Marc R Birtwistle

Marc R Birtwistle

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Marc R Birtwistle

Marc R Birtwistle

Publications by authors named "Marc R Birtwistle"

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Predicting In Vivo Efficacy from In Vitro Data: Quantitative Systems Pharmacology Modeling for an Epigenetic Modifier Drug in Cancer.

Clin Transl Sci 2019 Nov 15. Epub 2019 Nov 15.

Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland.

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http://dx.doi.org/10.1111/cts.12727DOI Listing
November 2019

Wilm's tumor 1 promotes memory flexibility.

Nat Commun 2019 08 21;10(1):3756. Epub 2019 Aug 21.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, 10029, NY, USA.

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http://dx.doi.org/10.1038/s41467-019-11781-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704057PMC
August 2019

Mitochondrial origins of fractional control in regulated cell death.

Nat Commun 2019 03 21;10(1):1313. Epub 2019 Mar 21.

IBM T.J. Watson Research Center, 1101 Kitchawan Road, Yorktown Heights, NY, 10598, USA.

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http://dx.doi.org/10.1038/s41467-019-09275-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428895PMC
March 2019

Fluorescence Multiplexing with Spectral Imaging and Combinatorics.

ACS Comb Sci 2018 11 30;20(11):653-659. Epub 2018 Oct 30.

Department of Pharmacological Sciences , Icahn School of Medicine at Mount Sinai , New York , New York 10029 , United States.

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http://dx.doi.org/10.1021/acscombsci.8b00101DOI Listing
November 2018

Validating Antibodies for Quantitative Western Blot Measurements with Microwestern Array.

Sci Rep 2018 07 27;8(1):11329. Epub 2018 Jul 27.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1038/s41598-018-29436-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063895PMC
July 2018

Analysis of copy number loss of the ErbB4 receptor tyrosine kinase in glioblastoma.

PLoS One 2018 17;13(1):e0190664. Epub 2018 Jan 17.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190664PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771580PMC
February 2018

Integrating Transcriptomic Data with Mechanistic Systems Pharmacology Models for Virtual Drug Combination Trials.

ACS Chem Neurosci 2018 01 6;9(1):118-129. Epub 2017 Oct 6.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.

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http://pubs.acs.org/doi/10.1021/acschemneuro.7b00197
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http://dx.doi.org/10.1021/acschemneuro.7b00197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771884PMC
January 2018

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.

Authors:
Alexandra B Keenan Sherry L Jenkins Kathleen M Jagodnik Simon Koplev Edward He Denis Torre Zichen Wang Anders B Dohlman Moshe C Silverstein Alexander Lachmann Maxim V Kuleshov Avi Ma'ayan Vasileios Stathias Raymond Terryn Daniel Cooper Michele Forlin Amar Koleti Dusica Vidovic Caty Chung Stephan C Schürer Jouzas Vasiliauskas Marcin Pilarczyk Behrouz Shamsaei Mehdi Fazel Yan Ren Wen Niu Nicholas A Clark Shana White Naim Mahi Lixia Zhang Michal Kouril John F Reichard Siva Sivaganesan Mario Medvedovic Jaroslaw Meller Rick J Koch Marc R Birtwistle Ravi Iyengar Eric A Sobie Evren U Azeloglu Julia Kaye Jeannette Osterloh Kelly Haston Jaslin Kalra Steve Finkbiener Jonathan Li Pamela Milani Miriam Adam Renan Escalante-Chong Karen Sachs Alex Lenail Divya Ramamoorthy Ernest Fraenkel Gavin Daigle Uzma Hussain Alyssa Coye Jeffrey Rothstein Dhruv Sareen Loren Ornelas Maria Banuelos Berhan Mandefro Ritchie Ho Clive N Svendsen Ryan G Lim Jennifer Stocksdale Malcolm S Casale Terri G Thompson Jie Wu Leslie M Thompson Victoria Dardov Vidya Venkatraman Andrea Matlock Jennifer E Van Eyk Jacob D Jaffe Malvina Papanastasiou Aravind Subramanian Todd R Golub Sean D Erickson Mohammad Fallahi-Sichani Marc Hafner Nathanael S Gray Jia-Ren Lin Caitlin E Mills Jeremy L Muhlich Mario Niepel Caroline E Shamu Elizabeth H Williams David Wrobel Peter K Sorger Laura M Heiser Joe W Gray James E Korkola Gordon B Mills Mark LaBarge Heidi S Feiler Mark A Dane Elmar Bucher Michel Nederlof Damir Sudar Sean Gross David F Kilburn Rebecca Smith Kaylyn Devlin Ron Margolis Leslie Derr Albert Lee Ajay Pillai

Cell Syst 2018 01 29;6(1):13-24. Epub 2017 Nov 29.

NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cels.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799026PMC
January 2018

Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics.

Front Physiol 2017 8;8:651. Epub 2017 Sep 8.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount SinaiNew York, NY, United States.

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http://dx.doi.org/10.3389/fphys.2017.00651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599787PMC
September 2017

A Mechanistic Beta-Binomial Probability Model for mRNA Sequencing Data.

PLoS One 2016 21;11(6):e0157828. Epub 2016 Jun 21.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157828PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915702PMC
July 2017

Cell size assays for mass cytometry.

Cytometry A 2017 01 21;91(1):14-24. Epub 2016 Oct 21.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, 10029.

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http://dx.doi.org/10.1002/cyto.a.23000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5250533PMC
January 2017

Drug response consistency in CCLE and CGP.

Nature 2016 11;540(7631):E9-E10

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/nature20580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554885PMC
November 2016

Network pharmacodynamic models for customized cancer therapy.

Wiley Interdiscip Rev Syst Biol Med 2015 Jul-Aug;7(4):243-51. Epub 2015 Apr 24.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1002/wsbm.1300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457588PMC
March 2016

Creating Complex Fluorophore Spectra on Antibodies Through Combinatorial Labeling.

Transl Sci 2016 Mar 31;2(3). Epub 2016 Mar 31.

Department of Pharmacology and Systems Therapeutics | Icahn School of Medicine at Mount Sinai | New York, NY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896637PMC
March 2016

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches.

Cell Syst 2016 01 27;2(1):38-48. Epub 2016 Jan 27.

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland; Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland; School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland; Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, Australia.

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http://dx.doi.org/10.1016/j.cels.2016.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802415PMC
January 2016

In silico model-based inference: an emerging approach for inverse problems in engineering better medicines.

Curr Opin Chem Eng 2015 Nov;10:14-24

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY.

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http://dx.doi.org/10.1016/j.coche.2015.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545575PMC
November 2015

CNS Anticancer Drug Discovery and Development Conference White Paper.

Neuro Oncol 2015 Nov;17 Suppl 6:vi1-26

Kaiser Permanente, Redwood City, California, USA (V.A.L.); University of Texas MD Anderson Cancer Center, Houston, TX, USA (V.A.L.); University of California, San Francisco, CA, USA (V.A.L.); SUNY Stony Brook University, Stony Brook, NY, USA (P.J.T.); Icahn School of Medicine at Mount Sinai, New York, NY, USA (J.M.G., M.R.B., A.C.D.); Columbia University Institute for Cancer Genetics, New York, NY, USA (A.I.); Fred Hutchinson Cancer Research Center, Seattle, WA, USA (P.J.P.); Genentech, Inc., South San Francisco, CA, USA (T.P.H.); University of Minnesota School of Pharmacy, Minneapolis, MN, USA (W.F.E.); Angiochem, Inc., Montreal, Quebec, Canada (J.E.L.); Pfizer Oncology, San Diego, CA, USA (T.W.J.); Massachusetts Institute of Technology, Cambridge, MA, USA (F.M.W.); US Food and Drug Administration, Silver Spring, MD, USA (J.S.); Texas Tech University School of Pharmacy, Amarillo, TX, USA (Q.R.S., R.S.); NewGen Therapeutics, Inc., Menlo Park, CA, USA (W.S.); Mayo Clinic, Rochester, MN, USA (J.N.S.); Dana-Farber Cancer Institute, Boston, MA, USA (P.Y.W.); University of Texas MD Anderson Cancer Center, Houston, TX, USA (D.A.B.); Celgene Avilomics Research, Bedford, MA, USA (R.C.P.).

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http://dx.doi.org/10.1093/neuonc/nov169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581696PMC
November 2015

Silence on the relevant literature and errors in implementation.

Nat Biotechnol 2015 Apr;33(4):336-9

1] Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland. [2] Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland. [3] School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland.

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http://dx.doi.org/10.1038/nbt.3185DOI Listing
April 2015

Analytical reduction of combinatorial complexity arising from multiple protein modification sites.

J R Soc Interface 2015 Feb;12(103)

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA

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http://dx.doi.org/10.1098/rsif.2014.1215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305424PMC
February 2015

Evaluating strategies to normalise biological replicates of Western blot data.

PLoS One 2014 27;9(1):e87293. Epub 2014 Jan 27.

Systems Biology Ireland, University College Dublin, Dublin, Republic of Ireland ; Conway Institute of Biomolecular & Biomedical Research, University College Dublin, Dublin, Republic of Ireland ; School of Medicine and Medical Science, University College Dublin, Dublin, Republic of Ireland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087293PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903630PMC
September 2014

Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses.

J R Soc Interface 2014 Sep;11(98):20140383

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland

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http://dx.doi.org/10.1098/rsif.2014.0383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233687PMC
September 2014

Dimerization-based control of cooperativity.

Mol Biosyst 2014 Jul;10(7):1824-32

Icahn School of Medicine at Mount Sinai, Department of Pharmacology and Systems Therapeutics, New York, NY 10029, USA.

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http://dx.doi.org/10.1039/c4mb00022fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060435PMC
July 2014

A Comparison of Methods for RNA-Seq Differential Expression Analysis and a New Empirical Bayes Approach.

Biosensors (Basel) 2013 Sep 28;3(3):238-58. Epub 2013 Jun 28.

Division of Biostatistics, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.3390/bios3030238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263583PMC
September 2013

Bayesian multivariate Poisson abundance models for T-cell receptor data.

J Theor Biol 2013 Jun 1;326:1-10. Epub 2013 Mar 1.

Department of Biostatistics, Georgia Health Sciences University, Augusta, GA 30912, USA.

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http://dx.doi.org/10.1016/j.jtbi.2013.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972257PMC
June 2013

Novel somatic mutations to PI3K pathway genes in metastatic melanoma.

PLoS One 2012 17;7(8):e43369. Epub 2012 Aug 17.

Georgia Health Sciences University Cancer Center, Georgia Health Sciences University, Augusta, Georgia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043369PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422312PMC
March 2013

Mammalian protein expression noise: scaling principles and the implications for knockdown experiments.

Mol Biosyst 2012 Nov;8(11):3068-76

Mount Sinai School of Medicine, Dept. of Pharmacology and Systems Therapeutics, New York, NY 10029, USA.

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http://xlink.rsc.org/?DOI=c2mb25168j
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http://dx.doi.org/10.1039/c2mb25168jDOI Listing
November 2012

Biology using engineering tools: the negative feedback amplifier.

Cell Cycle 2011 Jul 1;10(13):2069-76. Epub 2011 Jul 1.

Systems Biology Ireland, University College Dublin, Belfield, Dublin, Republic of Ireland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154361PMC
http://dx.doi.org/10.4161/cc.10.13.16245DOI Listing
July 2011

Four-dimensional dynamics of MAPK information processing systems.

Wiley Interdiscip Rev Syst Biol Med 2009 Jul-Aug;1(1):28-44

Departement of Chemical Engineering, University of Delaware, Newark, DE 19716, USA.

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http://dx.doi.org/10.1002/wsbm.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826817PMC
December 2010

Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics.

Cell 2010 May 20;141(5):884-96. Epub 2010 May 20.

Computational Systems Biology Research Group, Advanced Computational Sciences Department, RIKEN Advanced Science Institute, 1-7-22 Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1016/j.cell.2010.03.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888034PMC
May 2010

Endocytosis and signalling: a meeting with mathematics.

Mol Oncol 2009 Aug 16;3(4):308-20. Epub 2009 Jun 16.

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland.

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http://dx.doi.org/10.1016/j.molonc.2009.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745732PMC
August 2009

Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses.

Mol Syst Biol 2007 13;3:144. Epub 2007 Nov 13.

Department of Chemical Engineering, University of Delaware, Newark, DE, USA.

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http://dx.doi.org/10.1038/msb4100188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2132449PMC
December 2007