Marcel Smid

Marcel Smid

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Marcel Smid

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An increased cell cycle gene network determines MEK and Akt inhibitor double resistance in triple-negative breast cancer.

Authors:
Vera E van der Noord Ronan P McLaughlin Marcel Smid John A Foekens John W M Martens Yinghui Zhang Bob van de Water

Sci Rep 2019 Sep 16;9(1):13308. Epub 2019 Sep 16.

Division of Drug Discovery and Safety, Leiden Academic Center for Drug Research, Leiden University, PO box 9502, 2300, RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41598-019-49809-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746778PMC
September 2019

Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression.

Authors:
Jiang Ren Marcel Smid Josephine Iaria Daniela C F Salvatori Hans van Dam Hong Jian Zhu John W M Martens Peter Ten Dijke

Breast Cancer Res 2019 09 18;21(1):109. Epub 2019 Sep 18.

Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.

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https://breast-cancer-research.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s13058-019-1194-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751614PMC
September 2019

The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies.

Authors:
Lindsay Angus Marcel Smid Saskia M Wilting Job van Riet Arne Van Hoeck Luan Nguyen Serena Nik-Zainal Tessa G Steenbruggen Vivianne C G Tjan-Heijnen Mariette Labots Johanna M G H van Riel Haiko J Bloemendal Neeltje Steeghs Martijn P Lolkema Emile E Voest Harmen J G van de Werken Agnes Jager Edwin Cuppen Stefan Sleijfer John W M Martens

Nat Genet 2019 Sep 30. Epub 2019 Sep 30.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41588-019-0507-7DOI Listing
September 2019

Androgen receptor expression in circulating tumor cells of patients with metastatic breast cancer.

Authors:
Ingeborg E de Kruijff Anieta M Sieuwerts Wendy Onstenk Agnes Jager Paul Hamberg Felix E de Jongh Marcel Smid Jaco Kraan Mieke A Timmermans John W M Martens Stefan Sleijfer

Int J Cancer 2019 Aug 27;145(4):1083-1089. Epub 2019 Feb 27.

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/ijc.32209DOI Listing
August 2019

Circulating Tumor Cell Enumeration and Characterization in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Cabazitaxel.

Authors:
Ingeborg E de Kruijff Anieta M Sieuwerts Wendy Onstenk Jaco Kraan Marcel Smid Mai N Van Michelle van der Vlugt-Daane Esther Oomen-de Hoop Ron H J Mathijssen Martijn P Lolkema Ronald de Wit Paul Hamberg Hielke J Meulenbeld Aart Beeker Geert-Jan Creemers John W M Martens Stefan Sleijfer

Cancers (Basel) 2019 Aug 20;11(8). Epub 2019 Aug 20.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands.

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http://dx.doi.org/10.3390/cancers11081212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721462PMC
August 2019

A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy.

Authors:
Ronan P McLaughlin Jichao He Vera E van der Noord Jevin Redel John A Foekens John W M Martens Marcel Smid Yinghui Zhang Bob van de Water

Breast Cancer Res 2019 07 1;21(1):77. Epub 2019 Jul 1.

Department of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, 2300 RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/s13058-019-1161-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604188PMC
July 2019

Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes.

Authors:
Esmee Koedoot Michiel Fokkelman Vasiliki-Maria Rogkoti Marcel Smid Iris van de Sandt Hans de Bont Chantal Pont Janna E Klip Steven Wink Mieke A Timmermans Erik A C Wiemer Peter Stoilov John A Foekens Sylvia E Le Dévédec John W M Martens Bob van de Water

Nat Commun 2019 07 5;10(1):2983. Epub 2019 Jul 5.

Division of Drug Discovery and Safety, LACDR, Leiden University, Einsteinweg 55, Leiden, 2333 CC, Netherlands.

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http://dx.doi.org/10.1038/s41467-019-11020-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611796PMC
July 2019

Downregulation of matrix Gla protein is a biomarker for tamoxifen-resistant and radioresistant breast cancer.

Authors:
Annemarie Em Post Johan Bussink Marcel Smid Fred Cgj Sweep Paul N Span

Biomark Med 2019 Jul 18;13(10):841-850. Epub 2019 Jul 18.

Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.2217/bmm-2019-0050DOI Listing
July 2019

Molecular Comparison of Imatinib-Naïve and Resistant Gastrointestinal Stromal Tumors: Differentially Expressed microRNAs and mRNAs.

Authors:
Azadeh Amirnasr Caroline M M Gits Patricia F van Kuijk Marcel Smid Anne L M Vriends Piotr Rutkowski Raf Sciot Patrick Schöffski Maria Debiec-Rychter Stefan Sleijfer Erik A C Wiemer

Cancers (Basel) 2019 Jun 24;11(6). Epub 2019 Jun 24.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands.

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http://dx.doi.org/10.3390/cancers11060882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627192PMC
June 2019

Correction: Functional Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects.

Authors:
Titia G Meijer Nicole S Verkaik Anieta M Sieuwerts Job van Riet Kishan A T Naipal Carolien H M van Deurzen Michael A den Bakker Hein F B M Sleddens Hendrikus-Jan Dubbink T Dorine den Toom Winand N M Dinjens Esther Lips Petra M Nederlof Marcel Smid Harmen J G van de Werken Roland Kanaar John W M Martens Agnes Jager Dik C van Gent

Clin Cancer Res 2019 May;25(9):2935

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0936DOI Listing
May 2019

MicroRNAs as possible indicators of drug sensitivity in breast cancer cell lines.

Authors:
Katharina Uhr Wendy J C Prager-van der Smissen Anouk A J Heine Bahar Ozturk Marijn T M van Jaarsveld Antonius W M Boersma Agnes Jager Erik A C Wiemer Marcel Smid John A Foekens John W M Martens

PLoS One 2019 7;14(5):e0216400. Epub 2019 May 7.

Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216400PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504094PMC
May 2019

Wnt targets genes are not differentially expressed in desmoid tumors bearing different activating β-catenin mutations.

Authors:
Milea J M Timbergen Matthijs L Janssen Cornelis Verhoef Dirk J Grünhagen Frederic Chibon Marcel Smid Stefan Sleijfer Erik A C Wiemer

Eur J Surg Oncol 2019 04 18;45(4):691-698. Epub 2018 Oct 18.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus Medical Center Rotterdam, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07487983183143
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http://dx.doi.org/10.1016/j.ejso.2018.09.019DOI Listing
April 2019

Co-regulated gene expression of splicing factors as drivers of cancer progression.

Authors:
Esmee Koedoot Marcel Smid John A Foekens John W M Martens Sylvia E Le Dévédec Bob van de Water

Sci Rep 2019 Apr 2;9(1):5484. Epub 2019 Apr 2.

Division of Drug Discovery and Safety, LACDR, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41598-019-40759-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445126PMC
April 2019

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation.

Authors:
Arie B Brinkman Serena Nik-Zainal Femke Simmer F Germán Rodríguez-González Marcel Smid Ludmil B Alexandrov Adam Butler Sancha Martin Helen Davies Dominik Glodzik Xueqing Zou Manasa Ramakrishna Johan Staaf Markus Ringnér Anieta Sieuwerts Anthony Ferrari Sandro Morganella Thomas Fleischer Vessela Kristensen Marta Gut Marc J van de Vijver Anne-Lise Børresen-Dale Andrea L Richardson Gilles Thomas Ivo G Gut John W M Martens John A Foekens Michael R Stratton Hendrik G Stunnenberg

Nat Commun 2019 04 15;10(1):1749. Epub 2019 Apr 15.

Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, PO Box 9101, Nijmegen, 6500 HB, The Netherlands.

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http://dx.doi.org/10.1038/s41467-019-09828-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465362PMC
April 2019

The circular RNome of primary breast cancer.

Authors:
Marcel Smid Saskia M Wilting Katharina Uhr F Germán Rodríguez-González Vanja de Weerd Wendy J C Prager-Van der Smissen Michelle van der Vlugt-Daane Anne van Galen Serena Nik-Zainal Adam Butler Sancha Martin Helen R Davies Johan Staaf Marc J van de Vijver Andrea L Richardson Gaëten MacGrogan Roberto Salgado Gert G G M van den Eynden Colin A Purdie Alastair M Thompson Carlos Caldas Paul N Span Fred C G J Sweep Peter T Simpson Sunil R Lakhani Steven Van Laere Christine Desmedt Angelo Paradiso Jorunn Eyfjord Annegien Broeks Anne Vincent-Salomon Andrew P Futreal Stian Knappskog Tari King Alain Viari Anne-Lise Børresen-Dale Hendrik G Stunnenberg Mike Stratton John A Foekens Anieta M Sieuwerts John W M Martens

Genome Res 2019 03 28;29(3):356-366. Epub 2019 Jan 28.

Erasmus MC Cancer Institute and Cancer Genomics Netherlands, University Medical Center Rotterdam, Department of Medical Oncology, 3015GD Rotterdam, the Netherlands.

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http://genome.cshlp.org/lookup/doi/10.1101/gr.238121.118
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http://dx.doi.org/10.1101/gr.238121.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396421PMC
March 2019

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Authors:
Serena Nik-Zainal Helen Davies Johan Staaf Manasa Ramakrishna Dominik Glodzik Xueqing Zou Inigo Martincorena Ludmil B Alexandrov Sancha Martin David C Wedge Peter Van Loo Young Seok Ju Marcel Smid Arie B Brinkman Sandro Morganella Miriam R Aure Ole Christian Lingjærde Anita Langerød Markus Ringnér Sung-Min Ahn Sandrine Boyault Jane E Brock Annegien Broeks Adam Butler Christine Desmedt Luc Dirix Serge Dronov Aquila Fatima John A Foekens Moritz Gerstung Gerrit K J Hooijer Se Jin Jang David R Jones Hyung-Yong Kim Tari A King Savitri Krishnamurthy Hee Jin Lee Jeong-Yeon Lee Yilong Li Stuart McLaren Andrew Menzies Ville Mustonen Sarah O'Meara Iris Pauporté Xavier Pivot Colin A Purdie Keiran Raine Kamna Ramakrishnan F Germán Rodríguez-González Gilles Romieu Anieta M Sieuwerts Peter T Simpson Rebecca Shepherd Lucy Stebbings Olafur A Stefansson Jon Teague Stefania Tommasi Isabelle Treilleux Gert G Van den Eynden Peter Vermeulen Anne Vincent-Salomon Lucy Yates Carlos Caldas Laura Van't Veer Andrew Tutt Stian Knappskog Benita Kiat Tee Tan Jos Jonkers Åke Borg Naoto T Ueno Christos Sotiriou Alain Viari P Andrew Futreal Peter J Campbell Paul N Span Steven Van Laere Sunil R Lakhani Jorunn E Eyfjord Alastair M Thompson Ewan Birney Hendrik G Stunnenberg Marc J van de Vijver John W M Martens Anne-Lise Børresen-Dale Andrea L Richardson Gu Kong Gilles Thomas Michael R Stratton

Nature 2019 02;566(7742):E1

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

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http://www.nature.com/articles/s41586-019-0883-2
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http://dx.doi.org/10.1038/s41586-019-0883-2DOI Listing
February 2019

Functional Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects.

Authors:
Titia G Meijer Nicole S Verkaik Anieta M Sieuwerts Job van Riet Kishan A T Naipal Carolien H M van Deurzen Michael A den Bakker Hein F B M Sleddens Hendrikus-Jan Dubbink T Dorine den Toom Winand N M Dinjens Esther Lips Petra M Nederlof Marcel Smid Harmen J G van de Werken Roland Kanaar John W M Martens Agnes Jager Dik C van Gent

Clin Cancer Res 2018 12 23;24(24):6277-6287. Epub 2018 Aug 23.

Department of Molecular Genetics and Oncode Institute, Erasmus MC University Medical Center Rotterdam, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0063DOI Listing
December 2018

Mitochondrial RNA Expression and Single Nucleotide Variants in Association with Clinical Parameters in Primary Breast Cancers.

Authors:
Marjolein J A Weerts Marcel Smid John A Foekens Stefan Sleijfer John W M Martens

Cancers (Basel) 2018 Dec 9;10(12). Epub 2018 Dec 9.

Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.

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http://dx.doi.org/10.3390/cancers10120500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318759PMC
December 2018

Epithelial-Mesenchymal Transition in Human Prostate Cancer Demonstrates Enhanced Immune Evasion Marked by IDO1 Expression.

Authors:
Kimberley Kolijn Esther I Verhoef Marcel Smid René Böttcher Guido W Jenster Reno Debets Geert J L H van Leenders

Cancer Res 2018 08 19;78(16):4671-4679. Epub 2018 Jun 19.

Department of Pathology, Erasmus Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3752DOI Listing
August 2018

Correction: MicroRNA expression in pre-treatment plasma of patients with benign breast diseases and breast cancer.

Authors:
Mirelle Lagendijk Sepideh Saadatmand Linetta B Koppert Madeleine M A Tilanus-Linthorst Vanja de Weerd Raquel Ramírez-Moreno Marcel Smid Anieta M Sieuwerts John W M Martens

Oncotarget 2018 08 10;9(62):32096. Epub 2018 Aug 10.

Department of Medical Oncology, Erasmus MC Cancer Institute, EA 3075, Rotterdam, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.25979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112841PMC
August 2018

Interferon-Stimulated Genes Are Involved in Cross-resistance to Radiotherapy in Tamoxifen-Resistant Breast Cancer.

Authors:
Annemarie E M Post Marcel Smid Anika Nagelkerke John W M Martens Johan Bussink Fred C G J Sweep Paul N Span

Clin Cancer Res 2018 07 16;24(14):3397-3408. Epub 2018 Apr 16.

Department of Radiation Oncology, Radiotherapy and OncoImmunology Laboratory, Radboud university medical center, Nijmegen, the Netherlands.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-2551DOI Listing
July 2018

The mTORC1 Complex Is Significantly Overactivated in SDHX-Mutated Paragangliomas.

Authors:
Lindsey Oudijk Thomas Papathomas Ronald de Krijger Esther Korpershoek Anne-Paule Gimenez-Roqueplo Judith Favier Letizia Canu Massimo Mannelli Ida Rapa Maria Currás-Freixes Mercedes Robledo Marcel Smid Mauro Papotti Marco Volante

Neuroendocrinology 2017 26;105(4):384-393. Epub 2017 Jan 26.

Department of Pathology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1159/000455864DOI Listing
June 2018

Gene length corrected trimmed mean of M-values (GeTMM) processing of RNA-seq data performs similarly in intersample analyses while improving intrasample comparisons.

Authors:
Marcel Smid Robert R J Coebergh van den Braak Harmen J G van de Werken Job van Riet Anne van Galen Vanja de Weerd Michelle van der Vlugt-Daane Sandra I Bril Zarina S Lalmahomed Wigard P Kloosterman Saskia M Wilting John A Foekens Jan N M IJzermans John W M Martens Anieta M Sieuwerts

BMC Bioinformatics 2018 06 22;19(1):236. Epub 2018 Jun 22.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus MC University Medical Center, 3015 CE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s12859-018-2246-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013957PMC
June 2018

The Prevalence of CD146 Expression in Breast Cancer Subtypes and Its Relation to Outcome.

Authors:
Ingeborg E de Kruijff Anna M Timmermans Michael A den Bakker Anita M A C Trapman-Jansen Renée Foekens Marion E Meijer-Van Gelder Esther Oomen-de Hoop Marcel Smid Antoinette Hollestelle Carolien H M van Deurzen John A Foekens John W M Martens Stefan Sleijfer

Cancers (Basel) 2018 May 5;10(5). Epub 2018 May 5.

Department of Medical Oncology, Erasmus MC Cancer Institute, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.

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http://dx.doi.org/10.3390/cancers10050134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977107PMC
May 2018

MicroRNA expression in pre-treatment plasma of patients with benign breast diseases and breast cancer.

Authors:
Mirelle Lagendijk Sepideh Sadaatmand Linetta B Koppert Madeleine M A Tilanus-Linthorst Vanja de Weerd Raquel Ramírez-Moreno Marcel Smid Anieta M Sieuwerts John W M Martens

Oncotarget 2018 May 11;9(36):24335-24346. Epub 2018 May 11.

Department of Medical Oncology, Erasmus MC Cancer Institute, EA 3075, Rotterdam, The Netherlands.

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http://www.oncotarget.com/fulltext/25262
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http://dx.doi.org/10.18632/oncotarget.25262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966243PMC
May 2018

T lymphocytes facilitate brain metastasis of breast cancer by inducing Guanylate-Binding Protein 1 expression.

Authors:
Dana A M Mustafa Rute M S M Pedrosa Marcel Smid Marcel van der Weiden Vanja de Weerd Alex L Nigg Cor Berrevoets Lona Zeneyedpour Neibla Priego Manuel Valiente Theo M Luider Reno Debets John W M Martens John A Foekens Anieta M Sieuwerts Johan M Kros

Acta Neuropathol 2018 04 19;135(4):581-599. Epub 2018 Jan 19.

Department of Pathology, Erasmus Medical Center, Wytemaweg 80, 3000 DR, Rotterdam, The Netherlands.

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http://link.springer.com/10.1007/s00401-018-1806-2
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http://dx.doi.org/10.1007/s00401-018-1806-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5978929PMC
April 2018

Confirmation of a metastasis-specific microRNA signature in primary colon cancer.

Authors:
Robert R J Coebergh van den Braak Anieta M Sieuwerts Zarina S Lalmahomed Marcel Smid Saskia M Wilting Sandra I Bril Shanshan Xiang Michelle van der Vlugt-Daane Vanja de Weerd Anne van Galen Katharina Biermann J Han J M van Krieken Wigard P Kloosterman John A Foekens John W M Martens Jan N M IJzermans

Sci Rep 2018 03 27;8(1):5242. Epub 2018 Mar 27.

Department of Surgery, Erasmus MC Medical Center, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41598-018-22532-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869672PMC
March 2018

High mRNA expression of splice variant SYK short correlates with hepatic disease progression in chemonaive lymph node negative colon cancer patients.

Authors:
Robert R J Coebergh van den Braak Anieta M Sieuwerts Raju Kandimalla Zarina S Lalmahomed Sandra I Bril Anne van Galen Marcel Smid Katharina Biermann J Han J M van Krieken Wigard P Kloosterman John A Foekens Ajay Goel John W M Martens Jan N M IJzermans

PLoS One 2017 28;12(9):e0185607. Epub 2017 Sep 28.

Department of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185607PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5619807PMC
November 2017

Corrigendum: A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers.

Authors:
Dominik Glodzik Sandro Morganella Helen Davies Peter T Simpson Yilong Li Xueqing Zou Javier Diez-Perez Johan Staaf Ludmil B Alexandrov Marcel Smid Arie B Brinkman Inga Hansine Rye Hege Russnes Keiran Raine Colin A Purdie Sunil R Lakhani Alastair M Thompson Ewan Birney Hendrik G Stunnenberg Marc J van de Vijver John W M Martens Anne-Lise Børresen-Dale Andrea L Richardson Gu Kong Alain Viari Douglas Easton Gerard Evan Peter J Campbell Michael R Stratton Serena Nik-Zainal

Nat Genet 2017 10;49(11):1661

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http://dx.doi.org/10.1038/ng1117-1661aDOI Listing
October 2017

A Systematic Analysis of Oncogenic Gene Fusions in Primary Colon Cancer.

Authors:
Wigard P Kloosterman Robert R J Coebergh van den Braak Mark Pieterse Markus J van Roosmalen Anieta M Sieuwerts Christina Stangl Ronne Brunekreef Zarina S Lalmahomed Salo Ooft Anne van Galen Marcel Smid Armel Lefebvre Fried Zwartkruis John W M Martens John A Foekens Katharina Biermann Marco J Koudijs Jan N M Ijzermans Emile E Voest

Cancer Res 2017 07 16;77(14):3814-3822. Epub 2017 May 16.

Division of Molecular Oncology, Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, the Netherlands.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-16-3563DOI Listing
July 2017

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer.

Authors:
Tommaso De Marchi Mieke A Timmermans Anieta M Sieuwerts Marcel Smid Maxime P Look Nicolai Grebenchtchikov Fred C G J Sweep Jan G Smits Viktor Magdolen Carolien H M van Deurzen John A Foekens Arzu Umar John W Martens

Sci Rep 2017 05 18;7(1):2099. Epub 2017 May 18.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41598-017-02296-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5437008PMC
May 2017

Identification of microRNA biomarkers for response of advanced soft tissue sarcomas to eribulin: Translational results of the EORTC 62052 trial.

Authors:
Erik A C Wiemer Agnieszka Wozniak Herman Burger Marcel Smid Giuseppe Floris Axelle Nzokirantevye Raf Sciot Stefan Sleijfer Patrick Schöffski

Eur J Cancer 2017 04 16;75:33-40. Epub 2017 Feb 16.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium; Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.ejca.2016.12.018DOI Listing
April 2017

Proteomic characterization of microdissected breast tissue environment provides a protein-level overview of malignant transformation.

Authors:
René B H Braakman Christoph Stingl Madeleine M A Tilanus-Linthorst Carolien H M van Deurzen Mieke A M Timmermans Marcel Smid John A Foekens Theo M Luider John W M Martens Arzu Umar

Proteomics 2017 03;17(5)

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1002/pmic.201600213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347865PMC
March 2017

A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers.

Authors:
Dominik Glodzik Sandro Morganella Helen Davies Peter T Simpson Yilong Li Xueqing Zou Javier Diez-Perez Johan Staaf Ludmil B Alexandrov Marcel Smid Arie B Brinkman Inga Hansine Rye Hege Russnes Keiran Raine Colin A Purdie Sunil R Lakhani Alastair M Thompson Ewan Birney Hendrik G Stunnenberg Marc J van de Vijver John W M Martens Anne-Lise Børresen-Dale Andrea L Richardson Gu Kong Alain Viari Douglas Easton Gerard Evan Peter J Campbell Michael R Stratton Serena Nik-Zainal

Nat Genet 2017 Mar 23;49(3):341-348. Epub 2017 Jan 23.

Wellcome Trust Sanger Institute, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988034PMC
March 2017

Molecular characteristics of circulating tumor cells resemble the liver metastasis more closely than the primary tumor in metastatic colorectal cancer.

Authors:
Wendy Onstenk Anieta M Sieuwerts Bianca Mostert Zarina Lalmahomed Joan B Bolt-de Vries Anne van Galen Marcel Smid Jaco Kraan Mai Van Vanja de Weerd Raquel Ramírez-Moreno Katharina Biermann Cornelis Verhoef Dirk J Grünhagen Jan N M IJzermans Jan W Gratama John W M Martens John A Foekens Stefan Sleijfer

Oncotarget 2016 Sep;7(37):59058-59069

Erasmus MC Cancer Institute, Department of Medical Oncology and Cancer Genomics Netherlands, Rotterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312295PMC
September 2016

Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration.

Authors:
Marcel Smid F Germán Rodríguez-González Anieta M Sieuwerts Roberto Salgado Wendy J C Prager-Van der Smissen Michelle van der Vlugt-Daane Anne van Galen Serena Nik-Zainal Johan Staaf Arie B Brinkman Marc J van de Vijver Andrea L Richardson Aquila Fatima Kim Berentsen Adam Butler Sancha Martin Helen R Davies Reno Debets Marion E Meijer-Van Gelder Carolien H M van Deurzen Gaëtan MacGrogan Gert G G M Van den Eynden Colin Purdie Alastair M Thompson Carlos Caldas Paul N Span Peter T Simpson Sunil R Lakhani Steven Van Laere Christine Desmedt Markus Ringnér Stefania Tommasi Jorunn Eyford Annegien Broeks Anne Vincent-Salomon P Andrew Futreal Stian Knappskog Tari King Gilles Thomas Alain Viari Anita Langerød Anne-Lise Børresen-Dale Ewan Birney Hendrik G Stunnenberg Mike Stratton John A Foekens John W M Martens

Nat Commun 2016 Sep 26;7:12910. Epub 2016 Sep 26.

Department of Medical Oncology, Erasmus MC Cancer Institute and Cancer Genomics Netherlands, Erasmus University Medical Center, 3015CN Rotterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052682PMC
September 2016

Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients.

Authors:
Ning Qing Liu Tommaso De Marchi Annemieke Timmermans Anita M A C Trapman-Jansen Renée Foekens Maxime P Look Marcel Smid Carolien H M van Deurzen Paul N Span Fred C G J Sweep Julie Benedicte Brask Vera Timmermans-Wielenga John A Foekens John W M Martens Arzu Umar

Sci Rep 2016 08 25;6:32027. Epub 2016 Aug 25.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/srep32027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997324PMC
August 2016

Predicting paclitaxel-induced neutropenia using the DMET platform.

Authors:
Annemieke J M Nieuweboer Marcel Smid Anne-Joy M de Graan Samira Elbouazzaoui Peter de Bruijn John W Martens Ron H J Mathijssen Ron H N van Schaik

Pharmacogenomics 2015 12;16(11):1231-41. Epub 2015 Aug 12.

Department of Clinical Chemistry, Erasmus University Medical Center, s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.

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http://dx.doi.org/10.2217/pgs.15.68DOI Listing
June 2016

A Method to Correlate mRNA Expression Datasets Obtained from Fresh Frozen and Formalin-Fixed, Paraffin-Embedded Tissue Samples: A Matter of Thresholds.

Authors:
Dana A M Mustafa Anieta M Sieuwerts Marcel Smid Vania de Weerd Marcel van der Weiden Marion E Meijer-van Gelder John W M Martens John A Foekens Johan M Kros

PLoS One 2015 30;10(12):e0144097. Epub 2015 Dec 30.

Dept. of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696787PMC
June 2016

GATA3 mRNA expression, but not mutation, associates with longer progression-free survival in ER-positive breast cancer patients treated with first-line tamoxifen for recurrent disease.

Authors:
Jingjing Liu Wendy J C Prager-van der Smissen Maxime P Look Anieta M Sieuwerts Marcel Smid Marion E Meijer-van Gelder John A Foekens Antoinette Hollestelle John W M Martens

Cancer Lett 2016 06 24;376(1):104-9. Epub 2016 Mar 24.

Department of Medical Oncology, Erasmus MC Cancer Institute, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands. Electronic address:

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June 2016

Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Authors:
Serena Nik-Zainal Helen Davies Johan Staaf Manasa Ramakrishna Dominik Glodzik Xueqing Zou Inigo Martincorena Ludmil B Alexandrov Sancha Martin David C Wedge Peter Van Loo Young Seok Ju Marcel Smid Arie B Brinkman Sandro Morganella Miriam R Aure Ole Christian Lingjærde Anita Langerød Markus Ringnér Sung-Min Ahn Sandrine Boyault Jane E Brock Annegien Broeks Adam Butler Christine Desmedt Luc Dirix Serge Dronov Aquila Fatima John A Foekens Moritz Gerstung Gerrit K J Hooijer Se Jin Jang David R Jones Hyung-Yong Kim Tari A King Savitri Krishnamurthy Hee Jin Lee Jeong-Yeon Lee Yilong Li Stuart McLaren Andrew Menzies Ville Mustonen Sarah O'Meara Iris Pauporté Xavier Pivot Colin A Purdie Keiran Raine Kamna Ramakrishnan F Germán Rodríguez-González Gilles Romieu Anieta M Sieuwerts Peter T Simpson Rebecca Shepherd Lucy Stebbings Olafur A Stefansson Jon Teague Stefania Tommasi Isabelle Treilleux Gert G Van den Eynden Peter Vermeulen Anne Vincent-Salomon Lucy Yates Carlos Caldas Laura van't Veer Andrew Tutt Stian Knappskog Benita Kiat Tee Tan Jos Jonkers Åke Borg Naoto T Ueno Christos Sotiriou Alain Viari P Andrew Futreal Peter J Campbell Paul N Span Steven Van Laere Sunil R Lakhani Jorunn E Eyfjord Alastair M Thompson Ewan Birney Hendrik G Stunnenberg Marc J van de Vijver John W M Martens Anne-Lise Børresen-Dale Andrea L Richardson Gu Kong Gilles Thomas Michael R Stratton

Nature 2016 06 2;534(7605):47-54. Epub 2016 May 2.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910866PMC
June 2016

The advantage of laser-capture microdissection over whole tissue analysis in proteomic profiling studies.

Authors:
Tommaso De Marchi Rene B H Braakman Christoph Stingl Martijn M van Duijn Marcel Smid John A Foekens Theo M Luider John W M Martens Arzu Umar

Proteomics 2016 05 28;16(10):1474-85. Epub 2016 Apr 28.

Department of Medical Oncology, Erasmus University Medical Center - Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/pmic.201600004DOI Listing
May 2016

Mitochondrial DNA content in breast cancer: Impact on in vitro and in vivo phenotype and patient prognosis.

Authors:
Marjolein J A Weerts Anieta M Sieuwerts Marcel Smid Maxime P Look John A Foekens Stefan Sleijfer John W M Martens

Oncotarget 2016 May;7(20):29166-76

Department of Medical Oncology and Cancer Genomics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.8688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045386PMC
May 2016

An International Ki67 Reproducibility Study in Adrenal Cortical Carcinoma.

Authors:
Thomas G Papathomas Eugenio Pucci Thomas J Giordano Hao Lu Eleonora Duregon Marco Volante Mauro Papotti Ricardo V Lloyd Arthur S Tischler Francien H van Nederveen Vania Nose Lori Erickson Ozgur Mete Sylvia L Asa John Turchini Anthony J Gill Xavier Matias-Guiu Kassiani Skordilis Timothy J Stephenson Frédérique Tissier Richard A Feelders Marcel Smid Alex Nigg Esther Korpershoek Peter J van der Spek Winand N M Dinjens Andrew P Stubbs Ronald R de Krijger

Am J Surg Pathol 2016 Apr;40(4):569-76

Departments of *Pathology ∥Bioinformatics ¶¶¶Medical Oncology ∥∥∥Internal Medicine, Division of Endocrinology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam ††Laboratory for Pathology, PAL Dordrecht, Dordrecht ###Department of Pathology, Reinier de Graaf Hospital, Delft ****Department of Pathology, University Medical Center Utrecht, Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands †Department of Histopathology, King's College Hospital, London ***Department of Pathology, University Hospitals Birmingham, Birmingham †††Department of Histopathology, Royal Hallamshire Hospital, Sheffield, UK ‡Department of Clinical and Molecular Medicine, Pathology Unit, Sant' Andrea Hospital, Sapienza University, Rome ¶Department of Oncology, University of Turin at San Luigi Hospital, Orbassano, Italy §Department of Pathology, Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI #Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI **Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine ‡‡Department of Pathology, Massachusetts General Hospital, Boston, MA §§Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN ∥∥Department of Pathology, University Health Network, University of Toronto, Toronto, ON, Canada ¶¶Department of Anatomical Pathology, Royal North Shore Hospital and University of Sydney, Sydney, NSW, Australia ##Department of Pathology and Molecular Genetics and Research Laboratory, Hospital Universitari Arnau de Vilanova, IRBLLEIDA, University of Lleida, Lleida, Spain ‡‡‡INSERM U1016 CNRS UMR8104, Institut Cochin, Paris Descartes University, Sorbonne Paris Cité §§§Department of Pathology, Pitié-Salpetrière Hospital, APHP, Pierre and Marie Curie Univers

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http://dx.doi.org/10.1097/PAS.0000000000000574DOI Listing
April 2016

Vascular pattern analysis for the prediction of clinical behaviour in pheochromocytomas and paragangliomas.

Authors:
Lindsey Oudijk Francien van Nederveen Cécile Badoual Frédérique Tissier Arthur S Tischler Marcel Smid José Gaal Charlotte Lepoutre-Lussey Anne-Paule Gimenez-Roqueplo Winand N M Dinjens Esther Korpershoek Ronald de Krijger Judith Favier

PLoS One 2015 20;10(3):e0121361. Epub 2015 Mar 20.

Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, F-75006 Paris, France; INSERM, UMR970, Paris Cardiovascular Research Center, F-75015 Paris, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368716PMC
February 2016

An 8-gene mRNA expression profile in circulating tumor cells predicts response to aromatase inhibitors in metastatic breast cancer patients.

Authors:
Esther A Reijm Anieta M Sieuwerts Marcel Smid Joan Bolt-de Vries Bianca Mostert Wendy Onstenk Dieter Peeters Luc Y Dirix Caroline M Seynaeve Agnes Jager Felix E de Jongh Paul Hamberg Anne van Galen Jaco Kraan Maurice P H M Jansen Jan W Gratama John A Foekens John W M Martens Els M J J Berns Stefan Sleijfer

BMC Cancer 2016 Feb 18;16:123. Epub 2016 Feb 18.

Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC - Cancer Institute, Erasmus University Medical Center, Room He 116, P.O. Box 2040, Rotterdam, 3000 CA, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759736PMC
February 2016

Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.

Authors:
Corine M Beaufort Jean C A Helmijr Anna M Piskorz Marlous Hoogstraat Kirsten Ruigrok-Ritstier Nicolle Besselink Muhammed Murtaza Wilfred F J van IJcken Anouk A J Heine Marcel Smid Marco J Koudijs James D Brenton Els M J J Berns Jozien Helleman

PLoS One 2014 17;9(9):e103988. Epub 2014 Sep 17.

Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167545PMC
January 2016

4-protein signature predicting tamoxifen treatment outcome in recurrent breast cancer.

Authors:
Tommaso De Marchi Ning Qing Liu Cristoph Stingl Mieke A Timmermans Marcel Smid Maxime P Look Mila Tjoa Rene B H Braakman Mark Opdam Sabine C Linn Fred C G J Sweep Paul N Span Mike Kliffen Theo M Luider John A Foekens John W M Martens Arzu Umar

Mol Oncol 2016 Jan 7;10(1):24-39. Epub 2015 Aug 7.

Department of Medical Oncology, Erasmus MC Cancer Institute, University Medical Center, Wytemaweg 80, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528925PMC
January 2016

Annexin-A1 and caldesmon are associated with resistance to tamoxifen in estrogen receptor positive recurrent breast cancer.

Authors:
Tommaso De Marchi Anne M Timmermans Marcel Smid Maxime P Look Christoph Stingl Mark Opdam Sabine C Linn Fred C G J Sweep Paul N Span Mike Kliffen Carolien H M van Deurzen Theo M Luider John A Foekens John W Martens Arzu Umar

Oncotarget 2016 Jan;7(3):3098-110

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.6521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823093PMC
January 2016

Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines.

Authors:
Haatisha Jandu Kristina Aluzaite Louise Fogh Sebastian Wingaard Thrane Julie B Noer Joanna Proszek Khoa Nguyen Do Stine Ninel Hansen Britt Damsgaard Signe Lykke Nielsen Magnus Stougaard Birgitta R Knudsen José Moreira Petra Hamerlik Madhavsai Gajjar Marcel Smid John Martens John Foekens Yves Pommier Nils Brünner Anne-Sofie Schrohl Jan Stenvang

BMC Cancer 2016 Jan 22;16:34. Epub 2016 Jan 22.

Faculty of Health and Medical Sciences, Department of Veterinary Disease Biology, Section for Molecular Disease Biology and Sino-Danish Breast Cancer Research Centre, University of Copenhagen, Strandboulevarden 49, DK-2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1186/s12885-016-2071-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722663PMC
January 2016

PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients.

Authors:
Kaspar Draaisma Maarten M J Wijnenga Bas Weenink Ya Gao Marcel Smid P Robe Martin J van den Bent Pim J French

Acta Neuropathol Commun 2015 Dec 23;3:88. Epub 2015 Dec 23.

Department of Neurology, Erasmus MC, Room Be 430A, POBox 2040, 3000 CA, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s40478-015-0265-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690424PMC
December 2015

Global proteomic characterization of microdissected estrogen receptor positive breast tumors.

Authors:
Tommaso De Marchi Ning Qing Liu Christoph Sting Marcel Smid Mila Tjoa René B H Braakman Theo M Luider John A Foekens John W M Martens Arzu Umar

Data Brief 2015 Dec 8;5:399-402. Epub 2015 Oct 8.

Department of Medical Oncology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.dib.2015.09.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773412PMC
December 2015

Understanding drugs in breast cancer through drug sensitivity screening.

Authors:
Katharina Uhr Wendy J C Prager-van der Smissen Anouk A J Heine Bahar Ozturk Marcel Smid Hinrich W H Göhlmann Agnes Jager John A Foekens John W M Martens

Springerplus 2015 15;4:611. Epub 2015 Oct 15.

Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center, Postbus 2040, 's-Gravendijkwal 230, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s40064-015-1406-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628005PMC
November 2015

SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T).

Authors:
Thomas G Papathomas Lindsey Oudijk Alexandre Persu Anthony J Gill Francien van Nederveen Arthur S Tischler Frédérique Tissier Marco Volante Xavier Matias-Guiu Marcel Smid Judith Favier Elena Rapizzi Rosella Libe Maria Currás-Freixes Selda Aydin Thanh Huynh Urs Lichtenauer Anouk van Berkel Letizia Canu Rita Domingues Roderick J Clifton-Bligh Magdalena Bialas Miikka Vikkula Gustavo Baretton Mauro Papotti Gabriella Nesi Cécile Badoual Karel Pacak Graeme Eisenhofer Henri J Timmers Felix Beuschlein Jérôme Bertherat Massimo Mannelli Mercedes Robledo Anne-Paule Gimenez-Roqueplo Winand Nm Dinjens Esther Korpershoek Ronald R de Krijger

Mod Pathol 2015 Jun 27;28(6):807-21. Epub 2015 Feb 27.

1] Department of Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands [2] Department of Pathology, Reinier de Graaf Hospital, Delft, The Netherlands [3] Department of Pathology, University Medical Center Utrecht, Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/modpathol.2015.41DOI Listing
June 2015

Gene expression profiles of circulating tumor cells versus primary tumors in metastatic breast cancer.

Authors:
Wendy Onstenk Anieta M Sieuwerts Marleen Weekhout Bianca Mostert Esther A Reijm Carolien H M van Deurzen Joan B Bolt-de Vries Dieter J Peeters Paul Hamberg Caroline Seynaeve Agnes Jager Felix E de Jongh Marcel Smid Luc Y Dirix Diederik F S Kehrer Anne van Galen Raquel Ramirez-Moreno Jaco Kraan Mai Van Jan W Gratama John W M Martens John A Foekens Stefan Sleijfer

Cancer Lett 2015 Jun 19;362(1):36-44. Epub 2015 Mar 19.

Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.canlet.2015.03.020DOI Listing
June 2015

Proper genomic profiling of (BRCA1-mutated) basal-like breast carcinomas requires prior removal of tumor infiltrating lymphocytes.

Authors:
Maarten P G Massink Irsan E Kooi Saskia E van Mil Ekaterina S Jordanova Najim Ameziane Josephine C Dorsman Daphne M van Beek J Patrick van der Voorn Daoud Sie Bauke Ylstra Carolien H M van Deurzen John W Martens Marcel Smid Anieta M Sieuwerts Vanja de Weerd John A Foekens Ans M W van den Ouweland Ewald van Dyk Petra M Nederlof Quinten Waisfisz Hanne Meijers-Heijboer

Mol Oncol 2015 Apr 13;9(4):877-88. Epub 2015 Jan 13.

Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:

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http://doi.wiley.com/10.1016/j.molonc.2014.12.012
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528776PMC
April 2015

mRNA expression profiles in circulating tumor cells of metastatic colorectal cancer patients.

Authors:
Bianca Mostert Anieta M Sieuwerts Joan Bolt-de Vries Jaco Kraan Zarina Lalmahomed Anne van Galen Petra van der Spoel Vanja de Weerd Raquel Ramírez-Moreno Marcel Smid Cornelis Verhoef Jan N M IJzermans Jan W Gratama Stefan Sleijfer John A Foekens John W M Martens

Mol Oncol 2015 Apr 21;9(4):920-32. Epub 2015 Jan 21.

Department of Medical Oncology and Cancer Genomics Netherlands, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2015.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528769PMC
April 2015

Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant.

Authors:
Wies van Roosmalen Sylvia E Le Dévédec Ofra Golani Marcel Smid Irina Pulyakhina Annemieke M Timmermans Maxime P Look Di Zi Chantal Pont Marjo de Graauw Suha Naffar-Abu-Amara Catherine Kirsanova Gabriella Rustici Peter A C 't Hoen John W M Martens John A Foekens Benjamin Geiger Bob van de Water

J Clin Invest 2015 Apr 16;125(4):1648-64. Epub 2015 Mar 16.

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http://dx.doi.org/10.1172/JCI74440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396474PMC
April 2015

Integrative analysis of genomics and proteomics data on clinical breast cancer tissue specimens extracted with acid guanidinium thiocyanate-phenol-chloroform.

Authors:
René B H Braakman Karel Bezstarosti Anieta M Sieuwerts Vanja de Weerd Anne M van Galen Christoph Stingl Theo M Luider Mieke A M Timmermans Marcel Smid John W M Martens John A Foekens Jeroen A A Demmers Arzu Umar

J Proteome Res 2015 Mar 2;14(3):1627-36. Epub 2015 Feb 2.

Department of Medical Oncology, Erasmus MC Cancer Institute, University Medical Center Rotterdam , Be401, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1021/acs.jproteome.5b00046DOI Listing
March 2015

Prognostic relevance of acquired uniparental disomy in serous ovarian cancer.

Authors:
Musaffe Tuna Zhenlin Ju Marcel Smid Christopher I Amos Gordon B Mills

Mol Cancer 2015 Feb 3;14:29. Epub 2015 Feb 3.

Departments of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1186/s12943-015-0289-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320828PMC
February 2015

DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells.

Authors:
Marleen Ansems Jonas Nørskov Søndergaard Anieta M Sieuwerts Maaike W G Looman Marcel Smid Annemarie M A de Graaf Vanja de Weerd Malou Zuidscherwoude John A Foekens John W M Martens Gosse J Adema

Breast Cancer Res Treat 2015 Feb 8;149(3):693-703. Epub 2015 Feb 8.

Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands,

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http://dx.doi.org/10.1007/s10549-015-3281-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326655PMC
February 2015

Response.

Authors:
Ning Qing Liu Marcel Smid John W M Martens John A Foekens Arzu Umar

J Natl Cancer Inst 2014 Sep 29;106(9). Epub 2014 Sep 29.

: Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, 3015 CE Rotterdam, the Netherlands. *Current affiliation: Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, 6525 GA, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1093/jnci/dju254DOI Listing
September 2014

MicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors.

Authors:
Caroline M M Gits Patricia F van Kuijk Moniek B E Jonkers Antonius W M Boersma Marcel Smid Wilfred F van Ijcken Jean-Michel Coindre Fréderic Chibon Cornelis Verhoef Ron H J Mathijssen Michael A den Bakker Jaap Verweij Stefan Sleijfer Erik A C Wiemer

Int J Cancer 2014 Jul 16;135(2):348-61. Epub 2014 Jan 16.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

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July 2014

Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways.

Authors:
Wim Verhaegh Henk van Ooijen Márcia A Inda Pantelis Hatzis Rogier Versteeg Marcel Smid John Martens John Foekens Paul van de Wiel Hans Clevers Anja van de Stolpe

Cancer Res 2014 Jun 2;74(11):2936-45. Epub 2014 Apr 2.

Authors' Affiliations: Molecular Diagnostics, Philips Research, Eindhoven; Hubrecht Institute, Utrecht; Human Genetics, AMC, Amsterdam; and Medical Oncology, Erasmus MC, Rotterdam, the Netherlands.

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http://cancerres.aacrjournals.org/content/early/2014/05/14/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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June 2014

Integrating meta-analysis of microarray data and targeted proteomics for biomarker identification: application in breast cancer.

Authors:
Maria P Pavlou Apostolos Dimitromanolakis Eduardo Martinez-Morillo Marcel Smid John A Foekens Eleftherios P Diamandis

J Proteome Res 2014 Jun 14;13(6):2897-909. Epub 2014 May 14.

Department of Laboratory Medicine and Pathobiology, University of Toronto , 1 King's College Circle, Toronto, ON M5S 1A8, Canada.

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June 2014

DNA damage responsive microRNAs misexpressed in human cancer modulate therapy sensitivity.

Authors:
Marijn T M van Jaarsveld Maikel D Wouters Antonius W M Boersma Marcel Smid Wilfred F J van Ijcken Ron H J Mathijssen Jan H J Hoeijmakers John W M Martens Steven van Laere Erik A C Wiemer Joris Pothof

Mol Oncol 2014 May 31;8(3):458-68. Epub 2013 Dec 31.

Department of Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address:

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May 2014

Comparative proteome analysis revealing an 11-protein signature for aggressive triple-negative breast cancer.

Authors:
Ning Qing Liu Christoph Stingl Maxime P Look Marcel Smid René B H Braakman Tommaso De Marchi Anieta M Sieuwerts Paul N Span Fred C G J Sweep Barbro K Linderholm Anita Mangia Angelo Paradiso Luc Y Dirix Steven J Van Laere Theo M Luider John W M Martens John A Foekens Arzu Umar

J Natl Cancer Inst 2014 Feb 7;106(2):djt376. Epub 2014 Jan 7.

Affiliations of authors: Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands (NQL, MPL, MS, RBHB, TDM, AMS, JWMM, JAF, AU); Department of Neurology (CS, TML) and Postgraduate School of Molecular Medicine (NQL, RBHB, TDM, AMS, JWMM, JAF, AU), Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Radiation Oncology (PNS) and Department of Laboratory Medicine (FCGJS), Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden (BKL); Department of Oncology/Pathology, Karolinska Institute, Stockholm, Sweden (BKL); Clinical Experimental Oncology Laboratory, National Cancer Centre Giovanni Paolo II, Bari, Italy (AM, AP); Translational Cancer Research Unit, Oncology Center, GZA Hospitals St-Augustinus, Antwerp, Belgium (LYD, SJVL); Netherlands Proteomics Centre, Utrecht, The Netherlands (NQL, AU); Cancer Genomics Centre, Utrecht, The Netherlands (MS, AMS, JWMM, JAF, AU); Center for Translational Molecular Medicine, Eindhoven, The Netherlands (RBHB, JAF, AU).

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February 2014

A pharmacogenetic predictive model for paclitaxel clearance based on the DMET platform.

Authors:
Anne-Joy M de Graan Laure Elens Marcel Smid John W Martens Alex Sparreboom Annemieke J M Nieuweboer Lena E Friberg Samira Elbouazzaoui Erik A C Wiemer Bronno van der Holt Jaap Verweij Ron H N van Schaik Ron H J Mathijssen

Clin Cancer Res 2013 Sep 5;19(18):5210-7. Epub 2013 Aug 5.

Authors' Affiliations: Departments of Medical Oncology, Clinical Chemistry, and Trials and Statistics, Erasmus University Medical Center, Erasmus MC Cancer Institute, Rotterdam, the Netherlands; Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee; and Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.

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September 2013

Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma.

Authors:
Xiang H-F Zhang Xin Jin Srinivas Malladi Yilong Zou Yong H Wen Edi Brogi Marcel Smid John A Foekens Joan Massagué

Cell 2013 Aug;154(5):1060-1073

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Howard Hughes Medical Institute, Chevy Chase, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.07.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974915PMC
August 2013

miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.

Authors:
Muhammad Riaz Marijn T M van Jaarsveld Antoinette Hollestelle Wendy J C Prager-van der Smissen Anouk A J Heine Antonius W M Boersma Jingjing Liu Jean Helmijr Bahar Ozturk Marcel Smid Erik A Wiemer John A Foekens John W M Martens

Breast Cancer Res 2013 Apr 19;15(2):R33. Epub 2013 Apr 19.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672661PMC
April 2013

Loss of E-cadherin is not a necessity for epithelial to mesenchymal transition in human breast cancer.

Authors:
Antoinette Hollestelle Justine K Peeters Marcel Smid Mieke Timmermans Leon C Verhoog Pieter J Westenend Anouk A J Heine Alan Chan Anieta M Sieuwerts Erik A C Wiemer Jan G M Klijn Peter J van der Spek John A Foekens Mieke Schutte Michael A den Bakker John W M Martens

Breast Cancer Res Treat 2013 Feb 22;138(1):47-57. Epub 2013 Jan 22.

Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.

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February 2013

KLF6-SV1 drives breast cancer metastasis and is associated with poor survival.

Authors:
Raheleh Hatami Anieta M Sieuwerts Sudeh Izadmehr Zhong Yao Rui Fang Qiao Luena Papa Maxime P Look Marcel Smid Jessica Ohlssen Alice C Levine Doris Germain David Burstein Alexander Kirschenbaum Analisa DiFeo John A Foekens Goutham Narla

Sci Transl Med 2013 Jan;5(169):169ra12

Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scitranslmed.3004688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661785PMC
January 2013

Validation of a radiosensitivity molecular signature in breast cancer.

Authors:
Steven A Eschrich William J Fulp Yudi Pawitan John A Foekens Marcel Smid John W M Martens Michelle Echevarria Vidya Kamath Ji-Hyun Lee Eleanor E Harris Jonas Bergh Javier F Torres-Roca

Clin Cancer Res 2012 Sep 25;18(18):5134-43. Epub 2012 Jul 25.

Department of Bioinformatics, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993974PMC
September 2012

High TWIST1 mRNA expression is associated with poor prognosis in lymph node-negative and estrogen receptor-positive human breast cancer and is co-expressed with stromal as well as ECM related genes.

Authors:
Muhammad Riaz Anieta M Sieuwerts Maxime P Look Mieke A Timmermans Marcel Smid John A Foekens John W M Martens

Breast Cancer Res 2012 Sep 11;14(5):R123. Epub 2012 Sep 11.

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http://dx.doi.org/10.1186/bcr3317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053101PMC
September 2012

CD49f-based selection of circulating tumor cells (CTCs) improves detection across breast cancer subtypes.

Authors:
Bianca Mostert Jaco Kraan Anieta M Sieuwerts Petra van der Spoel Joan Bolt-de Vries Wendy J C Prager-van der Smissen Marcel Smid Annemieke M Timmermans John W M Martens Jan W Gratama John A Foekens Stefan Sleijfer

Cancer Lett 2012 Jun 24;319(1):49-55. Epub 2011 Dec 24.

Erasmus MC, Department of Medical Oncology, Daniel den Hoed Cancer Center and Laboratory of Translational Tumor Immunology, Groene Hilledijk 301, 3075 EA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.canlet.2011.12.031DOI Listing
June 2012

Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes.

Authors:
Jord H A Nagel Justine K Peeters Marcel Smid Anieta M Sieuwerts Marijke Wasielewski Vanja de Weerd Anita M A C Trapman-Jansen Ans van den Ouweland Hennie Brüggenwirth Wilfred F J van I Jcken Jan G M Klijn Peter J van der Spek John A Foekens John W M Martens Mieke Schutte Hanne Meijers-Heijboer

Breast Cancer Res Treat 2012 Apr 26;132(2):439-48. Epub 2011 May 26.

Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands.

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April 2012

Prognostic value of acquired uniparental disomy (aUPD) in primary breast cancer.

Authors:
Musaffe Tuna Marcel Smid John W M Martens John A Foekens

Breast Cancer Res Treat 2012 Feb 21;132(1):189-96. Epub 2011 May 21.

Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Unit 1340, 1515 Holcombe Blvd, Houston, TX 77030-4009, USA.

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February 2012

Patterns and incidence of chromosomal instability and their prognostic relevance in breast cancer subtypes.

Authors:
Marcel Smid Marlous Hoes Anieta M Sieuwerts Stefan Sleijfer Yi Zhang Yixin Wang John A Foekens John W M Martens

Breast Cancer Res Treat 2011 Jul 15;128(1):23-30. Epub 2010 Jul 15.

Department of Medical Oncology, Josephine Nefkens Institute, Erasmus MC, DR, Rotterdam, The Netherlands.

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July 2011

mRNA and microRNA expression profiles in circulating tumor cells and primary tumors of metastatic breast cancer patients.

Authors:
Anieta M Sieuwerts Bianca Mostert Joan Bolt-de Vries Dieter Peeters Felix E de Jongh Jacqueline M L Stouthard Luc Y Dirix Peter A van Dam Anne Van Galen Vanja de Weerd Jaco Kraan Petra van der Spoel Raquel Ramírez-Moreno Carolien H M van Deurzen Marcel Smid Jack X Yu John Jiang Yixin Wang Jan W Gratama Stefan Sleijfer John A Foekens John W M Martens

Clin Cancer Res 2011 Jun 19;17(11):3600-18. Epub 2011 Apr 19.

Department of Medical Oncology, Josephine Nefkens Institute and Cancer Genomics Centre, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-0255DOI Listing
June 2011

MicroRNA-30c expression level is an independent predictor of clinical benefit of endocrine therapy in advanced estrogen receptor positive breast cancer.

Authors:
F Germán Rodríguez-González Anieta M Sieuwerts Marcel Smid Maxime P Look Marion E Meijer-van Gelder Vanja de Weerd Stefan Sleijfer John W M Martens John A Foekens

Breast Cancer Res Treat 2011 May 19;127(1):43-51. Epub 2010 May 19.

Department of Medical Oncology, Erasmus Medical Center Rotterdam, Josephine Nefkens Institute and Cancer Genomics Centre, Dr. Molewaterplein 50, Be 4.02 (lab)/4.35b (office), PO Box 2040, 3000 CA Rotterdam, The Netherlands.

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May 2011

Association between acquired uniparental disomy and homozygous mutations and HER2/ER/PR status in breast cancer.

Authors:
Musaffe Tuna Marcel Smid Dakai Zhu John W M Martens Christopher I Amos

PLoS One 2010 Nov 30;5(11):e15094. Epub 2010 Nov 30.

Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994899PMC
November 2010

Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.

Authors:
Antoinette Hollestelle Jord H A Nagel Marcel Smid Suzanne Lam Fons Elstrodt Marijke Wasielewski Ser Sue Ng Pim J French Justine K Peeters Marieke J Rozendaal Muhammad Riaz Daphne G Koopman Timo L M Ten Hagen Bertie H C G M de Leeuw Ellen C Zwarthoff Amina Teunisse Peter J van der Spek Jan G M Klijn Winand N M Dinjens Stephen P Ethier Hans Clevers Aart G Jochemsen Michael A den Bakker John A Foekens John W M Martens Mieke Schutte

Breast Cancer Res Treat 2010 May 11;121(1):53-64. Epub 2009 Jul 11.

Department of Medical Oncology, Josephine Nefkens Institute, Erasmus, The Netherlands.

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May 2010

Pathway analysis of gene lists associated with platinum-based chemotherapy resistance in ovarian cancer: the big picture.

Authors:
Jozien Helleman Marcel Smid Maurice P H M Jansen Maria E L van der Burg Els M J J Berns

Gynecol Oncol 2010 May 4;117(2):170-6. Epub 2010 Feb 4.

Department of Medical Oncology, Erasmus MC-JNI-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ygyno.2010.01.010DOI Listing
May 2010

Latent bone metastasis in breast cancer tied to Src-dependent survival signals.

Authors:
Xiang H-F Zhang Qiongqing Wang William Gerald Clifford A Hudis Larry Norton Marcel Smid John A Foekens Joan Massagué

Cancer Cell 2009 Jul;16(1):67-78

Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749247PMC
July 2009

Copy number alterations that predict metastatic capability of human breast cancer.

Authors:
Yi Zhang John W M Martens Jack X Yu John Jiang Anieta M Sieuwerts Marcel Smid Jan G M Klijn Yixin Wang John A Foekens

Cancer Res 2009 May 31;69(9):3795-801. Epub 2009 Mar 31.

Veridex LLC, a Johnson & Johnson Company, San Diego, California, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4596DOI Listing
May 2009

Functional identification of genes causing estrogen independence of human breast cancer cells.

Authors:
Ton van Agthoven Jos Veldscholte Marcel Smid Thecla L A van Agthoven Lilian Vreede Marieke Broertjes Ingrid de Vries Danielle de Jong Roya Sarwari Lambert C J Dorssers

Breast Cancer Res Treat 2009 Mar 21;114(1):23-30. Epub 2008 Mar 21.

Department of Pathology, Josephine Nefkens Institute, Be 432, Erasmus MC-University Medical Center Rotterdam, P.O. Box 2040, Rotterdam, CA, 3000, The Netherlands.

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March 2009

Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance.

Authors:
Ton van Agthoven Anieta M Sieuwerts Marion E Meijer-van Gelder Maxime P Look Marcel Smid Jos Veldscholte Stefan Sleijfer John A Foekens Lambert C J Dorssers

J Clin Oncol 2009 Feb 15;27(4):542-9. Epub 2008 Dec 15.

Department of Pathology, Cancer Genomics Center, Josephine Nefkens Institute, Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2008.17.1462DOI Listing
February 2009

Urokinase receptor splice variant uPAR-del4/5-associated gene expression in breast cancer: identification of rab31 as an independent prognostic factor.

Authors:
Matthias Kotzsch Anieta M Sieuwerts Marianne Grosser Axel Meye Susanne Fuessel Marion E Meijer-van Gelder Marcel Smid Manfred Schmitt Gustavo Baretton Thomas Luther Viktor Magdolen John A Foekens

Breast Cancer Res Treat 2008 Sep 20;111(2):229-40. Epub 2007 Oct 20.

Institute of Pathology, Dresden University of Technology, Fetscherstr. 74, 01307, Dresden, Germany.

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http://dx.doi.org/10.1007/s10549-007-9782-6DOI Listing
September 2008

Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer.

Authors:
John A Foekens Anieta M Sieuwerts Marcel Smid Maxime P Look Vanja de Weerd Antonius W M Boersma Jan G M Klijn Erik A C Wiemer John W M Martens

Proc Natl Acad Sci U S A 2008 Sep 28;105(35):13021-6. Epub 2008 Aug 28.

Department of Medical Oncology, Erasmus Medical Center Rotterdam, Josephine Nefkens Institute, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1073/pnas.0803304105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529088PMC
September 2008

Subtypes of breast cancer show preferential site of relapse.

Authors:
Marcel Smid Yixin Wang Yi Zhang Anieta M Sieuwerts Jack Yu Jan G M Klijn John A Foekens John W M Martens

Cancer Res 2008 May;68(9):3108-14

Department of Medical Oncology, Erasmus MC, Josephine Nefkens Institute, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5644DOI Listing
May 2008

Gene expression profiles associated with the presence of a fibrotic focus and the growth pattern in lymph node-negative breast cancer.

Authors:
Gert G Van den Eynden Marcel Smid Steven J Van Laere Cecile G Colpaert Ilse Van der Auwera Trinh Xuan Bich Peter van Dam Michael A den Bakker Luc Y Dirix Eric A Van Marck Peter B Vermeulen John A Foekens

Clin Cancer Res 2008 May;14(10):2944-52

Translational Cancer Research Group (Lab Pathology University of Antwerp/University Hospital Antwerp), Wilrijk, Belgium.

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May 2008

Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer.

Authors:
Jack X Yu Anieta M Sieuwerts Yi Zhang John W M Martens Marcel Smid Jan G M Klijn Yixin Wang John A Foekens

BMC Cancer 2007 Sep 25;7:182. Epub 2007 Sep 25.

Veridex LLC, a Johnson & Johnson Company, 3210 Merryfield Row, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1186/1471-2407-7-182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2077336PMC
September 2007

Differential role of basal keratinocytes in UV-induced immunosuppression and skin cancer.

Authors:
Judith Jans George A Garinis Wouter Schul Adri van Oudenaren Michael Moorhouse Marcel Smid Yurda-Gul Sert Albertina van der Velde Yvonne Rijksen Frank R de Gruijl Peter J van der Spek Akira Yasui Jan H J Hoeijmakers Pieter J M Leenen Gijsbertus T J van der Horst

Mol Cell Biol 2006 Nov 11;26(22):8515-26. Epub 2006 Sep 11.

MGC, Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636796PMC
November 2006

Genes associated with breast cancer metastatic to bone.

Authors:
Marcel Smid Yixin Wang Jan G M Klijn Anieta M Sieuwerts Yi Zhang David Atkins John W M Martens John A Foekens

J Clin Oncol 2006 May 24;24(15):2261-7. Epub 2006 Apr 24.

Department of Medical Oncology, Erasmus MC-Daniel den Hoed, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1200/JCO.2005.03.8802DOI Listing
May 2006

Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway.

Authors:
Lambert C J Dorssers Ton van Agthoven Arend Brinkman Jos Veldscholte Marcel Smid Koen J Dechering

Breast Cancer Res 2005 16;7(1):R82-92. Epub 2004 Nov 16.

Department of Pathology, Josephine Nefkens Institute, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/bcr954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1064102PMC
January 2006

Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks.

Authors:
George A Garinis James R Mitchell Michael J Moorhouse Katsuhiro Hanada Harm de Waard Dimitri Vandeputte Judith Jans Karl Brand Marcel Smid Peter J van der Spek Jan H J Hoeijmakers Roland Kanaar Gijsbertus T J van der Horst

EMBO J 2005 Nov 27;24(22):3952-62. Epub 2005 Oct 27.

Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283948PMC
November 2005

Storing, linking, and mining microarray databases using SRS.

Authors:
Antoine Veldhoven Don de Lange Marcel Smid Victor de Jager Jan A Kors Guido Jenster

BMC Bioinformatics 2005 Jul 27;6:192. Epub 2005 Jul 27.

Department of Urology, Josephine Nefkens Institute, Erasmus MC, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/1471-2105-6-192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1187877PMC
July 2005

GO-Mapper: functional analysis of gene expression data using the expression level as a score to evaluate Gene Ontology terms.

Authors:
Marcel Smid Lambert C J Dorssers

Bioinformatics 2004 Nov 6;20(16):2618-25. Epub 2004 May 6.

Department of Pathology, Josephine Nefkens Institute, Erasmus MC, P.O. Box 1738, 3000DR Rotterdam, The Netherlands.

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November 2004

Venn Mapping: clustering of heterologous microarray data based on the number of co-occurring differentially expressed genes.

Authors:
Marcel Smid Lambert C J Dorssers Guido Jenster

Bioinformatics 2003 Nov;19(16):2065-71

Department of Pathology, Josephine Nefkens Institute, Erasmus MC, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.

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November 2003