M.M.V.), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen; Department of Laboratory Medicine (T.M.M., H.B.K., M.M.V.), Radboud University Medical Center, Nijmegen; Parkinson Center Nijmegen (T.M.M., A.v.R., R.A.J.E., B.R.B., M.M.V.), the Netherlands; and Department of Neurology (P.O., M.O.), Ulm University Hospital, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000007179DOI Listing
March 2019

The impact of preanalytical variables on measuring cerebrospinal fluid biomarkers for Alzheimer's disease diagnosis: A review.

Alzheimers Dement 2018 10 23;14(10):1313-1333. Epub 2018 Jun 23.

Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.jalz.2018.05.008DOI Listing
October 2018

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

Authors:
Niklas Mattsson Colin Groot Willemijn J Jansen Susan M Landau Victor L Villemagne Sebastiaan Engelborghs Mark M Mintun Alberto Lleo José Luis Molinuevo William J Jagust Giovanni B Frisoni Adrian Ivanoiu Gaël Chételat Catarina Resende de Oliveira Karen M Rodrigue Johannes Kornhuber Anders Wallin Aleksandra Klimkowicz-Mrowiec Ramesh Kandimalla Julius Popp Pauline P Aalten Dag Aarsland Daniel Alcolea Ina S Almdahl Inês Baldeiras Mark A van Buchem Enrica Cavedo Kewei Chen Ann D Cohen Stefan Förster Juan Fortea Kristian S Frederiksen Yvonne Freund-Levi Kiran Dip Gill Olymbia Gkatzima Timo Grimmer Harald Hampel Sanna-Kaisa Herukka Peter Johannsen Koen van Laere Mony J de Leon Wolfgang Maier Jan Marcusson Olga Meulenbroek Hanne M Møllergård John C Morris Barbara Mroczko Arto Nordlund Sudesh Prabhakar Oliver Peters Lorena Rami Eloy Rodríguez-Rodríguez Catherine M Roe Eckart Rüther Isabel Santana Johannes Schröder Sang W Seo Hilkka Soininen Luiza Spiru Erik Stomrud Hanne Struyfs Charlotte E Teunissen Frans R J Verhey Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Åsa K Wallin Jens Wiltfang Rik Vandenberghe David J Brooks Tormod Fladby Christopher C Rowe Alexander Drzezga Marcel M Verbeek Marie Sarazin David A Wolk Adam S Fleisher William E Klunk Duk L Na Pascual Sánchez-Juan Dong Young Lee Agneta Nordberg Magda Tsolaki Vincent Camus Juha O Rinne Anne M Fagan Henrik Zetterberg Kaj Blennow Gil D Rabinovici Oskar Hansson Bart N M van Berckel Wiesje M van der Flier Philip Scheltens Pieter Jelle Visser Rik Ossenkoppele

Alzheimers Dement 2018 07 28;14(7):913-924. Epub 2018 Mar 28.

Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden; Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.02.009DOI Listing
July 2018

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.

World J Biol Psychiatry 2018 06 27;19(4):244-328. Epub 2017 Oct 27.

a Department of Psychiatry and Psychotherapy , Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg , Erlangen , Germany.

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http://dx.doi.org/10.1080/15622975.2017.1375556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916324PMC
June 2018

Biomarkers in cerebrospinal fluid for synucleinopathies, tauopathies, and other neurodegenerative disorders.

Handb Clin Neurol 2017 ;146:99-113

Department of Neurology, Radboud University Medical Center, and Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, the Netherlands; Parkinson Center Nijmegen, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-804279-3.00007-1DOI Listing
June 2018

Plasma amyloid-β levels, cerebral atrophy and risk of dementia: a population-based study.

Alzheimers Res Ther 2018 06 30;10(1):63. Epub 2018 Jun 30.

Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Office no. 2505, Wytemaweg 80, 3015, CN, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-018-0395-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026500PMC
June 2018

Plasma Amyloid-β Levels, Cerebral Small Vessel Disease, and Cognition: The Rotterdam Study.

J Alzheimers Dis 2017 ;60(3):977-987

Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.3233/JAD-170458DOI Listing
May 2018

Parkinson's Disease Diagnostic Observations (PADDO): study rationale and design of a prospective cohort study for early differentiation of parkinsonism.

BMC Neurol 2018 May 16;18(1):69. Epub 2018 May 16.

Radboud university medical center, Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, P.O.Box 9101, 6500 HB, Nijmegen (935), The Netherlands.

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http://dx.doi.org/10.1186/s12883-018-1072-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954463PMC
May 2018

Plasma Aβ (Amyloid-β) Levels and Severity and Progression of Small Vessel Disease.

Stroke 2018 04 14;49(4):884-890. Epub 2018 Mar 14.

From the Department of Neurology (E.M.C.v.L., H.B.K., I.K., M.I.B., I.W.M.v.U., E.J.v.D., F.-E.d.L., M.M.V.), Department of Laboratory Medicine (H.B.K., I.K., M.M.V.), and Department of Geriatric Medicine (J.A.H.R.C.), Donders Institute for Brain, Cognition and Behaviour, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands; and ADx NeuroSciences, Ghent, Belgium (H.V., E.S.).

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http://dx.doi.org/10.1161/STROKEAHA.117.019810DOI Listing
April 2018

Mutations in Causing a Novel Orthostatic Hypotension Syndrome.

Circ Res 2018 03 17;122(6):846-854. Epub 2018 Jan 17.

From the Department of Cardiology (M.P.v.d.B., P.v.d.H., H.H.W.S., I.M.L.), Laboratory Medicine (M.v.F., I.P.K.), Department of Nephrology (G.N.), Department of Neurology (G.J.L.), and Department of Genetics (P.A.v.d.Z., J.D.H.J.), University Medical Center Groningen, University of Groningen, The Netherlands; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid (R.A.); Division of Clinical Pharmacology, Vanderbilt University, Medical Center, Nashville, TN (I.B.); Department of Internal Medicine, Medical Center Leeuwarden, The Netherlands (M.H.H.); Department of Genetics (A.P.M.d.B.), Centre for Molecular and Biomolecular Informatics (H.V.), and Translational Metabolic Laboratory, Department of Laboratory Medicine (M.M.V., R.A.W.), Radboud University Medical Center Nijmegen, The Netherlands; and Department of Genetics, Academic Medical Center, University of Amsterdam, The Netherlands (J.P.v.T.).

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.117.31194
Publisher Site
http://dx.doi.org/10.1161/CIRCRESAHA.117.311949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924476PMC
March 2018

Tau Rather than TDP-43 Proteins are Potential Cerebrospinal Fluid Biomarkers for Frontotemporal Lobar Degeneration Subtypes: A Pilot Study.

J Alzheimers Dis 2017 ;55(2):585-595

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.3233/JAD-160386DOI Listing
February 2018

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.

Authors:
Willemijn J Jansen Rik Ossenkoppele Betty M Tijms Anne M Fagan Oskar Hansson William E Klunk Wiesje M van der Flier Victor L Villemagne Giovanni B Frisoni Adam S Fleisher Alberto Lleó Mark A Mintun Anders Wallin Sebastiaan Engelborghs Duk L Na Gäel Chételat José Luis Molinuevo Susan M Landau Niklas Mattsson Johannes Kornhuber Osama Sabri Christopher C Rowe Lucilla Parnetti Julius Popp Tormod Fladby William J Jagust Pauline Aalten Dong Young Lee Rik Vandenberghe Catarina Resende de Oliveira Elisabeth Kapaki Lutz Froelich Adrian Ivanoiu Tomasz Gabryelewicz Marcel M Verbeek Páscual Sanchez-Juan Helmut Hildebrandt Vincent Camus Marzena Zboch David J Brooks Alexander Drzezga Juha O Rinne Andrew Newberg Alexandre de Mendonça Marie Sarazin Gil D Rabinovici Karine Madsen Milica G Kramberger Agneta Nordberg Vincent Mok Barbara Mroczko David A Wolk Philipp T Meyer Magda Tsolaki Philip Scheltens Frans R J Verhey Pieter Jelle Visser Dag Aarsland Daniel Alcolea Myriam Alexander Ina S Almdahl Steven E Arnold Inês Baldeiras Henryk Barthel Bart N M van Berckel Kaj Blennow Mark A van Buchem Enrica Cavedo Kewei Chen Elena Chipi Ann D Cohen Stefan Förster Juan Fortea Kristian S Frederiksen Yvonne Freund-Levi Olymbia Gkatzima Mark Forrest Gordon Timo Grimmer Harald Hampel Lucrezia Hausner Sabine Hellwig Sanna-Kaisa Herukka Peter Johannsen Aleksandra Klimkowicz-Mrowiec Sebastian Köhler Norman Koglin Koen van Laere Mony de Leon Viviana Lisetti Wolfgang Maier Jan Marcusson Olga Meulenbroek Hanne M Møllergård John C Morris Arto Nordlund Gerald P Novak George P Paraskevas Gayan Perera Oliver Peters Inez H G B Ramakers Lorena Rami Eloy Rodríguez-Rodríguez Catherine M Roe Uros Rot Eckart Rüther Isabel Santana Johannes Schröder Sang W Seo Hilkka Soininen Luiza Spiru Erik Stomrud Hanne Struyfs Charlotte E Teunissen Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Åsa K Wallin Jens Wiltfang Henrik Zetterberg

JAMA Psychiatry 2018 01;75(1):84-95

Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.3391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786156PMC
January 2018

Multicenter evaluation of neurofilaments in early symptom onset amyotrophic lateral sclerosis.

Neurology 2018 01 6;90(1):e22-e30. Epub 2017 Dec 6.

From the Nuffield Department of Clinical Neurosciences (E.F., E.G., M.R.T.), University of Oxford, UK; Department of Neurology (P.O., P.S., F.V., J.H.W., P.W., A.C.L., M.O.), Ulm University Hospital, Germany; Department of Pathophysiology and Transplantation (F.V., V.S.), Università degli Studi di Milano; Department of Neurology-Stroke Unit and Laboratory of Neuroscience (F.V., C.M., V.S.), IRCCS Istituto Auxologico Italiano, Milan, Italy; Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine (C.B., J.K.), University Hospital and University of Basel, Switzerland; Department of Neurology (P.V.D.) and Laboratory of Molecular Neurobiomarker Research and Laboratory Medicine (K.P.), University Hospitals Leuven; KU Leuven-University of Leuven (P.V.D.); Department of Neurosciences (P.V.D.), VIB-Center for Brain & Disease Research, Leuven, Belgium; Department of Neurology (J.G., P.M., B.S.), Jena University Hospital, Germany; Department of Metabolic Biochemistry (C.J., F.L.) and Neurological Diseases Department (M.d.M.A., F.S.), Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Paris, France; Department of Neurology (S.K., S.P.), Hannover Medical School; Institute for Epidemiology and Medical Biometry (B.M.) Ulm University, Germany; Donders Institute for Brain, Cognition and Behaviour, Department of Neurology (J.R., M.M.V.), and Radboud Alzheimer Center, Department of Laboratory Medicine (M.M.V.), Radboud University Medical Center, Nijmegen, the Netherlands; and Department of Neurodegenerative Disease and Gerontopsychiatry/Neurology (P.W.), Bonn University Hospital, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000004761DOI Listing
January 2018

MicroRNAs in Cerebrospinal Fluid as Potential Biomarkers for Parkinson's Disease and Multiple System Atrophy.

Mol Neurobiol 2017 Dec 14;54(10):7736-7745. Epub 2016 Nov 14.

Department of Neurology, Radboud University Medical Center and Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s12035-016-0253-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684261PMC
December 2017

Regulator of oligodendrocyte maturation, miR-219, a potential biomarker for MS.

J Neuroinflammation 2017 Dec 4;14(1):235. Epub 2017 Dec 4.

Department of Neurology, Donders Institute for Brain Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1186/s12974-017-1006-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716023PMC
December 2017

The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice.

J Neurol Neurosurg Psychiatry 2017 11 26;88(11):982-994. Epub 2017 Aug 26.

Stroke Research Centre, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, UK.

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http://dx.doi.org/10.1136/jnnp-2016-314697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740546PMC
November 2017

Animal models of cerebral amyloid angiopathy.

Clin Sci (Lond) 2017 Oct 28;131(19):2469-2488. Epub 2017 Sep 28.

Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Departments of Neurology and Laboratory Medicine, Radboud Alzheimer Centre, Nijmegen, The Netherlands

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http://dx.doi.org/10.1042/CS20170033DOI Listing
October 2017

Serum S100B: A proxy marker for grey and white matter status in the absence and presence of (increased risk of) psychotic disorder?

PLoS One 2017 30;12(3):e0174752. Epub 2017 Mar 30.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, EURON, Maastricht University Medical Centre, Maastricht, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174752PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373815PMC
August 2017

Limitations of the hCMEC/D3 cell line as a model for Aβ clearance by the human blood-brain barrier.

J Neurosci Res 2017 07 11;95(7):1513-1522. Epub 2016 Oct 11.

Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Departments of Neurology and Laboratory Medicine, Radboud Alzheimer Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1002/jnr.23964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484315PMC
July 2017

Upstream SLC2A1 translation initiation causes GLUT1 deficiency syndrome.

Eur J Hum Genet 2017 06 5;25(6):771-774. Epub 2017 Apr 5.

Department of Human Genetics, Donders Centre for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1038/ejhg.2017.45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477372PMC
June 2017

β-Amyloid in CSF: Biomarker for preclinical cerebral amyloid angiopathy.

Neurology 2017 Jan 30;88(2):169-176. Epub 2016 Nov 30.

From the Departments of Neurology (E.S.v.E., R.Z., J.H., M.J.H.W., G.M.T.), Radiology (J.v.d.G., S.v.R., A.M.v.O., M.A.v.B.), and Biostatistics (E.W.v.Z.), Leiden University Medical Center; Departments of Neurology and Laboratory Medicine (M.M.V.), Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen; Department of Neurology (J.H.), Alrijne Hospital, Leiderdorp, the Netherlands; and J. Philip Kistler Stroke Research Center (S.M.G.), Massachusetts General Hospital, Boston.

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http://dx.doi.org/10.1212/WNL.0000000000003486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224714PMC
January 2017

Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders.

J Neurochem 2016 10 10;139 Suppl 1:290-317. Epub 2016 Feb 10.

Program in Neuroscience and Division of Neurology, The Ottawa Hospital, University of Ottawa Brain & Mind Research Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1111/jnc.13390DOI Listing
October 2016

The utility of α-synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature.

Biomark Med 2016 28;10(1):19-34. Epub 2015 Aug 28.

Paracelsus-Elena-Klinik, Kassel & University Medical Center (Departments of Neuropathology & Neurosurgery), Georg-August University Goettingen, Germany.

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http://dx.doi.org/10.2217/BMM.14.105DOI Listing
September 2016

MicroRNA-29a Is a Candidate Biomarker for Alzheimer's Disease in Cell-Free Cerebrospinal Fluid.

Mol Neurobiol 2016 07 21;53(5):2894-2899. Epub 2015 Apr 21.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s12035-015-9156-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902829PMC
July 2016

Cerebrospinal Fluid NrCAM is not a Suitable Biomarker to Discriminate between Dementia Disorders--A Pilot Study.

J Alzheimers Dis 2015 ;46(3):605-9

Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.3233/JAD-142901DOI Listing
June 2016

CSF d-serine concentrations are similar in Alzheimer's disease, other dementias, and elderly controls.

Neurobiol Aging 2016 06 23;42:213-6. Epub 2016 Mar 23.

Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Departments of Neurology and Laboratory Medicine, Radboud Alzheimer Centre, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.03.017DOI Listing
June 2016

Hourly analysis of cerebrospinal fluid glucose shows large diurnal fluctuations.

J Cereb Blood Flow Metab 2016 05 4;36(5):899-902. Epub 2016 Mar 4.

Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1177/0271678X16637612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853846PMC
May 2016

Validation of microRNAs in Cerebrospinal Fluid as Biomarkers for Different Forms of Dementia in a Multicenter Study.

J Alzheimers Dis 2016 04;52(4):1321-33

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.3233/JAD-160038DOI Listing
April 2016

Amyloid-β oligomers relate to cognitive decline in Alzheimer's disease.

J Alzheimers Dis 2015 ;45(1):35-43

Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.3233/JAD-142136DOI Listing
February 2016

A multifunctional ELISA to measure proteins: oxPin1 in Alzheimer's brain as an example.

BBA Clin 2015 Dec 30;4:1-6. Epub 2015 Apr 30.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, The Netherlands ; Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, The Netherlands.

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http://dx.doi.org/10.1016/j.bbacli.2015.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661596PMC
December 2015

Dickkopf-related protein 3 is a potential Aβ-associated protein in Alzheimer's Disease.

J Neurochem 2015 Sep 16;134(6):1152-62. Epub 2015 Jul 16.

Department of Neurology, Department of Laboratory Medicine, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/jnc.13216DOI Listing
September 2015

Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.

Neurobiol Dis 2015 Aug 15;80:29-41. Epub 2015 May 15.

Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.05.004DOI Listing
August 2015

Conventional 3T brain MRI and diffusion tensor imaging in the diagnostic workup of early stage parkinsonism.

Neuroradiology 2015 Jul 7;57(7):655-69. Epub 2015 Apr 7.

Department of Radiology and Nuclear Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein 10, Postbus 9101, 6500 HB, Nijmegen, The Netherlands,

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http://dx.doi.org/10.1007/s00234-015-1515-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495265PMC
July 2015

Has CXCL13 an added value in diagnosis of neurosyphilis?

J Clin Microbiol 2015 May 18;53(5):1693-6. Epub 2015 Mar 18.

Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1128/JCM.02917-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400737PMC
May 2015

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.

Authors:
Willemijn J Jansen Rik Ossenkoppele Dirk L Knol Betty M Tijms Philip Scheltens Frans R J Verhey Pieter Jelle Visser Pauline Aalten Dag Aarsland Daniel Alcolea Myriam Alexander Ina S Almdahl Steven E Arnold Inês Baldeiras Henryk Barthel Bart N M van Berckel Kristen Bibeau Kaj Blennow David J Brooks Mark A van Buchem Vincent Camus Enrica Cavedo Kewei Chen Gael Chetelat Ann D Cohen Alexander Drzezga Sebastiaan Engelborghs Anne M Fagan Tormod Fladby Adam S Fleisher Wiesje M van der Flier Lisa Ford Stefan Förster Juan Fortea Nadia Foskett Kristian S Frederiksen Yvonne Freund-Levi Giovanni B Frisoni Lutz Froelich Tomasz Gabryelewicz Kiran Dip Gill Olymbia Gkatzima Estrella Gómez-Tortosa Mark Forrest Gordon Timo Grimmer Harald Hampel Lucrezia Hausner Sabine Hellwig Sanna-Kaisa Herukka Helmut Hildebrandt Lianna Ishihara Adrian Ivanoiu William J Jagust Peter Johannsen Ramesh Kandimalla Elisabeth Kapaki Aleksandra Klimkowicz-Mrowiec William E Klunk Sebastian Köhler Norman Koglin Johannes Kornhuber Milica G Kramberger Koen Van Laere Susan M Landau Dong Young Lee Mony de Leon Viviana Lisetti Alberto Lleó Karine Madsen Wolfgang Maier Jan Marcusson Niklas Mattsson Alexandre de Mendonça Olga Meulenbroek Philipp T Meyer Mark A Mintun Vincent Mok José Luis Molinuevo Hanne M Møllergård John C Morris Barbara Mroczko Stefan Van der Mussele Duk L Na Andrew Newberg Agneta Nordberg Arto Nordlund Gerald P Novak George P Paraskevas Lucilla Parnetti Gayan Perera Oliver Peters Julius Popp Sudesh Prabhakar Gil D Rabinovici Inez H G B Ramakers Lorena Rami Catarina Resende de Oliveira Juha O Rinne Karen M Rodrigue Eloy Rodríguez-Rodríguez Catherine M Roe Uros Rot Christopher C Rowe Eckart Rüther Osama Sabri Páscual Sanchez-Juan Isabel Santana Marie Sarazin Johannes Schröder Christin Schütte Sang W Seo Femke Soetewey Hilkka Soininen Luiza Spiru Hanne Struyfs Charlotte E Teunissen Magda Tsolaki Rik Vandenberghe Marcel M Verbeek Victor L Villemagne Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Anders Wallin Åsa K Wallin Jens Wiltfang David A Wolk Marzena Zboch Henrik Zetterberg

JAMA 2015 May;313(19):1924-38

Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden87UCL Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1001/jama.2015.4668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486209PMC
May 2015

CSF Neurofilament Light Chain but not FLT3 Ligand Discriminates Parkinsonian Disorders.

Front Neurol 2015 5;6:91. Epub 2015 May 5.

Department of Neurology and Parkinson Center, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre , Nijmegen , Netherlands ; Department of Laboratory Medicine, Radboud University Medical Centre , Nijmegen , Netherlands ; Parkinson Center , Nijmegen , Netherlands.

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http://dx.doi.org/10.3389/fneur.2015.00091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419719PMC
May 2015

Total glutamine synthetase levels in cerebrospinal fluid of Alzheimer's disease patients are unchanged.

Neurobiol Aging 2015 Mar 12;36(3):1271-3. Epub 2014 Dec 12.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.12.010DOI Listing
March 2015

Serum angiogenin levels are elevated in ALS, but not Parkinson's disease.

J Neurol Neurosurg Psychiatry 2014 Dec 29;85(12):1439-40. Epub 2014 May 29.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2013-307168DOI Listing
December 2014

Cerebral level of vGlut1 is increased and level of glycine is decreased in TgSwDI mice.

J Alzheimers Dis 2014 ;39(1):89-101

Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud university medical center, Nijmegen, The Netherlands Department of Laboratory Medicine, Laboratory of Genetic, Endocrine and Metabolic Diseases, Radboud university medical center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.3233/JAD-130437DOI Listing
September 2014

Replicated evidence of absence of association between serum S100B and (risk of) psychotic disorder.

PLoS One 2013 17;8(12):e82535. Epub 2013 Dec 17.

Departments of Psychiatry and Neuroscience, Erasmus Medical Centre, Rotterdam, The Netherlands ; Department "Nieuwe Kennis", Delta Centre for Mental Health Care, Rotterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082535PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866164PMC
September 2014

Effect of 1 night of total sleep deprivation on cerebrospinal fluid β-amyloid 42 in healthy middle-aged men: a randomized clinical trial.

JAMA Neurol 2014 Aug;71(8):971-7

Donders Institute for Brain, Cognition, and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands2Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands3Department of Geriatric Medicine, Radboud University.

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http://dx.doi.org/10.1001/jamaneurol.2014.1173DOI Listing
August 2014

Saffold cardiovirus and multiple sclerosis: no evidence for an association.

Ann Clin Transl Neurol 2014 Aug 23;1(8):618-21. Epub 2014 Jul 23.

Department of Medical Microbiology, Radboud University Medical Centre 6500 HB, Nijmegen, The Netherlands ; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/acn3.82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184563PMC
August 2014

Addition of MHPG to Alzheimer's disease biomarkers improves differentiation of dementia with Lewy bodies from Alzheimer's disease but not other dementias.

Alzheimers Dement 2014 Jul 13;10(4):448-455.e2. Epub 2013 Nov 13.

Department of Neurology, Radboud University Medical Centre, and Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands; Radboud Alzheimer Centre, Nijmegen, The Netherlands; Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2013.05.1775DOI Listing
July 2014

Aromatic L-Amino acid decarboxylase deficiency: A new case from Turkey with a novel mutation.

Ann Indian Acad Neurol 2014 Apr;17(2):234-6

Department of Neurology and Laboratory Medicine, Alzheimer Center Nijmegen, Nijmegen, Netherlands.

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http://dx.doi.org/10.4103/0972-2327.132652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090859PMC
April 2014

MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid.

Neurobiol Aging 2014 Jan 17;35(1):152-8. Epub 2013 Aug 17.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Centre, Nijmegen, the Netherlands; Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.07.005DOI Listing
January 2014

CSF levels of DJ-1 and tau distinguish MSA patients from PD patients and controls.

Parkinsonism Relat Disord 2014 Jan 12;20(1):112-5. Epub 2013 Sep 12.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands; Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13538020130031
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http://dx.doi.org/10.1016/j.parkreldis.2013.09.003DOI Listing
January 2014

Alzheimer biomarkers and clinical Alzheimer disease were not associated with increased cerebrovascular disease in a memory clinic population.

Curr Alzheimer Res 2014 Jan;11(1):40-6

Radboud university Medical Center, 925, Dept. Geriatric Medicine, P.O.Box 9101, 6500 HB Nijmegen, The Netherlands.

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January 2014

The diagnostic value of CSF amyloid-β(43) in differentiation of dementia syndromes.

Curr Alzheimer Res 2013 Dec;10(10):1034-40

Department of Neurology, 830 LGEM, Radboud University Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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December 2013

Child neurology: differential diagnosis of a low CSF glucose in children and young adults.

Neurology 2013 Dec;81(24):e178-81

From the Department of Neurology (W.G.L., B.G.E., M.M.V.) and Department of Pediatric Neurology (M.A.W.), Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands; Department of Pediatrics (C.J.d.W.), Genetics (E.J.K.), and Laboratory Medicine (M.M.V., R.A.W.), Radboud University Medical Centre, Nijmegen, the Netherlands; and Department of Pediatrics and Pediatric Neurology (J.K.), Children's Hospital, Aschaffenburg, Germany.

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http://dx.doi.org/10.1212/01.wnl.0000437294.20817.99DOI Listing
December 2013

Cerebrospinal fluid analysis in the workup of GLUT1 deficiency syndrome: a systematic review.

JAMA Neurol 2013 Nov;70(11):1440-4

Department of Neurology, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1001/jamaneurol.2013.3090DOI Listing
November 2013

Serum neuron-specific enolase levels from the same patients differ between laboratories: assessment of a prospective post-cardiac arrest cohort.

Neurocrit Care 2013 Oct;19(2):161-6

Stanford Neurocritical Care Program, Stanford Stroke Center, Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, CA, USA.

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http://dx.doi.org/10.1007/s12028-013-9867-5DOI Listing
October 2013

Movement disorders in GLUT1 deficiency syndrome respond to the modified Atkins diet.

Mov Disord 2013 Sep 25;28(10):1439-42. Epub 2013 Jun 25.

Department of Neurology, Radboud University Medical Centre, Donders Institute for Brain, Cognition, and Behaviour, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1002/mds.25515DOI Listing
September 2013

Identification of coronin-1a as a novel antibody target for clinically isolated syndrome and multiple sclerosis.

J Neurochem 2013 Aug 1;126(4):483-92. Epub 2013 Jul 1.

Hasselt University, Biomedical Research Institute (BIOMED) and transnationale Universiteit Limburg, School of Life Sciences, Diepenbeek, Belgium.

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http://dx.doi.org/10.1111/jnc.12335DOI Listing
August 2013

A prediction model to calculate probability of Alzheimer's disease using cerebrospinal fluid biomarkers.

Alzheimers Dement 2013 May 2;9(3):262-8. Epub 2012 Nov 2.

Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.jalz.2012.01.010DOI Listing
May 2013

Autoantibodies to cytosolic 5'-nucleotidase 1A in inclusion body myositis.

Ann Neurol 2013 Mar 4;73(3):397-407. Epub 2013 Mar 4.

Department of Biomolecular Chemistry, Institute for Molecules and Materials and Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1002/ana.23822DOI Listing
March 2013

Amyloid-β oligomer detection by ELISA in cerebrospinal fluid and brain tissue.

Anal Biochem 2013 Feb 26;433(2):112-20. Epub 2012 Sep 26.

Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.ab.2012.09.014DOI Listing
February 2013

The paradox of hyperdopaminuria in aromatic L-amino Acid deficiency explained.

JIMD Rep 2012 2;4:39-45. Epub 2011 Nov 2.

Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Centre for Brain, Cognition and Behaviour, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/8904_2011_84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520506PMC
February 2013

Reciprocal interactions between sleep, circadian rhythms and Alzheimer's disease: focus on the role of hypocretin and melatonin.

Ageing Res Rev 2013 Jan 30;12(1):188-200. Epub 2012 Apr 30.

Radboud University Nijmegen Medical Centre, Department of Geriatric Medicine, The Netherlands.

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http://dx.doi.org/10.1016/j.arr.2012.04.003DOI Listing
January 2013

Cerebrospinal fluid glucose and lactate: age-specific reference values and implications for clinical practice.

PLoS One 2012 6;7(8):e42745. Epub 2012 Aug 6.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042745PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412827PMC
January 2013

Association between hypocretin-1 and amyloid-β42 cerebrospinal fluid levels in Alzheimer's disease and healthy controls.

Curr Alzheimer Res 2012 Dec;9(10):1119-25

Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, 925, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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December 2012

Novel cerebrospinal fluid and serum autoantibody targets for clinically isolated syndrome.

J Neurochem 2012 Nov 28;123(4):568-77. Epub 2012 Sep 28.

Hasselt University, Biomedical Research Institute (BIOMED) and transnationale Universiteit Limburg, School of Life Sciences, Diepenbeek, Belgium.

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http://dx.doi.org/10.1111/jnc.12005DOI Listing
November 2012

TDP-43 plasma levels are higher in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler 2012 Sep 8;13(5):446-51. Epub 2012 Aug 8.

Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.3109/17482968.2012.703208DOI Listing
September 2012

Optimisation of the quantification of glutamine synthetase and myelin basic protein in cerebrospinal fluid by a combined acidification and neutralisation protocol.

J Immunol Methods 2012 Jul 19;381(1-2):1-8. Epub 2012 Apr 19.

Radboud University Nijmegen Medical Centre, Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Nijmegen, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S002217591200104
Publisher Site
http://dx.doi.org/10.1016/j.jim.2012.04.001DOI Listing
July 2012

Serum GFAP levels in optic neuropathies.

J Neurol Sci 2012 Jun 10;317(1-2):117-22. Epub 2012 Mar 10.

Moorfields Eye Hospital, London, United Kingdom.

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http://dx.doi.org/10.1016/j.jns.2012.02.012DOI Listing
June 2012

Reviewing reasons for the decreased CSF Abeta42 concentration in Alzheimer disease.

Front Biosci (Landmark Ed) 2012 Jun 1;17:2024-34. Epub 2012 Jun 1.

Department of Geriatric Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

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June 2012