Marc S Horwitz

Marc S Horwitz

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Marc S Horwitz

Marc S Horwitz

Publications by authors named "Marc S Horwitz"

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A Caulobacter crescentus Microbicide Protects from Vaginal Infection with HIV-1 in Humanized Bone Marrow-Liver-Thymus Mice.

J Virol 2019 Sep 28;93(18). Epub 2019 Aug 28.

Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada

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http://dx.doi.org/10.1128/JVI.00614-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714793PMC
September 2019

Editorial: Fresh Ideas, Foundational Experiments: Immunology and Diabetes.

Front Endocrinol (Lausanne) 2019 16;10:315. Epub 2019 May 16.

Department of Medicine, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN, United States.

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http://dx.doi.org/10.3389/fendo.2019.00315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532014PMC
May 2019

Virus envelope tissue factor promotes infection in mice.

J Thromb Haemost 2019 Mar 20;17(3):482-491. Epub 2019 Feb 20.

Canadian Blood Services, Center for Innovation, Vancouver, Canada.

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http://dx.doi.org/10.1111/jth.14389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397068PMC
March 2019

Carbamazepine, a beta-cell protecting drug, reduces type 1 diabetes incidence in NOD mice.

Sci Rep 2018 03 15;8(1):4588. Epub 2018 Mar 15.

Diabetes Research Group, UBC Life Sciences Institute, Department of Cellular and Physiological Sciences, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/s41598-018-23026-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854601PMC
March 2018

Generation of a Dual-Target, Safe, Inexpensive Microbicide that Protects Against HIV-1 and HSV-2 Disease.

Sci Rep 2018 02 12;8(1):2786. Epub 2018 Feb 12.

Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1038/s41598-018-21134-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809452PMC
February 2018

Fresh Ideas, Foundational Experiments (FIFE): Immunology and Diabetes 2016 FIFE Symposium.

Front Endocrinol (Lausanne) 2017 19;8:238. Epub 2017 Sep 19.

Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fendo.2017.00238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610696PMC
September 2017

Innate Viral Receptor Signaling Determines Type 1 Diabetes Onset.

Front Endocrinol (Lausanne) 2017 26;8:249. Epub 2017 Sep 26.

Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3389/fendo.2017.00249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623193PMC
September 2017

Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas.

EBioMedicine 2017 Aug 21;22:10-17. Epub 2017 Jun 21.

Department of Microbiology and Immunology, Infection, Inflammation, and Immunity (I3) Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552106PMC
August 2017

Landscape review of current HIV 'kick and kill' cure research - some kicking, not enough killing.

BMC Infect Dis 2017 08 29;17(1):595. Epub 2017 Aug 29.

Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1186/s12879-017-2683-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576299PMC
August 2017

Inhibition of Autoimmune Diabetes in NOD Mice by miRNA Therapy.

PLoS One 2015 16;10(12):e0145179. Epub 2015 Dec 16.

Centre for Innovation, Canadian Blood Services, Ottawa, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145179PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692265PMC
June 2016

miR, miR in the Cell, Does the Virus Control Them All?

Diabetes 2016 04;65(4):823-5

The University of British Columbia, Vancouver, Canada

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/dbi1
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http://dx.doi.org/10.2337/dbi15-0039DOI Listing
April 2016

Reduced expression of the MDA5 Gene IFIH1 prevents autoimmune diabetes.

Diabetes 2015 Jun 15;64(6):2184-93. Epub 2015 Jan 15.

Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada

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http://dx.doi.org/10.2337/db14-1223DOI Listing
June 2015

Is type 1 diabetes "going viral"?

Diabetes 2014 Jul;63(7):2203-5

University of British Columbia, Vancouver, Canada

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db14-05
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http://dx.doi.org/10.2337/db14-0510DOI Listing
July 2014

Selective pharmacological inhibition of phosphoinositide 3-kinase p110delta opposes the progression of autoimmune diabetes in non-obese diabetic (NOD) mice.

Autoimmunity 2013 Feb;46(1):62-73

Department of Microbiology and Immunology, Infection, Inflammation, and Immunity (I3) Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.3109/08916934.2012.732130DOI Listing
February 2013

Gammaherpesvirus latency accentuates EAE pathogenesis: relevance to Epstein-Barr virus and multiple sclerosis.

PLoS Pathog 2012 17;8(5):e1002715. Epub 2012 May 17.

Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.plos.org/10.1371/journal.ppat.1002715
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http://dx.doi.org/10.1371/journal.ppat.1002715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355105PMC
November 2012

Immunomodulation of antigen presenting cells promotes natural regulatory T cells that prevent autoimmune diabetes in NOD mice.

PLoS One 2012 15;7(2):e31153. Epub 2012 Feb 15.

Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031153PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280284PMC
June 2012

PSGL-1 regulates the migration and proliferation of CD8(+) T cells under homeostatic conditions.

J Immunol 2012 Feb 16;188(4):1638-46. Epub 2012 Jan 16.

Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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http://dx.doi.org/10.4049/jimmunol.1103026DOI Listing
February 2012

Enhanced neutralization of HIV by antibodies displayed on the S-layer of Caulobacter crescentus.

Antimicrob Agents Chemother 2011 Dec 6;55(12):5547-52. Epub 2011 Sep 6.

Department of Medicine, Beth Israel Deaconess Medical Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1128/AAC.00509-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232825PMC
December 2011

Epstein-Barr virus infection of human brain microvessel endothelial cells: a novel role in multiple sclerosis.

J Neuroimmunol 2011 Jan 9;230(1-2):173-7. Epub 2010 Sep 9.

Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.jneuroim.2010.08.003DOI Listing
January 2011

The innate immune response: an important partner in shaping coxsackievirus-mediated autoimmunity.

J Innate Immun 2009 24;1(5):421-34. Epub 2009 Jun 24.

Department of Microbiology and Immunology, The University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1159/000226247DOI Listing
July 2010

IL-6 during viral-induced chronic autoimmune myocarditis.

Ann N Y Acad Sci 2009 Sep;1173:318-25

Department Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/j.1749-6632.2009.04850.xDOI Listing
September 2009

Coxsackievirus infection as an environmental factor in the etiology of type 1 diabetes.

Autoimmun Rev 2009 Jun 11;8(7):611-5. Epub 2009 Feb 11.

Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S156899720900039
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http://dx.doi.org/10.1016/j.autrev.2009.02.006DOI Listing
June 2009

Toll-like receptor 3 signaling on macrophages is required for survival following coxsackievirus B4 infection.

PLoS One 2009 5;4(1):e4127. Epub 2009 Jan 5.

Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004127PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606033PMC
February 2009

Regulatory T-cells protect from type 1 diabetes after induction by coxsackievirus infection in the context of transforming growth factor-beta.

Diabetes 2008 May 11;57(5):1302-11. Epub 2008 Feb 11.

Department of Microbiology and Immunology, The University of British Columbia, 3551-2350 Health Sciences Mall, Vancouver, BC, Canada.

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http://diabetes.diabetesjournals.org/content/57/5/1302.full.
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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db07-14
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http://dx.doi.org/10.2337/db07-1460DOI Listing
May 2008

Chronic immunodeficiency in mice lacking RasGRP1 results in CD4 T cell immune activation and exhaustion.

J Immunol 2007 Aug;179(4):2143-52

Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada.

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http://www.jimmunol.org/content/179/4/2143.full.pdf
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http://dx.doi.org/10.4049/jimmunol.179.4.2143DOI Listing
August 2007

Transforming growth factor-beta inhibits coxsackievirus-mediated autoimmune myocarditis.

Viral Immunol 2006 ;19(4):722-33

Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1089/vim.2006.19.722DOI Listing
February 2007

Toll-like receptor 4-induced cytokine production circumvents protection conferred by TGF-beta in coxsackievirus-mediated autoimmune myocarditis.

Clin Immunol 2006 Dec 11;121(3):339-49. Epub 2006 Sep 11.

Microbiology and Immunology, The University of British Columbia, 3551-2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3.

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http://dx.doi.org/10.1016/j.clim.2006.07.009DOI Listing
December 2006

Induction of antigen specific peripheral humoral tolerance to cardiac myosin does not prevent CB3-mediated autoimmune myocarditis.

J Autoimmun 2005 Sep 11;25(2):102-11. Epub 2005 Jul 11.

Department of Immunology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.jaut.2005.05.007DOI Listing
September 2005

Coxsackieviral-mediated diabetes: induction requires antigen-presenting cells and is accompanied by phagocytosis of beta cells.

Clin Immunol 2004 Feb;110(2):134-44

Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.clim.2003.09.014DOI Listing
February 2004

Coxsackievirus-mediated hyperglycemia is enhanced by reinfection and this occurs independent of T cells.

Virology 2003 Sep;314(2):510-20

Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC V6T 123, Canada.

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http://dx.doi.org/10.1016/s0042-6822(03)00462-8DOI Listing
September 2003

Presented antigen from damaged pancreatic beta cells activates autoreactive T cells in virus-mediated autoimmune diabetes.

J Clin Invest 2002 Jan;109(1):79-87

Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1172/JCI11198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150813PMC
January 2002

Primary demyelination in transgenic mice expressing interferon-gamma.

Nat Med 1997 Sep;3(9):1037-1041

Neuropharmacology, the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321678PMC
http://dx.doi.org/10.1038/nm0997-1037DOI Listing
September 1997