Marc Devocelle

Marc Devocelle

UNVERIFIED PROFILE

Are you Marc Devocelle?   Register this Author

Register author
Marc Devocelle

Marc Devocelle

Publications by authors named "Marc Devocelle"

Are you Marc Devocelle?   Register this Author

49Publications

597Reads

31Profile Views

Poly(ethylene glycol)-Based Peptidomimetic "PEGtide" of Oligo-Arginine Allows for Efficient siRNA Transfection and Gene Inhibition.

ACS Omega 2019 Jun 10;4(6):10078-10088. Epub 2019 Jun 10.

Tissue Engineering Research Group, Department of Anatomy, Department of Chemistry, and Drug Delivery & Advanced Materials Team, School of Pharmacy, Royal College of Surgeons in Ireland (RCSI), 123 St. Stephen's Green, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.9b00265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647993PMC
June 2019

Chemoselective Synthesis of N-Terminal Cysteinyl Thioesters via β,γ-C,S Thiol-Michael Addition.

Org Lett 2019 05 24;21(9):3281-3285. Epub 2019 Apr 24.

School of Chemistry and Trinity Biomedical Sciences Institute (TBSI) , Trinity College Dublin, The University of Dublin , Dublin 2 , Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.orglett.9b01013DOI Listing
May 2019

A novel medical device coating prevents Staphylococcus aureus biofilm formation on medical device surfaces.

FEMS Microbiol Lett 2019 May;366(9)

Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9, Ireland.

View Article

Download full-text PDF

Source
https://academic.oup.com/femsle/advance-article/doi/10.1093/
Publisher Site
http://dx.doi.org/10.1093/femsle/fnz107DOI Listing
May 2019

Vibrating Mesh Nebulisation of Pro-Antimicrobial Peptides for Use in Cystic Fibrosis.

Pharmaceutics 2019 May 17;11(5). Epub 2019 May 17.

Department of Chemistry, Royal College of Surgeons in Ireland (RCSI), 123 St. Stephen's Green, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/pharmaceutics11050239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571777PMC
May 2019

Regeneration of aged DMF for use in solid-phase peptide synthesis.

J Pept Sci 2019 Jan;25(1):e3139

Molecular Design and Synthesis Group, Centre of Applied Science for Health, Institute of Technology Tallaght, Dublin, Ireland.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/psc.3139
Publisher Site
http://dx.doi.org/10.1002/psc.3139DOI Listing
January 2019

Action of antimicrobial peptides and their prodrugs on model and biological membranes.

J Pept Sci 2018 Jul 24;24(7):e3086. Epub 2018 May 24.

Department of Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/psc.3086DOI Listing
July 2018

Using Disease-Associated Enzymes to Activate Antimicrobial Peptide Prodrugs.

Methods Mol Biol 2017 ;1548:359-368

Department of Pharmaceutical and Medicinal Chemistry, Centre for Synthesis and Chemical Biology, Royal College of Surgeons in Ireland, 123 Stephen's Green, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-6737-7_26DOI Listing
February 2018

Biosynthesis of 2-aminooctanoic acid and its use to terminally modify a lactoferricin B peptide derivative for improved antimicrobial activity.

Appl Microbiol Biotechnol 2018 Jan 25;102(2):789-799. Epub 2017 Nov 25.

UCD Earth Institute and School of Biomolecular and Biomedical Science, O'Brien Centre for Science, University College Dublin, Belfield, Dublin 4, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00253-017-8655-0DOI Listing
January 2018

Stabilization of Angiotensin-(1-7) by key substitution with a cyclic non-natural amino acid.

Amino Acids 2017 10 25;49(10):1733-1742. Epub 2017 Jul 25.

School of Chemistry, University College Dublin, Dublin, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00726-017-2471-9DOI Listing
October 2017

Eradication of Staphylococcus aureus Biofilm Infections Using Synthetic Antimicrobial Peptides.

J Infect Dis 2017 03;215(6):975-983

Department of Clinical Microbiology, Education and Research Centre at Beaumont Hospital, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/infdis/jix062DOI Listing
March 2017

Differential In Vitro and In Vivo Toxicities of Antimicrobial Peptide Prodrugs for Potential Use in Cystic Fibrosis.

Antimicrob Agents Chemother 2016 05 22;60(5):2813-21. Epub 2016 Apr 22.

Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.00157-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862519PMC
May 2016

Synthesis and assessment of a maleimide functionalized BF2 azadipyrromethene near-infrared fluorochrome.

Chem Commun (Camb) 2015 Dec 1;51(93):16667-70. Epub 2015 Oct 1.

Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c5cc06137gDOI Listing
December 2015

Computational approaches to developing short cyclic peptide modulators of protein-protein interactions.

Methods Mol Biol 2015 ;1268:241-71

School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-2285-7_11DOI Listing
August 2015

The chain length of biologically produced (R)-3-hydroxyalkanoic acid affects biological activity and structure of anti-cancer peptides.

J Biotechnol 2015 Jun 24;204:7-12. Epub 2015 Mar 24.

School of Biomolecular and Biomedical Sciences and Centre for Synthesis and Chemical Biology, UCD Conway Institute, University College Dublin, Dublin, Ireland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbiotec.2015.02.036DOI Listing
June 2015

Virtual screening using combinatorial cyclic peptide libraries reveals protein interfaces readily targetable by cyclic peptides.

J Chem Inf Model 2015 Mar 20;55(3):600-13. Epub 2015 Feb 20.

†School of Medicine and Medical Science, ‡Complex and Adaptive Systems Laboratory, ¶Conway Institute of Biomolecular and Biomedical Research, and §School of Biomolecular and Biomedical Science, University College Dublin, Dublin 4, Ireland, and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ci500431qDOI Listing
March 2015

A novel role for the fibrinogen Asn-Gly-Arg (NGR) motif in platelet function.

Thromb Haemost 2015 Feb 20;113(2):290-304. Epub 2014 Nov 20.

Dermot Cox, BSc, PhD, Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland, Tel.: +35 3 1 402 2152, Fax: +35 3 1 402 2453, E-mail:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1160/TH14-04-0366DOI Listing
February 2015

Pro-moieties of antimicrobial peptide prodrugs.

Molecules 2015 Jan 13;20(1):1210-27. Epub 2015 Jan 13.

Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules20011210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6272668PMC
January 2015

Poly(Ethylene glycol)-based backbones with high peptide loading capacities.

Molecules 2014 Oct 30;19(11):17559-77. Epub 2014 Oct 30.

Department of Pharmaceutical and Medicinal Chemistry, Centre for Synthesis and Chemical Biology, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules191117559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270934PMC
October 2014

Potential of host defense peptide prodrugs as neutrophil elastase-dependent anti-infective agents for cystic fibrosis.

Antimicrob Agents Chemother 2014 25;58(2):978-85. Epub 2013 Nov 25.

Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, Dublin, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01167-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910818PMC
September 2014

Computational survey of peptides derived from disulphide-bonded protein loops that may serve as mediators of protein-protein interactions.

BMC Bioinformatics 2014 Sep 17;15:305. Epub 2014 Sep 17.

School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2105-15-305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262234PMC
September 2014

In vitro investigations of the efficacy of cyclodextrin-siRNA complexes modified with lipid-PEG-Octaarginine: towards a formulation strategy for non-viral neuronal siRNA delivery.

Pharm Res 2013 Apr 29;30(4):1086-98. Epub 2012 Nov 29.

Pharmacodelivery Group, School of Pharmacy, University College Cork, Cavanagh Pharmacy Building College Rd., Cork, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-012-0945-8DOI Listing
April 2013

The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate.

Biomaterials 2013 Apr 21;34(11):2710-8. Epub 2013 Jan 21.

School of Biomolecular and Biomedical Sciences and Centre for Synthesis and Chemical Biology, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biomaterials.2012.12.032DOI Listing
April 2013

Peptide directed transmembrane transport and nuclear localization of Ru(II) polypyridyl complexes in mammalian cells.

Chem Commun (Camb) 2013 Apr;49(26):2658-60

National Centre for Sensor Research, School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c3cc40453fDOI Listing
April 2013

Cell uptake and cytotoxicity of a novel cyclometalated iridium(III) complex and its octaarginine peptide conjugate.

J Inorg Biochem 2013 Feb 10;119:65-74. Epub 2012 Nov 10.

School of Chemical Sciences, National Centre for Sensor Research, Dublin City University, Glasnevin, Dublin, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinorgbio.2012.11.001DOI Listing
February 2013

Targeted antimicrobial peptides.

Authors:
Marc Devocelle

Front Immunol 2012 5;3:309. Epub 2012 Oct 5.

Department of Pharmaceutical and Medicinal Chemistry, Centre for Synthesis and Chemical Biology, Royal College of Surgeons in Ireland Dublin, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2012.00309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464401PMC
October 2012

Beyond conventional antibiotics for the future treatment of methicillin-resistant Staphylococcus aureus infections: two novel alternatives.

FEMS Immunol Med Microbiol 2012 Aug 4;65(3):399-412. Epub 2012 Apr 4.

Department of Clinical Microbiology, Education and Research Centre, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1574-695X.2012.00954.xDOI Listing
August 2012

Inhibition of platelet adhesion by peptidomimetics mimicking the interactive β-hairpin of glycoprotein Ibα.

Bioorg Med Chem Lett 2012 May 11;22(9):3323-6. Epub 2012 Mar 11.

Centre for Synthesis & Chemical Biology, Department of Pharmaceutical & Medicinal Chemistry, 123, St. Stephen's Green, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S0960894X1200330
Publisher Site
http://dx.doi.org/10.1016/j.bmcl.2012.03.022DOI Listing
May 2012

Luminescent lanthanide-binding peptides: sensitising the excited states of Eu(III) and Tb(III) with a 1,8-naphthalimide-based antenna.

Org Biomol Chem 2012 Jan 31;10(1):126-33. Epub 2011 Oct 31.

School of Chemistry, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin,2, Ireland.

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=C1OB06567J
Publisher Site
http://dx.doi.org/10.1039/c1ob06567jDOI Listing
January 2012

Synthesis of mutual azo prodrugs of anti-inflammatory agents and peptides facilitated by α-aminoisobutyric acid.

J Org Chem 2011 Dec 9;76(23):9641-7. Epub 2011 Nov 9.

Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo201358eDOI Listing
December 2011

A theoretical analysis of the prodrug delivery system for treating antibiotic-resistant bacteria.

IEEE/ACM Trans Comput Biol Bioinform 2011 May-Jun;8(3):650-8

Centre for Scientific Computing and Complex Systems Modelling, School of Computing, Dublin City University, Dublin 9, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1109/TCBB.2010.58DOI Listing
August 2011

High content analysis to determine cytotoxicity of the antimicrobial peptide, melittin and selected structural analogs.

Peptides 2011 Aug 15;32(8):1764-73. Epub 2011 Jun 15.

UCD School of Veterinary Medicine and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.peptides.2011.06.006DOI Listing
August 2011

In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens.

Antimicrob Agents Chemother 2011 May 22;55(5):2487-9. Epub 2011 Feb 22.

Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AAC.01384-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088215PMC
May 2011

CycloPs: generating virtual libraries of cyclized and constrained peptides including nonnatural amino acids.

J Chem Inf Model 2011 Apr 24;51(4):829-36. Epub 2011 Mar 24.

UCD Complex and Applied Systems Laboratory, Conway Institute of Biomolecular and Biomedical Sciences, and School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin 4, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ci100431rDOI Listing
April 2011

AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis.

J Cell Biol 2010 Apr 29;189(1):83-94. Epub 2010 Mar 29.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland Research Institute, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.200909166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854380PMC
April 2010

Impact of amino acid replacements on in vitro permeation enhancement and cytotoxicity of the intestinal absorption promoter, melittin.

Int J Pharm 2010 Mar 16;387(1-2):154-60. Epub 2009 Dec 16.

UCD School of Agriculture, Food Science and Veterinary Medicine and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2009.12.022DOI Listing
March 2010

Multimodal cell imaging by ruthenium polypyridyl labelled cell penetrating peptides.

Chem Commun (Camb) 2010 Jan 19;46(1):103-5. Epub 2009 Nov 19.

National Bioimaging Platform, National Centre for Sensor Research, The School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b918611eDOI Listing
January 2010

Regulation of glucose transporter 3 surface expression by the AMP-activated protein kinase mediates tolerance to glutamate excitation in neurons.

J Neurosci 2009 Mar;29(9):2997-3008

Department of Physiology and Medical Physics and Royal College of Surgeons in Ireland Neuroscience Research Centre, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0354-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6666202PMC
March 2009

Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging.

Chem Commun (Camb) 2008 Nov 12(42):5307-9. Epub 2008 Sep 12.

The Biomedical Diagnostics Institute, Dublin City University, Dublin 9, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b810403dDOI Listing
November 2008

Structural studies in aqueous solution of new binuclear lanthanide luminescent peptide conjugates.

Chem Commun (Camb) 2008 Oct 12(38):4552-4. Epub 2008 Sep 12.

Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://xlink.rsc.org/?DOI=b811388b
Publisher Site
http://dx.doi.org/10.1039/b811388bDOI Listing
October 2008

A computational model of antibiotic-resistance mechanisms in methicillin-resistant Staphylococcus aureus (MRSA).

J Theor Biol 2008 Sep 4;254(2):284-93. Epub 2008 Jun 4.

Modelling and Scientific Computing Group, School of Computing, Faculty of Engineering and Computing, Dublin City University, Glasnevin, Dublin 9, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtbi.2008.05.037DOI Listing
September 2008

A peptide affinity column for the identification of integrin alpha IIb-binding proteins.

Anal Biochem 2008 Mar 4;374(1):203-12. Epub 2007 Dec 4.

Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Republic of Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2007.11.033DOI Listing
March 2008

Benzyl N-[2-(1H-indol-3-yl)eth-yl]dithio-carbamate.

Acta Crystallogr Sect E Struct Rep Online 2007 Dec 18;64(Pt 1):o288-9. Epub 2007 Dec 18.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1107/S1600536807066524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915340PMC
December 2007

Bioinformatic discovery of novel bioactive peptides.

Nat Chem Biol 2007 Feb 14;3(2):108-12. Epub 2007 Jan 14.

Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio854DOI Listing
February 2007

Absolute net charge and the biological activity of oligopeptides.

J Chem Inf Model 2006 Sep-Oct;46(5):2183-90

UCD Conway Institute of Biomolecular and Biomedical Sciences, University College Dublin, Dublin 4, Republic of Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ci0600760DOI Listing
November 2006

Increased intracellular targeting to airway cells using octaarginine-coated liposomes: in vitro assessment of their suitability for inhalation.

Mol Pharm 2006 Mar-Apr;3(2):104-12

Advanced Drug Delivery Research Centre, School of Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/mp050070i
Publisher Site
http://dx.doi.org/10.1021/mp050070iDOI Listing
June 2006

Parallel synthesis and in vitro activity of novel anthranilic hydroxamate-based inhibitors of the prostaglandin H2 synthase peroxidase activity.

Org Biomol Chem 2005 Oct 8;3(20):3678-85. Epub 2005 Sep 8.

Centre for Synthesis and Chemical Biology, Department of Pharmaceutical and Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b505525cDOI Listing
October 2005

Calreticulin-independent regulation of the platelet integrin alphaIIbbeta3 by the KVGFFKR alphaIIb-cytoplasmic motif.

Platelets 2004 Feb;15(1):43-54

Centre for Sythesis and Chemical Biology, Department of Chemistry, Royal College of Surgeons in Ireland, Dublin.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09537100310001640055DOI Listing
February 2004

A convenient parallel synthesis of low molecular weight hydroxamic acids using polymer-supported 1-hydroxybenzotriazole.

Org Biomol Chem 2003 Mar;1(5):850-3

Centre for Synthesis and Chemical Biology, Department of Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/b211526cDOI Listing
March 2003