Marcel Leist

Marcel Leist

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Marcel Leist

Marcel Leist

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Corrigendum to Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity Toxicol Appl Pharmacol, 354 (2018) 64-80.

Toxicol Appl Pharmacol 2019 Jun 16;372:70. Epub 2019 Apr 16.

In Vitro Toxicology and Biomedicine, Dept Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, 78457 Konstanz, Germany; CAAT-Europe, University of Konstanz, Konstanz 78457, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2019.04.010DOI Listing
June 2019

Functionalized DNA Hydrogels Produced by Polymerase-Catalyzed Incorporation of Non-Natural Nucleotides as a Surface Coating for Cell Culture Applications.

Adv Healthc Mater 2019 May 12;8(9):e1900080. Epub 2019 Mar 12.

Departments of Chemistry and Biology, Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstraße 10, 78464, Konstanz, Germany.

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http://dx.doi.org/10.1002/adhm.201900080DOI Listing
May 2019

Chemical concentrations in cell culture compartments (C5) - concentration definitions.

ALTEX 2019 ;36(1):154-160

In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.14573/altex.1901031DOI Listing
April 2019

A high-throughput approach to identify specific neurotoxicants/ developmental toxicants in human neuronal cell function assays.

ALTEX 2018 21;35(2):235-253. Epub 2018 Jan 21.

In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.14573/altex.1712182DOI Listing
January 2019

Major changes of cell function and toxicant sensitivity in cultured cells undergoing mild, quasi-natural genetic drift.

Arch Toxicol 2018 Dec 8;92(12):3487-3503. Epub 2018 Oct 8.

Department for in vitro toxicology and biomedicine (Doerenkamp-Zbinden chair), University of Konstanz, PO Box M657, 78457, Konstanz, Germany.

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http://dx.doi.org/10.1007/s00204-018-2326-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290691PMC
December 2018

Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.

Arch Toxicol 2018 Dec 13;92(12):3505-3515. Epub 2018 Oct 13.

Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), 44139, Dortmund, Germany.

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http://link.springer.com/10.1007/s00204-018-2302-0
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http://dx.doi.org/10.1007/s00204-018-2302-0DOI Listing
December 2018

Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress.

Cell Death Differ 2018 Dec 2;25(12):2101-2117. Epub 2018 Nov 2.

In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, 78457, Konstanz, Germany.

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http://www.nature.com/articles/s41418-018-0229-x
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http://dx.doi.org/10.1038/s41418-018-0229-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261954PMC
December 2018

Animal testing and its alternatives - the most important omics is economics.

ALTEX 2018 ;35(3):275-305

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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http://dx.doi.org/10.14573/altex.1807041DOI Listing
November 2018

Essential components of methods papers.

ALTEX 2018 ;35(3):429-432

Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany.

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http://dx.doi.org/10.14573/altex.1807031DOI Listing
November 2018

Reduced Aβ secretion by human neurons under conditions of strongly increased BACE activity.

J Neurochem 2018 Oct 26;147(2):256-274. Epub 2018 Sep 26.

Chair for in vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1111/jnc.14467DOI Listing
October 2018

Normalization of data for viability and relative cell function curves.

ALTEX 2018 ;35(2):268-271

In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.14573/1803231DOI Listing
October 2018

Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity.

Toxicol Appl Pharmacol 2018 09 24;354:64-80. Epub 2017 Dec 24.

In Vitro Toxicology and Biomedicine, Dept Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, 78457 Konstanz, Germany; CAAT-Europe, University of Konstanz, Konstanz 78457, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2017.12.013DOI Listing
September 2018

Carbamylated Erythropoietin Decreased Proliferation and Neurogenesis in the Subventricular Zone, but Not the Dentate Gyrus, After Irradiation to the Developing Rat Brain.

Front Neurol 2018 12;9:738. Epub 2018 Sep 12.

Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Gothenburg University, Gothenburg, Sweden.

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http://dx.doi.org/10.3389/fneur.2018.00738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143677PMC
September 2018

A structure-activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins.

Arch Toxicol 2018 Mar 21;92(3):1225-1247. Epub 2017 Nov 21.

In vitro Toxicology and Biomedicine, Department Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Konstanz, Germany.

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http://dx.doi.org/10.1007/s00204-017-2125-4DOI Listing
March 2018

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition.

Arch Toxicol 2018 Jan 5;92(1):41-82. Epub 2017 Dec 5.

In Vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Universitätsstr. 10, PO Box M657, 78457, Konstanz, Germany.

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http://dx.doi.org/10.1007/s00204-017-2133-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773657PMC
January 2018

Simultaneous IR-Spectroscopic Observation of α-Synuclein, Lipids, and Solvent Reveals an Alternative Membrane-Induced Oligomerization Pathway.

Chembiochem 2017 12 2;18(23):2312-2316. Epub 2017 Nov 2.

Department of Chemistry, University of Konstanz, Universitätsstrasse 10, 78457, Konstanz, Germany.

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http://dx.doi.org/10.1002/cbic.201700355DOI Listing
December 2017

Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library.

Arch Toxicol 2017 Nov 5;91(11):3613-3632. Epub 2017 May 5.

In Vitro Toxicology and Biomedicine, Department inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Box 657, Universitaetsstr. 10, 78457, Konstanz, Germany.

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http://dx.doi.org/10.1007/s00204-017-1977-yDOI Listing
November 2017

New animal-free concepts and test methods for developmental toxicity and peripheral neurotoxicity.

Authors:
Marcel Leist

Altern Lab Anim 2017 Nov;45(5):253-260

In Vitro Toxicology and Biomedicine Laboratory, Department of Biology, University of Konstanz, Konstanz, Germany; CAAT-Europe, University of Konstanz, Konstanz, Germany; Konstanz Research School Chemical Biology, Konstanz, Germany; Co-operative Research Training Group on In Vitro Testing of Active Ingredients, Konstanz-Sigmaringen, Germany.

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http://dx.doi.org/10.1177/026119291704500505DOI Listing
November 2017

Impairment of human neural crest cell migration by prolonged exposure to interferon-beta.

Arch Toxicol 2017 Oct 1;91(10):3385-3402. Epub 2017 Apr 1.

Department of In Vitro Toxicology and Biomedicine, University of Konstanz, Box 657, 78457, Konstanz, Germany.

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http://dx.doi.org/10.1007/s00204-017-1966-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608792PMC
October 2017

Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP.

Trends Pharmacol Sci 2017 06 23;38(6):541-555. Epub 2017 Apr 23.

In vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, D-78457 Konstanz, Germany.

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http://dx.doi.org/10.1016/j.tips.2017.03.010DOI Listing
June 2017

Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity.

Chem Res Toxicol 2017 04 21;30(4):905-922. Epub 2016 Dec 21.

In Vitro Toxicology and Biomedicine, Department inaugurated by the Doerenkamp-Zbinden Chair Foundation, University of Konstanz , 78457 Konstanz, Germany.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00259DOI Listing
April 2017

Design of a high-throughput human neural crest cell migration assay to indicate potential developmental toxicants.

ALTEX 2017 27;34(1):75-94. Epub 2016 Jul 27.

In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden Foundation at the University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.14573/altex.1605031DOI Listing
February 2017

Switching from astrocytic neuroprotection to neurodegeneration by cytokine stimulation.

Arch Toxicol 2017 Jan 6;91(1):231-246. Epub 2016 Apr 6.

Doerenkamp-Zbinden Chair for In Vitro Toxicology and Biomedicine, University of Konstanz, PO Box M657, 78457, Constance, Germany.

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http://dx.doi.org/10.1007/s00204-016-1702-2DOI Listing
January 2017

Quantification of Metabolic Rearrangements During Neural Stem Cells Differentiation into Astrocytes by Metabolic Flux Analysis.

Neurochem Res 2017 Jan 12;42(1):244-253. Epub 2016 Apr 12.

IBET, Instituto de Biologia Experimental e Tecnológica, Apartado 12, 2780-901, Oeiras, Portugal.

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http://dx.doi.org/10.1007/s11064-016-1907-zDOI Listing
January 2017

Conversion of Nonproliferating Astrocytes into Neurogenic Neural Stem Cells: Control by FGF2 and Interferon-γ.

Stem Cells 2016 12 23;34(12):2861-2874. Epub 2016 Sep 23.

Department of Biology, The Doerenkamp-Zbinden Chair of in-vitro Toxicology and Biomedicine/Alternatives to Animal Experimentation, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1002/stem.2483DOI Listing
December 2016

Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research.

Front Cell Neurosci 2016 26;10:215. Epub 2016 Sep 26.

BioTalentum LtdGödöllő, Hungary; Molecular Animal Biotechnology Laboratory, Szent Istvan UniversityGödöllő, Hungary.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035736PMC
http://dx.doi.org/10.3389/fncel.2016.00215DOI Listing
September 2016

Systems Toxicology: The Future of Risk Assessment.

Int J Toxicol 2015 Jul-Aug;34(4):346-8. Epub 2015 Mar 23.

Harvard University, Cambridge, MA, USA University of Massachusetts School of Public Health, Amherst, MA, USA

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http://dx.doi.org/10.1177/1091581815576551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778743PMC
June 2016

Cellular resilience.

ALTEX 2015 ;32(4):247-60

Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;

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http://dx.doi.org/10.14573/altex.1509271DOI Listing
June 2016

Animal use for science in Europe.

ALTEX 2015 ;32(4):261-74

Center for Alternatives to Animal Testing - Europe, University of Konstanz, Germany.

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http://dx.doi.org/10.14573/altex.1509081DOI Listing
June 2016

Functional and phenotypic differences of pure populations of stem cell-derived astrocytes and neuronal precursor cells.

Glia 2016 May 22;64(5):695-715. Epub 2015 Dec 22.

The Doerenkamp-Zbinden Chair of in-Vitro Toxicology and Biomedicine/Alternatives to Animal Experimentation, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1002/glia.22954DOI Listing
May 2016

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk.

Arch Toxicol 2016 May 26;90(5):1021-4. Epub 2016 Mar 26.

Division of Toxicology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00204-016-1698-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830874PMC
May 2016

Toxicity of organic and inorganic mercury species in differentiated human neurons and human astrocytes.

J Trace Elem Med Biol 2015 Oct 15;32:200-8. Epub 2015 Jul 15.

Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114 - 116, 14558 Nuthetal, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jtemb.2015.06.008DOI Listing
October 2015

Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling.

Neurotoxicology 2015 Sep 31;50:56-70. Epub 2015 Jul 31.

Doerenkamp-Zbinden Chair of In Vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1016/j.neuro.2015.07.008DOI Listing
September 2015

Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolism.

Br J Pharmacol 2015 Aug 26;172(16):4119-32. Epub 2015 Jun 26.

Doerenkamp-Zbinden Chair for In Vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1111/bph.13193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543617PMC
August 2015

From smoking guns to footprints: mining for critical events of toxicity pathways in transcriptome data.

Arch Toxicol 2015 May 8;89(5):813-7. Epub 2015 Apr 8.

Department of Statistics, TU Dortmund University, Dortmund, Germany.

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http://link.springer.com/10.1007/s00204-015-1497-6
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http://dx.doi.org/10.1007/s00204-015-1497-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396704PMC
May 2015

Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities.

ALTEX 2014 ;31(2):129-56

Centers for Alternatives to Animal Testing (CAAT) at Johns Hopkins Bloomberg School of Public Health, USA.

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http://dx.doi.org/10.14573/altex.1403271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778747PMC
January 2015

Impairment of glutamate signaling in mouse central nervous system neurons in vitro by tri-ortho-cresyl phosphate at noncytotoxic concentrations.

Toxicol Sci 2014 Nov 8;142(1):274-84. Epub 2014 Sep 8.

IfADo - Leibniz Research Center for Working Environment and Human Factors, 44139 Dortmund, Germany Department of Animal Physiology, Ruhr-University Bochum, 44801 Bochum, Germany.

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http://toxsci.oxfordjournals.org/content/142/1/274.full.pdf
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http://www.toxsci.oxfordjournals.org/cgi/doi/10.1093/toxsci/
Publisher Site
http://dx.doi.org/10.1093/toxsci/kfu174DOI Listing
November 2014

Alpha-synuclein binds to the inner membrane of mitochondria in an α-helical conformation.

Chembiochem 2014 Nov 10;15(17):2499-502. Epub 2014 Sep 10.

Department of Chemistry and Biology, Konstanz Research School Chemical Biology (KoRS-CB) and the Zukunftskolleg, University of Konstanz, 78457 Konstanz (Germany).

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http://dx.doi.org/10.1002/cbic.201402281DOI Listing
November 2014

Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis.

Nat Commun 2014 Sep 11;5:4839. Epub 2014 Sep 11.

1] University of Konstanz, 78464 Konstanz, Germany [2] Biotechnology Institute Thurgau, University of Konstanz, Kreuzlingen CH-8280, Switzerland.

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http://dx.doi.org/10.1038/ncomms5839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449154PMC
September 2014

Identification and affinity-quantification of ß-amyloid and α-synuclein polypeptides using on-line SAW-biosensor-mass spectrometry.

J Am Soc Mass Spectrom 2014 Aug 21;25(8):1472-81. Epub 2014 May 21.

Laboratory of Analytical Chemistry and Steinbeis Center for Biopolymer Structure Analysis, University of Konstanz, 78457, Konstanz, Germany.

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http://dx.doi.org/10.1007/s13361-014-0904-1DOI Listing
August 2014

Epigenetics and transcriptomics to detect adverse drug effects in model systems of human development.

Basic Clin Pharmacol Toxicol 2014 Jul 3;115(1):59-68. Epub 2014 Mar 3.

Doerenkamp-Zbinden Chair for In Vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1111/bcpt.12203DOI Listing
July 2014

Acrylamide alters neurotransmitter induced calcium responses in murine ESC-derived and primary neurons.

Neurotoxicology 2014 Jul 12;43:117-126. Epub 2014 Apr 12.

IfADo - Leibniz Research Center for Working Environment and Human Factors, Dortmund, Germany.

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http://dx.doi.org/10.1016/j.neuro.2014.03.010DOI Listing
July 2014

Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases.

ALTEX 2013 ;30(4):427-44

Doerenkamp-Zbinden Chair for in vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.14573/altex.2013.4.427DOI Listing
June 2014

Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants.

Arch Toxicol 2013 Dec 14;87(12):2215-31. Epub 2013 May 14.

Doerenkamp-Zbinden Chair for In Vitro Toxicology and Biomedicine, University of Konstanz, Universitätsstr. 10, Box 657, 78457, Constance, Germany,

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https://kops.uni-konstanz.de/bitstream/handle/123456789/2653
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http://link.springer.com/content/pdf/10.1007/s00204-013-1072
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http://link.springer.com/10.1007/s00204-013-1072-y
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http://dx.doi.org/10.1007/s00204-013-1072-yDOI Listing
December 2013

Reprint: Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice.

ALTEX 2013 ;30(2):227-30

University of Konstanz, Box M657, 78457 Konstanz, Germany.

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http://www.altex.org/index.php/altex/article/view/388
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http://dx.doi.org/10.14573/altex.2013.2.227DOI Listing
October 2013

Monocrotophos in Gandaman village: India school lunch deaths and need for improved toxicity testing.

Arch Toxicol 2013 Oct 13;87(10):1877-81. Epub 2013 Aug 13.

Department of Pathology and Immunology, Geneva Medical Faculty, Centre Medical Universitaire, University of Geneva (UNIGE), 1, rue Michel-Servet, 1211, Geneva 4, Switzerland,

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http://dx.doi.org/10.1007/s00204-013-1113-6DOI Listing
October 2013

Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies.

J Neurochem 2013 May 19;125(4):491-511. Epub 2013 Mar 19.

Department of Biology, Doerenkamp-Zbinden Chair for In vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.1111/jnc.12226DOI Listing
May 2013

Characterization of mouse cell line IMA 2.1 as a potential model system to study astrocyte functions.

ALTEX 2012 ;29(3):261-74

Doerenkamp-Zbinden Chair for in vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.14573/altex.2012.3.261DOI Listing
December 2012

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome.

Hum Mol Genet 2012 Sep 20;21(18):4104-14. Epub 2012 Jun 20.

Doerenkamp-Zbinden Chair for In Vitro Toxicology and Biomedicine, University of Konstanz, D-78457 Konstanz, Germany.

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http://dx.doi.org/10.1093/hmg/dds239DOI Listing
September 2012

Compound selection for in vitro modeling of developmental neurotoxicity.

Front Biosci (Landmark Ed) 2012 Jun 1;17:2442-60. Epub 2012 Jun 1.

Doerenkamp-Zbinden Chair of in-vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Konstanz, Germany.

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June 2012