Marc Freeman

Marc Freeman

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Marc Freeman

Marc Freeman

Publications by authors named "Marc Freeman"

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85Publications

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Transcription factor Pebbled/RREB1 regulates injury-induced axon degeneration.

Proc Natl Acad Sci U S A 2018 02 2;115(6):1358-1363. Epub 2018 Jan 2.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01655;

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February 2018

The secreted neurotrophin Spätzle 3 promotes glial morphogenesis and supports neuronal survival and function.

Genes Dev 2017 10 14;31(20):2023-2038. Epub 2017 Nov 14.

Vollum Institute, Oregon Health and Sciences University, Portland, Oregon 97239, USA.

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October 2017

Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling.

Nat Commun 2017 Feb 6;8:14355. Epub 2017 Feb 6.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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February 2017

Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour.

Nature 2016 11 9;539(7629):428-432. Epub 2016 Nov 9.

Department of Neurobiology and Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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November 2016

Dendrites actively restrain axon outgrowth and regeneration.

Proc Natl Acad Sci U S A 2016 May 4;113(20):5465-6. Epub 2016 May 4.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605; Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605

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May 2016

Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species.

Proc Natl Acad Sci U S A 2016 May 9;113(21):6029-34. Epub 2016 May 9.

Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138; Department of Physics, Harvard University, Cambridge, MA 02138;

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May 2016

Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1.

Brain 2016 Apr 11;139(Pt 4):1094-105. Epub 2016 Feb 11.

1 Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

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April 2016

Conventional SPECT Versus 3D Thresholded SPECT Imaging in the Diagnosis of ADHD: A Retrospective Study.

J Neuropsychiatry Clin Neurosci 2014 ;26(4):335-43

From Sheppard Associates, Toronto, ON, Canada (HS); Rossiter-Thornton Associates, Toronto, ON, Canada (JFT); the Dept. of Nuclear Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada (MAF); Toronto, ON, Canada (MKM, MJvL); and the Dept. of Mathematics, Massachusetts Institute of Technology, Cambridge, MA (JS).

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December 2015

Letting Go of JuNK by Disassembly of Adhesive Complexes.

Neuron 2015 Dec;88(5):848-850

Department of Neurobiology/HHMI, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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December 2015

Age-Dependent TDP-43-Mediated Motor Neuron Degeneration Requires GSK3, hat-trick, and xmas-2.

Curr Biol 2015 Aug 30;25(16):2130-6. Epub 2015 Jul 30.

Howard Hughes Medical Institute and Department of Neurobiology, LRB-740A1, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01655, USA. Electronic address:

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August 2015

Drosophila Central Nervous System Glia.

Authors:
Marc R Freeman

Cold Spring Harb Perspect Biol 2015 Feb 26;7(11). Epub 2015 Feb 26.

Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605.

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February 2015

PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury.

PLoS Biol 2014 Nov 4;12(11):e1001985. Epub 2014 Nov 4.

Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

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November 2014

Activity-dependent regulation of astrocyte GAT levels during synaptogenesis.

Nat Neurosci 2014 Oct 24;17(10):1340-50. Epub 2014 Aug 24.

1] Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. [2] Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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October 2014

Diverse cellular and molecular modes of axon degeneration.

Trends Cell Biol 2014 Sep 27;24(9):515-23. Epub 2014 Apr 27.

Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, 704 LRB, 364 Plantation Street, Worcester, MA 01609, USA. Electronic address:

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September 2014

Signaling mechanisms regulating Wallerian degeneration.

Authors:
Marc R Freeman

Curr Opin Neurobiol 2014 Aug 5;27:224-31. Epub 2014 Jun 5.

Dept of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605-2324, United States. Electronic address:

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August 2014

DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris.

Proc Natl Acad Sci U S A 2014 Aug 6;111(34):12544-9. Epub 2014 Aug 6.

Department of Neurobiology and Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605

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August 2014

Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila.

Proc Natl Acad Sci U S A 2014 Jul 23;111(27):9965-70. Epub 2014 Jun 23.

Department of Neurobiology andHoward Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605; and

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July 2014

Neuron-glia interactions through the Heartless FGF receptor signaling pathway mediate morphogenesis of Drosophila astrocytes.

Neuron 2014 Jul;83(2):388-403

Department of Neurobiology, University of Massachusetts Medical School, Howard Hughes Medical Institute, Worcester, MA 01605, USA. Electronic address:

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July 2014

Neuroscience. Astrocytes eyeball axonal mitochondria.

Science 2014 Jul;345(6195):385-6

Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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July 2014

Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo.

Sci Rep 2013 ;3:2567

Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.

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February 2014

Glial wingless/Wnt regulates glutamate receptor clustering and synaptic physiology at the Drosophila neuromuscular junction.

J Neurosci 2014 Feb;34(8):2910-20

Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, Howard Hughes Medical Institute, Worcester, Massachusetts 01605, and National Center for Behavioral Genomics, Department of Biology, Brandeis University, Waltham, Massachusetts 02454.

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February 2014

Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons.

Genes Dev 2014 Jan 20;28(1):20-33. Epub 2013 Dec 20.

Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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January 2014

Probing the enigma: unraveling glial cell biology in invertebrates.

Curr Opin Neurobiol 2013 Dec 26;23(6):1073-9. Epub 2013 Jul 26.

Neurobiology Department, University of Massachusetts Medical School, Worcester, MA 01605, United States.

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December 2013

Cell biology in neuroscience: Architects in neural circuit design: glia control neuron numbers and connectivity.

J Cell Biol 2013 Nov;203(3):395-405

Department of Neurobiology, University of Massachusetts Medical School, Howard Hughes Medical Institute, Worcester, MA 01605.

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November 2013

Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years.

Neuron 2013 Oct;80(3):613-23

University of Massachusetts, and Howard Hughes Medical Institute, Worcester, MA 01605, USA. Electronic address:

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October 2013

Whole Genome Sequencing and a New Bioinformatics Platform Allow for Rapid Gene Identification in D. melanogaster EMS Screens.

Biology (Basel) 2012 Dec 5;1(3):766-77. Epub 2012 Dec 5.

Dr. John T. Macdonald Foundation Department of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

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December 2012

Integration of a retrograde signal during synapse formation by glia-secreted TGF-β ligand.

Curr Biol 2012 Oct 6;22(19):1831-8. Epub 2012 Sep 6.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA.

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October 2012

Cervical stimulation activates A1 and locus coeruleus neurons that project to the paraventricular nucleus of the hypothalamus.

Brain Res Bull 2012 Sep 23;88(6):566-73. Epub 2012 Jun 23.

Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270-910, Brazil.

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September 2012

Prevalence of gastroparesis before and after lung transplantation and its association with lung allograft outcomes.

Clin Transplant 2012 Jan-Feb;26(1):133-42. Epub 2011 Mar 21.

Toronto Lung Transplant Program and Joint Department of Medical Imaging, Toronto General Hospital, University of Toronto, Toronto, ON, Canada.

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June 2012

Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy.

Nat Neurosci 2012 Jun 17;15(7):979-87. Epub 2012 Jun 17.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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June 2012

WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering.

Curr Biol 2012 Apr 15;22(7):596-600. Epub 2012 Mar 15.

Department of Neurobiology, University of Massachusetts Medical School, and Howard Hughes Medical Institute, Worcester, MA 01605-2324, USA.

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April 2012

Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury.

Nat Neurosci 2012 Mar 18;15(5):722-30. Epub 2012 Mar 18.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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March 2012

Analysis of glial cell development and function in Drosophila.

Cold Spring Harb Protoc 2012 Jan 1;2012(1):1-17. Epub 2012 Jan 1.

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January 2012

Systemic oxytocin induces a prolactin secretory rhythm via the pelvic nerve in ovariectomized rats.

Am J Physiol Regul Integr Comp Physiol 2011 Sep 15;301(3):R676-81. Epub 2011 Jun 15.

Departments of Biological Science, Biomedical Research Facility, Florida State University, Tallahassee, FL, USA.

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September 2011

Invertebrate glia. Introduction.

Glia 2011 Sep;59(9):1213-4

Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, USA.

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September 2011

Wallerian degeneration, wld(s), and nmnat.

Annu Rev Neurosci 2010 ;33:245-67

Laboratory of Molecular Signaling, The Babraham Institute, Cambridge CB223AT, United Kingdom.

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January 2011

Specification and morphogenesis of astrocytes.

Authors:
Marc R Freeman

Science 2010 Nov;330(6005):774-8

Department of Neurobiology, Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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November 2010

PET CT thresholds for radiotherapy target definition in non-small-cell lung cancer: how close are we to the pathologic findings?

Int J Radiat Oncol Biol Phys 2010 Jul 14;77(3):699-706. Epub 2009 Oct 14.

Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

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July 2010

Central clock regulates the cervically stimulated prolactin surges by modulation of dopamine and vasoactive intestinal polypeptide release in ovariectomized rats.

Neuroendocrinology 2010 29;91(2):179-88. Epub 2009 Oct 29.

Biological Science and Program in Neuroscience, Florida State University, Tallahassee, FL, USA.

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June 2010

Activation of autophagy during cell death requires the engulfment receptor Draper.

Nature 2010 Jun;465(7301):1093-6

Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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June 2010

Variations in the response of pituitary lactotrophs to oxytocin during the rat estrous cycle.

Endocrinology 2010 Apr 22;151(4):1806-13. Epub 2010 Feb 22.

Department of Biological Science, Florida State University, BRF 206, Tallahassee, Florida 32306, USA.

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April 2010

Assessment of tumor recurrence in patients with colorectal cancer and elevated carcinoembryonic antigen level: FDG PET/CT versus contrast-enhanced 64-MDCT of the chest and abdomen.

AJR Am J Roentgenol 2010 Mar;194(3):766-71

Department of Medical Imaging, Princess Margaret Hospital, University Health Network, 610 University Ave., Ste. 3-960, Toronto, ON, M5G 2M9 Canada.

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March 2010

Dopamine-regulated adrenocorticotropic hormone secretion in lactating rats: functional plasticity of melanotropes.

Neuroendocrinology 2009 30;90(4):391-401. Epub 2009 Jul 30.

Neuromorphological and Neuroendocrine Research Laboratory, Department of Human Morphology and Developmental Biology, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary.

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February 2010

Neuronal death or dismemberment mediated by Sox14.

Nat Neurosci 2009 Dec;12(12):1479-80

Howard Hughes Medical Institute and Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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December 2009

Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris.

PLoS Biol 2009 Aug 25;7(8):e1000184. Epub 2009 Aug 25.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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August 2009

The rhythmic secretion of mating-induced prolactin secretion is controlled by prolactin acting centrally.

Endocrinology 2009 Jul 12;150(7):3245-51. Epub 2009 Mar 12.

Department of Biological Science, Florida State University, Tallahassee, Florida 32306-4340, USA.

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July 2009

Antagonism of oxytocin prevents suckling- and estradiol-induced, but not progesterone-induced, secretion of prolactin.

Endocrinology 2009 May 23;150(5):2292-9. Epub 2008 Dec 23.

Department of Biological Science, and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306, USA.

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May 2009

Ensheathing glia function as phagocytes in the adult Drosophila brain.

J Neurosci 2009 Apr;29(15):4768-81

Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605-2324, USA.

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April 2009

Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration.

J Cell Biol 2009 Feb;184(4):501-13

Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

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February 2009

Rationale and evidence for sunitinib in the treatment of malignant paraganglioma/pheochromocytoma.

J Clin Endocrinol Metab 2009 Jan 11;94(1):5-9. Epub 2008 Nov 11.

Department of Medical Oncology, Princess Margaret Hospital, University Health Network, 610 University Avenue, M5G 2M9 Toronto, Ontario, Canada.

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January 2009

Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling.

Nature 2008 Jun 23;453(7197):935-9. Epub 2008 Apr 23.

Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605-2324, USA.

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June 2008

A-type K(+) current can act as a trigger for bursting in the absence of a slow variable.

Neural Comput 2008 Feb;20(2):436-51

Department of Mathematics, Florida State University, Tallahassee, FL 32306, USA.

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February 2008

Vasoactive intestinal polypeptide modulates the estradiol-induced prolactin surge by entraining oxytocin neuronal activity.

Brain Res 2008 Feb 3;1196:65-73. Epub 2008 Jan 3.

Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

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February 2008

Knockdown of clock genes in the suprachiasmatic nucleus blocks prolactin surges and alters FRA expression in the locus coeruleus of female rats.

Am J Physiol Endocrinol Metab 2007 Nov 28;293(5):E1325-34. Epub 2007 Aug 28.

Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306-4340, USA.

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November 2007

Oxytocin action at the lactotroph is required for prolactin surges in cervically stimulated ovariectomized rats.

Endocrinology 2007 Oct 5;148(10):4649-57. Epub 2007 Jul 5.

Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA.

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October 2007

Glia got rhythm.

Neuron 2007 Aug;55(3):337-9

Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.

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August 2007

Low dose of dopamine may stimulate prolactin secretion by increasing fast potassium currents.

J Comput Neurosci 2007 Apr;22(2):211-22

Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

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April 2007

The scoop on the fly brain: glial engulfment functions in Drosophila.

Neuron Glia Biol 2007 Feb;3(1):63-74

University of Massachusetts Medical School, Department of Neurobiology 770P, 364 Plantation Street, Worcester, MA 01605, USA.

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February 2007

A look inside.

Authors:
Marc R Freeman

Neuron Glia Biol 2007 Feb;3(1):1-3

Neuron Glia Biology.

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February 2007

The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons.

Neuron 2006 Jun;50(6):869-81

Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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June 2006

Anatomical and functional characterization of clock gene expression in neuroendocrine dopaminergic neurons.

Am J Physiol Regul Integr Comp Physiol 2006 May 22;290(5):R1309-23. Epub 2005 Dec 22.

Department of Biological Science, Florida State Univ., Tallahassee, Florida, USA.

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May 2006

Prolactin secretory rhythm of mated rats induced by a single injection of oxytocin.

Am J Physiol Endocrinol Metab 2006 Mar;290(3):E566-72

Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

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March 2006

A mathematical model for the mating-induced prolactin rhythm of female rats.

Am J Physiol Endocrinol Metab 2006 Mar;290(3):E573-82

Department of Biological Science, Florida State University, Tallahassee, FL 32306, USA.

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March 2006

Glial cell biology in Drosophila and vertebrates.

Trends Neurosci 2006 Feb 10;29(2):82-90. Epub 2006 Jan 10.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA.

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February 2006

Sculpting the nervous system: glial control of neuronal development.

Authors:
Marc R Freeman

Curr Opin Neurobiol 2006 Feb 4;16(1):119-25. Epub 2006 Jan 4.

Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA.

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February 2006

Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins.

Sci STKE 2006 Feb;2006(321):er2

Department of Mathematics, Florida State University, Tallahassee, FL 32306, USA.

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February 2006

Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins.

Sci STKE 2006 Jan 24;2006(319):pe4. Epub 2006 Jan 24.

Department of Mathematics, Florida State University, Tallahassee, FL 32306, USA.

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January 2006

Species differences in anxiety-related responses in male prairie and meadow voles: the effects of social isolation.

Physiol Behav 2005 Oct 22;86(3):369-78. Epub 2005 Aug 22.

Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA.

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October 2005

Glial (and neuronal) cells missing.

Authors:
Marc R Freeman

Neuron 2005 Oct;48(2):163-5

Department of Neurobiology, University of Massachusetts Medical School, 719 Lazare Research Building, 364 Plantation Street, Worcester, Massachusetts 01605, USA.

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October 2005

Glial control of synaptogenesis.

Authors:
Marc R Freeman

Cell 2005 Feb;120(3):292-3

Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

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February 2005

Rhythmic secretion of prolactin in rats: action of oxytocin coordinated by vasoactive intestinal polypeptide of suprachiasmatic nucleus origin.

Endocrinology 2004 Jul 19;145(7):3386-94. Epub 2004 Mar 19.

Department of Biological Sciecne, Florida State University, Tallahassee, Florida 32306-4340, USA.

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July 2004

Ovarian steroid hormones modulate circadian rhythms of neuroendocrine dopaminergic neuronal activity.

Brain Res 2004 Apr;1005(1-2):164-81

Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306, USA.

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April 2004

Autocrine regulation of prolactin secretion by endothelins throughout the estrous cycle.

Endocrine 2003 Feb-Mar;20(1-2):53-8

Department of Biological Science, Florida State University, Tallahassee, FL 32306-4340, USA.

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December 2003

Newly proliferated cells in the adult male amygdala are affected by gonadal steroid hormones.

J Neurobiol 2003 Dec;57(3):257-69

Department of Psychology, Program in Neuroscience, Florida State University, Tallahassee, Florida 32306, USA.

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December 2003

Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function.

Neuron 2003 May;38(4):567-80

Institutes of Neuroscience and Molecular Biology, University of Oregon, Eugene, OR 97403, USA.

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May 2003

Circadian rhythms of neuroendocrine dopaminergic neuronal activity in ovariectomized rats.

Neuroendocrinology 2003 Jan;77(1):59-70

Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, Fla 32306-4340, USA.

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January 2003

Antagonism of vasoactive intestinal peptide mRNA in the suprachiasmatic nucleus disrupts the rhythm of FRAs expression in neuroendocrine dopaminergic neurons.

J Comp Neurol 2002 Aug;450(2):135-43

Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee 32306, USA.

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August 2002