Marc Cruts

Marc Cruts

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Data Mining: Applying the AD&FTD Mutation Database to Progranulin.

Authors:
Marc Cruts Christine Van Broeckhoven

Methods Mol Biol 2018 ;1806:81-92

Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, University of Antwerp - CDE, Antwerp, Belgium.

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http://dx.doi.org/10.1007/978-1-4939-8559-3_6DOI Listing
March 2019

NanoPack: visualizing and processing long-read sequencing data.

Authors:
Wouter De Coster Svenn D'Hert Darrin T Schultz Marc Cruts Christine Van Broeckhoven

Bioinformatics 2018 08;34(15):2666-2669

Neurodegenerative Brain Diseases Group, VIB & University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1093/bioinformatics/bty149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061794PMC
August 2018

Clinical variability and onset age modifiers in an extended Belgian GRN founder family.

Authors:
Eline Wauters Sara Van Mossevelde Kristel Sleegers Julie van der Zee Sebastiaan Engelborghs Anne Sieben Rik Vandenberghe Stéphanie Philtjens Marleen Van den Broeck Karin Peeters Ivy Cuijt Wouter De Coster Tim Van Langenhove Patrick Santens Adrian Ivanoiu Patrick Cras Jan L De Bleecker Jan Versijpt Roeland Crols Nina De Klippel Jean-Jacques Martin Peter P De Deyn Marc Cruts Christine Van Broeckhoven

Neurobiol Aging 2018 07 10;67:84-94. Epub 2018 Mar 10.

Center for Molecular Neurology, VIB, Antwerp, Belgium; Institute Born-Bunge and University of Antwerp, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.03.007DOI Listing
July 2018

Rare nonsynonymous variants in SORT1 are associated with increased risk for frontotemporal dementia.

Authors:
Stéphanie Philtjens Sara Van Mossevelde Julie van der Zee Eline Wauters Lubina Dillen Mathieu Vandenbulcke Rik Vandenberghe Adrian Ivanoiu Anne Sieben Christiana Willems Luisa Benussi Roberta Ghidoni Giuliano Binetti Barbara Borroni Alessandro Padovani Pau Pastor Monica Diez-Fairen Miquel Aguilar Alexandre de Mendonça Gabriel Miltenberger-Miltényi Isabel Hernández Merce Boada Agustín Ruiz Benedetta Nacmias Sandro Sorbi Maria Rosário Almeida Isabel Santana Jordi Clarimón Alberto Lleó Giovanni B Frisoni Raquel Sanchez-Valle Albert Lladó Estrella Gómez-Tortosa Ellen Gelpi Marleen Van den Broeck Karin Peeters Patrick Cras Peter P De Deyn Sebastiaan Engelborghs Marc Cruts Christine Van Broeckhoven

Neurobiol Aging 2018 06 17;66:181.e3-181.e10. Epub 2018 Feb 17.

Neurodegenerative Brain Diseases Group, Center for Molecular Neurology VIB, Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.02.011DOI Listing
June 2018

The Genetics of Expansions.

Authors:
Ilse Gijselinck Marc Cruts Christine Van Broeckhoven

Cold Spring Harb Perspect Med 2018 04 2;8(4). Epub 2018 Apr 2.

Department of Molecular Genetics, VIB, University of Antwerp, 2610 Antwerp, Belgium.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a026757DOI Listing
April 2018

Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort.

Authors:
Jan Verheijen Julie van der Zee Ilse Gijselinck Tobi Van den Bossche Lubina Dillen Bavo Heeman Estrella Gómez-Tortosa Albert Lladó Raquel Sanchez-Valle Caroline Graff Pau Pastor Maria A Pastor Luisa Benussi Roberta Ghidoni Giuliano Binetti Jordi Clarimon Alexandre de Mendonça Ellen Gelpi Magda Tsolaki Janine Diehl-Schmid Benedetta Nacmias Maria Rosário Almeida Barbara Borroni Radoslav Matej Agustín Ruiz Sebastiaan Engelborghs Rik Vandenberghe Peter P De Deyn Marc Cruts Christine Van Broeckhoven Kristel Sleegers

Neurobiol Aging 2018 02 25;62:245.e1-245.e7. Epub 2017 Oct 25.

Neurodegenerative Brain Diseases group, VIB Center for Molecular Neurology, University of Antwerp, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.10.012DOI Listing
February 2018

Extended FTLD pedigree segregating a Belgian GRN-null mutation: neuropathological heterogeneity in one family.

Authors:
Anne Sieben Sara Van Mossevelde Eline Wauters Sebastiaan Engelborghs Julie van der Zee Tim Van Langenhove Patrick Santens Marleen Praet Paul Boon Marijke Miatton Sofie Van Hoecke Mathieu Vandenbulcke Rik Vandenberghe Patrick Cras Marc Cruts Peter Paul De Deyn Christine Van Broeckhoven Jean-Jacques Martin

Alzheimers Res Ther 2018 01 22;10(1). Epub 2018 Jan 22.

Institute Born-Bunge, Neuropathology and Laboratory of Neurochemistry and Behavior, University of Antwerp, Universiteitsplein 1, B-2160, Antwerp, Belgium.

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http://dx.doi.org/10.1186/s13195-017-0334-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389176PMC
January 2018

Familial primary lateral sclerosis or dementia associated with Arg573Gly mutation.

Authors:
Estrella Gómez-Tortosa Julie Van der Zee María Ruggiero Ilse Gijselinck Jesús Esteban-Pérez Alberto García-Redondo Daniel Borrego-Hernández Eloísa Navarro M José Sainz Julián Pérez-Pérez Marc Cruts Christine Van Broeckhoven Rosa Guerrero-López

J Neurol Neurosurg Psychiatry 2017 11 1;88(11):996-997. Epub 2017 Apr 1.

Department of Neurology, Fundación Jiménez Díaz, Madrid, Spain.

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http://dx.doi.org/10.1136/jnnp-2016-315250DOI Listing
November 2017

Modifiers of GRN-Associated Frontotemporal Lobar Degeneration.

Authors:
Eline Wauters Sara Van Mossevelde Julie Van der Zee Marc Cruts Christine Van Broeckhoven

Trends Mol Med 2017 10 7;23(10):962-979. Epub 2017 Sep 7.

Neurodegenerative Brain Diseases, Center for Molecular Neurology, VIB, Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2017.08.004DOI Listing
October 2017

Relationship between C9orf72 repeat size and clinical phenotype.

Authors:
Sara Van Mossevelde Julie van der Zee Marc Cruts Christine Van Broeckhoven

Curr Opin Genet Dev 2017 Jun 17;44:117-124. Epub 2017 Mar 17.

Center for Molecular Neurology, VIB, Universiteitsplein 1, 2610 Antwerp, Belgium; Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.gde.2017.02.008DOI Listing
June 2017

Clinical Evidence of Disease Anticipation in Families Segregating a C9orf72 Repeat Expansion.

Authors:
Sara Van Mossevelde Julie van der Zee Ilse Gijselinck Kristel Sleegers Jan De Bleecker Anne Sieben Rik Vandenberghe Tim Van Langenhove Jonathan Baets Olivier Deryck Patrick Santens Adrian Ivanoiu Christiana Willems Veerle Bäumer Marleen Van den Broeck Karin Peeters Maria Mattheijssens Peter De Jonghe Patrick Cras Jean-Jacques Martin Marc Cruts Peter P De Deyn Sebastiaan Engelborghs Christine Van Broeckhoven

JAMA Neurol 2017 04;74(4):445-452

Center for Molecular Neurology, VIB, Antwerp, Belgium2Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1001/jamaneurol.2016.4847DOI Listing
April 2017

TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.

Authors:
Julie van der Zee Ilse Gijselinck Sara Van Mossevelde Federica Perrone Lubina Dillen Bavo Heeman Veerle Bäumer Sebastiaan Engelborghs Jan De Bleecker Jonathan Baets Ellen Gelpi Ricardo Rojas-García Jordi Clarimón Alberto Lleó Janine Diehl-Schmid Panagiotis Alexopoulos Robert Perneczky Matthis Synofzik Jennifer Just Ludger Schöls Caroline Graff Håkan Thonberg Barbara Borroni Alessandro Padovani Albena Jordanova Stayko Sarafov Ivailo Tournev Alexandre de Mendonça Gabriel Miltenberger-Miltényi Frederico Simões do Couto Alfredo Ramirez Frank Jessen Michael T Heneka Estrella Gómez-Tortosa Adrian Danek Patrick Cras Rik Vandenberghe Peter De Jonghe Peter P De Deyn Kristel Sleegers Marc Cruts Christine Van Broeckhoven Johan Goeman Dirk Nuytten Katrien Smets Wim Robberecht Philip Van Damme Jan De Bleecker Patrick Santens Bart Dermaut Jan Versijpt Alex Michotte Adrian Ivanoiu Olivier Deryck Bruno Bergmans Jean Delbeck Marc Bruyland Christiana Willems Eric Salmon Pau Pastor Sara Ortega-Cubero Luisa Benussi Roberta Ghidoni Giuliano Binetti Isabel Hernández Mercè Boada Agustín Ruiz Sandro Sorbi Benedetta Nacmias Silvia Bagnoli Sandro Sorbi Raquel Sanchez-Valle Albert Llado Isabel Santana Maria Rosário Almeida Giovanni B Frisoni Walter Maetzler Radoslav Matej Matthew J Fraidakis Gabor G Kovacs Gian Maria Fabrizi Silvia Testi

Hum Mutat 2017 03 19;38(3):297-309. Epub 2017 Jan 19.

Center for Molecular Neurology, VIB, Antwerp, Belgium.

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http://dx.doi.org/10.1002/humu.23161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324646PMC
March 2017

Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin.

Authors:
Gernot Kleinberger Anja Capell Nathalie Brouwers Katrin Fellerer Kristel Sleegers Marc Cruts Christine Van Broeckhoven Christian Haass

Neurobiol Aging 2016 Mar 29;39:220.e17-26. Epub 2015 Dec 29.

Biochemistry, Biomedical Center (BMC), Ludwig-Maximilians University, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; German Center for Neurodegenerative Diseases, DZNE, Munich, Germany.

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.12.014DOI Listing
March 2016

Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort.

Authors:
Sara Van Mossevelde Julie van der Zee Ilse Gijselinck Sebastiaan Engelborghs Anne Sieben Tim Van Langenhove Jan De Bleecker Jonathan Baets Mathieu Vandenbulcke Koen Van Laere Sarah Ceyssens Marleen Van den Broeck Karin Peeters Maria Mattheijssens Patrick Cras Rik Vandenberghe Peter De Jonghe Jean-Jacques Martin Peter P De Deyn Marc Cruts Christine Van Broeckhoven

Brain 2016 Feb 15;139(Pt 2):452-67. Epub 2015 Dec 15.

1 Department of Molecular Genetics, VIB, Antwerp, Belgium 2 Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://brain.oxfordjournals.org/content/brain/early/2015/12/
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http://dx.doi.org/10.1093/brain/awv358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805085PMC
February 2016

Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD.

Authors:
Steven Boeynaems Elke Bogaert Emiel Michiels Ilse Gijselinck Anne Sieben Ana Jovičić Greet De Baets Wendy Scheveneels Jolien Steyaert Ivy Cuijt Kevin J Verstrepen Patrick Callaerts Frederic Rousseau Joost Schymkowitz Marc Cruts Christine Van Broeckhoven Philip Van Damme Aaron D Gitler Wim Robberecht Ludo Van Den Bosch

Sci Rep 2016 Feb 12;6:20877. Epub 2016 Feb 12.

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1038/srep20877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751451PMC
February 2016

Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort.

Authors:
Ilse Gijselinck Sara Van Mossevelde Julie van der Zee Anne Sieben Stéphanie Philtjens Bavo Heeman Sebastiaan Engelborghs Mathieu Vandenbulcke Greet De Baets Veerle Bäumer Ivy Cuijt Marleen Van den Broeck Karin Peeters Maria Mattheijssens Frederic Rousseau Rik Vandenberghe Peter De Jonghe Patrick Cras Peter P De Deyn Jean-Jacques Martin Marc Cruts Christine Van Broeckhoven

Neurology 2015 Dec 18;85(24):2116-25. Epub 2015 Nov 18.

From the Department of Molecular Genetics (I.G., S.V.M., J.v.d.Z., A.S., S.P., B.H., V.B., I.C., M.V.d.B., K.P., M.M., P.D.J., M.C., C.V.B.), VIB, Antwerp; Institute Born-Bunge (I.G., S.V.M., J.v.d.Z., A.S., S.P., B.H., S.E., V.B., I.C., M.V.d.B., K.P., M.M., P.D.J., P.C., P.P.D.D., J.-J.M., M.C., C.V.B.), University of Antwerp; the Department of Neurology (A.S.), University Hospital Ghent and University of Ghent; the Department of Neurology and Memory Clinic (S.E., P.P.D.D.), Hospital Network Antwerp Middelheim and Hoge Beuken; the Brain and Emotion Laboratory, Department of Psychiatry (M.V.), SWITCH Laboratory, VIB (G.D.B., F.R.), and Laboratory for Cognitive Neurology, Department of Neurology (R.V.), University of Leuven; the Department of Neurology (M.V., R.V.), University Hospitals Leuven, Gasthuisberg; and the Department of Neurology (P.D.J., P.C.), Antwerp University Hospital, Edegem, Belgium. P.P.D.D. is also affiliated with the Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000002220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691687PMC
December 2015

Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains.

Authors:
Jonathan Janssens Stéphanie Philtjens Gernot Kleinberger Sara Van Mossevelde Julie van der Zee Rita Cacace Sebastiaan Engelborghs Anne Sieben Julia Banzhaf-Strathmann Lubina Dillen Céline Merlin Ivy Cuijt Caroline Robberecht Bettina Schmid Patrick Santens Adrian Ivanoiu Mathieu Vandenbulcke Rik Vandenberghe Patrick Cras Peter P De Deyn Jean-Jacques Martin Stuart Maudsley Christian Haass Marc Cruts Christine Van Broeckhoven

Acta Neuropathol Commun 2015 Nov 10;3:68. Epub 2015 Nov 10.

Neurodegenerative Brain Diseases group, VIB Department of Molecular Genetics, University of Antwerp - CDE, Universiteitsplein 1, B-2610, Antwerp, Belgium.

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http://dx.doi.org/10.1186/s40478-015-0246-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641381PMC
November 2015

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations.

Authors:
Karolien Bettens Steven Vermeulen Caroline Van Cauwenberghe Bavo Heeman Bob Asselbergh Caroline Robberecht Sebastiaan Engelborghs Mathieu Vandenbulcke Rik Vandenberghe Peter Paul De Deyn Marc Cruts Christine Van Broeckhoven Kristel Sleegers

Mol Neurodegener 2015 Jul 16;10:30. Epub 2015 Jul 16.

VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium.

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http://dx.doi.org/10.1186/s13024-015-0024-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502563PMC
July 2015

Global investigation and meta-analysis of the C9orf72 (G4C2)n repeat in Parkinson disease.

Authors:
Jessie Theuns Aline Verstraeten Kristel Sleegers Eline Wauters Ilse Gijselinck Stefanie Smolders David Crosiers Ellen Corsmit Ellen Elinck Manu Sharma Rejko Krüger Suzanne Lesage Alexis Brice Sun Ju Chung Mi-Jung Kim Young Jin Kim Owen A Ross Zbigniew K Wszolek Ekaterina Rogaeva Zhengrui Xi Anthony E Lang Christine Klein Anne Weissbach George D Mellick Peter A Silburn Georgios M Hadjigeorgiou Efthimios Dardiotis Nobutaka Hattori Kotaro Ogaki Eng-King Tan Yi Zhao Jan Aasly Enza Maria Valente Simona Petrucci Grazia Annesi Aldo Quattrone Carlo Ferrarese Laura Brighina Angela Deutschländer Andreas Puschmann Christer Nilsson Gaëtan Garraux Mark S LeDoux Ronald F Pfeiffer Magdalena Boczarska-Jedynak Grzegorz Opala Demetrius M Maraganore Sebastiaan Engelborghs Peter Paul De Deyn Patrick Cras Marc Cruts Christine Van Broeckhoven

Neurology 2014 Nov 17;83(21):1906-13. Epub 2014 Oct 17.

Authors' affiliations are listed at the end of the article.

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http://dx.doi.org/10.1212/WNL.0000000000001012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248456PMC
November 2014

Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration.

Authors:
Julie van der Zee Tim Van Langenhove Gabor G Kovacs Lubina Dillen William Deschamps Sebastiaan Engelborghs Radoslav Matěj Mathieu Vandenbulcke Anne Sieben Bart Dermaut Katrien Smets Philip Van Damme Céline Merlin Annelies Laureys Marleen Van Den Broeck Maria Mattheijssens Karin Peeters Luisa Benussi Giuliano Binetti Roberta Ghidoni Barbara Borroni Alessandro Padovani Silvana Archetti Pau Pastor Cristina Razquin Sara Ortega-Cubero Isabel Hernández Mercè Boada Agustín Ruiz Alexandre de Mendonça Gabriel Miltenberger-Miltényi Frederico Simões do Couto Sandro Sorbi Benedetta Nacmias Silvia Bagnoli Caroline Graff Huei-Hsin Chiang Håkan Thonberg Robert Perneczky Janine Diehl-Schmid Panagiotis Alexopoulos Giovanni B Frisoni Christian Bonvicini Matthis Synofzik Walter Maetzler Jennifer Müller vom Hagen Ludger Schöls Tobias B Haack Tim M Strom Holger Prokisch Oriol Dols-Icardo Jordi Clarimón Alberto Lleó Isabel Santana Maria Rosário Almeida Beatriz Santiago Michael T Heneka Frank Jessen Alfredo Ramirez Raquel Sanchez-Valle Albert Llado Ellen Gelpi Stayko Sarafov Ivailo Tournev Albena Jordanova Eva Parobkova Gian Maria Fabrizi Silvia Testi Eric Salmon Thomas Ströbel Patrick Santens Wim Robberecht Peter De Jonghe Jean-Jacques Martin Patrick Cras Rik Vandenberghe Peter Paul De Deyn Marc Cruts Kristel Sleegers Christine Van Broeckhoven

Acta Neuropathol 2014 Sep 5;128(3):397-410. Epub 2014 Jun 5.

Department of Molecular Genetics, VIB, Antwerp, Belgium.

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http://dx.doi.org/10.1007/s00401-014-1298-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131163PMC
September 2014

Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins.

Authors:
Shai Carmi Ken Y Hui Ethan Kochav Xinmin Liu James Xue Fillan Grady Saurav Guha Kinnari Upadhyay Dan Ben-Avraham Semanti Mukherjee B Monica Bowen Tinu Thomas Joseph Vijai Marc Cruts Guy Froyen Diether Lambrechts Stéphane Plaisance Christine Van Broeckhoven Philip Van Damme Herwig Van Marck Nir Barzilai Ariel Darvasi Kenneth Offit Susan Bressman Laurie J Ozelius Inga Peter Judy H Cho Harry Ostrer Gil Atzmon Lorraine N Clark Todd Lencz Itsik Pe'er

Nat Commun 2014 Sep 9;5:4835. Epub 2014 Sep 9.

1] Department of Computer Science, Columbia University, 500 W 120th Street, New York, New York 10027, USA [2] Center for Computational Biology and Bioinformatics, Columbia University, 1130 St Nicholas Avenue, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/ncomms5835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164776PMC
September 2014

Frontotemporal dementia and its subtypes: a genome-wide association study.

Authors:
Raffaele Ferrari Dena G Hernandez Michael A Nalls Jonathan D Rohrer Adaikalavan Ramasamy John B J Kwok Carol Dobson-Stone William S Brooks Peter R Schofield Glenda M Halliday John R Hodges Olivier Piguet Lauren Bartley Elizabeth Thompson Eric Haan Isabel Hernández Agustín Ruiz Mercè Boada Barbara Borroni Alessandro Padovani Carlos Cruchaga Nigel J Cairns Luisa Benussi Giuliano Binetti Roberta Ghidoni Gianluigi Forloni Daniela Galimberti Chiara Fenoglio Maria Serpente Elio Scarpini Jordi Clarimón Alberto Lleó Rafael Blesa Maria Landqvist Waldö Karin Nilsson Christer Nilsson Ian R A Mackenzie Ging-Yuek R Hsiung David M A Mann Jordan Grafman Christopher M Morris Johannes Attems Timothy D Griffiths Ian G McKeith Alan J Thomas P Pietrini Edward D Huey Eric M Wassermann Atik Baborie Evelyn Jaros Michael C Tierney Pau Pastor Cristina Razquin Sara Ortega-Cubero Elena Alonso Robert Perneczky Janine Diehl-Schmid Panagiotis Alexopoulos Alexander Kurz Innocenzo Rainero Elisa Rubino Lorenzo Pinessi Ekaterina Rogaeva Peter St George-Hyslop Giacomina Rossi Fabrizio Tagliavini Giorgio Giaccone James B Rowe Johannes C M Schlachetzki James Uphill John Collinge Simon Mead Adrian Danek Vivianna M Van Deerlin Murray Grossman John Q Trojanowski Julie van der Zee William Deschamps Tim Van Langenhove Marc Cruts Christine Van Broeckhoven Stefano F Cappa Isabelle Le Ber Didier Hannequin Véronique Golfier Martine Vercelletto Alexis Brice Benedetta Nacmias Sandro Sorbi Silvia Bagnoli Irene Piaceri Jørgen E Nielsen Lena E Hjermind Matthias Riemenschneider Manuel Mayhaus Bernd Ibach Gilles Gasparoni Sabrina Pichler Wei Gu Martin N Rossor Nick C Fox Jason D Warren Maria Grazia Spillantini Huw R Morris Patrizia Rizzu Peter Heutink Julie S Snowden Sara Rollinson Anna Richardson Alexander Gerhard Amalia C Bruni Raffaele Maletta Francesca Frangipane Chiara Cupidi Livia Bernardi Maria Anfossi Maura Gallo Maria Elena Conidi Nicoletta Smirne Rosa Rademakers Matt Baker Dennis W Dickson Neill R Graff-Radford Ronald C Petersen David Knopman Keith A Josephs Bradley F Boeve Joseph E Parisi William W Seeley Bruce L Miller Anna M Karydas Howard Rosen John C van Swieten Elise G P Dopper Harro Seelaar Yolande A L Pijnenburg Philip Scheltens Giancarlo Logroscino Rosa Capozzo Valeria Novelli Annibale A Puca Massimo Franceschi Alfredo Postiglione Graziella Milan Paolo Sorrentino Mark Kristiansen Huei-Hsin Chiang Caroline Graff Florence Pasquier Adeline Rollin Vincent Deramecourt Florence Lebert Dimitrios Kapogiannis Luigi Ferrucci Stuart Pickering-Brown Andrew B Singleton John Hardy Parastoo Momeni

Lancet Neurol 2014 Jul;13(7):686-99

Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, Texas, USA.

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http://dx.doi.org/10.1016/S1474-4422(14)70065-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112126PMC
July 2014

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia.

Authors:
Elise Cuyvers Karolien Bettens Stéphanie Philtjens Tim Van Langenhove Ilse Gijselinck Julie van der Zee Sebastiaan Engelborghs Mathieu Vandenbulcke Jasper Van Dongen Nathalie Geerts Githa Maes Maria Mattheijssens Karin Peeters Patrick Cras Rik Vandenberghe Peter P De Deyn Christine Van Broeckhoven Marc Cruts Kristel Sleegers

Neurobiol Aging 2014 Mar 9;35(3):726.e11-9. Epub 2013 Oct 9.

Neurodegenerative Brain Diseases group, Department of Molecular Genetics, VIB, Antwerp, Belgium; Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.09.009DOI Listing
March 2014

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.

Authors:
Michael D Gallagher Eunran Suh Murray Grossman Lauren Elman Leo McCluskey John C Van Swieten Safa Al-Sarraj Manuela Neumann Ellen Gelpi Bernardino Ghetti Jonathan D Rohrer Glenda Halliday Christine Van Broeckhoven Danielle Seilhean Pamela J Shaw Matthew P Frosch Irina Alafuzoff Anna Antonell Nenad Bogdanovic William Brooks Nigel J Cairns Johnathan Cooper-Knock Carl Cotman Patrick Cras Marc Cruts Peter P De Deyn Charles DeCarli Carol Dobson-Stone Sebastiaan Engelborghs Nick Fox Douglas Galasko Marla Gearing Ilse Gijselinck Jordan Grafman Päivi Hartikainen Kimmo J Hatanpaa J Robin Highley John Hodges Christine Hulette Paul G Ince Lee-Way Jin Janine Kirby Julia Kofler Jillian Kril John B J Kwok Allan Levey Andrew Lieberman Albert Llado Jean-Jacques Martin Eliezer Masliah Christopher J McDermott Ann McKee Catriona McLean Simon Mead Carol A Miller Josh Miller David G Munoz Jill Murrell Henry Paulson Olivier Piguet Martin Rossor Raquel Sanchez-Valle Mary Sano Julie Schneider Lisa C Silbert Salvatore Spina Julie van der Zee Tim Van Langenhove Jason Warren Stephen B Wharton Charles L White Randall L Woltjer John Q Trojanowski Virginia M Y Lee Vivianna Van Deerlin Alice S Chen-Plotkin

Acta Neuropathol 2014 Mar 19;127(3):407-18. Epub 2014 Jan 19.

Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00401-013-1239-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003885PMC
March 2014

Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins.

Authors:
Kohji Mori Thomas Arzberger Friedrich A Grässer Ilse Gijselinck Stephanie May Kristin Rentzsch Shih-Ming Weng Martin H Schludi Julie van der Zee Marc Cruts Christine Van Broeckhoven Elisabeth Kremmer Hans A Kretzschmar Christian Haass Dieter Edbauer

Acta Neuropathol 2013 Dec 17;126(6):881-93. Epub 2013 Oct 17.

Adolf Butenandt Institute, Biochemistry, Ludwig-Maximilians University Munich, Schillerstr. 44, 80336, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-013-1189-3DOI Listing
December 2013

Current insights into the C9orf72 repeat expansion diseases of the FTLD/ALS spectrum.

Authors:
Marc Cruts Ilse Gijselinck Tim Van Langenhove Julie van der Zee Christine Van Broeckhoven

Trends Neurosci 2013 Aug 7;36(8):450-9. Epub 2013 Jun 7.

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Universiteitsplein 1, B-2610 Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.tins.2013.04.010DOI Listing
August 2013

Explorative genetic study of UBQLN2 and PFN1 in an extended Flanders-Belgian cohort of frontotemporal lobar degeneration patients.

Authors:
Lubina Dillen Tim Van Langenhove Sebastiaan Engelborghs Mathieu Vandenbulcke Stayko Sarafov Ivailo Tournev Celine Merlin Patrick Cras Rik Vandenberghe Peter P De Deyn Albena Jordanova Marc Cruts Christine Van Broeckhoven Julie van der Zee

Neurobiol Aging 2013 Jun 9;34(6):1711.e1-5. Epub 2013 Jan 9.

Department of Molecular Genetics, VIB, Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.12.007DOI Listing
June 2013

C9orf72 G4C2 repeat expansions in Alzheimer's disease and mild cognitive impairment.

Authors:
Rita Cacace Caroline Van Cauwenberghe Karolien Bettens Ilse Gijselinck Julie van der Zee Sebastiaan Engelborghs Mathieu Vandenbulcke Jasper Van Dongen Veerle Bäumer Lubina Dillen Maria Mattheijssens Karin Peeters Marc Cruts Rik Vandenberghe Peter P De Deyn Christine Van Broeckhoven Kristel Sleegers

Neurobiol Aging 2013 Jun 24;34(6):1712.e1-7. Epub 2013 Jan 24.

Department of Molecular Genetics, VIB, Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.12.019DOI Listing
June 2013

Promoter DNA methylation regulates progranulin expression and is altered in FTLD.

Authors:
Julia Banzhaf-Strathmann Rainer Claus Oliver Mücke Kristin Rentzsch Julie van der Zee Sebastiaan Engelborghs Peter P De Deyn Marc Cruts Christine van Broeckhoven Christoph Plass Dieter Edbauer

Acta Neuropathol Commun 2013 May 13;1:16. Epub 2013 May 13.

German Center for Neurodegenerative Diseases (DZNE), University of Munich, Schillerstr, 44, Munich 80336, Germany.

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http://dx.doi.org/10.1186/2051-5960-1-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893557PMC
May 2013

Distinct clinical characteristics of C9orf72 expansion carriers compared with GRN, MAPT, and nonmutation carriers in a Flanders-Belgian FTLD cohort.

Authors:
Tim Van Langenhove Julie van der Zee Ilse Gijselinck Sebastiaan Engelborghs Rik Vandenberghe Mathieu Vandenbulcke Jan De Bleecker Anne Sieben Jan Versijpt Adrian Ivanoiu Olivier Deryck Christiana Willems Lubina Dillen Stéphanie Philtjens Githa Maes Veerle Bäumer Marleen Van Den Broeck Maria Mattheijssens Karin Peeters Jean-Jacques Martin Alex Michotte Patrick Santens Peter De Jonghe Patrick Cras Peter P De Deyn Marc Cruts Christine Van Broeckhoven

JAMA Neurol 2013 Mar;70(3):365-73

VIB–Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, University of Antwerp–CDE, Universiteitsplein 1, Antwerp, Belgium.

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http://dx.doi.org/10.1001/2013.jamaneurol.181DOI Listing
March 2013

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations.

Authors:
Kohji Mori Sven Lammich Ian R A Mackenzie Ignasi Forné Sonja Zilow Hans Kretzschmar Dieter Edbauer Jonathan Janssens Gernot Kleinberger Marc Cruts Jochen Herms Manuela Neumann Christine Van Broeckhoven Thomas Arzberger Christian Haass

Acta Neuropathol 2013 Mar 5;125(3):413-23. Epub 2013 Feb 5.

Adolf-Butenandt-Institute, Biochemistry, Ludwig-Maximilians-University, Schillerstr. 44, 80336, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-013-1088-7DOI Listing
March 2013

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

Authors:
Kohji Mori Shih-Ming Weng Thomas Arzberger Stephanie May Kristin Rentzsch Elisabeth Kremmer Bettina Schmid Hans A Kretzschmar Marc Cruts Christine Van Broeckhoven Christian Haass Dieter Edbauer

Science 2013 Mar 7;339(6125):1335-8. Epub 2013 Feb 7.

Adolf Butenandt-Institute, Biochemistry, Ludwig-Maximilians University (LMU) Munich, Munich, Germany.

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http://dx.doi.org/10.1126/science.1232927DOI Listing
March 2013

Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth.

Authors:
Bettina Schmid Alexander Hruscha Sebastian Hogl Julia Banzhaf-Strathmann Katrin Strecker Julie van der Zee Mathias Teucke Stefan Eimer Jan Hegermann Maike Kittelmann Elisabeth Kremmer Marc Cruts Barbara Solchenberger Laura Hasenkamp Frauke van Bebber Christine Van Broeckhoven Dieter Edbauer Stefan F Lichtenthaler Christian Haass

Proc Natl Acad Sci U S A 2013 Mar 1;110(13):4986-91. Epub 2013 Mar 1.

German Center for Neurodegenerative Diseases, 80336 Munich, Germany.

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http://dx.doi.org/10.1073/pnas.1218311110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612625PMC
March 2013

A pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeats.

Authors:
Julie van der Zee Ilse Gijselinck Lubina Dillen Tim Van Langenhove Jessie Theuns Sebastiaan Engelborghs Stéphanie Philtjens Mathieu Vandenbulcke Kristel Sleegers Anne Sieben Veerle Bäumer Githa Maes Ellen Corsmit Barbara Borroni Alessandro Padovani Silvana Archetti Robert Perneczky Janine Diehl-Schmid Alexandre de Mendonça Gabriel Miltenberger-Miltenyi Sónia Pereira José Pimentel Benedetta Nacmias Silvia Bagnoli Sandro Sorbi Caroline Graff Huei-Hsin Chiang Marie Westerlund Raquel Sanchez-Valle Albert Llado Ellen Gelpi Isabel Santana Maria Rosário Almeida Beatriz Santiago Giovanni Frisoni Orazio Zanetti Cristian Bonvicini Matthis Synofzik Walter Maetzler Jennifer Müller Vom Hagen Ludger Schöls Michael T Heneka Frank Jessen Radoslav Matej Eva Parobkova Gabor G Kovacs Thomas Ströbel Stayko Sarafov Ivailo Tournev Albena Jordanova Adrian Danek Thomas Arzberger Gian Maria Fabrizi Silvia Testi Eric Salmon Patrick Santens Jean-Jacques Martin Patrick Cras Rik Vandenberghe Peter Paul De Deyn Marc Cruts Christine Van Broeckhoven Julie van der Zee Ilse Gijselinck Lubina Dillen Tim Van Langenhove Jessie Theuns Stéphanie Philtjens Kristel Sleegers Veerle Bäumer Githa Maes Ellen Corsmit Marc Cruts Christine Van Broeckhoven Julie van der Zee Ilse Gijselinck Lubina Dillen Tim Van Langenhove Stéphanie Philtjens Jessie Theuns Kristel Sleegers Veerle Bäumer Githa Maes Marc Cruts Christine Van Broeckhoven Sebastiaan Engelborghs Peter P De Deyn Patrick Cras Sebastiaan Engelborghs Peter P De Deyn Mathieu Vandenbulcke Mathieu Vandenbulcke Barbara Borroni Alessandro Padovani Silvana Archetti Robert Perneczky Janine Diehl-Schmid Matthis Synofzik Walter Maetzler Jennifer Müller Vom Hagen Ludger Schöls Matthis Synofzik Walter Maetzler Jennifer Müller Vom Hagen Ludger Schöls Michael T Heneka Frank Jessen Alfredo Ramirez Delia Kurzwelly Carmen Sachtleben Wolfgang Mairer Alexandre de Mendonça Gabriel Miltenberger-Miltenyi Sónia Pereira Clara Firmo José Pimentel Raquel Sanchez-Valle Albert Llado Anna Antonell Jose Molinuevo Ellen Gelpi Caroline Graff Huei-Hsin Chiang Marie Westerlund Caroline Graff Anne Kinhult Ståhlbom Håkan Thonberg Inger Nennesmo Anne Börjesson-Hanson Benedetta Nacmias Silvia Bagnoli Sandro Sorbi Valentina Bessi Irene Piaceri Isabel Santana Beatriz Santiago Isabel Santana Maria Helena Ribeiro Maria Rosário Almeida Catarina Oliveira João Massano Carolina Garret Paula Pires Giovanni Frisoni Orazio Zanetti Cristian Bonvicini Stayko Sarafov Ivailo Tournev Albena Jordanova Ivailo Tournev Gabor G Kovacs Thomas Ströbel Michael T Heneka Frank Jessen Alfredo Ramirez Delia Kurzwelly Carmen Sachtleben Wolfgang Mairer Frank Jessen Radoslav Matej Eva Parobkova Adrian Danel Thomas Arzberger Gian Maria Fabrizi Silvia Testi Sergio Ferrari Tiziana Cavallaro Eric Salmon Patrick Santens Patrick Cras

Hum Mutat 2013 Feb 4;34(2):363-73. Epub 2013 Jan 4.

Department of Molecular Genetics, VIB, Antwerp, Belgium.

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http://dx.doi.org/10.1002/humu.22244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638346PMC
February 2013

Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism.

Authors:
Lili-Naz Hazrati Caroline Van Cauwenberghe Patricia L Brooks Nathalie Brouwers Mahdi Ghani Christine Sato Marc Cruts Kristel Sleegers Peter St George-Hyslop Christine Van Broeckhoven Ekaterina Rogaeva

Neurobiol Aging 2012 Dec 21;33(12):2949.e5-2949.e12. Epub 2012 Jul 21.

Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.07.001DOI Listing
December 2012

Locus-specific mutation databases for neurodegenerative brain diseases.

Authors:
Marc Cruts Jessie Theuns Christine Van Broeckhoven

Hum Mutat 2012 Sep 2;33(9):1340-4. Epub 2012 Jul 2.

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium.

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http://dx.doi.org/10.1002/humu.22117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465795PMC
September 2012

The genetics and neuropathology of frontotemporal lobar degeneration.

Authors:
Anne Sieben Tim Van Langenhove Sebastiaan Engelborghs Jean-Jacques Martin Paul Boon Patrick Cras Peter-Paul De Deyn Patrick Santens Christine Van Broeckhoven Marc Cruts

Acta Neuropathol 2012 Sep 14;124(3):353-72. Epub 2012 Aug 14.

Institute Born-Bunge, University of Antwerp, Antwerpen, Belgium.

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http://link.springer.com/10.1007/s00401-012-1029-x
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http://dx.doi.org/10.1007/s00401-012-1029-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422616PMC
September 2012

Ataxin-2 polyQ expansions in FTLD-ALS spectrum disorders in Flanders-Belgian cohorts.

Authors:
Tim Van Langenhove Julie van der Zee Sebastiaan Engelborghs Rik Vandenberghe Patrick Santens Marleen Van den Broeck Maria Mattheijssens Karin Peeters Dirk Nuytten Patrick Cras Peter P De Deyn Peter De Jonghe Marc Cruts Christine Van Broeckhoven

Neurobiol Aging 2012 May 27;33(5):1004.e17-20. Epub 2011 Oct 27.

Department of Molecular Genetics, VIB, Universiteitsplein 1, Antwerpen, Belgium.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.09.025DOI Listing
May 2012

A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study.

Authors:
Ilse Gijselinck Tim Van Langenhove Julie van der Zee Kristel Sleegers Stéphanie Philtjens Gernot Kleinberger Jonathan Janssens Karolien Bettens Caroline Van Cauwenberghe Sandra Pereson Sebastiaan Engelborghs Anne Sieben Peter De Jonghe Rik Vandenberghe Patrick Santens Jan De Bleecker Githa Maes Veerle Bäumer Lubina Dillen Geert Joris Ivy Cuijt Ellen Corsmit Ellen Elinck Jasper Van Dongen Steven Vermeulen Marleen Van den Broeck Carolien Vaerenberg Maria Mattheijssens Karin Peeters Wim Robberecht Patrick Cras Jean-Jacques Martin Peter P De Deyn Marc Cruts Christine Van Broeckhoven

Lancet Neurol 2012 Jan 7;11(1):54-65. Epub 2011 Dec 7.

Department of Molecular Genetics, VIB, Antwerp, Belgium.

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http://linkinghub.elsevier.com/retrieve/pii/S147444221170261
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http://dx.doi.org/10.1016/S1474-4422(11)70261-7DOI Listing
January 2012

Call for participation in the neurogenetics consortium within the Human Variome Project.

Authors:
Andrea Haworth Lars Bertram Paola Carrera Joanna L Elson Corey D Braastad Diane W Cox Marc Cruts Johann T den Dunnen Matthew J Farrer John K Fink Sherifa A Hamed Henry Houlden Dennis R Johnson Karen Nuytemans Francesc Palau Dipa L Raja Rayan Peter N Robinson Antonio Salas Birgitt Schüle Mary G Sweeney Michael O Woods Jorge Amigo Richard G H Cotton Maria-Jesus Sobrido

Neurogenetics 2011 Aug 1;12(3):169-73. Epub 2011 Jun 1.

Neurogenetics Unit, Department of Molecular Neurosciences, National Hospital of Neurology and Neurosurgery, Queen Square, London, UK.

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http://dx.doi.org/10.1007/s10048-011-0287-4DOI Listing
August 2011

Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration.

Authors:
Alice S Chen-Plotkin Maria Martinez-Lage Patrick M A Sleiman William Hu Robert Greene Elisabeth McCarty Wood Shaoxu Bing Murray Grossman Gerard D Schellenberg Kimmo J Hatanpaa Myron F Weiner Charles L White William S Brooks Glenda M Halliday Jillian J Kril Marla Gearing Thomas G Beach Neill R Graff-Radford Dennis W Dickson Rosa Rademakers Bradley F Boeve Stuart M Pickering-Brown Julie Snowden John C van Swieten Peter Heutink Harro Seelaar Jill R Murrell Bernardino Ghetti Salvatore Spina Jordan Grafman Jeffrey A Kaye Randall L Woltjer Marsel Mesulam Eileen Bigio Albert Lladó Bruce L Miller Ainhoa Alzualde Fermin Moreno Jonathan D Rohrer Ian R A Mackenzie Howard H Feldman Ronald L Hamilton Marc Cruts Sebastiaan Engelborghs Peter P De Deyn Christine Van Broeckhoven Thomas D Bird Nigel J Cairns Allison Goate Matthew P Frosch Peter F Riederer Nenad Bogdanovic Virginia M Y Lee John Q Trojanowski Vivianna M Van Deerlin

Arch Neurol 2011 Apr;68(4):488-97

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1001/archneurol.2011.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160280PMC
April 2011

TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort.

Authors:
Julie van der Zee Tim Van Langenhove Gernot Kleinberger Kristel Sleegers Sebastiaan Engelborghs Rik Vandenberghe Patrick Santens Marleen Van den Broeck Geert Joris Jolien Brys Maria Mattheijssens Karin Peeters Patrick Cras Peter P De Deyn Marc Cruts Christine Van Broeckhoven

Brain 2011 Mar;134(Pt 3):808-15

Neurodegenerative Brain Disease Group, VIB Department of Molecular Genetics, University of Antwerp-CDE, Universiteitsplein 1, 2610 Antwerpen, Belgium.

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http://dx.doi.org/10.1093/brain/awr007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044834PMC
March 2011

Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.

Authors:
Anja Capell Sabine Liebscher Katrin Fellerer Nathalie Brouwers Michael Willem Sven Lammich Ilse Gijselinck Tobias Bittner Aaron M Carlson Florenz Sasse Brigitte Kunze Heinrich Steinmetz Rolf Jansen Dorothee Dormann Kristel Sleegers Marc Cruts Jochen Herms Christine Van Broeckhoven Christian Haass

J Neurosci 2011 Feb;31(5):1885-94

German Center for Neurodegenerative Diseases, Ludwig Maximilians University, 80336 Munich, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.5757-10.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6623716PMC
February 2011

Molecular pathways of frontotemporal lobar degeneration.

Authors:
Kristel Sleegers Marc Cruts Christine Van Broeckhoven

Annu Rev Neurosci 2010 ;33:71-88

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Universiteitsplein 1, B-2610 Antwerpen, Belgium.

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http://www.annualreviews.org/doi/10.1146/annurev-neuro-06090
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http://dx.doi.org/10.1146/annurev-neuro-060909-153144DOI Listing
January 2011

Contribution of TARDBP to Alzheimer's disease genetic etiology.

Authors:
Nathalie Brouwers Karolien Bettens Ilse Gijselinck Sebastiaan Engelborghs Barbara A Pickut Helen Van Miegroet Ana Gil Montoya Maria Mattheijssens Karin Peeters Peter P De Deyn Marc Cruts Kristel Sleegers Christine Van Broeckhoven

J Alzheimers Dis 2010 ;21(2):423-30

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium.

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http://dx.doi.org/10.3233/JAD-2010-100198DOI Listing
December 2010

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update.

Authors:
Karen Nuytemans Jessie Theuns Marc Cruts Christine Van Broeckhoven

Hum Mutat 2010 Jul;31(7):763-80

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium.

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http://doi.wiley.com/10.1002/humu.21277
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http://dx.doi.org/10.1002/humu.21277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056147PMC
July 2010

Identification of 2 Loci at chromosomes 9 and 14 in a multiplex family with frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Authors:
Ilse Gijselinck Sebastiaan Engelborghs Githa Maes Ivy Cuijt Karin Peeters Maria Mattheijssens Geert Joris Patrick Cras Jean-Jacques Martin Peter P De Deyn Samir Kumar-Singh Christine Van Broeckhoven Marc Cruts

Arch Neurol 2010 May;67(5):606-16

University of Antwerp, B-2610 Antwerp, Belgium.

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http://dx.doi.org/10.1001/archneurol.2010.82DOI Listing
May 2010

The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects.

Authors:
Kristel Sleegers Jean-Charles Lambert Lars Bertram Marc Cruts Philippe Amouyel Christine Van Broeckhoven

Trends Genet 2010 Feb 18;26(2):84-93. Epub 2010 Jan 18.

Neurodegenerative Brain Diseases Group, VIB-Department of Molecular Genetics; Universiteitsplein 1, B-2610 Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.tig.2009.12.004DOI Listing
February 2010

Novel PSEN1 mutation in a Bulgarian patient with very early-onset Alzheimer's disease, spastic paraparesis, and extrapyramidal signs.

Authors:
Latchezar Dintchov Traykov Shima Mehrabian Marleen Van den Broeck Margarita Radoslavova Raycheva Marc Cruts Albena Kirilova Jordanova Christine Van Broeckhoven

Am J Alzheimers Dis Other Demen 2009 Oct-Nov;24(5):404-7

Department of Neurology, Medical University, Sofia, Bulgaria.

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http://dx.doi.org/10.1177/1533317509341464DOI Listing
January 2010

Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS.

Authors:
Ilse Gijselinck Kristel Sleegers Sebastiaan Engelborghs Wim Robberecht Jean-Jacques Martin Rik Vandenberghe Raf Sciot Bart Dermaut Dirk Goossens Julie van der Zee Tim De Pooter Jurgen Del-Favero Patrick Santens Peter De Jonghe Peter P De Deyn Christine Van Broeckhoven Marc Cruts

Neurobiol Aging 2009 Aug 10;30(8):1329-31. Epub 2008 Jan 10.

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Belgium.

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http://dx.doi.org/10.1016/j.neurobiolaging.2007.11.002DOI Listing
August 2009

Serum biomarker for progranulin-associated frontotemporal lobar degeneration.

Authors:
Kristel Sleegers Nathalie Brouwers Philip Van Damme Sebastiaan Engelborghs Ilse Gijselinck Julie van der Zee Karin Peeters Maria Mattheijssens Marc Cruts Rik Vandenberghe Peter P De Deyn Wim Robberecht Christine Van Broeckhoven

Ann Neurol 2009 May;65(5):603-9

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB (Flanders Institute for Biotechnology), University of Antwerp, Universiteitsplein 1, Antwerp, Belgium.

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http://dx.doi.org/10.1002/ana.21621DOI Listing
May 2009

Molecular pathogenesis of frontotemporal lobar degeneration: basic science seminar in neurology.

Authors:
Kristel Sleegers Samir Kumar-Singh Marc Cruts Christine Van Broeckhoven

Arch Neurol 2008 Jun;65(6):700-4

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Institute for Biotechnology, Flanders, and Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1001/archneur.65.6.700DOI Listing
June 2008

Loss of progranulin function in frontotemporal lobar degeneration.

Authors:
Marc Cruts Christine Van Broeckhoven

Trends Genet 2008 Apr 6;24(4):186-94. Epub 2008 Mar 6.

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.tig.2008.01.004DOI Listing
April 2008

Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21.

Authors:
Robert Lyle Paola Prandini Kazutoyo Osoegawa Boudewijn ten Hallers Sean Humphray Baoli Zhu Eduardo Eyras Robert Castelo Christine P Bird Sarantos Gagos Carol Scott Antony Cox Samuel Deutsch Catherine Ucla Marc Cruts Sophie Dahoun Xinwei She Frederique Bena Sheng-Yue Wang Christine Van Broeckhoven Evan E Eichler Roderic Guigo Jane Rogers Pieter J de Jong Alexandre Reymond Stylianos E Antonarakis

Genome Res 2007 Nov 25;17(11):1690-6. Epub 2007 Sep 25.

Department of Genetic Medicine and Development, University of Geneva Medical School, and University Hospitals, 1211 Geneva, Switzerland.

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http://dx.doi.org/10.1101/gr.6675307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2045151PMC
November 2007

Frontotemporal lobar degeneration with ubiquitin-positive inclusions: a molecular genetic update.

Authors:
Julie van der Zee Ilse Gijselinck Daniel Pirici Samir Kumar-Singh Marc Cruts Christine Van Broeckhoven

Neurodegener Dis 2007 ;4(2-3):227-35

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Laboratory of Neurogenetics, Institute Born-Bunge, and University of Antwerp, Antwerp, Belgium.

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http://biology4.wustl.edu/EEPB/eepb_papers/archive/2007/Muhk
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http://www.karger.com/doi/10.1159/000101847
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http://dx.doi.org/10.1159/000101847DOI Listing
October 2007

Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family.

Authors:
Nathalie Brouwers Karen Nuytemans Julie van der Zee Ilse Gijselinck Sebastiaan Engelborghs Jessie Theuns Samir Kumar-Singh Barbara A Pickut Philippe Pals Bart Dermaut Veerle Bogaerts Tim De Pooter Sally Serneels Marleen Van den Broeck Ivy Cuijt Maria Mattheijssens Karin Peeters Raf Sciot Jean-Jacques Martin Patrick Cras Patrick Santens Rik Vandenberghe Peter P De Deyn Marc Cruts Christine Van Broeckhoven Kristel Sleegers

Arch Neurol 2007 Oct;64(10):1436-46

VIB Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, University of Antwerp CDE, Universiteitsplein 1, BE-2610 Antwerpen, Belgium.

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http://dx.doi.org/10.1001/archneur.64.10.1436DOI Listing
October 2007

Progranulin null mutations in both sporadic and familial frontotemporal dementia.

Authors:
Isabelle Le Ber Julie van der Zee Didier Hannequin Ilse Gijselinck Dominique Campion Michèle Puel Annie Laquerrière Tim De Pooter Agnès Camuzat Marleen Van den Broeck Bruno Dubois François Sellal Lucette Lacomblez Martine Vercelletto Catherine Thomas-Antérion Bernard-François Michel Véronique Golfier Mira Didic François Salachas Charles Duyckaerts Marc Cruts Patrice Verpillat Christine Van Broeckhoven Alexis Brice

Hum Mutat 2007 Sep;28(9):846-55

INSERM, UMR679, Paris, France.

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http://dx.doi.org/10.1002/humu.20520DOI Listing
September 2007

Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.

Authors:
Julie van der Zee Isabelle Le Ber Sebastian Maurer-Stroh Sebastiaan Engelborghs Ilse Gijselinck Agnès Camuzat Nathalie Brouwers Rik Vandenberghe Kristel Sleegers Didier Hannequin Bart Dermaut Joost Schymkowitz Dominique Campion Patrick Santens Jean-Jacques Martin Lucette Lacomblez Tim De Pooter Karin Peeters Maria Mattheijssens Martine Vercelletto Marleen Van den Broeck Marc Cruts Peter P De Deyn Frederic Rousseau Alexis Brice Christine Van Broeckhoven

Hum Mutat 2007 Apr;28(4):416

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium.

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http://dx.doi.org/10.1002/humu.9484DOI Listing
April 2007

Cholesterol and triglycerides moderate the effect of apolipoprotein E on memory functioning in older adults.

Authors:
Cindy M de Frias David Bunce Ake Wahlin Rolf Adolfsson Kristel Sleegers Marc Cruts Christine Van Broeckhoven Lars-Göran Nilsson

J Gerontol B Psychol Sci Soc Sci 2007 Mar;62(2):P112-8

Department of Psychology, Stockholm University, Sweden.

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http://dx.doi.org/10.1093/geronb/62.2.p112DOI Listing
March 2007

Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.

Authors:
Marc Cruts Samir Kumar-Singh Christine Van Broeckhoven

Curr Alzheimer Res 2006 Dec;3(5):485-91

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium.

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http://dx.doi.org/10.2174/156720506779025251DOI Listing
December 2006

APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy.

Authors:
Kristel Sleegers Nathalie Brouwers Ilse Gijselinck Jessie Theuns Dirk Goossens Jan Wauters Jurgen Del-Favero Marc Cruts Cornelia M van Duijn Christine Van Broeckhoven

Brain 2006 Nov 18;129(Pt 11):2977-83. Epub 2006 Aug 18.

Neurodegenerative Brain Diseases Group Antwerp, Belgium.

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http://dx.doi.org/10.1093/brain/awl203DOI Listing
November 2006

The influence of APOE status on episodic and semantic memory: data from a population-based study.

Authors:
Lars-Göran Nilsson Rolf Adolfsson Lars Bäckman Marc Cruts Lars Nyberg Brent J Small Christine Van Broeckoven

Neuropsychology 2006 Nov;20(6):645-57

Department of Psychology, Stockholm University, Stockholm, Sweden.

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http://dx.doi.org/10.1037/0894-4105.20.6.645DOI Listing
November 2006

Visualization of MAPT inversion on stretched chromosomes of tau-negative frontotemporal dementia patients.

Authors:
Ilse Gijselinck Veerle Bogaerts Rosa Rademakers Julie van der Zee Christine Van Broeckhoven Marc Cruts

Hum Mutat 2006 Oct;27(10):1057-9

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http://dx.doi.org/10.1002/humu.20391DOI Listing
October 2006

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.

Authors:
Marc Cruts Ilse Gijselinck Julie van der Zee Sebastiaan Engelborghs Hans Wils Daniel Pirici Rosa Rademakers Rik Vandenberghe Bart Dermaut Jean-Jacques Martin Cornelia van Duijn Karin Peeters Raf Sciot Patrick Santens Tim De Pooter Maria Mattheijssens Marleen Van den Broeck Ivy Cuijt Krist'l Vennekens Peter P De Deyn Samir Kumar-Singh Christine Van Broeckhoven

Nature 2006 Aug 16;442(7105):920-4. Epub 2006 Jul 16.

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Universiteitsplein 1, BE-2610 Antwerpen, Belgium.

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http://dx.doi.org/10.1038/nature05017DOI Listing
August 2006

Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.

Authors:
Samir Kumar-Singh Jessie Theuns Bianca Van Broeck Daniel Pirici Krist'l Vennekens Ellen Corsmit Marc Cruts Bart Dermaut Rong Wang Christine Van Broeckhoven

Hum Mutat 2006 Jul;27(7):686-95

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology, University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.1002/humu.20336DOI Listing
July 2006

Reduced functional brain activity response in cognitively intact apolipoprotein E epsilon4 carriers.

Authors:
Johanna Lind Jonas Persson Martin Ingvar Anne Larsson Marc Cruts Christine Van Broeckhoven Rolf Adolfsson Lars Bäckman Lars-Göran Nilsson Karl Magnus Petersson Lars Nyberg

Brain 2006 May 14;129(Pt 5):1240-8. Epub 2006 Mar 14.

Department of Clinical Neuroscience, MR Research Center, Karolinska Hospital N-8, Stockholm, Sweden.

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http://brain.oxfordjournals.org/content/brain/129/5/1240.ful
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http://dx.doi.org/10.1093/brain/awl054DOI Listing
May 2006

A Belgian ancestral haplotype harbours a highly prevalent mutation for 17q21-linked tau-negative FTLD.

Authors:
Julie van der Zee Rosa Rademakers Sebastiaan Engelborghs Ilse Gijselinck Veerle Bogaerts Rik Vandenberghe Patrick Santens Jo Caekebeke Tim De Pooter Karin Peeters Ursula Lübke Marleen Van den Broeck Jean-Jacques Martin Marc Cruts Peter P De Deyn Christine Van Broeckhoven Bart Dermaut

Brain 2006 Apr 22;129(Pt 4):841-52. Epub 2006 Feb 22.

Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.1093/brain/awl029DOI Listing
April 2006

Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memory.

Authors:
Johanna Lind Anne Larsson Jonas Persson Martin Ingvar Lars-Göran Nilsson Lars Bäckman Rolf Adolfsson Marc Cruts Kristel Sleegers Christine Van Broeckhoven Lars Nyberg

Neurosci Lett 2006 Mar 6;396(1):23-7. Epub 2006 Jan 6.

Department of Clinical Neuroscience, MR Research Center, Karolinska Hospital N-8, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neulet.2005.11.070DOI Listing
March 2006

Characterization of ubiquitinated intraneuronal inclusions in a novel Belgian frontotemporal lobar degeneration family.

Authors:
Daniel Pirici Rik Vandenberghe Rosa Rademakers Bart Dermaut Marc Cruts Krist'l Vennekens Ivy Cuijt Ursula Lübke Chantal Ceuterick Jean-Jacques Martin Christine Van Broeckhoven Samir Kumar-Singh

J Neuropathol Exp Neurol 2006 Mar;65(3):289-301

Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB8), Institute Born-Bunge, University of Antwerp, Belgium.

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http://dx.doi.org/10.1097/01.jnen.0000205147.39210.c7DOI Listing
March 2006

Dose dependent effect of APOE epsilon4 on behavioral symptoms in frontal lobe dementia.

Authors:
Sebastiaan Engelborghs Bart Dermaut Peter Mariën Anoek Symons Ellen Vloeberghs Karen Maertens Nore Somers Johan Goeman Rosa Rademakers Marleen Van den Broeck Barbara Pickut Marc Cruts Christine Van Broeckhoven Peter P De Deyn

Neurobiol Aging 2006 Feb;27(2):285-92

Department of Neurology and Memory Clinic, Middelheim General Hospital, ZNA, Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.neurobiolaging.2005.02.005DOI Listing
February 2006

Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum.

Authors:
Bart Dermaut Samir Kumar-Singh Rosa Rademakers Jessie Theuns Marc Cruts Christine Van Broeckhoven

Trends Genet 2005 Dec 10;21(12):664-72. Epub 2005 Oct 10.

Department of Molecular Genetics (VIB 8), Flanders Interuniversity Institute for Biotechnology, Neurodegenerative Brain Diseases Group, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B-2610 Antwerpen, Belgium.

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http://dx.doi.org/10.1016/j.tig.2005.09.005DOI Listing
December 2005

High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy.

Authors:
Rosa Rademakers Stacey Melquist Marc Cruts Jessie Theuns Jurgen Del-Favero Parvoneh Poorkaj Matt Baker Kristel Sleegers Richard Crook Tim De Pooter Samira Bel Kacem Jennifer Adamson Dirk Van den Bossche Marleen Van den Broeck Jennifer Gass Ellen Corsmit Peter De Rijk Natalie Thomas Sebastiaan Engelborghs Michael Heckman Irene Litvan Julia Crook Peter P De Deyn Dennis Dickson Gerard D Schellenberg Christine Van Broeckhoven Michael L Hutton

Hum Mol Genet 2005 Nov 29;14(21):3281-92. Epub 2005 Sep 29.

Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Belgium.

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http://dx.doi.org/10.1093/hmg/ddi361DOI Listing
November 2005

Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample.

Authors:
Rosa Rademakers Marc Cruts Kristel Sleegers Bart Dermaut Jessie Theuns Yurii Aulchenko Stefan Weckx Tim De Pooter Marleen Van den Broeck Ellen Corsmit Peter De Rijk Jurgen Del-Favero John van Swieten Cornelia M van Duijn Christine Van Broeckhoven

Am J Hum Genet 2005 Oct 30;77(4):643-52. Epub 2005 Aug 30.

Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerp, Belgium.

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http://dx.doi.org/10.1086/491749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1275613PMC
October 2005

Genomic architecture of human 17q21 linked to frontotemporal dementia uncovers a highly homologous family of low-copy repeats in the tau region.

Authors:
Marc Cruts Rosa Rademakers Ilse Gijselinck Julie van der Zee Bart Dermaut Tim de Pooter Peter de Rijk Jurgen Del-Favero Christine van Broeckhoven

Hum Mol Genet 2005 Jul 11;14(13):1753-62. Epub 2005 May 11.

Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium.

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http://hmg.oxfordjournals.org/content/14/13/1753.full.pdf
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http://www.hmg.oupjournals.org/cgi/doi/10.1093/hmg/ddi182
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http://dx.doi.org/10.1093/hmg/ddi182DOI Listing
July 2005

novoSNP, a novel computational tool for sequence variation discovery.

Authors:
Stefan Weckx Jurgen Del-Favero Rosa Rademakers Lieve Claes Marc Cruts Peter De Jonghe Christine Van Broeckhoven Peter De Rijk

Genome Res 2005 Mar;15(3):436-42

Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.1101/gr.2754005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC551570PMC
March 2005

Genetic testing has no place as a routine diagnostic test in sporadic and familial cases of Alzheimer's disease.

Authors:
Tischa J M van der Cammen Esther A Croes Bart Dermaut Marie-Claire de Jager Marc Cruts Christine Van Broeckhoven Cornelia M van Duijn

J Am Geriatr Soc 2004 Dec;52(12):2110-3

Memory Clinic, Section of Geriatric Medicine, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1111/j.1532-5415.2004.52573.xDOI Listing
December 2004

A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques.

Authors:
Bart Dermaut Samir Kumar-Singh Sebastian Engelborghs Jessie Theuns Rosa Rademakers Jos Saerens Barbara A Pickut Karin Peeters Marleen van den Broeck Krist'l Vennekens Stephen Claes Marc Cruts Patrick Cras Jean-Jacques Martin Christine Van Broeckhoven Peter Paul De Deyn

Ann Neurol 2004 May;55(5):617-26

Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology (VIB8), University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.1002/ana.20083DOI Listing
May 2004

Novel APP mutation V715A associated with presenile Alzheimer's disease in a German family.

Authors:
Marc Cruts Bart Dermaut Rosa Rademakers Marleen Van den Broeck Florian Stögbauer Christine Van Broeckhoven

J Neurol 2003 Nov;250(11):1374-5

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http://dx.doi.org/10.1007/s00415-003-0182-5DOI Listing
November 2003

Early cognitive decline is associated with prion protein codon 129 polymorphism.

Authors:
Esther A Croes Bart Dermaut Jeanine J Houwing-Duistermaat Marleen Van den Broeck Marc Cruts Monique M B Breteler Albert Hofman Christine van Broeckhoven Cornelia M van Duijn

Ann Neurol 2003 Aug;54(2):275-6

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http://dx.doi.org/10.1002/ana.10658DOI Listing
August 2003

Genetics of early-onset Alzheimer dementia.

Authors:
Rosa Rademakers Marc Cruts Christine Van Broeckhoven

ScientificWorldJournal 2003 Jun 16;3:497-519. Epub 2003 Jun 16.

Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.1100/tsw.2003.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974891PMC
June 2003

Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression.

Authors:
Jessie Theuns Jacques Remacle Richard Killick Ellen Corsmit Krist'l Vennekens Danny Huylebroeck Marc Cruts Christine Van Broeckhoven

Hum Mol Genet 2003 Apr;12(8):869-77

Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.

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http://dx.doi.org/10.1093/hmg/ddg098DOI Listing
April 2003

PRNP Val129 homozygosity increases risk for early-onset Alzheimer's disease.

Authors:
Bart Dermaut Esther A Croes Rosa Rademakers Marleen Van den Broeck Marc Cruts Albert Hofman Cornelia M van Duijn Christine Van Broeckhoven

Ann Neurol 2003 Mar;53(3):409-12

Department of Molecular Genetics, Flanders Interuniversity Institute of Biotechnology (VIB8), University of Antwerp, Antwerpen, Belgium.

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http://dx.doi.org/10.1002/ana.10507DOI Listing
March 2003

The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample.

Authors:
Bart Dermaut Jessie Theuns Kristel Sleegers Hiroshi Hasegawa Marleen Van den Broeck Krist'l Vennekens Ellen Corsmit Peter St George-Hyslop Marc Cruts Cornelia M van Duijn Christine Van Broeckhoven

Am J Hum Genet 2002 Jun 24;70(6):1568-74. Epub 2002 Apr 24.

Department of Molecular Genetics, University of Antwerp, Universiteitsplein 1, B-2610 Antwerpen, Belgium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC379144PMC
http://dx.doi.org/10.1086/340732DOI Listing
June 2002

Diagnostic accuracy of the Preclinical AD Scale (PAS) in cognitively mildly impaired subjects.

Authors:
Pieter Jelle Visser Frans R J Verhey Philip Scheltens Marc Cruts Rudolf W H M Ponds Christine L Van Broeckhoven Jellemer Jolles

J Neurol 2002 Mar;249(3):312-9

Department of Psychiatry and Neuropsychology, Institute of Brain and Behaviour, University of Maastricht, The Netherlands.

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http://dx.doi.org/10.1007/s004150200011DOI Listing
March 2002