Publications by authors named "Marcel R M van den Brink"

100Publications

Microbiota and Allogeneic Hematopoietic-Cell Transplantation. Reply.

N Engl J Med 2020 06;382(24):2378-2379

Memorial Sloan Kettering Cancer Center, New York, NY

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http://dx.doi.org/10.1056/NEJMc2006694DOI Listing
June 2020

Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation.

N Engl J Med 2020 02;382(9):822-834

From the Adult Bone Marrow Transplantation Service (J.U.P., M.M., A.G.C., K.A.M., N.K., D.G.B., M.S.-E., N.C.F., A.A.T., R.J.L., L.Y.S.S., G.L.S., C.C., M.S., I.P., B.G., D.M.P., J.N.B., M.-A.P., S.A.G., M.R.M.B.) and the Infectious Disease Service (Y.T., E.F., L.A.A., R.J.W., E.G.P.), Department of Medicine, the Department of Epidemiology and Biostatistics (S.M.D.), the Department of Immunology, Sloan Kettering Institute (A.L.C.G., E.R.L., A.E.S., J.B.S., C.K.S.-T., M.D.D., M.B.S., G.K.A., Y.S., M.R.M.B.), and the Program for Computational and Systems Biology (J.B.X.), Memorial Sloan Kettering Cancer Center, and the Department of Medicine, Weill Cornell Medical College (J.U.P., Y.T., K.A.M., M.D.D., R.J.L., G.L.S., C.C., M.S., I.P., B.G., D.M.P., J.N.B., M.-A.P., S.A.G., M.R.M.B.) - both in New York; Duchossois Family Institute of the University of Chicago, Chicago (E.R.L., E.G.P.); the Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University Medical Center (A.D.S., M.V.L., A.B., L.B., N.J.C.), the Division of Infectious Diseases, Department of Medicine, Duke University (J.A.M.), and the Duke Office of Clinical Research, Duke University School of Medicine (K.R.) - all in Durham, NC; the Department of Hematology and Oncology, Internal Medicine III, University Medical Center (D.W., E.H.), the Collaborative Research Center Transregio 221 (D.W., A.G., E.H.), and Institute of Clinical Microbiology and Hygiene, University Hospital Regensburg (A.G.) - all in Regensburg, Germany; the Department of Hematology, Hokkaido University Faculty of Medicine (D.H., Y.H., T.T.), and the Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital (K.H., T.T.) - both in Sapporo, Japan; Research Institute Marqués de Valdecilla-IDIVAL (M.S.-E.) and the Department of Hematology, Hospital Universitario Marqués de Valdecilla-IDIVAL, University of Cantabria (L.Y.S.S.), Santander, and Hospital Universitario Puerta de Hierro, Madrid (A.A.T.) - all in Spain; and the Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (R.R.J.).

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http://dx.doi.org/10.1056/NEJMoa1900623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534690PMC
February 2020

Therapeutics Targeting the Gut Microbiome: Rigorous Pipelines for Drug Development.

Cell Host Microbe 2020 02;27(2):169-172

Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1016/j.chom.2020.01.022DOI Listing
February 2020

Compositional flux within the intestinal microbiota and risk for bloodstream infection with gram-negative bacteria.

Clin Infect Dis 2020 Jan 24. Epub 2020 Jan 24.

Center for Microbes, Inflammation and Cancer, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center.

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http://dx.doi.org/10.1093/cid/ciaa068DOI Listing
January 2020

Constitutive Activation of the B Cell Receptor Underlies Dysfunctional Signaling in Chronic Lymphocytic Leukemia.

Cell Rep 2019 07;28(4):923-937.e3

ImmunoDynamics Group, Programs in Computational Biology and Immunology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Cancer Systems Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.06.069DOI Listing
July 2019

Diversification and Evolution of Vancomycin-Resistant Enterococcus faecium during Intestinal Domination.

Infect Immun 2019 07 20;87(7). Epub 2019 Jun 20.

Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA

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http://dx.doi.org/10.1128/IAI.00102-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589067PMC
July 2019

Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.

Cell Host Microbe 2018 04 22;23(4):447-457.e4. Epub 2018 Mar 22.

Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Medical College, New York, NY 10065, USA; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chom.2018.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897172PMC
April 2018

Gut microbiota injury in allogeneic haematopoietic stem cell transplantation.

Nat Rev Cancer 2018 05 16;18(5):283-295. Epub 2018 Feb 16.

Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1038/nrc.2018.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485905PMC
May 2018

Empiric antibiotic use in allogeneic hematopoietic cell transplantation: should we avoid anaerobe coverage?

Blood Adv 2017 Nov 17;1(25):2325-2328. Epub 2017 Nov 17.

Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1182/bloodadvances.2017005108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729613PMC
November 2017

Late Effects of Exposure to Ionizing Radiation and Age on Human Thymus Morphology and Function.

Radiat Res 2017 05 20;187(5):589-598. Epub 2017 Mar 20.

b   Department of Pathology and the Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina.

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http://dx.doi.org/10.1667/RR4554.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505072PMC
May 2017

Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation.

J Clin Oncol 2017 May 15;35(15):1650-1659. Epub 2017 Mar 15.

Jonathan U. Peled, Sean M. Devlin, Anna Staffas, Melissa Lumish, Raya Khanin, Eric R. Littmann, Lilan Ling, Satyajit Kosuri, Molly Maloy, John B. Slingerland, Katya F. Ahr, Kori A. Porosnicu Rodriguez, Yusuke Shono, Ann E. Slingerland, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Memorial Sloan Kettering Cancer Center; Jonathan U. Peled, Melissa D. Docampo, Boglarka Gyurkocza, Doris M. Ponce, Juliet N. Barker, Miguel-Angel Perales, Sergio A. Giralt, Ying Taur, Eric G. Pamer, Robert R. Jenq, and Marcel R.M. van den Brink, Weill Cornell Medical College; Melissa Lumish, New York University Langone Medical Center, New York, NY; Anthony D. Sung, Duke University Medical Center, Durham, NC; Daniela Weber, University Medical Center, Regensburg, Germany; and Amin M. Alousi, University of Texas MD Anderson Cancer Center, Houston, TX.

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http://dx.doi.org/10.1200/JCO.2016.70.3348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455763PMC
May 2017

Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation: Time To T Up the Thymus.

J Immunol 2017 01;198(1):40-46

Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065;

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http://dx.doi.org/10.4049/jimmunol.1601100DOI Listing
January 2017

The intestinal microbiota in allogeneic hematopoietic cell transplant and graft-versus-host disease.

Blood 2017 02 9;129(8):927-933. Epub 2016 Dec 9.

Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1182/blood-2016-09-691394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324712PMC
February 2017

Role of gut flora after bone marrow transplantation.

Nat Microbiol 2016 03 29;1:16036. Epub 2016 Mar 29.

Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nmicrobiol.2016.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027134PMC
March 2016

Thymus: the next (re)generation.

Immunol Rev 2016 May;271(1):56-71

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1111/imr.12418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837659PMC
May 2016

Immune reconstitution following stem cell transplantation.

Hematology Am Soc Hematol Educ Program 2015 ;2015:215-9

Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center, New York, NY; Weill Cornell Medical College, New York, NY;

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http://dx.doi.org/10.1182/asheducation-2015.1.215DOI Listing
October 2016

Ablation of B7-H3 but Not B7-H4 Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer.

Cancer Immunol Res 2015 Aug 29;3(8):849-54. Epub 2015 Jun 29.

Program in Immunology, Howard Hughes Medical Institute, and Ludwig Center for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, New York. Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939565PMC
August 2015

Interleukin-22: immunobiology and pathology.

Annu Rev Immunol 2015 11;33:747-85. Epub 2015 Feb 11.

Immunology Program and.

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http://dx.doi.org/10.1146/annurev-immunol-032414-112123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407497PMC
December 2015

Free-hand ultrasound guidance permits safe and efficient minimally invasive intrathymic injections in both young and aged mice.

Ultrasound Med Biol 2015 Apr 17;41(4):1105-11. Epub 2015 Feb 17.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1016/j.ultrasmedbio.2014.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346466PMC
April 2015

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile.

Nature 2015 Jan 22;517(7533):205-8. Epub 2014 Oct 22.

1] Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA [2] Lucille Castori Center for Microbes, Inflammation and Cancer, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA [3] Immunology Program, Sloan-Kettering Institute, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature13828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354891PMC
January 2015

Sex steroid blockade enhances thymopoiesis by modulating Notch signaling.

J Exp Med 2014 Nov 20;211(12):2341-9. Epub 2014 Oct 20.

Immunology Program, Department of Medicine, and Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065 Immunology Program, Department of Medicine, and Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10065 Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY 10021

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http://dx.doi.org/10.1084/jem.20131289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235646PMC
November 2014

Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells.

Immunity 2014 Oct 9;41(4):579-91. Epub 2014 Oct 9.

Kimmel Center for Biology and Medicine at the Skirball Institute, New York, NY 10016, USA; Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237219PMC
October 2014

The role of pattern-recognition receptors in graft-versus-host disease and graft-versus-leukemia after allogeneic stem cell transplantation.

Front Immunol 2014 18;5:337. Epub 2014 Jul 18.

III. Medizinische Klinik, Klinikum Rechts der Isar, Technische Universität München , Munich , Germany ; Department of Medicine and Immunology, Memorial Sloan-Kettering Cancer Center , New York, NY , USA.

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http://dx.doi.org/10.3389/fimmu.2014.00337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102927PMC
August 2014

Overcoming immunological barriers in regenerative medicine.

Nat Biotechnol 2014 Aug;32(8):786-94

1] Institute of Bioengineering, School of Life Sciences and School of Engineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. [2] Institute for Molecular Engineering, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/nbt.2960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409427PMC
August 2014

Histone deacetylation critically determines T cell subset radiosensitivity.

J Immunol 2014 Aug 2;193(3):1451-8. Epub 2014 Jul 2.

Department of Immunobiology, University of Arizona College of Medicine, Tucson, AZ 85724; Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ 85724; Graduate Interdisciplinary Program in Genetics, University of Arizona, Tucson, AZ 85719; BIO5 Institute, University of Arizona, Tucson, AZ 85719

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http://dx.doi.org/10.4049/jimmunol.1400434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108568PMC
August 2014

Linkage between dendritic and T cell commitments in human circulating hematopoietic progenitors.

J Immunol 2014 Jun 16;192(12):5749-60. Epub 2014 May 16.

Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima 732-0815, Japan;

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http://dx.doi.org/10.4049/jimmunol.1303260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048771PMC
June 2014

WNT signaling suppression in the senescent human thymus.

J Gerontol A Biol Sci Med Sci 2015 Mar 22;70(3):273-81. Epub 2014 Mar 22.

Laboratory of Immunovirology, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine. Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville, Spain.

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http://dx.doi.org/10.1093/gerona/glu030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351388PMC
March 2015

A small-molecule c-Rel inhibitor reduces alloactivation of T cells without compromising antitumor activity.

Cancer Discov 2014 May 18;4(5):578-91. Epub 2014 Feb 18.

Departments of 1Immunology, 2Computational Biology and Immunology, 3Pediatrics, and 4Medicine and Immunology, Memorial Sloan-Kettering Cancer Center; 5Department of Immunology, Weill-Cornell Medical Center, New York, New York; 6Program in Dermatopathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and 7Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011979PMC
May 2014

Multidimensional single-cell analysis of BCR signaling reveals proximal activation defect as a hallmark of chronic lymphocytic leukemia B cells.

PLoS One 2014 29;9(1):e79987. Epub 2014 Jan 29.

Center Cancer Systems Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America ; Program in Computational Biology, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079987PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906024PMC
September 2014

Enhanced responses to tumor immunization following total body irradiation are time-dependent.

PLoS One 2013 12;8(12):e82496. Epub 2013 Dec 12.

Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America ; Weill Cornell Medical College, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082496PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861406PMC
October 2014

Genetically engineered donor T cells to optimize graft-versus-tumor effects across MHC barriers.

Immunol Rev 2014 Jan;257(1):226-36

Department of Medicine and Immunology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Department of Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1111/imr.12142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874121PMC
January 2014

Clinical applications of palifermin: amelioration of oral mucositis and other potential indications.

J Cell Mol Med 2013 Nov 19;17(11):1371-84. Epub 2013 Nov 19.

Department of Sarcoma Medical Oncology, Section of Cytokines and Supportive Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1111/jcmm.12169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117550PMC
November 2013

Clinical strategies to enhance thymic recovery after allogeneic hematopoietic stem cell transplantation.

Immunol Lett 2013 Sep-Oct;155(1-2):31-5. Epub 2013 Oct 8.

Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, United States; Department of Clinical and Experimental Medicine, University of Perugia, 06122 Perugia, Italy.

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http://dx.doi.org/10.1016/j.imlet.2013.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871183PMC
July 2014

Immune tolerance and transplantation.

Semin Oncol 2012 Dec;39(6):629-42

Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2012.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514882PMC
December 2012

Extrathymic development of murine T cells after bone marrow transplantation.

J Clin Invest 2012 Dec 19;122(12):4716-26. Epub 2012 Nov 19.

Department of Immunology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI60630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533530PMC
December 2012

Transforming lymph nodes into tissue factories.

Nat Biotechnol 2012 Oct;30(10):958-9

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http://dx.doi.org/10.1038/nbt.2388DOI Listing
October 2012

Immune recovery after allogeneic hematopoietic stem cell transplantation: is it time to revisit how patients are monitored?

Biol Blood Marrow Transplant 2012 Nov 27;18(11):1617-9. Epub 2012 Sep 27.

Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Weill Cornell Medical College, New York, New York 10065, USA.

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http://dx.doi.org/10.1016/j.bbmt.2012.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001674PMC
November 2012