Publications by authors named "Marc Feldmann"

100Publications

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19.

Sci Immunol 2020 09;5(51)

Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Room 2.16, Core Technology Facility, 46 Grafton Street, Manchester, M13 9PL, UK.

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http://dx.doi.org/10.1126/sciimmunol.abd6197DOI Listing
September 2020

Identifying collagen VI as a target of fibrotic diseases regulated by CREBBP/EP300.

Proc Natl Acad Sci U S A 2020 08 5;117(34):20753-20763. Epub 2020 Aug 5.

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 7FY, United Kingdom;

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http://dx.doi.org/10.1073/pnas.2004281117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456151PMC
August 2020

Author Correction: Cellular census of human fibrosis defines functionally distinct stromal cell types and states.

Nat Commun 2020 06 24;11(1):3275. Epub 2020 Jun 24.

The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41467-020-17073-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314854PMC
June 2020

Cellular census of human fibrosis defines functionally distinct stromal cell types and states.

Nat Commun 2020 06 2;11(1):2768. Epub 2020 Jun 2.

The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/s41467-020-16264-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265502PMC
June 2020

Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed.

Lancet 2020 05 9;395(10234):1407-1409. Epub 2020 Apr 9.

Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1016/S0140-6736(20)30858-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158940PMC
May 2020

Single cell force profiling of human myofibroblasts reveals a biophysical spectrum of cell states.

Biol Open 2020 Mar 24;9(3). Epub 2020 Mar 24.

The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford OX3 7FY, UK

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http://dx.doi.org/10.1242/bio.049809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104857PMC
March 2020

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism.

Proc Natl Acad Sci U S A 2020 03 2;117(11):6056-6066. Epub 2020 Mar 2.

Botnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, National Institute for Health Research Oxford Biomedical Research Unit, University of Oxford, OX3 7LD Oxford, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1919893117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084125PMC
March 2020

Identification of TNFR2 and IL-33 as therapeutic targets in localized fibrosis.

Sci Adv 2019 12 4;5(12):eaay0370. Epub 2019 Dec 4.

The Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1126/sciadv.aay0370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892635PMC
December 2019

TNF receptor 2 signaling prevents DNA methylation at the promoter and prevents pathogenic conversion of regulatory T cells.

Proc Natl Acad Sci U S A 2019 10 9;116(43):21666-21672. Epub 2019 Oct 9.

Kennedy Institute of Rheumatology, University of Oxford, OX3 7FY Oxford, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1909687116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815167PMC
October 2019

Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to G.

Proc Natl Acad Sci U S A 2018 05 19;115(19):E4463-E4472. Epub 2018 Apr 19.

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, OX3 7FY Oxford, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1802893115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949009PMC
May 2018

Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells.

J Biol Chem 2018 02 4;293(7):2422-2437. Epub 2018 Jan 4.

From the Botnar Research Center, Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, National Institute of Health Research Oxford Biomedical Research Unit (BRU), University of Oxford, Oxford OX3 7DQ, United Kingdom,

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http://dx.doi.org/10.1074/jbc.RA117.000698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818173PMC
February 2018

Anti-TNF Therapy.

Microbiol Spectr 2016 08;4(4)

Kennedy Institute of Rheumatology, NDORMS, University of Oxford, Botnar Research Centre, Headington, Oxford OX3 7LD, United Kingdom.

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http://dx.doi.org/10.1128/microbiolspec.MCHD-0022-2015DOI Listing
August 2016

Macrophage heterogeneity in the context of rheumatoid arthritis.

Nat Rev Rheumatol 2016 08 7;12(8):472-85. Epub 2016 Jul 7.

Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Oxford OX3 7LF, UK.

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http://dx.doi.org/10.1038/nrrheum.2016.91DOI Listing
August 2016

Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development.

Proc Natl Acad Sci U S A 2015 Oct 5;112(42):13033-8. Epub 2015 Oct 5.

Nuffield Department of Orthopedics, Rheumatology, and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, Headington, Oxford OX3 7FY, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1517820112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620898PMC
October 2015

Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications.

Ther Adv Musculoskelet Dis 2015 Oct;7(5):206-19

Botnar Research Centre, NIHR Oxford Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, and Structural Genomics Consortium, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1177/1759720X15598307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572365PMC
October 2015

IRF5 controls both acute and chronic inflammation.

Proc Natl Acad Sci U S A 2015 Sep 17;112(35):11001-6. Epub 2015 Aug 17.

Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, United Kingdom;

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http://dx.doi.org/10.1073/pnas.1506254112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568217PMC
September 2015

Perspectives From Masters in Rheumatology and Autoimmunity: Can We Get Closer to a Cure for Rheumatoid Arthritis?

Arthritis Rheumatol 2015 Sep;67(9):2283-91

Kennedy Institute of Rheumatology and University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/art.39269DOI Listing
September 2015

Preclinical target validation using patient-derived cells.

Nat Rev Drug Discov 2015 Mar 20;14(3):149-50. Epub 2015 Feb 20.

Structural Genomics Consortium, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nrd4565DOI Listing
March 2015

Design and optimisation of bioactive cyclic peptides: generation of a down-regulator of TNF secretion.

Molecules 2014 Dec 22;19(12):21529-40. Epub 2014 Dec 22.

Kennedy Institute of Rheumatology, Roosevelt Drive, University of Oxford, Headington OX3 7FY, UK.

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http://dx.doi.org/10.3390/molecules191221529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271530PMC
December 2014

Anti-TNF therapy: past, present and future.

Int Immunol 2015 Jan 19;27(1):55-62. Epub 2014 Nov 19.

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7FY, UK

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http://dx.doi.org/10.1093/intimm/dxu102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279876PMC
January 2015

Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.

Mol Med 2015 Mar 17;20:667-75. Epub 2015 Mar 17.

Department of Anesthesia and Perioperative Care, UCSF Medical Center, San Francisco, California, United States of America.

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http://dx.doi.org/10.2119/molmed.2014.00143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398668PMC
March 2015

Reply: To PMID 23784528.

Arthritis Rheumatol 2014 Jul;66(7):1962-3

Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/art.38654DOI Listing
July 2014

OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.

Proc Natl Acad Sci U S A 2014 Feb 27;111(6):2289-94. Epub 2014 Jan 27.

Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1321071111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926072PMC
February 2014

A conversation with Marc Feldmann. Interviewed by Ushma S. Neill.

Authors:
Marc Feldmann

J Clin Invest 2014 Jan 2;124(1):1-2. Epub 2014 Jan 2.

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http://dx.doi.org/10.1172/JCI71860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871253PMC
January 2014

TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages.

Cell Signal 2014 Apr 27;26(4):683-90. Epub 2013 Dec 27.

Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Old Road Campus, Roosevelt Drive, Headington, Oxford OX3 7FY, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2013.12.009DOI Listing
April 2014

RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages.

Cytokine 2013 Mar 6;61(3):736-40. Epub 2013 Feb 6.

Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy.

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http://dx.doi.org/10.1016/j.cyto.2012.12.029DOI Listing
March 2013

Alarmins: awaiting a clinical response.

J Clin Invest 2012 Aug 1;122(8):2711-9. Epub 2012 Aug 1.

Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1172/JCI62423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408740PMC
August 2012

NF-κB as a target for modulating inflammatory responses.

Curr Pharm Des 2012 ;18(35):5735-45

Institute for Maternal and Child Health IRCCS “Burlo Garofolo”, Trieste, Italy.

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http://dx.doi.org/10.2174/138161212803530763DOI Listing
May 2013

Effective targeting of the tumor microenvironment for cancer therapy.

Anticancer Res 2012 Apr;32(4):1203-12

Halozyme Therapeutics, San Diego, CA 94121, USA.

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April 2012

Resolving postoperative neuroinflammation and cognitive decline.

Ann Neurol 2011 Dec;70(6):986-995

Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143-0648.

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http://dx.doi.org/10.1002/ana.22664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556354PMC
December 2011

Human epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade.

Arthritis Res Ther 2011 7;13(5):R161. Epub 2011 Oct 7.

Faculty of Medicine, Kennedy Institute of Rheumatology, 65 Aspenlea Road, London, W6 8LH, Imperial College London, London, UK.

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http://dx.doi.org/10.1186/ar3480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308094PMC
December 2012

IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration.

Pain 2011 Aug 19;152(8):1838-45. Epub 2011 Apr 19.

Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1016/j.pain.2011.03.035DOI Listing
August 2011

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.

Nat Immunol 2011 Mar 16;12(3):231-8. Epub 2011 Jan 16.

Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK.

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http://dx.doi.org/10.1038/ni.1990DOI Listing
March 2011

Unexpected protective role for Toll-like receptor 3 in the arterial wall.

Proc Natl Acad Sci U S A 2011 Feb 10;108(6):2372-7. Epub 2011 Jan 10.

Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London W6 8LH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1018515108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038746PMC
February 2011

TNF-alpha promotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells.

Proc Natl Acad Sci U S A 2011 Jan 5;108(4):1585-90. Epub 2011 Jan 5.

The Kennedy Institute of Rheumatology, Imperial College, Hammersmith, London W6 8LH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1018501108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029750PMC
January 2011

Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline.

Proc Natl Acad Sci U S A 2010 Nov 1;107(47):20518-22. Epub 2010 Nov 1.

Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143-0648, USA.

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http://dx.doi.org/10.1073/pnas.1014557107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996666PMC
November 2010

Role of interleukin-1beta in postoperative cognitive dysfunction.

Ann Neurol 2010 Sep;68(3):360-8

Department of Anesthetics, Pain Medicine, and Intensive Care, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom.

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http://dx.doi.org/10.1002/ana.22082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836445PMC
September 2010

IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages.

J Exp Med 2010 Sep 30;207(10):2081-8. Epub 2010 Aug 30.

Kennedy Institute of Rheumatology Division, Imperial College London, London W6 8LH, UK.

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http://dx.doi.org/10.1084/jem.20100414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947066PMC
September 2010

Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood.

J Immunol 2010 Sep 16;185(6):3694-701. Epub 2010 Aug 16.

The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1000906DOI Listing
September 2010

Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us?

J Immunol 2010 Jul;185(2):791-4

Kennedy Institute of Rheumatology, Imperial College, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1090051DOI Listing
July 2010

Regulation of the angiopoietin-Tie ligand-receptor system with a novel splice variant of Tie1 reduces the severity of murine arthritis.

Rheumatology (Oxford) 2010 Oct 14;49(10):1828-39. Epub 2010 Jun 14.

Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, Arthritis Research Campaign Building, London, UK.

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https://academic.oup.com/rheumatology/article-lookup/doi/10.
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http://dx.doi.org/10.1093/rheumatology/keq163DOI Listing
October 2010

The therapeutic activity of low-dose irradiation on experimental arthritis depends on the induction of endogenous regulatory T cell activity.

Ann Rheum Dis 2010 Aug 24;69(8):1519-26. Epub 2010 May 24.

Kennedy Institute of Rheumatology, Imperial College, London, UK.

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http://dx.doi.org/10.1136/ard.2009.121111DOI Listing
August 2010

The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction.

Crit Care 2010 14;14(3):R88. Epub 2010 May 14.

Department of Anesthetics, Pain Medicine and Intensive Care, Imperial College London, Chelsea & Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK.

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http://dx.doi.org/10.1186/cc9019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911722PMC
January 2011

Directed issue: novel concepts in inflammation.

Int J Biochem Cell Biol 2010 Apr 10;42(4):480-1. Epub 2010 Feb 10.

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http://dx.doi.org/10.1016/j.biocel.2010.02.003DOI Listing
April 2010

A view from a European medical academic who spends time in the US.

Authors:
Marc Feldmann

J Clin Invest 2009 Oct;119(10):2861-2

Imperial College London, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752103PMC
http://dx.doi.org/10.1172/jci41024DOI Listing
October 2009

Toll-like receptor-2 mediates inflammation and matrix degradation in human atherosclerosis.

Circulation 2009 Dec;120(24):2462-9

Kennedy Institute of Rheumatology Division, Imperial College, 65 Aspenlea Rd, London W6 8LH, UK.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.851881DOI Listing
December 2009

Investigating the role of the interleukin-23/-17A axis in rheumatoid arthritis.

Rheumatology (Oxford) 2009 Dec 8;48(12):1581-9. Epub 2009 Oct 8.

Kennedy Institute of Rheumatology, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK.

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http://dx.doi.org/10.1093/rheumatology/kep293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777488PMC
December 2009

Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis.

Nat Rev Rheumatol 2009 Oct;5(10):578-82

Kennedy Institute of Rheumatology Division, Imperial College, London, UK.

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http://dx.doi.org/10.1038/nrrheum.2009.181DOI Listing
October 2009

RelB/p50 regulates CCL19 production, but fails to promote human DC maturation.

Eur J Immunol 2009 Aug;39(8):2215-23

Kennedy Institute of Rheumatology Division, School of Medicine, Imperial College London, London, UK.

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http://doi.wiley.com/10.1002/eji.200939209
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http://dx.doi.org/10.1002/eji.200939209DOI Listing
August 2009

In memoriam: Professor Brian Maurice John Foxwell, 1956 to 2008.

Arthritis Res Ther 2009 27;11(1):104. Epub 2009 Feb 27.

The Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, Aspenlea Road, London W68LH, UK.

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http://dx.doi.org/10.1186/ar2628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688263PMC
September 2009

Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.

J Immunol 2008 Dec;181(11):8002-9

Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.181.11.8002DOI Listing
December 2008

Translating molecular insights in autoimmunity into effective therapy.

Authors:
Marc Feldmann

Annu Rev Immunol 2009 ;27:1-27

Kennedy Institute of Rheumatology Division, Imperial College London, London W6 8LH, UK.

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http://dx.doi.org/10.1146/annurev-immunol-082708-100732DOI Listing
May 2009

Many cytokines are very useful therapeutic targets in disease.

Authors:
Marc Feldmann

J Clin Invest 2008 Nov;118(11):3533-6

Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1172/JCI37346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575703PMC
November 2008

Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis.

Eur J Immunol 2008 Oct;38(10):2905-15

Infectious Diseases Laboratory, Department of Clinical Biochemistry, Faculty of Health Sciences, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel.

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http://doi.wiley.com/10.1002/eji.200838545
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http://dx.doi.org/10.1002/eji.200838545DOI Listing
October 2008

Antagonism of the human epidermal growth factor receptor family controls disease severity in murine collagen-induced arthritis.

Arthritis Rheum 2008 Oct;58(10):3071-80

Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UK.

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http://dx.doi.org/10.1002/art.23885DOI Listing
October 2008

Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system.

Arthritis Rheum 2008 Oct;58(10):3110-9

Kennedy Institute of Rheumatology, Imperial College London, London, UK.

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http://doi.wiley.com/10.1002/art.23870
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http://dx.doi.org/10.1002/art.23870DOI Listing
October 2008

Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics.

Immunol Rev 2008 Jun;223:7-19

Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, London, UK.

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http://dx.doi.org/10.1111/j.1600-065X.2008.00626.xDOI Listing
June 2008

Targeting intracellular signaling: a novel approach to vaccination.

Expert Rev Vaccines 2007 Dec;6(6):971-80

Imperial College London, Kennedy Institute of Rheumatology, The Charing Cross Hospital Campus, Arthritis Research Campaign Building, 1 Aspenlea Road, London W6 8LH, UK.

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http://dx.doi.org/10.1586/14760584.6.6.971DOI Listing
December 2007

Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.

Mol Immunol 2008 May 6;45(9):2446-54. Epub 2008 Feb 6.

Kennedy Institute of Rheumatology Division, Imperial College London, Hammersmith, London W6 8LH, United Kingdom.

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http://dx.doi.org/10.1016/j.molimm.2007.12.011DOI Listing
May 2008

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.

Arthritis Rheum 2008 Feb;58(2 Suppl):S92-S101

Clinical Immunology Division, Kennedy Institute of Rheumatology, London W6 7DW, United Kingdom.

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http://dx.doi.org/10.1002/art.23362DOI Listing
February 2008

Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.

Ann Rheum Dis 2007 Nov;66 Suppl 3:iii81-6

Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK.

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http://dx.doi.org/10.1136/ard.2007.079012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095278PMC
November 2007

Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems.

Blood 2007 Nov 27;110(9):3245-52. Epub 2007 Jul 27.

Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, 1 Aspenlea Road, Hammersmith, London, United Kingdom.

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http://dx.doi.org/10.1182/blood-2007-02-072934DOI Listing
November 2007

Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases.

Curr Opin Pharmacol 2007 Aug 12;7(4):412-7. Epub 2007 Jul 12.

The Kennedy Institute of Rheumatology Division, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK.

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http://dx.doi.org/10.1016/j.coph.2007.06.001DOI Listing
August 2007

Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent.

J Rheumatol 2007 Mar 15;34(3):523-33. Epub 2007 Jan 15.

Department of Rheumatology; Connective Tissue Biology Laboratories, Cardiff School of Biosciences, Cardiff University, Cardiff, UK.

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March 2007

Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling.

J Immunol 2007 Feb;178(4):2148-54

Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.178.4.2148DOI Listing
February 2007

The pitfalls in the development of biologic therapy.

Nat Clin Pract Rheumatol 2007 Jan;3(1)

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http://dx.doi.org/10.1038/ncprheum0373DOI Listing
January 2007

Is there a role for TNF-alpha in anti-neutrophil cytoplasmic antibody-associated vasculitis? Lessons from other chronic inflammatory diseases.

J Am Soc Nephrol 2006 May 19;17(5):1243-52. Epub 2006 Apr 19.

Renal Section, Division of Medicine, Imperial College London, Hammersmith Campus, London, UK.

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http://dx.doi.org/10.1681/ASN.2005121359DOI Listing
May 2006

Vascular endothelial growth factor signalling in endothelial cell survival: a role for NFkappaB.

Biochem Biophys Res Commun 2006 Feb 27;340(3):984-94. Epub 2005 Dec 27.

Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0502811
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http://dx.doi.org/10.1016/j.bbrc.2005.12.095DOI Listing
February 2006