Marcel Kaiser

Marcel Kaiser

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Marcel Kaiser

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Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors.

Bioorg Med Chem Lett 2020 Apr 22;30(8):127052. Epub 2020 Feb 22.

Departments of Chemistry and Biology, IRBM Spa, Via Pontina km 30, 600, 00071 Pomezia, Rome, Italy.

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http://dx.doi.org/10.1016/j.bmcl.2020.127052DOI Listing
April 2020

Antiprotozoal and antihelminthic properties of plants ingested by wild Japanese macaques (Macaca fuscata yakui) in Yakushima Island.

J Ethnopharmacol 2020 Jan 4;247:112270. Epub 2019 Oct 4.

Primate Research Institute, Kyoto University, Kanrin 41-2, 484-8506, Inuyama, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2019.112270DOI Listing
January 2020

Structure-Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents.

ChemMedChem 2020 Jan 12;15(1):68-78. Epub 2019 Nov 12.

Institut für Pharmazeutische Biologie und Phytochemie (IPBP), Westfälische Wilhelms-Universität Münster, Corrensstraße 48, 48149, Münster, Germany.

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http://dx.doi.org/10.1002/cmdc.201900544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003929PMC
January 2020

A new chemotype with promise against Trypanosoma cruzi.

Bioorg Med Chem Lett 2020 Jan 31;30(1):126778. Epub 2019 Oct 31.

College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.126778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892603PMC
January 2020

Synthesis, in-vitro antiprotozoal activity and molecular docking study of isothiocyanate derivatives.

Bioorg Med Chem 2020 Jan 9;28(1):115185. Epub 2019 Nov 9.

National and Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Birkat Al-Mauz, Nizwa 611, Oman.

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http://dx.doi.org/10.1016/j.bmc.2019.115185DOI Listing
January 2020

In Vitro Drug Efficacy Testing Against Trypanosoma brucei.

Methods Mol Biol 2020 ;2116:781-789

Swiss Tropical and Public Health Institute, Basel, Switzerland.

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http://dx.doi.org/10.1007/978-1-0716-0294-2_46DOI Listing
January 2020

Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity.

Malar J 2019 Dec 3;18(1):392. Epub 2019 Dec 3.

Instituto de Parasitología y Biomedicina López-Neyra. Consejo Superior de Investigaciones Científicas. Parque Tecnológico de Ciencias de la Salud, Avenida del Conocimiento, s/n 18016-Armilla, Granada, Spain.

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http://dx.doi.org/10.1186/s12936-019-3025-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889535PMC
December 2019

Structure, Biosynthesis, and Bioactivity of Photoditritide from Meg1.

J Nat Prod 2019 Dec 4;82(12):3499-3503. Epub 2019 Dec 4.

Institute of Organic Chemistry , Johannes Gutenberg University Mainz , 55128 Mainz , Germany.

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http://dx.doi.org/10.1021/acs.jnatprod.9b00932DOI Listing
December 2019

Phototemtide A, a Cyclic Lipopeptide Heterologously Expressed from Photorhabdus temperata Meg1, Shows Selective Antiprotozoal Activity.

Chembiochem 2019 Dec 9. Epub 2019 Dec 9.

Molecular Biotechnology, Department of Biosciences, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/cbic.201900665DOI Listing
December 2019

Antiprotozoal Activity of Turkish Essential Oil and Its Components.

Molecules 2019 Dec 3;24(23). Epub 2019 Dec 3.

Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.

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http://dx.doi.org/10.3390/molecules24234421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930659PMC
December 2019

Time to Insulin Initiation in Type 2 Diabetes Patients in 2010/2011 and 2016/2017 in Germany.

J Diabetes Sci Technol 2019 Nov 12;13(6):1129-1134. Epub 2019 Mar 12.

Klinik Innere Medizin III, Diabetologie / Nephrologie / Hypertensiologie, Sophien- und Hufeland-Klinikum Weimar, Weimar, Germany.

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http://dx.doi.org/10.1177/1932296819835196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835192PMC
November 2019

Ealamines A-H, a Series of Naphthylisoquinolines with the Rare 7,8'-Coupling Site, from the Congolese Liana , Targeting Pancreatic Cancer Cells.

J Nat Prod 2019 Nov 20;82(11):3150-3164. Epub 2019 Oct 20.

Institute of Organic Chemistry , University of Würzburg , Am Hubland , D-97074 Würzburg , Germany.

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http://dx.doi.org/10.1021/acs.jnatprod.9b00755DOI Listing
November 2019

A Near-Complete Series of Four Atropisomeric Jozimine A-Type Naphthylisoquinoline Dimers with Antiplasmodial and Cytotoxic Activities and Related Alkaloids from .

J Nat Prod 2019 Nov 23;82(11):3033-3046. Epub 2019 Oct 23.

Institute of Organic Chemistry , University of Würzburg , Am Hubland , D-97074 Würzburg , Germany.

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http://dx.doi.org/10.1021/acs.jnatprod.9b00589DOI Listing
November 2019

N-substituted noscapine derivatives as new antiprotozoal agents: Synthesis, antiparasitic activity and molecular docking study.

Bioorg Chem 2019 Oct 11;91:103116. Epub 2019 Jul 11.

National and Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Birkat Al-Mauz, Nizwa 611, Oman.

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http://dx.doi.org/10.1016/j.bioorg.2019.103116DOI Listing
October 2019

Targeting a Large Active Site: Structure-Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase.

Chemistry 2019 Sep 13;25(49):11416-11421. Epub 2019 Aug 13.

Laboratorium für Organische Chemie, ETH Zurich, Vladimir-Prelog-Weg 3, 8093, Zurich, Switzerland.

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http://dx.doi.org/10.1002/chem.201901664DOI Listing
September 2019

(±)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus P1210 Isolated from the Halophyte sp.

J Org Chem 2019 Sep 27;84(17):11203-11209. Epub 2019 Aug 27.

Institute of Organic Chemistry , Johannes Gutenberg University Mainz , 55128 Mainz , Germany.

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http://dx.doi.org/10.1021/acs.joc.9b01229DOI Listing
September 2019

Antiprotozoal Activities of Tetrazole-quinolines with Aminopiperidine Linker.

Med Chem 2019 ;15(4):409-416

Pharmaceutical Chemistry, Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria.

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http://www.eurekaselect.com/166231/article
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http://dx.doi.org/10.2174/1573406414666181015115101DOI Listing
June 2019

Preparation of Sesquiterpene Lactone-Loaded PLA Nanoparticles and Evaluation of Their Antitrypanosomal Activity.

Molecules 2019 Jun 4;24(11). Epub 2019 Jun 4.

Institute of Pharmaceutical Technology and Biopharmacy, University of Muenster, PharmaCampus Corrensstrasse 48, D-48149 Muenster, Germany.

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http://dx.doi.org/10.3390/molecules24112110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600441PMC
June 2019

Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity.

Bioorg Med Chem 2019 05 2;27(10):2052-2065. Epub 2019 Apr 2.

Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstraße 1, A-8010 Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.03.061DOI Listing
May 2019

Antiprotozoal Germacranolide Sesquiterpene Lactones from Tanacetum sonbolii.

Planta Med 2019 Mar 8;85(5):424-430. Epub 2019 Jan 8.

Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C., Evin, Tehran, Iran.

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http://dx.doi.org/10.1055/a-0824-1294DOI Listing
March 2019

Antitrypanosomal Activity of Sesquiterpene Lactones from L. Including a New Furanoheliangolide with an Unusual Structure.

Molecules 2019 Mar 18;24(6). Epub 2019 Mar 18.

Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, PharmaCampus⁻Corrensstrasse 48, D-48149 Münster, Germany.

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http://dx.doi.org/10.3390/molecules24061068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471283PMC
March 2019

Synthesis and biological investigation of (+)-3-hydroxymethylartemisinin.

Beilstein J Org Chem 2019 27;15:567-570. Epub 2019 Feb 27.

Faculty of Chemistry and Mineralogy, Institute of Organic Chemistry, University of Leipzig, Johannisallee 29, 04301 Leipzig, Germany.

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http://dx.doi.org/10.3762/bjoc.15.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404461PMC
February 2019

Antiprotozoal Isoprenoids from Salvia hydrangea.

J Nat Prod 2018 12 19;81(12):2682-2691. Epub 2018 Dec 19.

Department of Pharmaceutical Biology , University of Basel , Klingelbergstrasse 50 , 4056 Basel , Switzerland.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00498
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http://dx.doi.org/10.1021/acs.jnatprod.8b00498DOI Listing
December 2018

Precursor-Directed Diversification of Cyclic Tetrapeptidic Pseudoxylallemycins.

Chembiochem 2018 11 4;19(21):2307-2311. Epub 2018 Oct 4.

Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Beutenbergstraße 11a, 07745, Jena, Germany.

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http://dx.doi.org/10.1002/cbic.201800503DOI Listing
November 2018

Synthesis of Jacaranone-Derived Nitrogenous Cyclohexadienones and Their Antiproliferative and Antiprotozoal Activities.

Molecules 2018 Nov 7;23(11). Epub 2018 Nov 7.

Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstrasse 1, 8010 Graz, Austria.

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http://www.mdpi.com/1420-3049/23/11/2902
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http://dx.doi.org/10.3390/molecules23112902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278284PMC
November 2018

Complementary Quantitative Structure⁻Activity Relationship Models for the Antitrypanosomal Activity of Sesquiterpene Lactones.

Int J Mol Sci 2018 Nov 22;19(12). Epub 2018 Nov 22.

Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Muenster, PharmaCampus Corrensstrasse 48, D-48149 Muenster, Germany.

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http://dx.doi.org/10.3390/ijms19123721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321053PMC
November 2018

Methionine-Containing Rhabdopeptide/Xenortide-like Peptides from Heterologous Expression of the Biosynthetic Gene Cluster kj12ABC in Escherichia coli.

J Nat Prod 2018 10 10;81(10):2292-2295. Epub 2018 Oct 10.

Molekulare Biotechnologie, Fachbereich Biowissenschaften , Goethe Universität Frankfurt , 60438 Frankfurt am Main , Germany.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00425
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http://dx.doi.org/10.1021/acs.jnatprod.8b00425DOI Listing
October 2018

Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates.

Bioorg Med Chem 2018 09 10;26(16):4624-4634. Epub 2018 Jul 10.

Departament de Química Inorgànica i Orgànica, Universitat Jaume I, Avda. Sos Baynat s/n 12080 Castelló, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.07.015DOI Listing
September 2018

Rhabdopeptide/Xenortide-like Peptides from Xenorhabdus innexi with Terminal Amines Showing Potent Antiprotozoal Activity.

Org Lett 2018 09 10;20(17):5116-5120. Epub 2018 Aug 10.

Molekulare Biotechnologie, Fachbereich Biowissenschaften , Goethe Universität Frankfurt , 60438 Frankfurt am Main , Germany.

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http://dx.doi.org/10.1021/acs.orglett.8b01975DOI Listing
September 2018

Antiprotozoal Diterpenes from Perovskia abrotanoides.

Planta Med 2018 Aug 26;84(12-13):913-919. Epub 2018 Apr 26.

Division of Pharmaceutical Biology, University of Basel, Switzerland.

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http://dx.doi.org/10.1055/a-0608-4946DOI Listing
August 2018

C-H Activation Enables a Concise Total Synthesis of Quinine and Analogues with Enhanced Antimalarial Activity.

Angew Chem Int Ed Engl 2018 08 22;57(33):10737-10741. Epub 2018 Jun 22.

Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria.

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http://dx.doi.org/10.1002/anie.201804551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146912PMC
August 2018

Expanding the Rubterolone Family: Intrinsic Reactivity and Directed Diversification of PKS-derived Pyrans.

Chemistry 2018 Aug 16;24(44):11319-11324. Epub 2018 Jul 16.

Leibniz Institute for Natural Product Research, and Infection Biology-Hans Knöll Institute, Beutenbergstraße 11a, 07745, Jena, Germany.

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http://dx.doi.org/10.1002/chem.201802066DOI Listing
August 2018

Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.

Eur J Med Chem 2018 Aug 28;156:53-60. Epub 2018 Jun 28.

Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, "Sapienza" Università di Roma, p.le Aldo Moro 5, I-00185, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.06.063DOI Listing
August 2018

Total Synthesis and Biological Investigation of (-)-Artemisinin: The Antimalarial Activity of Artemisinin Is not Stereospecific.

Angew Chem Int Ed Engl 2018 07 10;57(27):8293-8296. Epub 2018 Jun 10.

Faculty of Chemistry and Mineralogy, Institute of Organic Chemistry, University of Leipzig, Johannisallee 29, 04301, Leipzig, Germany.

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http://doi.wiley.com/10.1002/anie.201802015
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http://dx.doi.org/10.1002/anie.201802015DOI Listing
July 2018

Phytochemical Study of Salvia leriifolia Roots: Rearranged Abietane Diterpenoids with Antiprotozoal Activity.

J Nat Prod 2018 06 13;81(6):1384-1390. Epub 2018 Jun 13.

Division of Pharmaceutical Biology , University of Basel , Klingelbergstrasse 50 , 4056 Basel , Switzerland.

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http://dx.doi.org/10.1021/acs.jnatprod.7b01019DOI Listing
June 2018

Discovery of a quinoline-based phenyl sulfone derivative as an antitrypanosomal agent.

Bioorg Med Chem Lett 2018 05 24;28(9):1647-1651. Epub 2018 Mar 24.

Department of Chemistry, Jackson State University, Jackson, MS 39217, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.03.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912169PMC
May 2018

Combined Approach of Backbone Amide Linking and On-Resin N-Methylation for the Synthesis of Bioactive and Metabolically Stable Peptides.

J Med Chem 2018 05 20;61(9):3930-3938. Epub 2018 Apr 20.

Molekulare Biotechnologie, Fachbereich Biowissenschaften , Goethe University Frankfurt , Max-von-Laue-Strasse 9 , D-60438 Frankfurt am Main , Germany.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01809DOI Listing
May 2018

-oxide alkaloids from (Amaryllidaceae).

Molecules 2018 May 26;23(6). Epub 2018 May 26.

Group of Natural Products, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, 27-31, 08028-Barcelona, Spain.

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http://dx.doi.org/10.3390/molecules23061277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099558PMC
May 2018

Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.

J Med Chem 2018 04 13;61(8):3350-3369. Epub 2018 Apr 13.

Roche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , 4070 Basel , Switzerland.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01869DOI Listing
April 2018

2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.

J Med Chem 2018 04 6;61(8):3370-3388. Epub 2018 Apr 6.

Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel , F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124 , 4070 Basel , Switzerland.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01870DOI Listing
April 2018

A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea.

Nat Prod Res 2018 Mar 8;32(6):695-701. Epub 2017 Jun 8.

b Faculty of Science , University of Magallanes , Punta Arenas , Chile.

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https://www.tandfonline.com/doi/full/10.1080/14786419.2017.1
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http://dx.doi.org/10.1080/14786419.2017.1338287DOI Listing
March 2018

Georatusin, a Specific Antiparasitic Polyketide-Peptide Hybrid from the Fungus Geomyces auratus.

Org Lett 2018 03 23;20(6):1563-1567. Epub 2018 Feb 23.

Institut für Biotechnologie und Wirkstoff-Forschung gGmbH (IBWF) , 67663 Kaiserslautern , Germany.

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http://dx.doi.org/10.1021/acs.orglett.8b00293DOI Listing
March 2018

Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity.

Eur J Med Chem 2018 Feb 31;146:651-667. Epub 2018 Jan 31.

Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, HR-10 000 Zagreb, Croatia. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.01.062DOI Listing
February 2018

Synthesis of new 1-benzyl tetrahydropyridinylidene ammonium salts and their antimicrobial and anticellular activities.

Eur J Med Chem 2018 Jan 10;143:97-106. Epub 2017 Nov 10.

Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstrasse 1, 8010 Graz, Austria.

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http://dx.doi.org/10.1016/j.ejmech.2017.11.025DOI Listing
January 2018

Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata.

J Nat Prod 2018 01 15;81(1):124-130. Epub 2017 Dec 15.

Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Muenster , PharmaCampus Corrensstrasse 48, Muenster D-48149, Germany.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.7b00747
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http://dx.doi.org/10.1021/acs.jnatprod.7b00747DOI Listing
January 2018

Sesquiterpene Lactones from Vernonia cinerascens Sch. Bip. and Their in Vitro Antitrypanosomal Activity.

Molecules 2018 Jan 27;23(2). Epub 2018 Jan 27.

Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, PharmaCampus Corrensstraße 48, D-48149 Münster, Germany.

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http://www.mdpi.com/1420-3049/23/2/248
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http://dx.doi.org/10.3390/molecules23020248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017816PMC
January 2018

Hippeastrum reticulatum (Amaryllidaceae): Alkaloid Profiling, Biological Activities and Molecular Docking.

Molecules 2017 Dec 9;22(12). Epub 2017 Dec 9.

Group of Natural Products, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, 27-31, 08028-Barcelona, Spain.

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http://dx.doi.org/10.3390/molecules22122191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149799PMC
December 2017

Acid-Induced Rearrangement of Epoxygermacranolides: Synthesis of Furanoheliangolides and Cadinanes from Nobilin.

Molecules 2017 Dec 18;22(12). Epub 2017 Dec 18.

Pharmaceutical Biology, Pharmazentrum, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.3390/molecules22122252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149915PMC
December 2017

Biosynthesis and function of simple amides in Xenorhabdus doucetiae.

Environ Microbiol 2017 11 13;19(11):4564-4575. Epub 2017 Oct 13.

Merk Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe-Universität Frankfurt, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1111/1462-2920.13919DOI Listing
November 2017

Synthesis and antimalarial evaluation of artesunate-polyamine and trioxolane-polyamine conjugates.

Eur J Med Chem 2017 Nov 22;140:595-603. Epub 2017 Sep 22.

School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.09.040DOI Listing
November 2017

Harnessing fungal nonribosomal cyclodepsipeptide synthetases for mechanistic insights and tailored engineering.

Chem Sci 2017 Nov 25;8(11):7834-7843. Epub 2017 Sep 25.

Fachgebiet Biologische Chemie , Institut für Chemie , Technische Universität Berlin , Strasse des 17. Juni 124 , 10623 Berlin , Germany . Email:

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http://dx.doi.org/10.1039/c7sc03093bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5674221PMC
November 2017

Terpenoids from the Oleo-Gum-Resin of Boswellia serrata and Their Antiplasmodial Effects In Vitro.

Planta Med 2017 Oct 24;83(14-15):1214-1226. Epub 2017 Jul 24.

Institute for Pharmaceutical Biology and Phytochemistry, University of Münster, Münster, Germany.

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http://dx.doi.org/10.1055/s-0043-116943DOI Listing
October 2017

Erratum: Terpenoids from the Oleo-Gum-Resin of Boswellia serrata and Their Antiplasmodial Effects In Vitro.

Planta Med 2017 10 28;83(14-15):E4. Epub 2017 Aug 28.

Institute for Pharmaceutical Biology and Phytochemistry, University of Münster, Münster, Germany.

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http://dx.doi.org/10.1055/s-0043-118649DOI Listing
October 2017

Antileukemic ancistrobenomine B and related 5,1'-coupled naphthylisoquinoline alkaloids from the Chinese liana Ancistrocladus tectorius.

Fitoterapia 2017 Sep 6;121:76-85. Epub 2017 Jul 6.

Institute of Pharmacy and Biochemistry, Department of Pharmaceutical Biology, University of Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.

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http://dx.doi.org/10.1016/j.fitote.2017.07.001DOI Listing
September 2017

The antitrypanosomal and antitubercular activity of some nitro(triazole/imidazole)-based aromatic amines.

Eur J Med Chem 2017 Sep 25;138:1106-1113. Epub 2017 Jul 25.

Swiss Tropical and Public Health Institute, Parasite Chemotherapy, Basel, Switzerland; University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.ejmech.2017.07.060DOI Listing
September 2017

Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles.

Bioorg Med Chem Lett 2017 09 31;27(17):3945-3949. Epub 2017 Jul 31.

Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

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http://dx.doi.org/10.1016/j.bmcl.2017.07.081DOI Listing
September 2017

Antiprotozoal Linear Furanosesterterpenoids from the Marine Sponge Ircinia oros.

J Nat Prod 2017 09 25;80(9):2566-2571. Epub 2017 Aug 25.

GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Products Chemistry, GEOMAR Helmholtz Centre for Ocean Research Kiel , Kiel 24106, Germany.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.7b00543
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http://dx.doi.org/10.1021/acs.jnatprod.7b00543DOI Listing
September 2017

Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of Plasmodium falciparum and farnesyltransferase.

Bioorg Med Chem 2017 08 19;25(16):4433-4443. Epub 2017 Jun 19.

School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

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http://dx.doi.org/10.1016/j.bmc.2017.06.029DOI Listing
August 2017

Bifurcatriol, a New Antiprotozoal Acyclic Diterpene from the Brown Alga Bifurcaria bifurcata.

Mar Drugs 2017 Aug 2;15(8). Epub 2017 Aug 2.

School of Chemistry, National University of Ireland Galway, University Road, Galway, Ireland.

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http://dx.doi.org/10.3390/md15080245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577600PMC
August 2017

Alkaloid Constituents of the Amaryllidaceae Plant Amaryllis belladonna L.

Molecules 2017 Aug 31;22(9). Epub 2017 Aug 31.

Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain.

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http://dx.doi.org/10.3390/molecules22091437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151567PMC
August 2017

Steroid Alkaloids from Holarrhena africana with Strong Activity against Trypanosoma brucei rhodesiense.

Molecules 2017 Jul 6;22(7). Epub 2017 Jul 6.

Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, PharmaCampus Corrensstraße 48, D-48149 Münster, Germany.

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http://www.mdpi.com/1420-3049/22/7/1129
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http://dx.doi.org/10.3390/molecules22071129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152089PMC
July 2017

Alkamides from Anacyclus pyrethrum L. and Their in Vitro Antiprotozoal Activity.

Molecules 2017 May 12;22(5). Epub 2017 May 12.

Institut für Pharmazeutische Biologie und Phytochemie (IPBP), University of Münster, PharmaCampus, Corrensstraße 48, Münster D-48149, Germany.

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http://dx.doi.org/10.3390/molecules22050796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154598PMC
May 2017

New derivatives of quinoline-4-carboxylic acid with antiplasmodial activity.

Bioorg Med Chem 2017 04 24;25(7):2251-2259. Epub 2017 Feb 24.

Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstraße 1, A-8010 Graz, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.02.043DOI Listing
April 2017

Synthesis and activity of nucleoside-based antiprotozoan compounds.

Bioorg Med Chem 2017 04 16;25(7):2091-2104. Epub 2017 Feb 16.

Department of Chemistry, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.02.016DOI Listing
April 2017

Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design.

Nat Chem 2017 04 5;9(4):379-386. Epub 2016 Dec 5.

Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany.

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http://dx.doi.org/10.1038/nchem.2671DOI Listing
April 2017

Structure and Biosynthesis of Isatropolones, Bioactive Amine-Scavenging Fluorescent Natural Products from Streptomyces Gö66.

Angew Chem Int Ed Engl 2017 04 30;56(18):4945-4949. Epub 2017 Mar 30.

Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe-Universität Frankfurt, Max-von-Laue-Strasse 9, 60438, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/anie.201701223DOI Listing
April 2017

Anti-Trypanosomatid Elemanolide Sesquiterpene Lactones from Vernonia lasiopus O. Hoffm.

Molecules 2017 Apr 8;22(4). Epub 2017 Apr 8.

Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, PharmaCampus Corrensstraße 48, D-48149 Münster, Germany.

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http://www.mdpi.com/1420-3049/22/4/597
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http://dx.doi.org/10.3390/molecules22040597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154322PMC
April 2017

New derivatives of 7-chloroquinolin-4-amine with antiprotozoal activity.

Bioorg Med Chem 2017 02 18;25(3):941-948. Epub 2016 Dec 18.

Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Austria.

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http://dx.doi.org/10.1016/j.bmc.2016.12.006DOI Listing
February 2017

Antiprotozoal Activity-Based Profiling of a Dichloromethane Extract from Anthemis nobilis Flowers.

J Nat Prod 2017 02 24;80(2):459-470. Epub 2017 Jan 24.

Department of Pharmaceutical Biology, University of Basel , Klingelbergstrasse 50, 4056 Basel, Switzerland.

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http://dx.doi.org/10.1021/acs.jnatprod.6b00980DOI Listing
February 2017

Biosynthesis of the Antibiotic Nematophin and Its Elongated Derivatives in Entomopathogenic Bacteria.

Org Lett 2017 02 30;19(4):806-809. Epub 2017 Jan 30.

Merck Endowed Chair for Molecular Biotechnology, Faculty of Biological Sciences, Goethe University Frankfurt , 60438 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1021/acs.orglett.6b03796DOI Listing
February 2017

Assessing anti-T. cruzi candidates in vitro for sterile cidality.

Int J Parasitol Drugs Drug Resist 2016 12 26;6(3):165-170. Epub 2016 Aug 26.

Swiss Tropical and Public Health Institute, CH-4051, Basel, Switzerland; University of Basel, CH-4003, Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ijpddr.2016.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030316PMC
December 2016

Ancistectorine D, a naphthylisoquinoline alkaloid with antiprotozoal and antileukemic activities, and further 5,8'- and 7,1'-linked metabolites from the Chinese liana Ancistrocladus tectorius.

Fitoterapia 2016 Dec 19;115:1-8. Epub 2016 Sep 19.

Institute of Pharmacy and Biochemistry, Department of Pharmaceutical Biology, University of Mainz, Staudinger Weg 5, D-55128 Mainz, Germany.

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http://dx.doi.org/10.1016/j.fitote.2016.09.009DOI Listing
December 2016

Directed Synthesis of All Four Pure Stereoisomers of the N,C-Coupled Naphthylisoquinoline Alkaloid Ancistrocladinium A.

Org Lett 2016 12 1;18(24):6508-6511. Epub 2016 Dec 1.

Institute of Organic Chemistry, University of Würzburg , Am Hubland, D-97074 Würzburg, Germany.

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http://dx.doi.org/10.1021/acs.orglett.6b03480DOI Listing
December 2016

Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity.

Eur J Med Chem 2016 Nov 9;123:895-904. Epub 2016 Aug 9.

Swiss Tropical and Public Health Institute, Parasite Chemotherapy, Basel, Switzerland; University of Basel, Basel, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049494PMC
http://dx.doi.org/10.1016/j.ejmech.2016.08.002DOI Listing
November 2016

The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes.

Arch Pharm Res 2016 Oct 1;39(10):1391-1403. Epub 2016 Sep 1.

Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstrasse 1, 8010, Graz, Austria.

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http://dx.doi.org/10.1007/s12272-016-0826-5DOI Listing
October 2016

Discovery of a Mosaic-Like Biosynthetic Assembly Line with a Decarboxylative Off-Loading Mechanism through a Combination of Genome Mining and Imaging.

Angew Chem Int Ed Engl 2016 10 26;55(43):13611-13614. Epub 2016 Sep 26.

Institut für Pharmazeutische Biologie, Universität Bonn, 53115, Bonn, Germany.

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http://dx.doi.org/10.1002/anie.201606655DOI Listing
October 2016

Synthesis and potent antiprotozoal activity of mono/di amidino 2-anilinobenzimidazoles versus Plasmodium falciparum and Trypanosoma brucei rhodesiense.

Bioorg Med Chem 2016 09 25;24(18):4038-4044. Epub 2016 Jun 25.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey.

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http://dx.doi.org/10.1016/j.bmc.2016.06.047DOI Listing
September 2016

ent-Pimarane and ent-Kaurane Diterpenes from Aldama discolor (Asteraceae) and Their Antiprotozoal Activity.

Molecules 2016 Sep 15;21(9). Epub 2016 Sep 15.

Institute of Pharmaceutical Biology and Phytochemistry (IPBP), University of Münster, PharmaCampus Corrensstraße 48, Münster D-48149, Germany.

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http://dx.doi.org/10.3390/molecules21091237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274167PMC
September 2016

Quinolone Amides as Antitrypanosomal Lead Compounds with In Vivo Activity.

Antimicrob Agents Chemother 2016 08 22;60(8):4442-52. Epub 2016 Jul 22.

Universität Würzburg, Institut für Pharmazie und Lebensmittelchemie, Würzburg, Germany

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http://dx.doi.org/10.1128/AAC.01757-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958235PMC
August 2016

Antiprotozoal activity of bicycles featuring a dimethylamino group at their bridgehead.

Bioorg Med Chem 2016 08 14;24(16):3781-9. Epub 2016 Jun 14.

Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Schubertstraße 1, A-8010 Graz, Austria.

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http://dx.doi.org/10.1016/j.bmc.2016.06.024DOI Listing
August 2016

Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians.

J Ethnopharmacol 2016 Jul 28;187:241-8. Epub 2016 Apr 28.

CNRS - Institut de Chimie des Substances Naturelles, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France; Sorbonne Universités, UPMC Univ Paris 06, CNRS, Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Observatoire Océanologique, 66650 Banyuls/Mer, France. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2016.04.053DOI Listing
July 2016

Novel nucleoside-based antimalarial compounds.

Bioorg Med Chem Lett 2016 06 23;26(12):2861-2865. Epub 2016 Apr 23.

Department of Chemistry, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.04.053DOI Listing
June 2016

A New Alkamide with an Endoperoxide Structure from Acmella ciliata (Asteraceae) and Its in Vitro Antiplasmodial Activity.

Molecules 2016 Jun 11;21(6). Epub 2016 Jun 11.

Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Bloco J/K, Universidade Federal de Santa Catarina, Florianópolis 88040-900, SC, Brazil.

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http://dx.doi.org/10.3390/molecules21060765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274185PMC
June 2016