Marc Chimowitz

Marc Chimowitz

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Marc Chimowitz

Marc Chimowitz

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Effects of Spaceflight on Astronaut Brain Structure as Indicated on MRI.

N Engl J Med 2017 11;377(18):1746-1753

From the Department of Radiology and Radiological Science, Division of Neuroradiology (D.R.R., M.H.A., H.R.C., D.A., A.R.C., M.V.S., M.U.A.), and the Department of Neurology (M.I.C.), Medical University of South Carolina, Charleston; the Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany (M.H.A.); and the Department of Psychology, Normal College, Shihezi University, Xinjiang, China (X.Z.).

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http://www.nejm.org/doi/10.1056/NEJMoa1705129
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http://dx.doi.org/10.1056/NEJMoa1705129DOI Listing
November 2017

Angioplasty, Stenting and Other Potential Treatments of Atherosclerotic Stenosis of the Intracranial Arteries: Past, Present and Future.

J Stroke 2017 Sep 29;19(3):271-276. Epub 2017 Sep 29.

Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.5853/jos.2017.01837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647644PMC
September 2017

Nonprocedural Symptomatic Infarction and In-Stent Restenosis After Intracranial Angioplasty and Stenting in the SAMMPRIS Trial (Stenting and Aggressive Medical Management for the Prevention of Recurrent Stroke in Intracranial Stenosis).

Stroke 2017 06 28;48(6):1501-1506. Epub 2017 Apr 28.

From the Departments of Radiology, Neurology, and Neurosurgery, University of Iowa Hospitals and Clinics (C.P.D.); Department of Neurosurgery, State University of New York, Stony Brook (D.F.); Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA (M.J.L., G.A.C., B.F.L., J.M.); Department of Neurology, Medical University of South Carolina, Charleston (T.N.T., M.I.C.); and National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD (L.S.J.).

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http://dx.doi.org/10.1161/STROKEAHA.116.014537DOI Listing
June 2017

Angioplasty and Stenting.

Front Neurol Neurosci 2016 2;40:152-163. Epub 2016 Dec 2.

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http://dx.doi.org/10.1159/000448311DOI Listing
March 2017

Postprandial Clearance of Oxidized Low-Density Lipoprotein in Patients with Stroke Due to Atherosclerosis.

J Stroke Cerebrovasc Dis 2017 Mar 6;26(3):488-493. Epub 2017 Jan 6.

Department of Neurology, Medical University of South Carolina, Charleston, South Carolina.

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https://linkinghub.elsevier.com/retrieve/pii/S10523057163060
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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2016.12.006DOI Listing
March 2017

Stroke Caused by Atherosclerosis of the Major Intracranial Arteries.

Circ Res 2017 Feb;120(3):502-513

From the Department of Neurology, Stroke Division, Medical University of South Carolina, Charleston.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.308441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312775PMC
February 2017

Relationship between risk factor control and vascular events in the SAMMPRIS trial.

Neurology 2017 Jan 21;88(4):379-385. Epub 2016 Dec 21.

From Medical University of South Carolina (T.N.T., M.F.L.-V., K.L.H., J.H., M.I.C.), Charleston; Emory University (A.N., M.J.L., B.L., J.M.), Atlanta, GA; University of South Carolina School of Medicine (B.M.E.), Greenville; Atlanta VAMC (N.-A.L.), Decatur, GA; Washington University (C.P.D.), St. Louis, MI; State University of New York at Stony Brook (D.F.); and National Institute of Neurological Disorders and Stroke (L.S.J.), Bethesda, MD.

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http://dx.doi.org/10.1212/WNL.0000000000003534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5272964PMC
January 2017

The urgent need for contemporary clinical trials in patients with asymptomatic carotid stenosis.

Neurology 2016 Nov 28;87(21):2271-2278. Epub 2016 Sep 28.

From the University of Miami Miller School of Medicine (S.C.), FL; Medical University of South Carolina (M.C.), Charleston; Mayo Clinic (R.D.B.), Rochester, MN; University of Maryland School of Medicine (B.K.L.), Baltimore; and Mayo Clinic (J.F.M.), Jacksonville, FL.

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http://dx.doi.org/10.1212/WNL.0000000000003267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123552PMC
November 2016

Assessing type I error and power of multistate Markov models for panel data-A simulation study.

Commun Stat Simul Comput 2017 23;46(9):7040-7061. Epub 2016 Sep 23.

Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC.

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http://dx.doi.org/10.1080/03610918.2016.1222425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722228PMC
September 2016

Rationale for ischemic conditioning to prevent stroke in patients with intracranial arterial stenosis.

Brain Circ 2016 Apr-Jun;2(2):67-71. Epub 2016 Jul 13.

Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.4103/2394-8108.186260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126250PMC
July 2016

Response from the SAMMPRIS trial principal investigators regarding inaccuracies in this editorial.

J Neurointerv Surg 2016 Jun 5;8(e1):e5-6. Epub 2012 Sep 5.

Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA.

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http://dx.doi.org/10.1136/neurintsurg-2012-010496DOI Listing
June 2016

Enrollment volume effect on risk factor control and outcomes in the SAMMPRIS trial.

Neurology 2015 Dec 11;85(24):2090-7. Epub 2015 Nov 11.

From Houston Methodist Hospital (D.C., R.P.K., C.D.M., L.B.K.), Weill Cornell Medical College, TX; Medical University of South Carolina (T.N.T., M.I.C.), Charleston; Emory University Rollins School of Public Health (M.J.L., A.N., B.F.L., J.M.), Atlanta, GA; Washington University School of Medicine (C.P.D.), St Louis, MO; State University of New York (D.F.), Stony Brook; and National Institute of Neurological Disorders and Stroke (S.J.), National Institute of Health, Bethesda, MD.

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http://dx.doi.org/10.1212/WNL.0000000000002191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691681PMC
December 2015

Characterization of intracranial atherosclerotic stenosis using high-resolution MRI study--rationale and design.

Brain Behav 2015 Dec 25;5(12):e00397. Epub 2015 Sep 25.

Department of Radiology and Radiological Sciences Medical University of South Carolina Charleston South Carolina.

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http://dx.doi.org/10.1002/brb3.397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714642PMC
December 2015

Does the Stenting Versus Aggressive Medical Therapy Trial Support Stenting for Subgroups With Intracranial Stenosis?

Stroke 2015 Nov 17;46(11):3282-4. Epub 2015 Sep 17.

From the Department of Neurology, Oregon Health and Science University, Portland (H.L.L.); Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA (M.J.L., G.A.C., B.F.L., J.M.); Department of Radiology, Washington University School of Medicine, St. Louis, MO (C.P.D.); Department of Neurology, Medical University of South Carolina, Charleston (T.N.T., M.I.C.); Department of Neurological Surgery, State University of New York, Old Westbury (D.F.); and National Institutes of Health, Bethesda, MD (L.S.J.).

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http://dx.doi.org/10.1161/STROKEAHA.115.009846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624506PMC
November 2015

Do Patient Characteristics Explain the Differences in Outcome Between Medically Treated Patients in SAMMPRIS and WASID?

Stroke 2015 Sep 6;46(9):2562-7. Epub 2015 Aug 6.

From the Department of Neurology, University of Miami, Miami, FL (S.C.); Department of Neurosciences, Medical University of South Carolina, Charleston, SC (T.N.T., M.I.C.); Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA (M.J.L.); Mallinckrodt Institute of Radiology and the Departments of Neurology and Neurosurgery, Washington University School of Medicine, St Louis MO (C.P.D.); Department of Neurosurgery, State University of New York, Stony Brook, NY (D.F.); and National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, MD (L.S.J.).

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http://dx.doi.org/10.1161/STROKEAHA.115.009656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4550543PMC
September 2015

Yet again no benefit of stenting over medical therapy.

Lancet Neurol 2015 Jun 20;14(6):565-6. Epub 2015 Apr 20.

Department of Neurology, Medical University of South Carolina Stroke Program, 19 Hagood Ave, Suite 501, Charleston, SC 29425, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(15)00049-6DOI Listing
June 2015

Endovascular therapy for atherosclerotic intracranial arterial stenosis: back to the drawing board.

JAMA 2015 Mar 24-31;313(12):1219-20

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri3Department of Neurology, Washington University School of Medicine, St Louis, Missouri4Department of Neurological Surgery, Washington University School of Med.

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http://dx.doi.org/10.1001/jama.2015.1276DOI Listing
April 2015

Outcome in patients previously on antithrombotic therapy in the SAMMPRIS trial: subgroup analysis.

Stroke 2015 Mar 15;46(3):775-9. Epub 2015 Jan 15.

From the Department of Neurology (H.L.L., D.T.L.), and Department of Neurological Surgery and Dotter Interventional Institute (S.L.B.), Oregon Health and Science University, Portland; Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA (M.J.L., M.H.); Department of Neurology, Medical University of South Carolina, Charleston (T.N.T., M.I.C.); Department of Radiology, Washington University School of Medicine, St. Louis, MO (C.P.D.); Department of Neurological Surgery, State University of New York, Stony Brook, NY (D.F.); and National Institutes of Health, Bethesda, MD (L.S.J.).

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http://dx.doi.org/10.1161/STROKEAHA.114.007752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342339PMC
March 2015

Racial/Ethnic differences in poststroke rehabilitation outcomes.

Stroke Res Treat 2014 15;2014:950746. Epub 2014 Jun 15.

Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1155/2014/950746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084586PMC
July 2014

Game changer for endovascular treatment of acute ischemic stroke?

Authors:
Marc I Chimowitz

J Neurointerv Surg 2014 May 12;6(4):252-3. Epub 2014 Mar 12.

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http://jnis.bmj.com/lookup/doi/10.1136/neurintsurg-2014-0111
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http://dx.doi.org/10.1136/neurintsurg-2014-011187DOI Listing
May 2014

Is calcification of intracranial arteries important and how?

JAMA Neurol 2014 Apr;71(4):401-2

Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

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http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaneurol.2013.6224DOI Listing
April 2014

In reply: Is there a contribution of anesthesia to the outcome of the SAMMPRIS trial?

Neurosurgery 2014 Feb;74(2):E235-6

St. Louis, Missouri Stony Brook, New York Charleston, South Carolina.

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http://dx.doi.org/10.1227/NEU.0000000000000227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905970PMC
February 2014

The challenge of stroke prevention with intracranial arterial stenosis.

Curr Cardiol Rep 2013 Dec;15(12):422

MUSC Stroke Program, Suite 501, Harborview Office Tower, 19 Hagood Ave, Charleston, SC, 29425, USA,

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http://dx.doi.org/10.1007/s11886-013-0422-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870590PMC
December 2013

Impact of operator and site experience on outcomes after angioplasty and stenting in the SAMMPRIS trial.

J Neurointerv Surg 2013 Nov 12;5(6):528-33. Epub 2012 Sep 12.

Mallinckrodt Institute of Radiology and the Departments of Neurology and Neurosurgery, Washington University School of Medicine, St Louis, Missouri, USA.

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http://jnis.bmj.com/lookup/doi/10.1136/neurintsurg-2012-0105
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http://dx.doi.org/10.1136/neurintsurg-2012-010504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652908PMC
November 2013

Atherosclerotic intracranial arterial stenosis: risk factors, diagnosis, and treatment.

Lancet Neurol 2013 Nov;12(11):1106-14

Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(13)70195-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005874PMC
November 2013

The Feinberg Award Lecture 2013: treatment of intracranial atherosclerosis: learning from the past and planning for the future.

Authors:
Marc I Chimowitz

Stroke 2013 Sep 2;44(9):2664-9. Epub 2013 Jul 2.

Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1161/STROKEAHA.113.001290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816508PMC
September 2013

Intracranial stenting: SAMMPRIS.

Stroke 2013 Jun;44(6 Suppl 1):S41-4

Mallinckrodt Institute of Radiology and the Departments of Neurology and Neurosurgery, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO, USA.

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http://dx.doi.org/10.1161/STROKEAHA.111.000370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812951PMC
June 2013

Mechanisms of stroke after intracranial angioplasty and stenting in the SAMMPRIS trial.

Neurosurgery 2013 May;72(5):777-95; discussion 795

Mallinckrodt Institute of Radiology, Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA.

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http://dx.doi.org/10.1227/NEU.0b013e318286fdc8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696348PMC
May 2013

Endovascular treatment for acute ischemic stroke--still unproven.

Authors:
Marc I Chimowitz

N Engl J Med 2013 Mar 8;368(10):952-5. Epub 2013 Feb 8.

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http://dx.doi.org/10.1056/NEJMe1215730DOI Listing
March 2013

Risk of cerebral angiography in patients with symptomatic intracranial atherosclerotic stenosis.

Cerebrovasc Dis 2011 12;31(6):588-91. Epub 2011 Apr 12.

Departments of Radiology and Neurosurgery, Mayo Clinic, Rochester, MN 55901, USA.

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https://www.karger.com/Article/FullText/324951
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http://dx.doi.org/10.1159/000324951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085522PMC
September 2011

Collateral circulation in symptomatic intracranial atherosclerosis.

J Cereb Blood Flow Metab 2011 May 15;31(5):1293-301. Epub 2010 Dec 15.

Department of Neurology, UCLA Stroke Center, University of California-Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1038/jcbfm.2010.224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099635PMC
May 2011

E-pearl: brachial artery embolus mimicking acute stroke.

Neurology 2011 May;76(18):e86-7

Harborview Office Tower, 19 Hagwood Ave., MSC 805, Medical University of South Carolina, Charleston, SC 29464, USA.

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http://dx.doi.org/10.1212/WNL.0b013e3182190cc0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269769PMC
May 2011

Intraplaque hemorrhage in symptomatic intracranial atherosclerotic disease.

J Neuroimaging 2011 Apr;21(2):e159-61

Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1111/j.1552-6569.2009.00442.xDOI Listing
April 2011

10 questions about intracranial atherosclerotic stenosis.

Neurologist 2010 Nov;16(6):400-5

Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1097/NRL.0b013e3181e52b8cDOI Listing
November 2010

Treatment of atherosclerotic intracranial arterial stenosis.

Stroke 2009 Jun 30;40(6):2257-61. Epub 2009 Apr 30.

Stroke Program, Medical University of South Carolina, 19 Hagood Ave, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1161/STROKEAHA.108.537589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537264PMC
June 2009

Racial differences in vascular risk factors and outcomes of patients with intracranial atherosclerotic arterial stenosis.

Stroke 2009 Mar 2;40(3):719-25. Epub 2008 Oct 2.

Department of Neurology, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1161/STROKEAHA.108.526624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830073PMC
March 2009

Treatment of intracranial atherosclerotic stenosis.

Rev Neurol Dis 2008 ;5(3):117-24

Department of Neurosciences, Division of Neurology, Medical University of South Carolina, Charleston, SC, USA.

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January 2009

Use of dose modification schedules is effective for blinding trials of warfarin: evidence from the WASID study.

Clin Trials 2008 ;5(1):23-30

Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1177/1740774507087781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506390PMC
June 2008

Early stroke risk after transient ischemic attack among individuals with symptomatic intracranial artery stenosis.

Arch Neurol 2008 Jun;65(6):733-7

Stroke Center and Department of Neurology, UCLA Medical Center, University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1001/archneur.65.6.733DOI Listing
June 2008

Systemic risk factors associated with progression of atherosclerosis from the coronary to the carotid arteries.

J Stroke Cerebrovasc Dis 2005 Jul-Aug;14(4):182-5

Department of Stroke and Cerebrovascular Diseases, Emory University Hospital, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2005.05.002DOI Listing
April 2008

Leukocyte count and vascular risk in symptomatic intracranial atherosclerosis.

Cerebrovasc Dis 2007 17;24(2-3):283-8. Epub 2007 Jul 17.

Stroke Center and Department of Neurology, UCLA Medical Center, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1159/000105681DOI Listing
October 2007

Echocardiography in patients with symptomatic intracranial stenosis.

J Stroke Cerebrovasc Dis 2007 Sep-Oct;16(5):216-9

Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2007.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063439PMC
September 2007

Angioplasty and stenting for atherosclerotic intracranial stenosis: rationale for a randomized clinical trial.

Neuroimaging Clin N Am 2007 Aug;17(3):355-63, viii-ix

Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.nic.2007.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040119PMC
August 2007

Gender differences in outcomes among patients with symptomatic intracranial arterial stenosis.

Stroke 2007 Jul 31;38(7):2055-62. Epub 2007 May 31.

Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1161/STROKEAHA.107.482240DOI Listing
July 2007

A clinical example of the "limping brain" syndrome: a case report.

AJNR Am J Neuroradiol 2005 Jun-Jul;26(6):1521-4

Department of Neurology, Emory University Hospital, Atlanta, GA 30322, USA.

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December 2005

Antithrombotic therapy for atherosclerotic intracranial arterial stenosis.

Authors:
Marc I Chimowitz

Adv Neurol 2003 ;92:271-4

Department of Neurology, Emory University, Stroke Program, Emory University Hospital, Atlanta, Georgia, USA.

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June 2003

Cryptogenic stroke in relation to genetic variation in clotting factors and other genetic polymorphisms among young men and women.

Stroke 2002 Dec;33(12):2762-8

Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Ga, USA.

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http://stroke.ahajournals.org/content/33/12/2762.full.pdf
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http://dx.doi.org/10.1161/01.str.0000038094.79901.3bDOI Listing
December 2002