Publications by authors named "Marc F Hoylaerts"

100Publications

Antiplatelet therapy abrogates platelet-assisted Staphylococcus aureus infectivity of biological heart valve conduits.

J Thorac Cardiovasc Surg 2019 Nov 23. Epub 2019 Nov 23.

Cardiovascular Developmental Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium. Electronic address:

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November 2019

Controlled NO-Release from 3D-Printed Small-Diameter Vascular Grafts Prevents Platelet Activation and Bacterial Infectivity.

ACS Biomater Sci Eng 2019 May 3;5(5):2284-2296. Epub 2019 Apr 3.

Cardiovascular Developmental Biology, Department of Cardiovascular Sciences, KU Leuven, 3000 Leuven, Belgium.

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May 2019

Are plasma proteins key players in the pathogenesis of infective endocarditis?

J Thorac Cardiovasc Surg 2018 08;156(2):738-739

Cardiovascular Developmental Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.

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August 2018

Assessment of the Dual Role of Clumping Factor A in S. Aureus Adhesion to Endothelium in Absence and Presence of Plasma.

Thromb Haemost 2018 Jul 17;118(7):1230-1241. Epub 2018 Jun 17.

Division of Cardiovascular Developmental Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.

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July 2018

Cell-Specific PEAR1 Methylation Studies Reveal a Locus that Coordinates Expression of Multiple Genes.

Int J Mol Sci 2018 Apr 3;19(4). Epub 2018 Apr 3.

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, 3000 Leuven, Belgium.

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April 2018

Biophysical aspects of biomineralization.

Biophys Rev 2017 Oct 29;9(5):747-760. Epub 2017 Aug 29.

Depto. Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, SP, 14040-901, Brazil.

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October 2017

Bacterial adherence to graft tissues in static and flow conditions.

J Thorac Cardiovasc Surg 2018 01 16;155(1):325-332.e4. Epub 2017 Jun 16.

Cardiovascular Developmental Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium. Electronic address:

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January 2018

Topographic analysis by atomic force microscopy of proteoliposomes matrix vesicle mimetics harboring TNAP and AnxA5.

Biochim Biophys Acta Biomembr 2017 Oct 23;1859(10):1911-1920. Epub 2017 May 23.

Depto. Química, FFCLRP-USP, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. Electronic address:

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October 2017

PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population.

BMC Med Genet 2017 04 27;18(1):45. Epub 2017 Apr 27.

Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences,, University of Leuven, Campus Sint Rafaël, Kapucijnenvoer 35, Box 7001, BE-3000, Leuven, Belgium.

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April 2017

A novel mechanism regulating human platelet activation by MMP-2-mediated PAR1 biased signaling.

Blood 2017 02 29;129(7):883-895. Epub 2016 Dec 29.

Division of Internal and Cardiovascular Medicine, Department of Medicine, University of Perugia, Perugia, Italy; and.

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February 2017

ADAMTS13 deficiency promotes microthrombosis in a murine model of diet-induced liver steatosis.

Thromb Haemost 2017 01 8;117(1):19-26. Epub 2016 Sep 8.

H. R. Lijnen, Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, CDG, Herestraat 49, Box 911, B-3000 Leuven, Belgium, Tel.: +32 16 372053, Fax: +32 16 345990, E-mail:

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January 2017

Allele-specific DNA methylation reinforces PEAR1 enhancer activity.

Blood 2016 08 16;128(7):1003-12. Epub 2016 Jun 16.

Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology.

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August 2016

Dextran sulfate triggers platelet aggregation via direct activation of PEAR1.

Platelets 2016 Jun 30;27(4):365-72. Epub 2015 Nov 30.

a Center for Molecular and Vascular Biology , Department of Cardiovascular Sciences , KU Leuven , Leuven , Belgium.

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June 2016

Thrombin Generation by Fetoscopic Trauma to the Fetal Membranes: An in vivo and in vitro Study.

Fetal Diagn Ther 2016 2;39(4):261-8. Epub 2015 Oct 2.

Department of Development and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium.

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February 2017

Proteoliposomes with the ability to transport Ca(2+) into the vesicles and hydrolyze phosphosubstrates on their surface.

Arch Biochem Biophys 2015 Oct 29;584:79-89. Epub 2015 Aug 29.

Depto. Química, FFCLRP-USP, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. Electronic address:

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October 2015

Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis.

Cardiovasc Res 2015 Oct 7;108(1):124-38. Epub 2015 Jul 7.

Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Herestraat 49, Bus 911, BE-3000 Leuven, Belgium.

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October 2015

Functional significance of calcium binding to tissue-nonspecific alkaline phosphatase.

PLoS One 2015 16;10(3):e0119874. Epub 2015 Mar 16.

Sanford Children's Health Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, United States of America.

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February 2016

Short-term effect of infliximab is reflected in the clot lysis profile of patients with inflammatory bowel disease: a prospective study.

Inflamm Bowel Dis 2015 Mar;21(3):570-8

*Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, Leuven, Belgium; †Systems and Modeling Unit, Montefiore Institute, University of Liège, Liège, Belgium; ‡Translational Research in Gastrointestinal Disorders, Department of Gastroenterology, Universitair Ziekenhuis Leuven, Leuven, Belgium; and §Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, Universitair Ziekenhuis Leuven, Leuven, Belgium.

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March 2015

Active PAI-1 as marker for venous thromboembolism: case-control study using a comprehensive panel of PAI-1 and TAFI assays.

Thromb Res 2014 Nov 20;134(5):1097-102. Epub 2014 Aug 20.

Laboratory for Therapeutic and Diagnostic Antibodies, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Belgium. Electronic address:

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November 2014

Ablation of osteopontin improves the skeletal phenotype of phospho1(-/-) mice.

J Bone Miner Res 2014 Nov;29(11):2369-81

Sanford Children's Health Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.

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November 2014

Supporting roles of platelet thrombospondin-1 and CD36 in thrombus formation on collagen.

Arterioscler Thromb Vasc Biol 2014 Jun 27;34(6):1187-92. Epub 2014 Mar 27.

From the Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands (M.J.E.K., S.d.W., R.N.-U., R.v.K., J.M.E.M.C., J.W.M.H.); Department of Vascular Hematology/Angiogenesis (M.T.), Department of Metabolic Research (P.J.V.), and Department of Biopharmaceutics (S.J.A.K.), Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands; Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, The Netherlands (S.J.A.K.); Department of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada (M.F.); Center for Molecular and Vascular Biology, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium (P.V., M.F.H.); Laboratory of Vascular Hematology/Angiogenesis, Institute for Transfusion Medicine, DRK Blutspendedienst B-W-Hessen, Goethe University and University Hospital Frankfurt, Frankfurt, Germany (M.T.); and Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom (P.J.V.).

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June 2014

Catalytic signature of a heat-stable, chimeric human alkaline phosphatase with therapeutic potential.

PLoS One 2014 24;9(2):e89374. Epub 2014 Feb 24.

Sanford Children's Health Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America.

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December 2014

Effects of pH on the production of phosphate and pyrophosphate by matrix vesicles' biomimetics.

Calcif Tissue Int 2013 Sep 31;93(3):222-32. Epub 2013 May 31.

Department of Chemistry, FFCLRP-USP, Av. Bandeirantes, 3900, Ribeirão Preto, SP, 14040-901, Brazil.

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September 2013

Age-associated pro-inflammatory adaptations of the mouse thoracic aorta.

Thromb Haemost 2013 Oct 8;110(4):785-94. Epub 2013 Aug 8.

H. R. Lijnen, Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, CDG, Herestraat 49, Box 911, 3000 Leuven, Belgium, Tel.: +32 16 345771, Fax: +32 16 345990, E-mail:

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October 2013

PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway.

Blood 2013 Jun 10;121(26):5208-17. Epub 2013 May 10.

Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.

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June 2013

The role of staphylothrombin-mediated fibrin deposition in catheter-related Staphylococcus aureus infections.

J Infect Dis 2013 Jul 26;208(1):92-100. Epub 2013 Mar 26.

Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.

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July 2013

Does rosiglitazone affect adiposity and cardiac function in genetic diabetic mice?

Eur J Pharmacol 2013 Jan 7;700(1-3):23-31. Epub 2012 Dec 7.

Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.

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January 2013

Platelet receptors.

Handb Exp Pharmacol 2012 (210):23-57

Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.

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January 2013

Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation.

Thromb Haemost 2012 Jun 22;107(6):1107-21. Epub 2012 Mar 22.

Center for Molecular and Vascular Biology, University of Leuven, University Hospitals Leuven, B-3000 Leuven, Belgium.

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June 2012

A novel mechanism of sustained platelet αIIbβ3 activation via PEAR1.

Blood 2012 Apr 27;119(17):4056-65. Epub 2012 Feb 27.

Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, Leuven, Belgium.

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April 2012

Effect of premature aging on murine adipose tissue.

Exp Gerontol 2012 Mar 12;47(3):256-62. Epub 2012 Jan 12.

Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.

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March 2012

Effect of ageing on the murine venous circulation.

Histochem Cell Biol 2012 Apr 18;137(4):537-46. Epub 2012 Jan 18.

Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, Leuven, Belgium.

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April 2012

Air pollution-associated procoagulant changes: the role of circulating microvesicles.

J Thromb Haemost 2012 Jan;10(1):96-106

Center for Molecular and Vascular Biology, Unit of Lung Toxicology, University of Leuven, Leuven, Belgium.

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January 2012

Progression of the prothrombotic state in aging Bmal1-deficient mice.

Arterioscler Thromb Vasc Biol 2011 Nov;31(11):2552-9

Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium.

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November 2011

Evaluation of the profibrinolytic properties of an anti-TAFI monoclonal antibody in a mouse thromboembolism model.

Blood 2011 Apr 22;117(17):4615-22. Epub 2011 Feb 22.

Laboratory for Pharmaceutical Biology, Faculty of Pharmaceutical Sciences, Faculty of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium.

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April 2011

Traffic air pollution and oxidized LDL.

PLoS One 2011 Jan 19;6(1):e16200. Epub 2011 Jan 19.

Occupational and Environmental Medicine, Unit of Lung Toxicology, Katholieke Universiteit Leuven, Leuven, Belgium.

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January 2011

Impact of clock gene Bmal1 deficiency on nutritionally induced obesity in mice.

Obesity (Silver Spring) 2011 Mar 28;19(3):659-61. Epub 2010 Oct 28.

Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.

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March 2011

To the heart of the APS puzzle.

Authors:
Marc F Hoylaerts

Blood 2010 Oct;116(16):2867-9

Center for Molecular and Vascular Biology of Leuven.

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October 2010

Dabigatran inhibits Staphylococcus aureus coagulase activity.

J Clin Microbiol 2010 Nov 1;48(11):4248-50. Epub 2010 Sep 1.

Center for Molecular and Vascular Biology, University of Leuven, B-3000 Leuven, Belgium.

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November 2010

Thrombopoietic effect of VPAC1 inhibition during megakaryopoiesis.

Br J Haematol 2010 Oct 5;151(1):54-61. Epub 2010 Aug 5.

Centre for Molecular and Vascular Biology ThromboGenics Department of Paediatrics, University of Leuven, Herestraat 49, Leuven, Belgium.

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October 2010

Effect of VPAC1 Blockade on Adipose Tissue Formation and Composition in Mouse Models of Nutritionally Induced Obesity.

J Obes 2010 30;2010. Epub 2010 Jun 30.

Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O & N 1, Herestraat 49, P.O. Box 911, B-3000 Leuven, Belgium.

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July 2011

Age-associated adaptations in murine adipose tissues.

Endocr J 2010 31;57(10):925-30. Epub 2010 Jul 31.

Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium.

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March 2011

Challenges in the diagnosis of the antiphospholipid syndrome.

Clin Chem 2010 Jun 1;56(6):930-40. Epub 2010 Apr 1.

Coagulation Laboratory, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent, Belgium.

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June 2010

The P2X1 ion channel in platelet function.

Platelets 2010 ;21(3):153-66

Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.

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February 2011

Air pollution related prothrombotic changes in persons with diabetes.

Environ Health Perspect 2010 Feb;118(2):191-6

Occupational and Environmental Medicine, Unit of Lung Toxicology, Katholique Universiteit Leuven, Leuven, Belgium.

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February 2010

Proteoliposomes harboring alkaline phosphatase and nucleotide pyrophosphatase as matrix vesicle biomimetics.

J Biol Chem 2010 Mar 4;285(10):7598-609. Epub 2010 Jan 4.

Department of Chemistry, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP 14040-901, Brazil.

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March 2010

Thrombotic risk assessment in the antiphospholipid syndrome requires more than the quantification of lupus anticoagulants.

Blood 2010 Jan 25;115(4):870-8. Epub 2009 Nov 25.

Coagulation Laboratory, Department of Clinical Chemistry, Microbiology, and Immunology, Ghent University Hospital, Ghent, Belgium.

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January 2010

Hemostasis and inflammation: two of a kind?

Thromb J 2009 Nov 18;7:15. Epub 2009 Nov 18.

Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.

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November 2009

Short-term ethinyl estradiol treatment suppresses inferior caval vein thrombosis in obese mice.

Thromb Haemost 2009 Nov;102(5):993-1000

Center for Molecular and Vascular Biology, KU Leuven,3000 Leuven, Belgium.

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November 2009

The uremic retention solute p-cresyl sulfate and markers of endothelial damage.

Am J Kidney Dis 2009 Nov 17;54(5):891-901. Epub 2009 Jul 17.

Department of Medicine, Division of Nephrology, University Hospitals Leuven, Leuven, Belgium.

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November 2009

Laboratory diagnosis of the antiphospholipid syndrome: a plethora of obstacles to overcome.

Eur J Haematol 2009 Jul 17;83(1):1-16. Epub 2009 Feb 17.

Department of Clinical Chemistry, Coagulation Laboratory, Ghent University Hospital, Ghent, Belgium.

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July 2009

Laboratory detection of the antiphospholipid syndrome via calibrated automated thrombography.

Thromb Haemost 2009 Jan;101(1):185-96

Coagulation Laboratroy, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent, Belgium.

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January 2009

Acute toxicity and prothrombotic effects of quantum dots: impact of surface charge.

Environ Health Perspect 2008 Dec 18;116(12):1607-13. Epub 2008 Jul 18.

Laboratory of Pneumology, Unit for Lung Toxicology, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium.

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December 2008

Thrombospondin-1 in von Willebrand factor function.

Curr Drug Targets 2008 Oct;9(10):822-32

INSERM U743, Centre de Recherche du Centre Hospitalier de l'Université de Montréal-Saint-Luc, Montréal QCH2X1P1, Canada.

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October 2008

Thrombospondin-1 deficiency accelerates atherosclerotic plaque maturation in ApoE-/- mice.

Circ Res 2008 Nov 25;103(10):1181-9. Epub 2008 Sep 25.

Center for Molecular and Vascular Biology, Department of Cardiovascular Diseases, University of Leuven, Belgium.

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November 2008

Prothrombotic effect of Rofecoxib in a murine venous thrombosis model.

Thromb Res 2008 20;122(5):668-73. Epub 2008 Jun 20.

Center for Molecular and Vascular Biology, K.U. Leuven, Leuven, Belgium.

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December 2008

Obesity promotes injury induced femoral artery thrombosis in mice.

Thromb Res 2008 29;122(4):549-55. Epub 2008 Jan 29.

Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.

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November 2008

PACAP and its receptor VPAC1 regulate megakaryocyte maturation: therapeutic implications.

Blood 2008 Feb 13;111(4):1885-93. Epub 2007 Nov 13.

Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.

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February 2008

Factor V Leiden mutation is associated with enhanced arterial thrombotic tendency in lean but not in obese mice.

Thromb Haemost 2007 Oct;98(4):858-63

Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O & N 1, Herestraat 49, Box 911, 3000 Leuven, Belgium.

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October 2007

A novel phosphatase upregulated in Akp3 knockout mice.

Am J Physiol Gastrointest Liver Physiol 2007 Nov 27;293(5):G1068-77. Epub 2007 Sep 27.

Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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November 2007

Thrombin generation in plasma of healthy adults and children: chromogenic versus fluorogenic thrombogram analysis.

Thromb Haemost 2007 Sep;98(3):600-13

Coagulation Laboratory, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent, Belgium.

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September 2007

Involvement of the mitogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation.

J Biol Chem 2007 Nov 4;282(44):31990-9. Epub 2007 Sep 4.

Centre de Recherche Cardiovasculaire INSERM Lariboisière, U689-E4, Hôpital Lariboisière, 8 rue Guy Patin, 75010 Paris, France.

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November 2007

Thrombospondin-1 activates medial smooth muscle cells and triggers neointima formation upon mouse carotid artery ligation.

Arterioscler Thromb Vasc Biol 2007 Oct 30;27(10):2163-9. Epub 2007 Aug 30.

Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.

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October 2007

Mechanical stress activates platelets at a subhemolysis level: an in vitro study.

Artif Organs 2007 Apr;31(4):316-23

Center for Experimental Surgery and Anesthesiology, Cardiovascular Research Unit, Catholic University of Leuven (KUL), Leuven, Belgium.

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April 2007

Effects of particulate air pollution on hemostasis.

Clin Occup Environ Med 2006 ;5(4):865-81

K.U. Leuven, Laboratory of Pneumology (Unit of Lung Toxicology), Herestraat 49, B-3000, Leuven, Belgium.

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March 2007

Activation of alphaIIbbeta3 is a sufficient but also an imperative prerequisite for activation of alpha2beta1 on platelets.

Blood 2007 Jan 19;109(2):595-602. Epub 2006 Sep 19.

Laboratory for Thrombosis Research, Katholieke Universiteit Leuven, KU Leuven Campus Kortrijk, E. Sabbelaan 53, B-8500 Kortrijk, Belgium, and Institut Fédératif No. 4, Hôpital Cardiologique, Pessac, France.

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January 2007