Publications by authors named "Marcel Smid"

100Publications

Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer.

Sci Rep 2020 12 18;10(1):22292. Epub 2020 Dec 18.

Department of Neurology, Laboratory of Neuro-Oncology Clinical and Cancer Proteomics, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.

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December 2020

Intratumoral heterogeneity of second-harmonic generation scattering from tumor collagen and its effects on metastatic risk prediction.

BMC Cancer 2020 Dec 10;20(1):1217. Epub 2020 Dec 10.

Department of Biomedical Engineering, Hajim School of Engineering and Applied Sciences, University of Rochester, Rochester, New York, USA.

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December 2020

A tale on rabbit ears and pan-handles, the rings that rule all.

EBioMedicine 2019 Nov 29;49:17-18. Epub 2019 Oct 29.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands. Electronic address:

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November 2019

Clonality, Antigen Recognition, and Suppression of CD8 T Cells Differentially Affect Prognosis of Breast Cancer Subtypes.

Clin Cancer Res 2020 01 24;26(2):505-517. Epub 2019 Oct 24.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.

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January 2020

Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression.

Breast Cancer Res 2019 09 18;21(1):109. Epub 2019 Sep 18.

Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.

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September 2019

An increased cell cycle gene network determines MEK and Akt inhibitor double resistance in triple-negative breast cancer.

Sci Rep 2019 09 16;9(1):13308. Epub 2019 Sep 16.

Division of Drug Discovery and Safety, Leiden Academic Center for Drug Research, Leiden University, PO box 9502, 2300, RA, Leiden, The Netherlands.

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September 2019

Downregulation of matrix Gla protein is a biomarker for tamoxifen-resistant and radioresistant breast cancer.

Biomark Med 2019 07 18;13(10):841-850. Epub 2019 Jul 18.

Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.

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July 2019

A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy.

Breast Cancer Res 2019 07 1;21(1):77. Epub 2019 Jul 1.

Department of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, 2300 RA, Leiden, The Netherlands.

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July 2019

MicroRNAs as possible indicators of drug sensitivity in breast cancer cell lines.

PLoS One 2019 7;14(5):e0216400. Epub 2019 May 7.

Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

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January 2020

Co-regulated gene expression of splicing factors as drivers of cancer progression.

Sci Rep 2019 04 2;9(1):5484. Epub 2019 Apr 2.

Division of Drug Discovery and Safety, LACDR, Leiden University, Leiden, The Netherlands.

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April 2019

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

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February 2019

Mitochondrial RNA Expression and Single Nucleotide Variants in Association with Clinical Parameters in Primary Breast Cancers.

Cancers (Basel) 2018 Dec 9;10(12). Epub 2018 Dec 9.

Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.

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December 2018

Wnt targets genes are not differentially expressed in desmoid tumors bearing different activating β-catenin mutations.

Eur J Surg Oncol 2019 04 18;45(4):691-698. Epub 2018 Oct 18.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus Medical Center Rotterdam, the Netherlands. Electronic address:

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April 2019

Interferon-Stimulated Genes Are Involved in Cross-resistance to Radiotherapy in Tamoxifen-Resistant Breast Cancer.

Clin Cancer Res 2018 07 16;24(14):3397-3408. Epub 2018 Apr 16.

Department of Radiation Oncology, Radiotherapy and OncoImmunology Laboratory, Radboud university medical center, Nijmegen, the Netherlands.

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July 2018

Identification of microRNA biomarkers for response of advanced soft tissue sarcomas to eribulin: Translational results of the EORTC 62052 trial.

Eur J Cancer 2017 04 16;75:33-40. Epub 2017 Feb 16.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium; Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.

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April 2017

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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June 2016

Mitochondrial DNA content in breast cancer: Impact on in vitro and in vivo phenotype and patient prognosis.

Oncotarget 2016 May;7(20):29166-76

Department of Medical Oncology and Cancer Genomics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

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May 2016

The advantage of laser-capture microdissection over whole tissue analysis in proteomic profiling studies.

Proteomics 2016 05 28;16(10):1474-85. Epub 2016 Apr 28.

Department of Medical Oncology, Erasmus University Medical Center - Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

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May 2016

Global proteomic characterization of microdissected estrogen receptor positive breast tumors.

Data Brief 2015 Dec 8;5:399-402. Epub 2015 Oct 8.

Department of Medical Oncology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.

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December 2015

Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines.

BMC Cancer 2016 Jan 22;16:34. Epub 2016 Jan 22.

Faculty of Health and Medical Sciences, Department of Veterinary Disease Biology, Section for Molecular Disease Biology and Sino-Danish Breast Cancer Research Centre, University of Copenhagen, Strandboulevarden 49, DK-2100, Copenhagen, Denmark.

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January 2016

PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients.

Acta Neuropathol Commun 2015 Dec 23;3:88. Epub 2015 Dec 23.

Department of Neurology, Erasmus MC, Room Be 430A, POBox 2040, 3000 CA, Rotterdam, The Netherlands.

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December 2015

An International Ki67 Reproducibility Study in Adrenal Cortical Carcinoma.

Am J Surg Pathol 2016 Apr;40(4):569-76

Departments of *Pathology ∥Bioinformatics ¶¶¶Medical Oncology ∥∥∥Internal Medicine, Division of Endocrinology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam ††Laboratory for Pathology, PAL Dordrecht, Dordrecht ###Department of Pathology, Reinier de Graaf Hospital, Delft ****Department of Pathology, University Medical Center Utrecht, Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands †Department of Histopathology, King's College Hospital, London ***Department of Pathology, University Hospitals Birmingham, Birmingham †††Department of Histopathology, Royal Hallamshire Hospital, Sheffield, UK ‡Department of Clinical and Molecular Medicine, Pathology Unit, Sant' Andrea Hospital, Sapienza University, Rome ¶Department of Oncology, University of Turin at San Luigi Hospital, Orbassano, Italy §Department of Pathology, Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI #Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI **Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine ‡‡Department of Pathology, Massachusetts General Hospital, Boston, MA §§Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN ∥∥Department of Pathology, University Health Network, University of Toronto, Toronto, ON, Canada ¶¶Department of Anatomical Pathology, Royal North Shore Hospital and University of Sydney, Sydney, NSW, Australia ##Department of Pathology and Molecular Genetics and Research Laboratory, Hospital Universitari Arnau de Vilanova, IRBLLEIDA, University of Lleida, Lleida, Spain ‡‡‡INSERM U1016 CNRS UMR8104, Institut Cochin, Paris Descartes University, Sorbonne Paris Cité §§§Department of Pathology, Pitié-Salpetrière Hospital, APHP, Pierre and Marie Curie Univers

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April 2016

Understanding drugs in breast cancer through drug sensitivity screening.

Springerplus 2015 15;4:611. Epub 2015 Oct 15.

Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center, Postbus 2040, 's-Gravendijkwal 230, 3000 CA Rotterdam, The Netherlands.

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November 2015

4-protein signature predicting tamoxifen treatment outcome in recurrent breast cancer.

Mol Oncol 2016 Jan 7;10(1):24-39. Epub 2015 Aug 7.

Department of Medical Oncology, Erasmus MC Cancer Institute, University Medical Center, Wytemaweg 80, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. Electronic address:

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January 2016

Predicting paclitaxel-induced neutropenia using the DMET platform.

Pharmacogenomics 2015 12;16(11):1231-41. Epub 2015 Aug 12.

Department of Clinical Chemistry, Erasmus University Medical Center, s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.

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June 2016

Vascular pattern analysis for the prediction of clinical behaviour in pheochromocytomas and paragangliomas.

PLoS One 2015 20;10(3):e0121361. Epub 2015 Mar 20.

Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, F-75006 Paris, France; INSERM, UMR970, Paris Cardiovascular Research Center, F-75015 Paris, France.

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February 2016

DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells.

Breast Cancer Res Treat 2015 Feb 8;149(3):693-703. Epub 2015 Feb 8.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands,

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February 2015

mRNA expression profiles in circulating tumor cells of metastatic colorectal cancer patients.

Mol Oncol 2015 Apr 21;9(4):920-32. Epub 2015 Jan 21.

Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands. Electronic address:

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April 2015

Prognostic relevance of acquired uniparental disomy in serous ovarian cancer.

Mol Cancer 2015 Feb 3;14:29. Epub 2015 Feb 3.

Departments of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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February 2015

Response.

J Natl Cancer Inst 2014 Sep 29;106(9). Epub 2014 Sep 29.

: Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CE Rotterdam, the Netherlands. *Current affiliation: Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, 6525 GA, Nijmegen, the Netherlands.

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September 2014

Integrating meta-analysis of microarray data and targeted proteomics for biomarker identification: application in breast cancer.

J Proteome Res 2014 Jun 14;13(6):2897-909. Epub 2014 May 14.

Department of Laboratory Medicine and Pathobiology, University of Toronto , 1 King's College Circle, Toronto, ON M5S 1A8, Canada.

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June 2014

Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways.

Cancer Res 2014 Jun 2;74(11):2936-45. Epub 2014 Apr 2.

Authors' Affiliations: Molecular Diagnostics, Philips Research, Eindhoven; Hubrecht Institute, Utrecht; Human Genetics, AMC, Amsterdam; and Medical Oncology, Erasmus MC, Rotterdam, the Netherlands.

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June 2014

Comparative proteome analysis revealing an 11-protein signature for aggressive triple-negative breast cancer.

J Natl Cancer Inst 2014 Feb 7;106(2):djt376. Epub 2014 Jan 7.

Affiliations of authors: Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (NQL, MPL, MS, RBHB, TDM, AMS, JWMM, JAF, AU); Department of Neurology (CS, TML) and Postgraduate School of Molecular Medicine (NQL, RBHB, TDM, AMS, JWMM, JAF, AU), Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Radiation Oncology (PNS) and Department of Laboratory Medicine (FCGJS), Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden (BKL); Department of Oncology/Pathology, Karolinska Institute, Stockholm, Sweden (BKL); Clinical Experimental Oncology Laboratory, National Cancer Centre Giovanni Paolo II, Bari, Italy (AM, AP); Translational Cancer Research Unit, Oncology Center, GZA Hospitals St-Augustinus, Antwerp, Belgium (LYD, SJVL); Netherlands Proteomics Centre, Utrecht, The Netherlands (NQL, AU); Cancer Genomics Centre, Utrecht, The Netherlands (MS, AMS, JWMM, JAF, AU); Center for Translational Molecular Medicine, Eindhoven, The Netherlands (RBHB, JAF, AU).

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February 2014

Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma.

Cell 2013 Aug;154(5):1060-1073

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, Chevy Chase, MD 21205, USA. Electronic address:

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August 2013

A pharmacogenetic predictive model for paclitaxel clearance based on the DMET platform.

Clin Cancer Res 2013 Sep 5;19(18):5210-7. Epub 2013 Aug 5.

Authors' Affiliations: Departments of Medical Oncology, Clinical Chemistry, and Trials and Statistics, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands; Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.

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September 2013

Loss of E-cadherin is not a necessity for epithelial to mesenchymal transition in human breast cancer.

Breast Cancer Res Treat 2013 Feb 22;138(1):47-57. Epub 2013 Jan 22.

Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.

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February 2013

CD49f-based selection of circulating tumor cells (CTCs) improves detection across breast cancer subtypes.

Cancer Lett 2012 Jun 24;319(1):49-55. Epub 2011 Dec 24.

Erasmus MC, Department of Medical Oncology, Daniel den Hoed Cancer Center and Laboratory of Translational Tumor Immunology, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands.

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June 2012

Prognostic value of acquired uniparental disomy (aUPD) in primary breast cancer.

Breast Cancer Res Treat 2012 Feb 21;132(1):189-96. Epub 2011 May 21.

Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Unit 1340, 1515 Holcombe Blvd, Houston, TX 77030-4009, USA.

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February 2012

Association between acquired uniparental disomy and homozygous mutations and HER2/ER/PR status in breast cancer.

PLoS One 2010 Nov 30;5(11):e15094. Epub 2010 Nov 30.

Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America.

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November 2010

Patterns and incidence of chromosomal instability and their prognostic relevance in breast cancer subtypes.

Breast Cancer Res Treat 2011 Jul 15;128(1):23-30. Epub 2010 Jul 15.

Department of Medical Oncology, Josephine Nefkens Institute, Erasmus MC, DR, Rotterdam, The Netherlands.

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July 2011

MicroRNA-30c expression level is an independent predictor of clinical benefit of endocrine therapy in advanced estrogen receptor positive breast cancer.

Breast Cancer Res Treat 2011 May 19;127(1):43-51. Epub 2010 May 19.

Department of Medical Oncology, Erasmus Medical Center Rotterdam, Josephine Nefkens Institute and Cancer Genomics Centre, Dr. Molewaterplein 50, Be 4.02 (lab)/4.35b (office), PO Box 2040, 3000 CA Rotterdam, The Netherlands.

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May 2011

Pathway analysis of gene lists associated with platinum-based chemotherapy resistance in ovarian cancer: the big picture.

Gynecol Oncol 2010 May 4;117(2):170-6. Epub 2010 Feb 4.

Department of Medical Oncology, Erasmus MC-JNI-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.

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May 2010

Latent bone metastasis in breast cancer tied to Src-dependent survival signals.

Cancer Cell 2009 Jul;16(1):67-78

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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July 2009

Copy number alterations that predict metastatic capability of human breast cancer.

Cancer Res 2009 May 31;69(9):3795-801. Epub 2009 Mar 31.

Veridex LLC, a Johnson & Johnson Company, San Diego, California, USA.

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May 2009

Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance.

J Clin Oncol 2009 Feb 15;27(4):542-9. Epub 2008 Dec 15.

Department of Pathology, Cancer Genomics Center, Josephine Nefkens Institute, Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands.

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February 2009

Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer.

Proc Natl Acad Sci U S A 2008 Sep 28;105(35):13021-6. Epub 2008 Aug 28.

Department of Medical Oncology, Erasmus Medical Center Rotterdam, Josephine Nefkens Institute, 3000 CA Rotterdam, The Netherlands.

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September 2008

Subtypes of breast cancer show preferential site of relapse.

Cancer Res 2008 May;68(9):3108-14

Department of Medical Oncology, Erasmus MC, Josephine Nefkens Institute, Rotterdam, the Netherlands.

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May 2008

Functional identification of genes causing estrogen independence of human breast cancer cells.

Breast Cancer Res Treat 2009 Mar 21;114(1):23-30. Epub 2008 Mar 21.

Department of Pathology, Josephine Nefkens Institute, Be 432, Erasmus MC-University Medical Center Rotterdam, P.O. Box 2040, Rotterdam, CA, 3000, The Netherlands.

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March 2009

Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer.

BMC Cancer 2007 Sep 25;7:182. Epub 2007 Sep 25.

Veridex LLC, a Johnson & Johnson Company, 3210 Merryfield Row, San Diego, CA 92121, USA.

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September 2007